I Took This Nootropic For 30 Days, Here's What Happened
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- เผยแพร่เมื่อ 30 พ.ค. 2024
- If you want to know more about the benefits and my nootropics review on phenylalanine than watch this video right here: 👉 • Phenylalanine Exposed ... 👈
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DISCLAIMER: This content is strictly the opinion of Dr. LeGrand and is for informational and educational purposes only. It is not intended to provide medical advice or to take the place of medical advice or treatment from a personal physician. All viewers of this content are advised to consult their doctors or qualified health professionals regarding specific health questions. Neither Dr. LeGrand nor the publisher of this content takes responsibility for possible health consequences of any person or persons reading or following the information in this educational content. All viewers of this content, especially those taking prescription or over-the-counter medications, should consult their physicians before beginning any nutrition, supplement or lifestyle program.
If you want to know more about the benefits and my nootropics review on phenylalanine than watch this video right here: 👉 th-cam.com/video/T-vnS0apU3c/w-d-xo.html 👈
Phenylalanine Hydroxylase deficiency what would you take to supplement if you have that disease
at 1:43 into the video you use a chart with neurotransmitters. I am trying to wrap my head around how all of this works as I've had great success from a few of these supplements. Where can I find that chart and the material that came with it? Is that a textbook I could order?
how can someone access that test?
What if you don't have short term memory. Just no desire in life at all?
Wher can you get them and what do you ask for if say going to a shop to buy it
First time I took 500mg of L-phenylalanine it blew my socks off. Was like taking the Limitless pill BUT my resting heart rate went through the roof and I found it extremely hard to sleep for 2 days. I would definitely titrate up from a low dose when you first start taking it, just in case.
Good to know!!
The peer reviewed studies I found do claim to have found positive outcomes in the use of DL-Phenylalanine for ADHD compared to placebo. However, it would appear that the effects of the drug wore off after 3 months.
Man, I really appreciate what you're doing!
GREAT INFO DR!! THIS IS AWESOME!!!!
I love DLPA. Very helpful for stimulant addiction and other dopamine issues as well as opiates.
This is really interesting, thank you so much for sharing. I have dyslexia and as I have been under a lot of stress in the last year I feel my executive functioning, mood and focus have been getting worse. How did you get the urine test at the beginning of the video? Some sites say that testing for neurotransmitters is inaccurate. It it more that you are testing for the protein precursors?
For those who may not mind diving one resolution layer deeper:
D [dextro-rotary] and L [levo-rotary] are stereo twins of eachother. L- and D-amino acids are two possible orientations of a particular amino acid in nature. With few exceptions [some bacterias use D aminos for building blocks] amino acids in human biology are usually the L variety.
They are the mirror image of each other.
Also, they can be considered as the isomeric forms, stereoisomers or enantiomers. while L-amino acids can rotate plane-polarized light counterclockwise in a process called levorotation, D-amino acids can rotate plane-polarized light clockwise in a process called dextrorotation. It has been considered that only L-amino acids are utilized in mammals, including humans. However, because of the recent development of sensitive and selective analytical methods for detecting chiral amino acids [125], diverse D-amino acids have been found in mammalian tissues. The physiological functions of these D-amino acids are being gradually clarified. Known exceptions are D-Serine used as a neurotransmitter that competitively docks at Glycine sites of the NMDA receptor complex, making it useful in addressing conditions such as schizophrenia, ADD, and some neuralgias. Similar activity with D-Alanine.THE D IN DLPA IS EXCLUSIVELY DERIVED SYNTHETICALLY D-Phenylalanine (DPA) is an inhibitor of the enzyme (enkephalinase-a carboxypeptidase) known to breakdown (catabolize) endorphins, especially enkephalins. Thus, if we increase brain enkephalins by administering DPA, the amount of enkephalins will increase in the brain. HOWEVER, the D form of Phenylalanine DOES NOT contribute to the L-DOPA >catecholamine pathway, only its L isomer does. It has also been demonstrated that D-amino acids, such as D-serine, D-aspartate, D-alanine, and D-cysteine, play important roles in the nervous and endocrine systems. It is VERY IMPORTANT TO NOTE that D and L forms of a chemical, DESPITE HAVING THE SAME NAME, ARE AS DIFFERENT FROM EACHOTHER AS ANY TWO CHEMICALS WITH DIFFERENT NAMES including their properties! As an example of this fact: The D form occurs commonly with many molecules you may be more familiar with such as glucose and other sugars, My favorite, Amphetamine, whose L form is Over The Counter in most countries including here in The USA. Yet whose D form may land you in a heap of trouble without proper approval or a reliable plug!
