TB-500 is just one thing we may use alongside BPC-157. Please note that TB-500 needs to be injectable, and this should be coming from a compounding pharmacy, not an online peptide lab. If you want to use the oral BPC-157 that we use ourselves and with our patients, you can find that here (with our 20% patient discount code too) - regenerativeperformance.com/supplements
Similar to your Short about BPC and cancer, what is your stance on TB-500 and cancer? It seems like the research is pretty mixed, yet some human studies with TB eye drops showed no adverse events wrt cancer.
I'm starting to see these in nasal spray.. my we hear your opinion on this? Also, I would like to say that I appreciate the intel you share with us on these peptides. These medicines are clearly undervalued. Thank you, sir!! 👋😁
@@craiglsu72 yes, and the issue i find is that you need a Rx to get a peptide from them. They are more expensive at a Compounding Pharmacy, but it seems you are Garrunteed a potent pure product. It seems, but may or may not be true. Study the Chemgraphs and learn to understand them for the peptide and compare with the different vendors. Doing the best I can with the dwindling what I have. The Doc gives good info!
low dose bpc-157 is 250mcg x 2 per day, which is 3.5g per week. Which is also right in the sweet spot for tb-500, so a logical and easy protocol would be to reconstitude both 5mg bpc-157 and 5mg tb-500 with 2ml each and inject 10 iu of each twice a day, you can draw both into the same syringe and inject once. Very simple and uncomplicated. 10 days for 5mg +5mg. If you want the higher 5 mg per week, just go for 14 IUs each twice per day.
It is, but very poorly. The molecular weight is 889, which is too big to absorb easily in mucous membranes. Anything over 1,000 is basically a complete waste. You are probably absorbing somewhere in the neighborhood of 15% of intranasal TB500.
im thinking of doing the wolwerine cyle with bpc and t500, im trying to fix my heritated disk i have issues with since 2021, what inject area and what dose do you recommend per week?? DOES I Have to be daily or can you do weekly or every 2-3 days as i also do test c + tren cycle
Injections do not need to be site specific, they can be in the subQ in the abdomen. As for dosing, the generic daily dose we recommend is 300mcg BPC-157 and 500mcg T500. We change that and individualize that for our patients, but I can't give you specifics as I don't know enough of your case.
If treating BOTH shoulders, would you inject each shoulder separately? This could get a bit hectic with BPC-157 and TB500, x4 injections every day. Is injecting into the stomach just as effective?
Hi doc. Can you tell what factors have to be considered for the decision of 3-5mg per week? I'm thinking about it for my herniated disc c6-c7 which is not getting smaller over a year now and has nervcontact. Would appreciate an answer.
I have what feels like a small horizontal tear in linea alba inch above belly button. No tissue poking through. Is this worth a shot? I am taking bpc 157 and b4 fragment capsules but considering injectible since seeing your opinion on it
Is that safe? I used 1.5mg TB500 split into 10 doses over 10 days and had to stop because of the nasty side effects. Insomnia, joint pain, rash and flu like symptoms
Thank you for all of the great content! If I have 10mg if TB500 would 4ml be an appropriate amount for bacteriostatic water? The dose per a week will be 3mg to start with twice a week. If I'm using a 1ml syringe would each dose be 1500mcg?
It could help support your natural healing response yes. If that doesn't fully work, we would use high dose PRP or bone marrow concentrate in our office. We've successfully healed full thickness tears with these approaches
Thank you for all the videos. I'm actually in your town so will most likely come see you soon. I am so confused on dose vs price. If a TB-500 vial is $100+ for 5mg, and the dosing is 3+mg per week, this sounds like an incredibly expensive Peptide to use. And if that is the most common dosing, why do they even come in 5mg or 10mg vials? Wouldn't they be best sold in a little larger quantities?
the vials we use are 15mg as this is what comes from the compounding pharmacy, and the price is $250 for 3-5 weeks (depends on the dosing strategy we use). Correct, peptides are not cheap.
Hi. Hope you don't mind me adding this. I get my peptides from Oxford Peptides on Amazon. They cost £18 for a 5mg vial. I've been using them for a while now for my elbow and they work a treat! Hope this helps in some way.
If you search on my channel for peptide therapy you'll find a full length lecture that goes over dosing as well. The dosing in that lecture for Tb4 is the same dosing for TB500. Bottles/vials last different amounts of time based on the dosing strategy used and how many mg is in your initial bottle
10mg (10,000 mcg) is always 40 doses at 250mcg (40x250=10,000). 10mg BPC in 4mL = 2500mcg/mL, so 10iu (0.1mL) = 250mcg. So you get 40 doses of 250mcg by injecting 10iu subQ
tough question to answer - we just don't know. We tend to not go above 750mcg per day for TB500 and BPC-157 we've done up to 2mg per day oral. We've done single infusions of 15mg of both, but that's on an infrequent basis, not daily
Any thoughts on TB4 Frag which is claimed to be bioavailable when ingested orally? Im speaking specifically of the Peptide Sciences product of oral BPC-157 and TB4 Frag in the same bottle. I really don't want to have to inject. Having shoulder labrum surgery tomorrow. Thanks!
Thanks so much for the response! I am 1 week post op and on oral BPC-157 from Infiniwell. Any experience with people using the oral version to recover from this surgery?@@DrewTimmermansND
Hey I have shoulder issues and a biceps tendon thats acting up. Also tore my meniscus. I am going to be using the 5MG bottles of BPBPC 157 & TB 500. How much bacteriostatic water do I add to each bottle & what dosage would you suggest, & how often for each. I dont want to guess. Much appreciated 🙏🏻
Also, if you want to look up a site called peptide, dosing, calculator, and it will do all of that for you with this super easy to use they maid just for this
Hi, thanks for the content and info! So I seem to have strained my pec major 24 hours ago.. there is no bleeding and I still have full range of motion just pain when pushing my hands together for example.. I have tb500 and want to start now.. would you recommend waiting 48 hours or would you say I could start injecting now? Thanks
When we have acute injuries or surgeries or injections, we start peptides immediately. You also might want to look into good BPC-157 (We use the InfiniWell brand as they use the arginate salt. We have a 20% patient discount code on our website regenerativeperformance.com/supplements) and also StemRegen, which helps release stem cells from your bone marrow into circulation to help heal injuries. You can also find that on our site
Blends can be treated as if they are one thing for the sake of dilution math (not saying for dosage). So for example: there are 10mg of total peptide powder in the vial, you would add 4ml of bacteriostatic water. At this dilution, every 0.1ml (10 units) on an insulin syringe is equivalent to 250mcg of total peptide. Because this blend is 50/50, you’d be getting 125mcg of each compound per 0.1ml of solution. So, determine your proper dose and draw it based on that dilution for easy counting. 👍
Hope the surgery went well! Our surgical protocols are individualized, and far too extensive and comprehensive for a comment on YT. If you'd like, reach out to my clinic to see about working with us regenerativeperformance.com
I bought 10mg of TB500 and 10mg of BPC 157 from core peptides. It came in rock/ powder form in the viles and they sent 30ml of bacteriostatic water. What should the mixtures be each injection and what size needles should I go and get? I have a sternum fracture and displacement so I was going to start injections in my stomach using the rotation method around the belly button two inches away at about 4mg a week. Is it also safe to pull the TB and BCP together in the same shot? @drewTimmermansND
Oh and I forgot to ask, how are you feeling now? Do you feel any improvement? Sternum fracture - I can’t even imagine the pain this must be causing you 😞 I think smaller needles are less painful, which ones did you end up buying?
