Sonogashira Coupling Reaction Mechanism
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- เผยแพร่เมื่อ 8 ก.พ. 2025
- This video looks at the proposed mechanism for the Sonogashira coupling reaction. This mechanism does not include arrow pushing; rather, it examines the factors that influence the formation of various hypothesized intermediates.
1 day till the exam and you have saved my life. Why I pay £9000 a year for lecturers to teach me is BEYONDDD ME because they DO NOT explain it like this.
Thank you! I am glad to hear that video was helpful :-)
Great content and a rock intro... uhhmm and why am I just learning about this channel?
Isn't it for the terminal alkyne that you've got a carbon carbon triple bond and than one of the carbon's of the alkyne is bound with an H group and the other one is bound with the R2 group? I see when you are doing the transmetalation step (2) you are not fully taking the alkyne thats bound to the copper. For my view you are transferring a C bound to an R2 with a triple bond with the metalation and idk why but didn't you forget an extra carbon at this step, because now the C of the triple bond is bound to an R2 group and not to a C. I hope it's understandable, but it brings confusion
She's back!
:-D
excellent way of teaching
Thank you :-)
Nice mam
its very important for chemist & students
Thank you!
Check out some of the work by McIndoe and Ahmadi on the Sonogashira mechanism - I think they go into some detail regarding the transmetallation step via MS analysis of the transient intermediates.
Great! Thank you for the info. I will take a look at that.
Wonderful as usual but please take a look on stile and buchwald hartwig coupling reaction
I definitely will - I hope to start recording later this month/early January.
Why the oxidative addition step leads to trans intermediate ?
Thanks you madam
gr8 .thanks
This is absolutely awesome!! Can you please explain Larock indole reaction? :)
Thank you so much !! :))
ma'am why the H2O molecule not attacking the positive charge on the carbon atom?
But why Iodide is specially better than other halides?, although if we are talking in terms of electron density on the adjacent carbon we will find that Chloride for example is better in activating the carbon for oxidative addition.
Hi mam thanks for your splendid explanation please suggest me a best book for couplin reaction
Madam, please explain the Asymmetric-Heck reaction with some example of reaction.
Sarah mam u r best
Thank you :-)
Isn't the electron negativity of Palladium 1.30?
There are different scales for electronegativity, so it would depend on the scale you were referencing. The number I am most familiar with is 2.2
This is real helpful for me. Thank you for your explain.~~ Love you~~ >_
Thank you! I'm happy to hear that the explanation was helpful! :-)
please, can I get the source of your information provided in this video?
The Sonogashira Reaction: A Booming Methodology in Synthetic Organic Chemistry†
Rafael Chinchilla* and Carmen Na´jera*
Departamento de Quı´mica Orga´ nica and Instituto de Sı´ntesis Orga´ nica (ISO), Universidad de Alicante, Facultad de Ciencias, Apartado 99, 03080 Alicante, Spain
a video on concerted and non concerted mechanism
Hi Aman. Are you looking for a video that discussed the differences or for specific examples?
Difference
Gotcha. Essentially concerted reactions happen in one step and non-concerted happen over a series of steps.
ohh
Correct me if I am wrong,
In concerted mechanism → breaking and formation of bonds take simultaneously whereas in non concerted reaction intermediates are formed
In chemistry practicals ,I struggle a lot .for the past two years I am just pretending that I know what to do but in reality I have no idea what I am doing,I mean I don't know what has been given and what I did and what I got ,I am just blank when it comes to practicals .So please make a video on that too(that is a brief of chemistry practicals) so that my interest could be generated in this too
can u please upload a video on topic OZONOLYSIS
thank u
Hi Guarav Kumar - I can, it may take a couple of weeks before I am able to record it.
Hi Guarav, I have made the first ozonolysis video (I am going to follow it up with one that looks at some components of the mechanism, but I will only be able to record that, hopefully, next week. Hope this one helps for now:
th-cam.com/video/j0q1EnXRWPw/w-d-xo.html
Great explanation. Everyone else who explained it had a indian accent that was too hard to understand.
Hi, thank you for your explanation. Actually, your explanation is good but it's too fast so I barely understand. So sad 😢
Sorry that it moves too quickly for you!
ok fine.
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Sarah I wanna couple with u...after understanding the complete mechanism