Amazing info. Thank you
Thanks for sharing! Ordering mine now.😊
You can get Amphetamine over the counter??
@@claudiatheobald9928 Adderral is a form of meth.
Would you recommend getting DLPA or just the L version?
You so genius to relating your content
Great video!
I love this! Thanks.
This is crazy 🤯 This is EXACTLY what I used to take every day, especially workdays, BEFORE I knew I had ADHD. I don’t even remember where I read about it but I do my research which is how I just found you on TH-cam. 😉 Btw, I was diagnosed less than 2 years ago at age 45. I still can’t focus. I’m going to purchase and start taking again. And I do take ADHD meds. Thank you!
I am 45 years old and I suspect that I have adhd.
What ADHD meds do you take?
Did it work again??
The Mood Cure by Dr Julia Ross. It's all in there.
So u have ADHD meds and they don't work?
What company do you use for neurotransmitter testing?
Very cool! Thanks for the video. Tell me if you have tried other nootropics, for example, normotim. I'm taking it now.
long time ago a friend tried to talk me into trying one of his proscacs. finally I gave in and it was so awful… I felt as if I had taken a psychedelic. I did not want to be on a psychedelic. I was not taking any drugs or drinking any alcohol and I still don’t but I wondered why I had such an extreme reaction to it.
Can I get more information on how to get tested on what my brain is lacking like you did before you took the dl-phenylanine? I totally agree, prescribing adhd drugs without testing is just guessing.
I would like to know the same
I'd like to know too
This is definitely something that I would like to try but here is my issue. I take so many supplements that I always worry about whether or not it's safe to keep adding more.
Through a lengthy duration, I've been conducting trials using various nootropics, and my observations point to normotim as the most efficacious option for fulfilling my unique requirements.
did you think about taking it before a high intensity exersice? pushups in the morning and squats in the evening.
the exercise makes a lot of lactate when the muscles run out of oxygen.
with the enzyme CNDP2, th body makes LAC-PHE from lactate and phenylalanine.
first, the brain can use lactate as a fuel source and seems to love it (better focus). second, the lac-phe acts as a hormone and lowers appetite (ghrelin).
the question is: does lac-phe has other benefits too?
I live in Canada, and I get told that there is no such thing as a test like the one you took showing all these neurotransmitters? Why??? Why if we are only an 8 hour drive north of the US is there such a difference. I can't even get told if my lipids are the big or little ones. This is really really frustrating. PS, I wish I were born 15 years later, as I too would have had a degree or two.
For those of you (who like me) wondered where I could get such a neurotransmitter test, here is the scoop. I wouldn't bother. There are places online that sell them but the truth is that there is no scientifically established link between theses levels in urine compared to what is in the brain. These test measure levels in urine - not in the brain. Also, consider that many of these substances have a half live of just seconds, so such a test is also just showing you one moment in time - you could get quite different results depending on when you take it. In addition there are scams out there, with one company being fined 6 million due to falsely adjusting results in order to then recommend certain supplements they sell. But there is another way, and it is free. There are question-based tests you can take on the net that will hone in on your symptoms and tell you the likely transmitters that are off.
can you tell me where these online tests are? i too have read that the urine tests are bogus, after spent the money of course..
so placebo
?
You can test for neurotransmitters or hormones excreted in urine using HPLC, ELISA assays, or GC. It is commonly known that neurotransmitters, while used or synthesized in the brain, circulate throughout the entire body. If you are not on any supplements or medications, your neurotransmitter levels have their "normal" (baseline) levels and are unlikely to fluctuate on a day to day basis such that your urine test results are all over the place if you were to take the test repeatedly over a specified time period.