You can pull both at once, just keep everything sterile. Use 4ml of bac water per 10mg of powdered peptides. This makes every 0.1ml (10 units on insulin syringe) of diluted solution equivalent to 250mcg (0.25mg) of peptide. It’s easy to count that way.
Hey, unfortunately I can't provide a proper response to this, as this would require a full workup in my clinic in order for me to deliver what I would deem high quality medical advice. If you'd like my expertise to help you with your unique situation and chronic pain, please head over to my website (regenerativeperformance.com) to learn more about becoming a patient of mine.
I cant make any recommendations for you. If you want to work with me in my clinic I can provide those types of medical recommendations. If not, you should consult with your doctor on what is appropriate for you
Can you comment on sublingual use of TB? I can understand oral not working but many substances prefer sublingual and therefore would not be affected by gut, acid etc.
@@DrewTimmermansND there's evidence in mice that oral administration leads to therapeutic effect; Oral Administration of N-Acetyl-seryl-aspartyl-lysyl-proline Ameliorates Kidney Disease in Both Type 1 and Type 2 Diabetic Mice via a Therapeutic Regimen.
Yea I've read that study and others. There are enough variations in human vs rat GI absorption that I'd like to see a study that showed AcSDKP is stable at the lower pH of human stomachs compared to rat stomachs, then I'd be more on board with recommending it. And truthfully, we still have access to TB500 for our patients, so I would prefer to use that over AcSDKP anyways. In the same way that I would love to have access to TB4 again because we found that worked better than TB500. Are you aware of any pH stability studies?
@@DrewTimmermansND this argument has been discussed already given that several companies sell AcSDKP (TB4-frag) as oral supplement, which is more accessible than injectable for the majority. Here's some info I found: Ac-SDKP (Thymosin Beta4 Fragment) Oral Bioavailability Research Studies Masuyer, Geoffrey, et al. “Structural Basis of Ac-SDKP Hydrolysis by Angiotensin-I Converting Enzyme.” Scientific Reports, vol. 5, no. 1, 25 Sept. 2015, 10.1038/srep13742. Nakagawa, Pablo, et al. “Ac-SDKP Decreases Mortality and Cardiac Rupture after Acute Myocardial Infarction.” PloS One, vol. 13, no. 1, 2018, p. e0190300, pubmed.ncbi.nlm.nih.gov/29364896/, 10.1371/journal.pone.0190300. Jin, Fuyu, et al. “Ac-SDKP Attenuates Activation of Lung Macrophages and Bone Osteoclasts in Rats Exposed to Silica by Inhibition of TLR4 and RANKL Signaling Pathways.” Journal of Inflammation Research, vol. 14, 2021, pp. 1647-1660, pubmed.ncbi.nlm.nih.gov/33948088/, 10.2147/JIR.S306883. Xu, Hong, et al. “A New Antifibrotic Target of Ac-SDKP: Inhibition of Myofibroblast Differentiation in Rat Lung with Silicosis.” PLoS ONE, vol. 7, no. 7, 3 July 2012, p. e40301, 10.1371/journal.pone.0040301. Srivastava, Swayam Prakash, et al. “Inhibition of Angiotensin-Converting Enzyme Ameliorates Renal Fibrosis by Mitigating DPP-4 Level and Restoring Antifibrotic MicroRNAs.” Genes, vol. 11, no. 2, 18 Feb. 2020, p. E211, pubmed.ncbi.nlm.nih.gov/32085655/, 10.3390/genes11020211. Shifeng, Li, et al. “Ac-SDKP Increases α-TAT 1 and Promotes the Apoptosis in Lung Fibroblasts and Epithelial Cells Double-Stimulated with TGF-β1 and Silica.” Toxicology and Applied Pharmacology, vol. 369, 15 Apr. 2019, pp. 17-29, www.sciencedirect.com/science/article/abs/pii/S0041008X19300729, 10.1016/j.taap.2019.02.015. Kumar, Nitin, and Congcong Yin. “The Anti-Inflammatory Peptide Ac-SDKP: Synthesis, Role in ACE Inhibition, and Its Therapeutic Potential in Hypertension and Cardiovascular Diseases.” Pharmacological Research, vol. 134, Aug. 2018, pp. 268-279, 10.1016/j.phrs.2018.07.006. Peng, Hongmei, et al. “Ac-SDKP Inhibits Transforming Growth Factor-β1-Induced Differentiation of Human Cardiac Fibroblasts into Myofibroblasts.” American Journal of Physiology-Heart and Circulatory Physiology, vol. 298, no. 5, May 2010, pp. H1357-H1364, 10.1152/ajpheart.00464.2009. Li, Shifeng, et al. “[Inhibition Effect of N-Acetyl-Seryl-Aspartyl-Lysyl-Proline on Myofibroblast Differentiation of MRC-5 Human Fetal Lung Fibroblasts Inuced by Ang II].” Zhonghua Lao Dong Wei Sheng Zhi Ye Bing Za Zhi = Zhonghua Laodong Weisheng Zhiyebing Zazhi = Chinese Journal of Industrial Hygiene and Occupational Diseases, vol. 32, no. 11, 1 Nov. 2014, pp. 801-805, pubmed.ncbi.nlm.nih.gov/25579022/. Xu, Hong, et al. “A New Antifibrotic Target of Ac-SDKP: Inhibition of Myofibroblast Differentiation in Rat Lung with Silicosis.” PLoS ONE, vol. 7, no. 7, 3 July 2012, p. e40301, 10.1371/journal.pone.0040301. Sharma, Umesh C., et al. “A Small Peptide Ac-SDKP Inhibits Radiation-Induced Cardiomyopathy.” Circulation: Heart Failure, vol. 11, no. 8, Aug. 2018, 10.1161/circheartfailure.117.004867. Cavasin, Maria A., et al. “Decreased Endogenous Levels of Ac-SDKP Promote