Cool 😎 I definitely have plans for 2022 on this lines. I’m prepping topics with things like this video that I can refer to later when looking at big molecule syntheses.
i discovered your channel through this video and i am very happy about it. i am looking forward to many more videos and hope that your channel gets its deserved growth. greetings from germany.
🙂 Thanks for the feedback and glad you enjoyed the video! I have my next few planned out but the day job has been getting in the way of me recording them recently - but definitely more on the way.
@@CasualChemistry Thank god :D. I thought you might stopped doing videos and was worried already. Currently going through your videos about asymmetric synthesis for my stereochemistry exam in a few days.
This week is looking good for me getting on track with more content. Are there any asymmetric synthesis topics in particular that might be worthwhile me thinking about making a video on? It’s my PhD/PostDoc area so I’m flexible with ideas but have a few ideas in the pharmaceutical area coming soon
🙂 Thanks for the feedback. These topics are on my to-do list to think about interesting ways of presenting them. I probably will need to collect together a few more ideas on a cyclic stereocontrol for this but it is one of my favourite topics.
Do you mean the “EN atom” bit at this time stamp ? I meant that as an abbreviation for electronegative. I haven’t defined absolute stereochemistry in the chain form.
Outstanding explanation, concise and straight to the point, always explaining the reason for which something happens. Ive discovered this channel a few days ago and I can say already say its top notch Keep up the good work sir Could you make a video about chiral bisoxazolines ?
🙂 Thanks - I spotted a gap I thought I could help fill to broaden out chemistry stuff online. I haven’t got one planned for BOX catalysts but I certainly want to do more asymmetric catalysis videos so I will have a think about a good way to present.
Many thanks for the feedback - much appreciated 🙂. This video’s been in the been in the back of my head for ages and I thought was going to be my first one. It’s really satisfying getting it done now that I’m more practised with my stylus and video making.
That’s going to totally depend on each individual molecule. So a way to approach is to first identify if your aldehyde is chiral, and then see if each of the assumptions of any model apply. For pure Felkin-Anh, the reaction must be irreversible, and there must be a stereocentre alpha to the aldehyde carbonyl with 3 very distinct groups - this can be on size but electronegative groups can also play the role of “big” groups. If none of these are true, try a different model. If none model available fits, it’s likely the reaction will not be very selective or not selective at all.
Ah - now I think I know the bit you mean with the orbitals drawn out. I didn’t shade them the way I’d intended and it was beyond my editing skills to tweak - I decided it was fine to leave in as it is still correct. I would have flipped all the shading on the sigma star to make the lower combined MO the obvious addition, and the higher combined MO the subtraction. Whereas the diagram actually still holds for the ones I’ve drawn, just that the lower combined one is actually the subtraction instead and the higher one the addition (here the anti bonding combination is actually the addition of the orbital wavefunctions). Apologies for any confusion on this - that was unintended. If I’d done this with maths and the symbols, it would probably make it clearer exactly how to combine them but I thought that might be a bit much for the video.
Going through some natural product synthesis in your style would be amazing!!
Cool 😎 I definitely have plans for 2022 on this lines. I’m prepping topics with things like this video that I can refer to later when looking at big molecule syntheses.
Very well explained starting from A with well clarity leading to Z! Awesome!
Thanks 🙂
i discovered your channel through this video and i am very happy about it. i am looking forward to many more videos and hope that your channel gets its deserved growth. greetings from germany.
🙂 Thanks for the feedback and glad you enjoyed the video! I have my next few planned out but the day job has been getting in the way of me recording them recently - but definitely more on the way.
@@CasualChemistry Thank god :D. I thought you might stopped doing videos and was worried already. Currently going through your videos about asymmetric synthesis for my stereochemistry exam in a few days.
This week is looking good for me getting on track with more content. Are there any asymmetric synthesis topics in particular that might be worthwhile me thinking about making a video on? It’s my PhD/PostDoc area so I’m flexible with ideas but have a few ideas in the pharmaceutical area coming soon
Pls come with lecture on 1,3 evans polar model and Reetz cyclic model with multiple stereocenters. Your lecture series is really awesome. 😊
🙂 Thanks for the feedback. These topics are on my to-do list to think about interesting ways of presenting them. I probably will need to collect together a few more ideas on a cyclic stereocontrol for this but it is one of my favourite topics.
At 9:40, I think in conformational analysis you wrote enantiomers to the one on top in chain form.
Do you mean the “EN atom” bit at this time stamp ? I meant that as an abbreviation for electronegative. I haven’t defined absolute stereochemistry in the chain form.
Outstanding explanation, concise and straight to the point, always explaining the reason for which something happens. Ive discovered this channel a few days ago and I can say already say its top notch
Keep up the good work sir
Could you make a video about chiral bisoxazolines ?
🙂 Thanks - I spotted a gap I thought I could help fill to broaden out chemistry stuff online. I haven’t got one planned for BOX catalysts but I certainly want to do more asymmetric catalysis videos so I will have a think about a good way to present.
Well done!
Thanks 🙂
Very well explained
Thanks 🙂
Thank you for making this video! The explanations were quite clear and well presented.
Many thanks for the feedback - much appreciated 🙂. This video’s been in the been in the back of my head for ages and I thought was going to be my first one. It’s really satisfying getting it done now that I’m more practised with my stylus and video making.
Prepping for final year organic exams, I have the Felkin Ahn down pretty well but it's a joy to get a refresher of this quality
Thanks for the feedback 🙂
Wonderful video with a fascinating ending. Unfortunately, I didn’t quite understand the interaction of MOs here. (
Thank you so much for this wonderful lecture
🙂 No worries - glad you enjoyed
This is excellent
😀 Thanks
How do I know which transition state model to use?
That’s going to totally depend on each individual molecule. So a way to approach is to first identify if your aldehyde is chiral, and then see if each of the assumptions of any model apply. For pure Felkin-Anh, the reaction must be irreversible, and there must be a stereocentre alpha to the aldehyde carbonyl with 3 very distinct groups - this can be on size but electronegative groups can also play the role of “big” groups. If none of these are true, try a different model. If none model available fits, it’s likely the reaction will not be very selective or not selective at all.
@ thank you.
Hi! How come Sigma * and pi* have the same symmetry? Is it even possible? Or did I get something wrong?
Ah - now I think I know the bit you mean with the orbitals drawn out. I didn’t shade them the way I’d intended and it was beyond my editing skills to tweak - I decided it was fine to leave in as it is still correct. I would have flipped all the shading on the sigma star to make the lower combined MO the obvious addition, and the higher combined MO the subtraction. Whereas the diagram actually still holds for the ones I’ve drawn, just that the lower combined one is actually the subtraction instead and the higher one the addition (here the anti bonding combination is actually the addition of the orbital wavefunctions). Apologies for any confusion on this - that was unintended. If I’d done this with maths and the symbols, it would probably make it clearer exactly how to combine them but I thought that might be a bit much for the video.
@@CasualChemistry Oh, now I think I see what was meant. Thank you very much for your explanation. I really appreciate it. 🙂
Thnx so much
No worries 🙂