There is research out there where children or adults with or without ADHD were tested for biomarkers in their urine (and blood plasma) that could be used to diagnose someone with ADHD. These studies revealed that those with ADHD have lower levels of phenethylamine and other neurotransmitters in both blood and urine. It makes total sense as scientists are always looking for non-invasive ways to test people for the presence of diseases because it is one way to diagnose or help prevent them. Just to solidify that claim, a team of scientists in Michigan recently created a urine test that can detect head and neck cancer through DNA that is secreted into urine that came from the tumor (ctDNA).
A few references:
1. www.michiganmedicine.org/health-lab/researchers-discover-urine-based-test-detect-head-and-neck-cancer
2. Baker, G. B., Bornstein, R. A., Rouget, A. C., Ashton, S., Van Muyden, J. C., & Coutts, R. T. (1991). Phenylethylaminergic mechanisms in attention-deficit disorder. Biological Psychiatry, 29(1), 15-22. doi.org/10.1016/0006-3223(91)90207-3
3. [Decreased beta-phenylethylamine in urine of children with attention deficit hyperactivity disorder and autistic disorder]. (2002, May 1). PubMed. pubmed.ncbi.nlm.nih.gov/12030014/
4. Marc, D. T., Ailts, J. W., Campeau, D. C. A., Bull, M. J., & Olson, K. L. (2011). Neurotransmitters excreted in the urine as biomarkers of nervous system activity: Validity and clinical applicability. Neuroscience & Biobehavioral Reviews/Neuroscience and Biobehavioral Reviews, 35(3), 635-644. doi.org/10.1016/j.neubiorev.2010.07.007
great ! thanks for this test .. do you think it’s better than phosphatildyserine ?
Glad you liked it. They both do different things and like I said in the video I took it because of what I was deficient in. phosphatidylserine is generally good for most people. But maybe I will need to do a 30 day challenge video of that one as well ya?
Great info as always! Did you test again, to see if the values improved?
Glad you liked it! No I have not tested again yet. The lab company recommends to test again in 6 months so I will need to do a follow up video when I have been consistently taking it for 6 months :)
@@doctorlegrand Which lab company do you use?
I'm interested in learning more about nootropic supplements, including whether normotim is a worthwhile choice.
Great info. Music is very distracting. Thanks.
Hi doc
Did you check your PEA after using Dl phenylalanine!
I have abeen Using DLPA for 5 yrs
I get same benefits like yrs !
But I still don't know if is increasing PEA or not !
PLEASE Let us know if you check yr PEA
Thx
Best thumbnail ever!!!
Hey there, would it make sense to take DL-Phenylalanine in combination with Noopept? It had a great impact in the beginning, lowering after a month. (Normal intake is 2-3 months on, 2 weeks off). I do take a choline source, too.
One thing that i could clearly notice was that my memory has moved from a way where i remembered through coherences to that "loose" kind of memory where you don't really know where it comes from, which i didn't know before. Impact on focus was noticiable, but not as much as on ritalin or something like that. My short term memory has also improved. I'm able to memorize larger numbers than before (was suffering dyscalculia besides ADHD until a few years ago).
My apologies, Dr. LeGrand, I'm new to your channel (18Aug23). I subscribed halfway thru my first of your videos, this is my second. One question: When you say "supplements," are you referring to prescription pharmaceuticals or over-the-counter nutritional supplements, or something else entirely?
I found this; "The high plasma phenylalanine concentrations increase phenylalanine entry into brain and restrict the entry of other large neutral amino acids. In the literature, emphasis has been on high brain phenylalanine as the pathological substrate that causes mental retardation"
Any thoughts about this?
What about gaba supplement can you try it?.
Do you seriuosly stop everything to test this stuff individually? I appreciate you being a guinea pig for us!
The more I research supplements that I think might benefit me, the more I'm finding.
The more I find, the more I think I need.