Organ Fibrosis.” Hypertension, vol. 50, no. 1, July 2007, pp. 130-136, 10.1161/hypertensionaha.106.084103. Kassem, Kamal M., et al. “Tβ4-Ac-SDKP Pathway: Any Relevance for the Cardiovascular System?” Canadian Journal of Physiology and Pharmacology, vol. 97, no. 7, 1 July 2019, pp. 589-599, www.ncbi.nlm.nih.gov/pmc/articles/PMC6824425/, 10.1139/cjpp-2018-0570. Referenced Citations [1] R. Rucman, “Stable pentadecapeptide salts, a process for preparation thereof, a use thereof in the manufacture of pharmaceutical preparations and a use thereof in therapy,” US9850282B2, Dec. 26, 2017. [2] A. Duzel et al., “Stable gastric pentadecapeptide BPC 157 in the treatment of colitis and ischemia and reperfusion in rats: New insights,” World J. Gastroenterol., vol. 23, no. 48, pp. 8465-8488, Dec. 2017, doi: 10.3748/wjg.v23.i48.8465. [3] M. Chopp and Z. G. Zhang, “Thymosin β4 as a restorative/regenerative therapy for neurological injury and neurodegenerative diseases,” Expert Opin. Biol. Ther., vol. 15, no. sup1, Art. no. sup1, Jun. 2015, doi: 10.1517/14712598.2015.1005596. [4] “Thymosin Beta-4 Molecule Prompts Damaged Cells To Repair Themselves After Heart Attack,” Science 2.0, Aug. 27, 2014. www.science20.com/news_releases/thymosin_beta4_molecule_prompts_damaged_cells_repair_themselves_after_heart_attack (accessed Dec. 02, 2015). [5] C.-H. Chang, W.-C. Tsai, M.-S. Lin, Y.-H. Hsu, and J.-H. S. Pang, “The promoting effect of pentadecapeptide BPC 157 on tendon healing involves tendon outgrowth, cell survival, and cell migration,” J. Appl. Physiol. Bethesda Md 1985, vol. 110, no. 3, pp. 774-780, Mar. 2011, doi: 10.1152/japplphysiol.00945.2010. [6] S. Pejman, M. Kamarehei, G. Riazi, S. Pooyan, and S. Balalaie, “Ac-SDKP ameliorates the progression of experimental autoimmune encephalomyelitis via inhibition of ER stress and oxidative stress in the hippocampus of C57BL/6 mice,” Brain Res. Bull., vol. 154, pp. 21-31, Jan. 2020, doi: 10.1016/j.brainresbull.2019.09.014. [7] D. Gwyer, N. M. Wragg, and S. L. Wilson, “Gastric pentadecapeptide body protection compound BPC 157 and its role in accelerating musculoskeletal soft tissue healing,” Cell Tissue Res., vol. 377, no. 2, pp. 153-159, Aug. 2019, doi: 10.1007/s00441-019-03016-8. [8] T. Cerovecki et al., “Pentadecapeptide BPC 157 (PL 14736) improves ligament healing in the rat,” J. Orthop. Res. Off. Publ. Orthop. Res. Soc., vol. 28, no. 9, pp. 1155-1161, Sep. 2010, doi: 10.1002/jor.21107. [9] C.-H. Chang, W.-C. Tsai, Y.-H. Hsu, and J.-H. S. Pang, “Pentadecapeptide BPC 157 enhances the growth hormone receptor expression in tendon fibroblasts,” Mol. Basel Switz., vol. 19, no. 11, pp. 19066-19077, Nov. 2014, doi: 10.3390/molecules191119066. [10] Song, Ran & Choi, Hyun & Yang, Hyung-In & Yoo, Myung & Park, Yong-Beom & Kim, Kyoung. (2012). Association between serum thymosin β4 levels of rheumatoid arthritis patients and disease activity and response to therapy. Clinical rheumatology. 31. 1253-8. 10.1007/s10067-012-2011-7. [Research Gate]
Natty generally refers to anabolic steroids. These peptides are not anabolic steroids, so I would say no. But I'm not the one who determines who is natty and who isn't lol
Both are prohibited by USADA, WADA, UFC, and a number of other sports organizations. They will NOT grant a medical exemption for prescribed treatments since there is no FDA approval. 🙄 SO, if you’re competing in drug tested leagues you cannot use these.
Quick question, hoping someone can help. How much of the bacteriostatic water do I need to mix into the BPC-157 (5mg) and the TB500 (5mg). I'm going to be taking these on separate days but need to make sure I get the right amount of water solution into them both. Help?
We normally create a concentration of 2mg/mL for the BPC-157 and 3mg/mL for the T500. So this would be 2.5mL BAC into the BPC vial and 1.67mL into the TB500 vial. If you want to make it easy, you can just make the TB500 2mg/mL (so 2.5mL BAC) as well. You just have to adjust your iu dosing to get the proper mcg dose.
You absolutely do get results from tablets... It's ridiculous to think that they don't work, I've no idea why he says that because they do, some of the tablet will be absorbed differently but it still goes systemic...
Surgery, or potentially PRP injections. Not everyone who has SRS is a candidate for the PRP injections though. I would need to see you in my office to see if you're a candidate
you could do 1mL or you could do 5mL. The amount of water doesn't matter, because there will always be the same amount of peptide in the total amount of liquid. Most people make their BPC-157 2mg/mL and TB500 3mg/mL
Thanks Doc! I qas doing TB500 daily at about 3mg a week total. If your daily dose of TB500 equals 3mg for the week, does your recommendation of 2 or 3 times a week still hold? Thanks!!
Doing 1000mcg a day bpc157 and 500mcg of tb500 twice a week for low back SI joint issues and disc buldge. I was hoping that would be enough? Can somone give me some clarity.
