Induced pluripotent stem cells - Rudolf Jaenisch
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- เผยแพร่เมื่อ 5 ก.ค. 2024
- Biologist Rudolf Jaenisch on invention of IPS cells, usage of epigenetic state of the genes, and making a liver in the Petri dish.
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he has the ability to communicate simply
indeed yes!
He makes thinking seem easy... awesome interview. Would be very interesting to hear his thoughts on differences in epigenetic states of identically cloned animals or even twins with newer sequencing methods detecting gene/RNA regulatory mechanisms.
When I did my PhD at the end of the 80ies on a breast cancer model system in mice we were able to induce - reversibly, or irreversibly, depending on what you subjected the cells to - "trans-differentiation" from epithelial to mesenchymal tumour cells, and vice versa. When injected into mice the cells formed the respective tumours - adenocarcinomas, or fibosarcomas. The mechanisms of this conversion was not understood at the time, our work declared to be "hokus pokus". and it was almost impossible to publish any results on this in a reputable journal, as no-one believed them. Decades later the situation has completely changed, and iPS cells are now a routine tool in molecular medicine and biomedical research., with Rudi Jaenisch being one of the drivers of this development.
What do we learn from this ? Scientific progress apparently has a strange, and sometimes erratic way to proceed, but the truth is out there somewhere, you just have to find it !
I feel like if you ask this guy for help, he'll throw a book at you.
He knows the art to make simple the complex issue.
people can do a Ph.D. but only a few can teach like him.
Stem cell therapy is to help those endogenous adult stem cells (ASCs) to
clear away so-called inhibitory molecules so that its regenerative potentials
can be triggered for regeneration.
iPS cells are garbage and can't be applied to humans forever.
Science is a march of the giants over decades. Cell biology is a journey that will take many more decades. Tissue engineering is just at its infancy. However, cell therapy without a full understanding of the cell biology inside our bodies, is gaining much popularity. The main driving force is Pain therapy. When patients can resume normal or close to normal lives, they are overwhelmed with joy. The world is blessed with scientists like this good professor.
can we make an organ in the petri dish? not in 2013. Enter the perfusion bioreactor, yes we can. 1 hell of an easy to understand explanation of what is a fairly simple process, like much of advanced bio engineering, it just a matter of moving colourless liquids form test tube to test tube, popping them in and out of machines, and waiting a while, not much more complex than the skills of a good chef. Skipping merrily along in the footsteps of the brilliant minds that carved the path before you is rarely hard, and loads of fun.
mooie luhl ben je ook Rudie