The list is getting pretty long, and every doctor I've talked to, are hesitant to give any recommendations, or opinions. I need to narrow down my list, and find the specific ones that would most benefit me.🤔
sounds like you are eating the wrong foods
So, I took PEA (not recommending it) once. It lasts very short time but it let me know what it does. I immediately felt europhphic if I remember, the the most interesting thing was, I got tunnel vision, a bit different than fight or flight tunnel vission I think. I'm all but positive I lost a lot of peripheral vision, the trade off being increased focus, like a round flashlight beam of anything in front of me. It's pretty crazy to think that vision plays a big roll probably in all of this. One idea i had is uncorrected vision might make you more in your head due to less visual processing. I do think things are physical oftentimes but I also think the brain and body comminicate back and fourth so it's not entirely one or the other. Kind of like the brain teaining the body and vice versa.
"One idea i had is uncorrected vision might make you more in your head due to less visual processing." - I agree with this 100%. On weekend when I don't wear any to help with my vision, everything just feel a bit more disconnected and I can't seem to be in the zone to do anything.
What exactly (brand) did you take so I can avoid it
Euphoria? proabably because PEA is a precursor of Dopamine.
I’m going to get the neurotransmitter urine test asap, I did not even know that was a thing!!!
I asked my doctor about it and evidently it isn't covered by health insurance, plus it's pretty expensive aswell so good luck with that. He also mentioned that the test isn't anything substantial as far as what you need for your brain and body since you can do a varity of other blood tests and if it is he hasn't read anything about so just letting you know it isn't necessary.
It might be testing of cerebral spinal fluid. Read Dr Julia Ross The Mood Cure
It's the same as L-Phenylalanine right? Thanks.
What causes someone to have low phenylalanine in the first place?
Where could I get a blood test done for these values?
How can I take a home test for nootropic evaluation?
Interesting. I lived with my ADHD for most of my life. I was not medicated, but I noticed that in my mid 50's it was starting to affect my job. I finally mentioned it to my doctor and he started me on adderal. I would like to do something more natural if possible. I am just curions where to start.
Stimulant medications are not benign, for many people. They are kind of a bandaid for symptoms. I hope you find what works for you. Intentionally eating natural foods, not processed, excercizing daily in nature if you have access, regular bed times, all of this can help you optimize your function.
Def the bed times go to bed early get up early make s a diff I started going to bed at 8:30 not literally in bed but in bedroom so wind down asleep by 10 up at 6 massive change in focus still take meds also use supplements as a software engineer it’s pretty complicated at times need full brain power but sleep was huge
@@Coral_dude it's good to hear you found something to help you!
Before start taking any supplement ask your Dr. So he can adjust your medication doses.
@@k8eekatt One of the hard parts of my job is that I work 12 hour rotating shifts. Niights and days. My sleep is not nrmal. Hasn't been for 26 years now.
What kind of test did you take? Was this a blood test? Who or where can we get this test? Memory is my worst ADHD problem.
Just watched 2 of your trial videos in a row where each time you had a gap of a few days in actually taking the supplement. I'm pretty surprised that, as a medical professional, you don't just have a daily/weekly pill container routine going that would probably eliminate such an issue by about 99.999%
I never knew that neurotransmitter tests existed 😮😮
If I take this with my vyvanse will that be too much? I understand if you can’t answer but just wondering
Hi Dr. LeGrand I'm going through benzo Wd. I take L-Teanene. It helped me some what. Can you mabe tell us more about Lithium Carbonite pls. Thank you very much.
How are you with your WD my son going through that now and want to see what you took to stop the horrific side of effect of the withdrawal.
Hello,
I have ADHD and similar worse I think that I 'run out' of adrenalin/noradrenalin due to intense physical exercise quite easily (one or two trainings go quite well but than I feel like don'T getting my pulse up, even I don'T feel TOO groggy overall(still can do some-weight lifting,.. but nothing that would require my pulse to go up TOO much).
But I dought that phenylalanine deficit should be a big issue because its an essential amino acid and things that I eat regulary contain tons of it(like peas,...)
But whats about L-Theanine, Ashwaganda,... what would you recommend to try out in my situation?
Have you tried nootropics from normotim? I would like to see a similar video about other supplements
I am curious as to why you would take phenyalanine as a supplement instead of phenethylamine since that is what you tested yourself for and saw that you were low on? What if your phenylalanine levels were normal but phenethylamine were low? Perhaps that means there is something going on with the conversion from phenylalanine to phenethylamine?? I consider this a critical detail that I need to know. Thanks!