Yea that dose should be sufficient. If you don't notice improvements after 4 weeks, let's hop on a call and see if you're a candidate for working one on one with me in Arizona regenerativeperformance.com/contact
Yes it can help some patients with EDS, but our approach is typically much more targeted with PRP or stem cell injections. We use the InfiniWell brand as they use the arginate salt. We specifically use the Rapid Pro capsules. We have a 20% patient discount code on our website regenerativeperformance.com/supplements
Perfect. Start off with that for 3 weeks, then do that dose both morning and evening, for another 3 weeks before you cycle off. Do a Trucheck before starting.
@@DP-jb4yofrom all I've researched and gathered, No it shouldn't have any interaction with Marijuana, but I'm not a doctor. Lol so don't take as an absolute.
Oral BPC-157 should be known empty stomach. We use the InfiniWell brand as they use the arginate salt. We have a 20% patient discount code on our website regenerativeperformance.com/supplements. You can taken them at the same time
@@DrewTimmermansNDhi Doc, another question if you don’t mind. Is the bpc157 once a day also as with the tb500 or is bpc 2 times a day? Can I take oral bpc157 while using the injectable too? Is in the stomach ok or should I do my thigh if my knee is bothering me? Thanks again Doc!
If I have a 10mg vial of TB500 and I mix 3 ml ……. My needle is 100 units where would I be on my syringe for a daily dosage ….. sorry it gets confusing I already mixed my bpc 157 I have spinal injury 9 mo post op just trying to get off this last oxy daily
@@DrewTimmermansND How about Sermorelin and Ipamorelin. Time of day, what if someone can only eat at 1030 at night. How long should I wait before taking sermorelin or Ipamorelin.
Ok thank you. But does IM work the same? Bc depending on where it is I find sub Q to be more painful. Can I draw the BPC and TB 500 into one syringe? Or does it need to be separate?
We use the BPC-157 capsules from InfiniWell as they use the arginate salt and they ship to Canada. To help out, we have a 20% patient discount code on our website regenerativeperformance.com/supplements (code is RP20). Once on that website, click the InfiniWell link, and then choose the product labeled 'BPC-157 Original 250mcg'. This is the version that does not have SNAC, which we find works better. As for TB500, I don't think they are compounding that in Canada. But you could research peptide docs in your area.
@@DrewTimmermansND you’re an absolute legend. Just ordered. Have been looking for quite some time. Appreciate the response very much and the discount helps to!! Take care 🙏 💪
@@DrewTimmermansND Yeah, fair call mate. Under normal circumstances I'd not consider it but I've an upcoming hiking trip in the Himalayas, which I've been planning for for many months and have a mild calf strain I'm trying to overcome. I'm running a short cycle of tb-500, so far there's been no negative sides I've noticed but I accept there is a degree of risk to this approach.
If you're open to a few other suggestions that could help, here are a few things we would consider using in our clinic: Vitamin C (we use vitality C) 1000mg 3x/day SPM Active (by Metagenics) 3 softgels 3x/day for 2 weeks Stem Regen Release 2 caps twice per day Those are probably the top 3 supplements we find effective for muscle strains. If you want discounts, you can find the first 2 supplements on our Fullscript account, and the 3rdis found directly from the Stem Regen Website. You can find discount codes here: regenerativeperformance.com/supplements
Sorry I don't have any European sources. You can check to see if the InfiniWell brand ships there, but i don't think so. If they do, you can get 20% discount with code RP20
Hey, I have blend of TB500 and BPC157 with 2 ML bacteriostatic water. As it is a blend, what dosage would you recommend? And instead of bacteriostatic water, Can I use sterile water?
@@rajivshonak2272 kya ye harmful hain steroids ki tarah?? Kya inhe normally le skte hain gym krte hue???? Kya bodybuilding me inka koi asar pdega body bnane me???
Hi doc, in one of your lectures i hear you say thay u like to start a cycle of thymesin beta 4 / tb500 with a high dose to reach a peak fast and then slowly build it down. Online i read some articles of suggested dosed between 5-20mg/weekly So i was thinking of starting with 10-15mg tb500 first week and then slowly building down to 3 while doing 500mcg BPC/daily for 4 weeks. But.. now i hear you recommend dosing 3-5mg weekly. So one vial (5mg) /weekly is more then enough u would say now?
Hey doc, Bpc 157 .2 ml daily, with tb 500 twice a week at . 5 ml twice a week. Is that enough for injury muscle repair? That's what I'm doing atm but would love your advice. I'd be greatful. Does body weight matter in regards to dosage?
If it's a blend (which we never recommend), it's better to do daily injections because you'll want the BPC-157 daily. Dosing recommendations don't change, so you'll just have to do the math to figure out how to get the right amount with both in the blend
@@thebigwilly123 yes, and I'm hearing people go up to 3 doses a day considering their situation. The argument is that the half life is at about 4-5 hours, and doses can go anywhere from 200- 800 mcg. Obviously only a dr. Can tell you that, but its a.. new trend, shall we say?
Hi I’m unsure on the dosing. If I mix 5mg of TB 500 with sterile water around 2.5 ml is it still classed as 5 mg? So I would need that full bottle for one week? Also how many units on the insulin syringe would I want for each injection going off a 5mg a week cycle? Any help would be fantastic Thanks 😊
5mg of TB500 in 2.5mL sterile water is 2mg/mL. 1mL is 100 units on an insulin syringe. If you are going to dose at 5mg/week for TB-500 (which is a high dose and you may not need that), then yes you would use a full vial each week. On the lower end, you could dose 3mg/week. Easy math - if you need to inject 2.5mL over 7 days (for the 5mg dosing), you would be injected 250iu/7 which equals 35.7iu per day (so just round that to 35iu per day).
Hey Thanks for your reply. Although I partly understand I’m Just wondering a couple more things. How much water would you advice to mix with the 5mg bottle of TB 500? How many units on the insulin syringe would you then draw from the bottle for each injection? Sorry just not 100% on this It’s for really bad tennis elbow. Thanks
Hey sorry, I’ve read through your last comment again and understand it all much better now I think I mite just got for a lower dose of maybe 2mg a week so I guess that would be around 30 units 4 days a week in the insulin syringe Would you recommend pinching the skin on the elbow like you would for BPC 157 or putting in the stomach? Thanks
Based on one of the mechanisms of BPC-157 I would also take Growth hormone, IGF-1. Their is a oral available form, Deer Antler Velvet Powder from Barlowes.