Dr. What is that test that you took that showed all of those levels?
Where can i get these test?
So what about taking eria jarensis instead?
As a person with a.d.d it would be helpful if you didn’t fast flash the info on the screen but instead left it visible a few seconds to give me time to read it. Thank you
Pause the video*
What is the cost of the lab testing?
Do you have a Canadian link?
Life extension does a simple test but it’s a start idk which one he does but these do work yall gotta start looking up things like neurotransmitter test kits type things in to see u gotta wanna learn
Isn't selegilinethe obvious way to go if you want to increase PEA?
I have PKU and ADHD my PKU is not treated because it is low and my PHE is not a high number. I wonder if I could use this to help my ADHD.
Wait, so you can test and see how your neurotransmitters are doing?
Not where it matters. This video is very misleading. You can define do blood tests to determine if you are low in certain vitamins, minerals, or hormones but it’s not possible to tell how many of what neurotransmitter is in your actual synapses or how many receptors remaining to each neurotransmitter you have
Didn’t he do urinalysis not blood?
@@arcrane11 pretty sure spinal taps are the most accurate way.
Cerebral spinal fluid. According to Dr. Julia Ross.
Life Extension has that test . It's called a Comprehensive Neurotransmitter Test.
Is PEA legal??? I see it online but i live in UK.. i Googled it and it says all PEA's are banned. Its a bit confusing
I really want to buy it but im not sure if it's legal
if i remember correctly phenylanine metabolises into tyrosine which breaks down into dopamine?
what if ppl dont know they are low on that...what going to happen if you take it and have no issues or deficiency ?
My son was diagnosed with ADHD and he's on three medications (ADHD, anxiety/depression). We haven't seen any improvement over the past three years. Thanks for your educational videos.
How is his gut health? Perhaps, you could have him take broccoli sprouts powder or make the sprouts yourself. That should shore up his immune system. Sulforophane also reduces autism symptoms and it is derived from broccoli sprouts. You could also look into probiotics that help with mood like Lifted Mood probiotics. How's his sleep? Does he toss and turn a lot?
@@QUINTUSMAXIMUS Thanks for the advice. He doesn't communicate much but I do know he was taking a good probiotic at one time. Not sure how he's been sleeping lately. Thanks again for your thoughtful response.
@Bleu Jasper I believe he's taking buspirone hydrochloride
Definitely research gut health and gut bacteria regarding ADHD.
@@BleuJasper-rb9ei His psychiatrist prescribed Buspirone Hydrochloride. Since he's an adult, I can't stop him from taking it. I just pray he'll eventually realize it's not the long-term answer and wean off of it and consider supplements.
I didn’t know you could get an in depth testing of your amino acids / neurotransmitter levels like that.. where can I get a test done like that?
I do these tests for my clients when working with them. If you are interested the best thing to do is book your first consultation with me so I have chance to deep dive in your medical history to determine what would be the best testing to do and what action plan to put together for you. Here is a discounted link: www.optimalmindperformance.com/offers/FvbWP5Fj?coupon_code=YTOMP400OFF to book a consultation with me if you are interested.
Cool! But no doctor in Uk would do this test without us paying private. I wonder what cost private would be?
Have you looked at methylation, mthfr and histamines vid, dr chris ...on youtube? Looking at hisexplanation of histamine n dopa was very interesting. For me personally i am waiting for glycine deluvery as anything i takesends me into overdrive and no sleep. But im more interested in full pathway recovery. Tyrosine has helped. Now i know why. Thanks n keep up great work.
FenAla-ninn is great! :D
Hey where can I get this test at???
I’m sure you covered this in another video but why wouldn’t you just take a proscribed adhd pill like Dexedrine ?
this essentially seems to not work if you stop taking it much like other meds. Not being rude or anything just curious.
Adhd meds take from your neurotransmitter supply, this adds to it. This supplement probably would help adhd meds work better.
How do you test? What do I ask my gp for?
I want to take that test, what kind of urine test it is? What should I look up and do test to get those results?
Great video. I started taking the dl Phenylalanine and did notice a difference. Can I send you an email? I would like to get more information on the testing you did and finding a therapist in my arear. Any assistance you can provide would be greatly appreciated.