I'm starting to suspect that if the patient has Mold Toxicity or living in a Moldy Home they should avoid BPC-157 because of the histamine Mast Cell Reaction. Also if they are taking high doses of Opiates for pain.
Why are you saying that TB-500 tsblets do not work? There are dozens of companies who have tablets out there, plus doctors advising that it will go systemic regardless of delivery method, i couldnt comment on potency, but to say its useless i believe is a lie..
ohhh so the product you have is a combination product (which we don't recommend because of dosing issues), so because it doesn't answer your exact question it's a worthless video for everyone else. Got it 👌. It's too bad you just didn't ask nicely in the comments how to navigate dosing when you have a combo product, as I most likely would have answered. But that time has passed because of your first comment. Best of luck to you
@@DrewTimmermansND clickbait title and your replying to a comment stating your video is worthless. The truth hurts that’s why you’re playing dumb and ignoring the fact that your video is worthless for the title advertised.
You recommend 3-5gs which is an insane spread. I would not take anything you say as credible seeing as your logic for medical recommendation you operate from is whether someone is “nice”. If you were a real dr not a phony you give medical advice that works or doesn’t. Sounds like you have some discriminatory contingencies in your medical advice. That’s pretty funny, you probably do TH-cam cause you can’t actually practice medicine due to your discriminatory behaviors.
I have a 10 mg bottle of TB 500 combined with Bpc 157 5 mg each,any suggestions on how much to take? I was thinking 1000 McG 5 days on 2 days off,thanks
@@DrewTimmermansND hello, I love all your information. I have some questions , regarding Tb-500 & bpc-157 ? I had a complete rupture of my left biceps tendon and had surgery last week that had to be allograft since my injury was of a sever impact that caused my tendon to retract 6cm with a 12cm hematoma. Had surgery and have been told to take the bpc-157 peptide and tb-500 peptides as they work very well in healing and recovery of then tendons and especially with my case of having a allograft done I need for it to completely heal and make a full recovery since I need to be 100% with the career I have. I have been told to do bpc-157 every day and tb-500 twice a week. I just need it for recovery and the recommended dosages for both? Any help woukd be extremely appreciated.
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TB-500 is just one thing we may use alongside BPC-157. Please note that TB-500 needs to be injectable, and this should be coming from a compounding pharmacy, not an online peptide lab.
If you want to use the oral BPC-157 that we use ourselves and with our patients, you can find that here (with our 20% patient discount code too) - regenerativeperformance.com/supplements
Similar to your Short about BPC and cancer, what is your stance on TB-500 and cancer? It seems like the research is pretty mixed, yet some human studies with TB eye drops showed no adverse events wrt cancer.
I'm starting to see these in nasal spray.. my we hear your opinion on this? Also, I would like to say that I appreciate the intel you share with us on these peptides. These medicines are clearly undervalued. Thank you, sir!! 👋😁
@@alfonsonajera2439 you can get nasal spray? That’s interesting
So why not an online lab and how do you find a compound pharmacy?
@@craiglsu72 yes, and the issue i find is that you need a Rx to get a peptide from them.
They are more expensive at a Compounding Pharmacy, but it seems you are Garrunteed a potent pure product. It seems, but may or may not be true.
Study the Chemgraphs and learn to understand them for the peptide and compare with the different vendors.
Doing the best I can with the dwindling what I have.
The Doc gives good info!
low dose bpc-157 is 250mcg x 2 per day, which is 3.5g per week. Which is also right in the sweet spot for tb-500, so a logical and easy protocol would be to reconstitude both 5mg bpc-157 and 5mg tb-500 with 2ml each and inject 10 iu of each twice a day, you can draw both into the same syringe and inject once. Very simple and uncomplicated. 10 days for 5mg +5mg.
If you want the higher 5 mg per week, just go for 14 IUs each twice per day.
Can you let me know if this is an intramuscular injection or not please?
@@dilbarae should be subcutaneous (in fat)
3.5mg** per week
How would you do this with 10mg vials?
@@AAD2120 You have double the peptide so you would double the water: use 4ml to reconstitute, the dosage remains the same.
Tb500 can also be aerosolized and In hailed threw the nose it absorbs in the lungs and sinuses
It is, but very poorly. The molecular weight is 889, which is too big to absorb easily in mucous membranes. Anything over 1,000 is basically a complete waste.
You are probably absorbing somewhere in the neighborhood of 15% of intranasal TB500.
Source ? Not doubting just don’t know I want to buy a nasal spray
@@kakuja1396the bioavailability is low, much like Testosterone creams! If you’re really looking for the best results, injectable is the way to go!
Also would like proof
Yeah, provide more details and source 🙏
im thinking of doing the wolwerine cyle with bpc and t500, im trying to fix my heritated disk i have issues with since 2021, what inject area and what dose do you recommend per week?? DOES I Have to be daily or can you do weekly or every 2-3 days as i also do test c + tren cycle
Injections do not need to be site specific, they can be in the subQ in the abdomen. As for dosing, the generic daily dose we recommend is 300mcg BPC-157 and 500mcg T500. We change that and individualize that for our patients, but I can't give you specifics as I don't know enough of your case.
If treating BOTH shoulders, would you inject each shoulder separately? This could get a bit hectic with BPC-157 and TB500, x4 injections every day. Is injecting into the stomach just as effective?
Hi doc. Can you tell what factors have to be considered for the decision of 3-5mg per week? I'm thinking about it for my herniated disc c6-c7 which is not getting smaller over a year now and has nervcontact. Would appreciate an answer.
major scar tissue, elderly age, severe symptoms - those are usually the things that make sway us towards a higher dose.
Clear as mud
Why so high dosages starting off. Wouldn't you want to go with the lowest effective dosage and titration up?
Where do I find a doctor that can do this?
I have what feels like a small horizontal tear in linea alba inch above belly button. No tissue poking through. Is this worth a shot? I am taking bpc 157 and b4 fragment capsules but considering injectible since seeing your opinion on it
3-5mg per week. You are welcome.
Of tb 500? Or bpc 157 or both?
@howtogoat3282 both
@@Alphabet7intramuscular OK?
@@gavincosgrove yeah
Is that safe?
I used 1.5mg TB500 split into 10 doses over 10 days and had to stop because of the nasty side effects. Insomnia, joint pain, rash and flu like symptoms
Is bcp157 useful for ecu sheath recovery?
surgical recovery?
Thank you for all of the great content!
If I have 10mg if TB500 would 4ml be an appropriate amount for bacteriostatic water?
The dose per a week will be 3mg to start with twice a week. If I'm using a 1ml syringe would each dose be 1500mcg?
My pleasure! You're a little off. 10mg in 4mL is 2.5mg per mL.
Where did you get yours from?
So for TB500 in 10mg vials you add 3ml of the bactostatic water to get to 3.5mg/ml per dose and do that 2 times per week?
Is the tb 500 supposed to be injected near the torn tendon, or just anywhere on the body intramuscularly?
doesn't need to be site specific, and it can be subQ, doesn't need to be IM
I have partial acl tear, mcl, meniscus and I’m not getting any surgery so can I take bpc157 and tb500 orally to heal it ?
It could help support your natural healing response yes. If that doesn't fully work, we would use high dose PRP or bone marrow concentrate in our office. We've successfully healed full thickness tears with these approaches
Do you recommend bpc157/tb500 protocol after tendon fenestration or dry needling partial tendon tears ?
That could be a synergistic approach
Thanks great info
How much should i take of each and how many days a week for back pain and bulging disc
Thank you for all the videos. I'm actually in your town so will most likely come see you soon.
I am so confused on dose vs price. If a TB-500 vial is $100+ for 5mg, and the dosing is 3+mg per week, this sounds like an incredibly expensive Peptide to use. And if that is the most common dosing, why do they even come in 5mg or 10mg vials? Wouldn't they be best sold in a little larger quantities?
the vials we use are 15mg as this is what comes from the compounding pharmacy, and the price is $250 for 3-5 weeks (depends on the dosing strategy we use).
Correct, peptides are not cheap.
@@DrewTimmermansNDwhy can't we get it from a reputable source online?
@@jonnsmith556because the money game between pharmacists and doctors would end
@@jonnsmith556 you can.
Hi. Hope you don't mind me adding this. I get my peptides from Oxford Peptides on Amazon. They cost £18 for a 5mg vial. I've been using them for a while now for my elbow and they work a treat! Hope this helps in some way.
What about topical BPC-157 & TB-500? They are able to be absorbed through the skin, correct?
How long does a bottle of each last and what's the dosing?
If you search on my channel for peptide therapy you'll find a full length lecture that goes over dosing as well. The dosing in that lecture for Tb4 is the same dosing for TB500. Bottles/vials last different amounts of time based on the dosing strategy used and how many mg is in your initial bottle
Hi. You recommend for UCL and ulnar nerve pain for baseball pitcher?
If there’s a 5:5 blend of both for a 173 lbs person what would you suggest
thank you! Is this match correct? 10mg with 4ml of bactostatic water would be 40 doses at 250mcgs?
10mg (10,000 mcg) is always 40 doses at 250mcg (40x250=10,000).
10mg BPC in 4mL = 2500mcg/mL, so 10iu (0.1mL) = 250mcg. So you get 40 doses of 250mcg by injecting 10iu subQ
How much is too much post surgery?
tough question to answer - we just don't know. We tend to not go above 750mcg per day for TB500 and BPC-157 we've done up to 2mg per day oral. We've done single infusions of 15mg of both, but that's on an infrequent basis, not daily
What's the recommended dosage for a combine 10mg each of TB 500 and BPC 157? (two peptides in one small bottle}
Could these help with gyno surgery?
Does the time of the day matter when injecting tb 500? Great video
Nope doesn't maatter
Does it need to be on empty stomach ?
nope not for injectable
What about sermorelin and ipamorelin. Fasted and time of day? What if I can only workout at 8pm eat 5 eggs at 11pm can I inject at 12am?
Any thoughts on TB4 Frag which is claimed to be bioavailable when ingested orally? Im speaking specifically of the Peptide Sciences product of oral BPC-157 and TB4 Frag in the same bottle. I really don't want to have to inject. Having shoulder labrum surgery tomorrow. Thanks!
eh, I'm not convinced on the data that it's absorbed orally, so we don't use it.
Hope surgery went well!
Thanks so much for the response! I am 1 week post op and on oral BPC-157 from Infiniwell. Any experience with people using the oral version to recover from this surgery?@@DrewTimmermansND
What’s the best way to reach out to you, I have a few questions, I’m considering using this stack
by speaking to my clinic staff about becoming a patient. Personalized advice and recommendations happen during medical appointments.
Hey I have shoulder issues and a biceps tendon thats acting up. Also tore my meniscus. I am going to be using the 5MG bottles of BPBPC 157 & TB 500. How much bacteriostatic water do I add to each bottle & what dosage would you suggest, & how often for each. I dont want to guess. Much appreciated 🙏🏻
1 ml
Also, if you want to look up a site called peptide, dosing, calculator, and it will do all of that for you with this super easy to use they maid just for this
when taking only one of these two peptides wich one is better and have more benefits in taking care of an injury?
Bpc rocks
Hi, thanks for the content and info!
So I seem to have strained my pec major 24 hours ago.. there is no bleeding and I still have full range of motion just pain when pushing my hands together for example..
I have tb500 and want to start now.. would you recommend waiting 48 hours or would you say I could start injecting now?
Thanks
When we have acute injuries or surgeries or injections, we start peptides immediately. You also might want to look into good BPC-157 (We use the InfiniWell brand as they use the arginate salt. We have a 20% patient discount code on our website regenerativeperformance.com/supplements) and also StemRegen, which helps release stem cells from your bone marrow into circulation to help heal injuries. You can also find that on our site
If I have a 5g/5g blend how would you dose?
I’d like to know that as well. I’m looking to buy a 5mg/5mg blend as well.
Blends can be treated as if they are one thing for the sake of dilution math (not saying for dosage). So for example: there are 10mg of total peptide powder in the vial, you would add 4ml of bacteriostatic water. At this dilution, every 0.1ml (10 units) on an insulin syringe is equivalent to 250mcg of total peptide. Because this blend is 50/50, you’d be getting 125mcg of each compound per 0.1ml of solution. So, determine your proper dose and draw it based on that dilution for easy counting. 👍
Im about to have surgery to repair a torn bicep tendon. What do you recommend?