What difference? 🙂
Helps me focus better. However, was interested in the test you mentioned before you took the dl phenylalanine so I can figure ot what exactly my brain is lacking. I'm looking for a more systematic approach then guessing what to take. Thus, is there a point of contact to find out a more about the test and possibly figure out a plan to treat my adult adhd? Any light word be greatly appreciated.
@@stuartsherman5975 I am just a dude on TH-cam. 🙂
Is this the same as Palmitoylethanolamide ?
So the effect is lost when you stop taking it? That's kind of unfortunate. I will give it a try tho and see what effect it has on me
Hey Dr. LeGrand I'm a veteran but I don't have ADHD, but I am very interested in learning more about getting lab tests for my neurotransmitter levels can you send some info regarding this Thanks Mashund
Hi Doc! I really love your videos and I also have short term memory problems due to ADHD. I wanted to ask what dosage were you taking during this 30 day period? I saw one from now foods brand where it contains about 500 mg of phenylalanine. Do you think this would work?
also, i'm taking rhodiola rosea for four weeks now, i wanted to ask if it is possible to stack it with DLPA? sorry if i ask too many questions.. I hope you could reply.. thank you so much.
1,000mg morning
1,000mg evening
So does L phenylalanin really work?
How can I get testing? Any one with info, please respond with suggestions. TIA.
I'm listening with headphones and the banging at 6:23 scared the shit out of me.
thanks
I really need to see a naturopath. I have such a major sensitivity to everything. B1 has helped me a lot and other vitamins but ugh. I had a major stress response Friday night and I'm ADHD w/o the H, and neuro divergent also. It's a shame that most Dr are taught pharmacology and not how to heal people. I'll figure it out eventually. The TH-cam AI has been extremely helpful with figuring my stuff out. It's amazing how accurate the suggestions have been, tbh.
Are these dangerous to take if you drink alcohol ?
I’m sorry to sound negative….but he didn’t super convincing that it works……..I was on the fence……..and I was really hoping he didn’t have a link to a particular brand…..and yup there it is…” hit the link to get 10% off” …..lates!
Just try it try em all they do work bro I had the worses of the worse cognitive depression decline just ashwagandha alone helped me then to add a helpful agent to increase benefits I bought hella more vitamins
How about taking PEA directly?
Very similar to my case, only I take another one - normotim. thanks for the video I will show it to my friends
Yes, I take it too, I recommend it to everyone.
@@Walter.Turner It helped me a lot, too.
I took oral PEA with an MAOI-B and it was the most euphoric and motivating substance ive ever tried. And i have tried alot. It was too good really and with thendoses i was taking gave me heart palpitations and chest pain. Felt like i came close to dying a couple times. Highly not recommended. By taking phenylalanine allows the body to produce more on a regulated level. Much lower doses than taling grams of it orally withiut an maoi-b or hundred of mg with an maoi-b. I believe PEA is what the runners high prosuces and also when we fall in love, with no tolerance. A potent substance that must be respected.
What MAO-B inhibitor did you take? I know there's a handful out there.
Also I'm confused. So you take regular phenylalanine now not PEA?
@@justinthompson5631 No i don't take regular Phenylalanine, i just take protein supplements with the proper amino acids.. And I was taking Selegeline.
MAOI-B generally are meds you need to be incredibly careful adding in supplements or other meds.
@@emilyb5557 any MOAI is true for this.
can you take L and DL at the same time? please someone please tell me and how much for both?
to my understanding, DL is the combination of L-phenylalaline and D-phenylalaline. So taking DL would essentially replace L, meaning you don't have to take both
Is that your favorite lab panel to check for neurotransmitters, The Doctors Data comprehensive neurotransmitter profile; urine?
Is DL-Phenylalanine something you take in the morning?
Yes. I take 1000mg DLPA w/B6 every day at 8am and 4pm. Helps tremendously.
I don't think that your brain being totally swollen and completely open and exposed is a good effect from a nootropic!!!
I get those where I go to look up stuff and totally forgot and was like damm but now I know learned something new. So I should be taking this then?
what test is that? normal blood test?