Hope the surgery went well! Our surgical protocols are individualized, and far too extensive and comprehensive for a comment on YT. If you'd like, reach out to my clinic to see about working with us regenerativeperformance.com
These inject subcu at ROI (like lower back) or subcu at a location know for high absorption?
Whats the best doses 5mg bpc157 and 5mg tb500 with 1ml of bac water in each vile
Do i get cancer if i use TB 500?
There's absolutely no evidence to suggest that TB500 could cause cancer
If you do equal 4ml of bactostatic water in each of the 10mg of BPC and TB500 can you mix the BPC and tb500 so only have to use one syringe or no?
We recommend keeping those in separate syringes
@@DrewTimmermansND thank you! Is this match correct? 10mg with 4ml of bactostatic water would be 40 doses at 250mcgs?
I bought 10mg of TB500 and 10mg of BPC 157 from core peptides. It came in rock/ powder form in the viles and they sent 30ml of bacteriostatic water. What should the mixtures be each injection and what size needles should I go and get? I have a sternum fracture and displacement so I was going to start injections in my stomach using the rotation method around the belly button two inches away at about 4mg a week. Is it also safe to pull the TB and BCP together in the same shot? @drewTimmermansND
I’m confused, he said 3-5 milligrams, not millilitres 🤔 I have dyscalculia so thinking about maths gives makes me panic/anxious/nervous 😐
Oh and I forgot to ask, how are you feeling now? Do you feel any improvement? Sternum fracture - I can’t even imagine the pain this must be causing you 😞 I think smaller needles are less painful, which ones did you end up buying?
You can pull both at once, just keep everything sterile.
Use 4ml of bac water per 10mg of powdered peptides. This makes every 0.1ml (10 units on insulin syringe) of diluted solution equivalent to 250mcg (0.25mg) of peptide. It’s easy to count that way.
Insulin syringes.
@@bravowhiskey4684and how would protocol be for each injection? BPC how many a day or week and same for TB. How many in a day and/ or per week?
How long do you do them for?
Do you have to cycle on and off
Hey, unfortunately I can't provide a proper response to this, as this would require a full workup in my clinic in order for me to deliver what I would deem high quality medical advice. If you'd like my expertise to help you with your unique situation and chronic pain, please head over to my website (regenerativeperformance.com) to learn more about becoming a patient of mine.
Is a little over 2.1 mg a week too little ? My doctor prescribed that to me weekly. First time trying.
injected at the site of the pain or just in the belly
Just in the belly. It gets to the point of injury or pain either way.
Finally someone else who gets it!
So, the 3mg is the total per week yes? Not 3 mg every time injecting?
correct
@@DrewTimmermansND great thanks
Hello doctor if I take tb 4 and bpc 157 orally and do a prp shot it’s going to be more effective ,Because I have all ready on my seastem??
So basically one ampule/week?
Would you recommend I take this instead of getting shoulder surgery? I have a slap tear
I cant make any recommendations for you. If you want to work with me in my clinic I can provide those types of medical recommendations. If not, you should consult with your doctor on what is appropriate for you
@@DrewTimmermansND where’s your clinic ? I’m located in Pennsylvania
We are in Gilbert Arizona. You can find more info here - regenerativeperformance.com/contact
Can you comment on sublingual use of TB? I can understand oral not working but many substances prefer sublingual and therefore would not be affected by gut, acid etc.
Haven't seen any literature on absorption of TB500 with sublingual forms so I cant comment on it. We only use injectable for this reason
Would you recommend this stack to assist in healing of chondromalacia patella?
Following aswell
Is tb500 safe for woman
Yes
Any BPC-157 and chronic urticaria studies???
what about tb500 and cancer
Does it work if TB-500 in a nasal spray
No
Can I inject this immediately after bpc 156? Say 1000mg BPC then 500mg TB daily?
It is not TB500 but TB4-frag that is available orally. TB4-frag is a fragment of the whole TB-500 peptide, and still has its healing properties.
I haven't seen any good literature yet to convince me that TB4-frag isn't broken down in the stomach
@@DrewTimmermansND there's evidence in mice that oral administration leads to therapeutic effect; Oral Administration of N-Acetyl-seryl-aspartyl-lysyl-proline Ameliorates Kidney Disease in Both Type 1 and Type 2 Diabetic Mice via a Therapeutic Regimen.
Yea I've read that study and others. There are enough variations in human vs rat GI absorption that I'd like to see a study that showed AcSDKP is stable at the lower pH of human stomachs compared to rat stomachs, then I'd be more on board with recommending it.
And truthfully, we still have access to TB500 for our patients, so I would prefer to use that over AcSDKP anyways. In the same way that I would love to have access to TB4 again because we found that worked better than TB500.
Are you aware of any pH stability studies?
@@DrewTimmermansND this argument has been discussed already given that several companies sell AcSDKP (TB4-frag) as oral supplement, which is more accessible than injectable for the majority. Here's some info I found:
Ac-SDKP (Thymosin Beta4 Fragment) Oral Bioavailability Research Studies
Masuyer, Geoffrey, et al. “Structural Basis of Ac-SDKP Hydrolysis by Angiotensin-I Converting Enzyme.” Scientific Reports, vol. 5, no. 1, 25 Sept. 2015, 10.1038/srep13742.
Nakagawa, Pablo, et al. “Ac-SDKP Decreases Mortality and Cardiac Rupture after Acute Myocardial Infarction.” PloS One, vol. 13, no. 1, 2018, p. e0190300, pubmed.ncbi.nlm.nih.gov/29364896/, 10.1371/journal.pone.0190300.
Jin, Fuyu, et al. “Ac-SDKP Attenuates Activation of Lung Macrophages and Bone Osteoclasts in Rats Exposed to Silica by Inhibition of TLR4 and RANKL Signaling Pathways.” Journal of Inflammation Research, vol. 14, 2021, pp. 1647-1660, pubmed.ncbi.nlm.nih.gov/33948088/, 10.2147/JIR.S306883.
Xu, Hong, et al. “A New Antifibrotic Target of Ac-SDKP: Inhibition of Myofibroblast Differentiation in Rat Lung with Silicosis.” PLoS ONE, vol. 7, no. 7, 3 July 2012, p. e40301, 10.1371/journal.pone.0040301.