How do you become a doctor with ADHD? My daughter can’t even complete any assignment
Thanks for watching these videos and helping your daughter ❤
LOL... because it's something he's passionate about.
The same reason I aced all my science and math classes and failed or
barely passed pretty much every other class.
I thought if you have ADHD you would just obsessively compulsively jump around and complete all the school assignments in half the time.
you're a doctor but you don't know what dyslexia is that's exactly how you can say that a dyslexic can have ADHD, that's the same thing as saying that a dwarf is short ????
is it intentional that you forget not to take for 3-4 days? seems the same with your 30-day L-theanine test.
Where can you test worthy physicians orders?
How can I do a neurotransmitter test without a doctor?
There are not too many doctors out their that do the testing. You would need to find a functional medicine doctor or Naturopathic doctor. Or you can reach out to us because we do that testing with our clients. You can schedule a FREE call with us here: msgsndr.com/widget/appointment/service/focused-mindset-session-yt?group=mma-d175626f-c494-4722-96e8-122cfa897dd2
Is there a big difference between DL-Phenylalanine? and L-Phenylalanine?
You know a answer yet? That's exactly what I want to know. 🙂
@@loveistheanswer5924 Supposedly the DL version is supposed to help a bit more with depression and anxiety.
D [dextro-rotary] and L [levo-rotary] are stereo twins of eachother. L- and D-amino acids are two possible orientations of a particular amino acid in nature. With few exceptions [some bacterias use D aminos for building blocks] amino acids in human biology are usually the L variety.
They are the mirror image of each other.
Also, they can be considered as the isomeric forms, stereoisomers or enantiomers. while L-amino acids can rotate plane-polarized light counterclockwise in a process called levorotation, D-amino acids can rotate plane-polarized light clockwise in a process called dextrorotation. It has been considered that only L-amino acids are utilized in mammals, including humans. However, because of the recent development of sensitive and selective analytical methods for detecting chiral amino acids [125], diverse D-amino acids have been found in mammalian tissues. The physiological functions of these D-amino acids are being gradually clarified. Known exceptions are D-Serine used as a neurotransmitter that competitively docks at Glycine sites of the NMDA receptor complex, making it useful in addressing conditions such as schizophrenia, ADD, and some neuralgias. Similar activity with D-Alanine.THE D IN DLPA IS EXCLUSIVELY DERIVED SYNTHETICALLY D-Phenylalanine (DPA) is an inhibitor of the enzyme (enkephalinase-a carboxypeptidase) known to breakdown (catabolize) endorphins, especially enkephalins. Thus, if we increase brain enkephalins by administering DPA, the amount of enkephalins will increase in the brain. HOWEVER, the D form of Phenylalanine DOES NOT contribute to the L-DOPA >catecholamine pathway, only its L isomer does. It has also been demonstrated that D-amino acids, such as D-serine, D-aspartate, D-alanine, and D-cysteine, play important roles in the nervous and endocrine systems. It is VERY IMPORTANT TO NOTE that D and L forms of a chemical, DESPITE HAVING THE SAME NAME, ARE AS DIFFERENT FROM EACHOTHER AS ANY TWO CHEMICALS WITH DIFFERENT NAMES including their properties! As an example of this fact: The D form occurs commonly with many molecules you may be more familiar with such as glucose and other sugars, My favorite, Amphetamine, whose L form is Over The Counter in most countries including here in The USA. Yet whose D form may land you in a heap of trouble without proper approval or a reliable plug!
D made in the lab. L = natural
@@THEMADPROFdj What is the name of the L form of amphetamine that is available over the counter in the US?
Dr. LeGrand, why do your labs have the name of Dallin Peterson as the patient?
I really enjoy a balance of everything, I havent tested but I'll do 1 gram tyrosine in morning with some caffeine source, around noon ill do 1-2 gram phenyalanine , and around 3-4pm ill do 10-20mg 5htp. An hour or two before bed ill take some l theanine, ksm 66 ashwaghanda and do some vagal nerve exercises and streching, meditate and go to bed =D
😊👍
@@doctorlegrand I have the same question trysorine + phenylalanine + theanine are complement all together? or I am duplicate effects
why didn't you try taking PEA directly?
Why not take PEA directly?