Srivastava, Swayam Prakash, et al. “Inhibition of Angiotensin-Converting Enzyme Ameliorates Renal Fibrosis by Mitigating DPP-4 Level and Restoring Antifibrotic MicroRNAs.” Genes, vol. 11, no. 2, 18 Feb. 2020, p. E211, pubmed.ncbi.nlm.nih.gov/32085655/, 10.3390/genes11020211.
Shifeng, Li, et al. “Ac-SDKP Increases α-TAT 1 and Promotes the Apoptosis in Lung Fibroblasts and Epithelial Cells Double-Stimulated with TGF-β1 and Silica.” Toxicology and Applied Pharmacology, vol. 369, 15 Apr. 2019, pp. 17-29, www.sciencedirect.com/science/article/abs/pii/S0041008X19300729, 10.1016/j.taap.2019.02.015.
Kumar, Nitin, and Congcong Yin. “The Anti-Inflammatory Peptide Ac-SDKP: Synthesis, Role in ACE Inhibition, and Its Therapeutic Potential in Hypertension and Cardiovascular Diseases.” Pharmacological Research, vol. 134, Aug. 2018, pp. 268-279, 10.1016/j.phrs.2018.07.006.
Peng, Hongmei, et al. “Ac-SDKP Inhibits Transforming Growth Factor-β1-Induced Differentiation of Human Cardiac Fibroblasts into Myofibroblasts.” American Journal of Physiology-Heart and Circulatory Physiology, vol. 298, no. 5, May 2010, pp. H1357-H1364, 10.1152/ajpheart.00464.2009.
Li, Shifeng, et al. “[Inhibition Effect of N-Acetyl-Seryl-Aspartyl-Lysyl-Proline on Myofibroblast Differentiation of MRC-5 Human Fetal Lung Fibroblasts Inuced by Ang II].” Zhonghua Lao Dong Wei Sheng Zhi Ye Bing Za Zhi = Zhonghua Laodong Weisheng Zhiyebing Zazhi = Chinese Journal of Industrial Hygiene and Occupational Diseases, vol. 32, no. 11, 1 Nov. 2014, pp. 801-805, pubmed.ncbi.nlm.nih.gov/25579022/.
Xu, Hong, et al. “A New Antifibrotic Target of Ac-SDKP: Inhibition of Myofibroblast Differentiation in Rat Lung with Silicosis.” PLoS ONE, vol. 7, no. 7, 3 July 2012, p. e40301, 10.1371/journal.pone.0040301.
Sharma, Umesh C., et al. “A Small Peptide Ac-SDKP Inhibits Radiation-Induced Cardiomyopathy.” Circulation: Heart Failure, vol. 11, no. 8, Aug. 2018, 10.1161/circheartfailure.117.004867.
Cavasin, Maria A., et al. “Decreased Endogenous Levels of Ac-SDKP Promote Organ Fibrosis.” Hypertension, vol. 50, no. 1, July 2007, pp. 130-136, 10.1161/hypertensionaha.106.084103.
Kassem, Kamal M., et al. “Tβ4-Ac-SDKP Pathway: Any Relevance for the Cardiovascular System?” Canadian Journal of Physiology and Pharmacology, vol. 97, no. 7, 1 July 2019, pp. 589-599, www.ncbi.nlm.nih.gov/pmc/articles/PMC6824425/, 10.1139/cjpp-2018-0570.
Referenced Citations
[1] R. Rucman, “Stable pentadecapeptide salts, a process for preparation thereof, a use thereof in the manufacture of pharmaceutical preparations and a use thereof in therapy,” US9850282B2, Dec. 26, 2017.
[2] A. Duzel et al., “Stable gastric pentadecapeptide BPC 157 in the treatment of colitis and ischemia and reperfusion in rats: New insights,” World J. Gastroenterol., vol. 23, no. 48, pp. 8465-8488, Dec. 2017, doi: 10.3748/wjg.v23.i48.8465.
[3] M. Chopp and Z. G. Zhang, “Thymosin β4 as a restorative/regenerative therapy for neurological injury and neurodegenerative diseases,” Expert Opin. Biol. Ther., vol. 15, no. sup1, Art. no. sup1, Jun. 2015, doi: 10.1517/14712598.2015.1005596.
[4] “Thymosin Beta-4 Molecule Prompts Damaged Cells To Repair Themselves After Heart Attack,” Science 2.0, Aug. 27, 2014. www.science20.com/news_releases/thymosin_beta4_molecule_prompts_damaged_cells_repair_themselves_after_heart_attack (accessed Dec. 02, 2015).
[5] C.-H. Chang, W.-C. Tsai, M.-S. Lin, Y.-H. Hsu, and J.-H. S. Pang, “The promoting effect of pentadecapeptide BPC 157 on tendon healing involves tendon outgrowth, cell survival, and cell migration,” J. Appl. Physiol. Bethesda Md 1985, vol. 110, no. 3, pp. 774-780, Mar. 2011, doi: 10.1152/japplphysiol.00945.2010.
[6] S. Pejman, M. Kamarehei, G. Riazi, S. Pooyan, and S. Balalaie, “Ac-SDKP ameliorates the progression of experimental autoimmune encephalomyelitis via inhibition of ER stress and oxidative stress in the hippocampus of C57BL/6 mice,” Brain Res. Bull., vol. 154, pp. 21-31, Jan. 2020, doi: 10.1016/j.brainresbull.2019.09.014.
[7] D. Gwyer, N. M. Wragg, and S. L. Wilson, “Gastric pentadecapeptide body protection compound BPC 157 and its role in accelerating musculoskeletal soft tissue healing,” Cell Tissue Res., vol. 377, no. 2, pp. 153-159, Aug. 2019, doi: 10.1007/s00441-019-03016-8.
[8] T. Cerovecki et al., “Pentadecapeptide BPC 157 (PL 14736) improves ligament healing in the rat,” J. Orthop. Res. Off. Publ. Orthop. Res. Soc., vol. 28, no. 9, pp. 1155-1161, Sep. 2010, doi: 10.1002/jor.21107.
[9] C.-H. Chang, W.-C. Tsai, Y.-H. Hsu, and J.-H. S. Pang, “Pentadecapeptide BPC 157 enhances the growth hormone receptor expression in tendon fibroblasts,” Mol. Basel Switz., vol. 19, no. 11, pp. 19066-19077, Nov. 2014, doi: 10.3390/molecules191119066.
[10] Song, Ran & Choi, Hyun & Yang, Hyung-In & Yoo, Myung & Park, Yong-Beom & Kim, Kyoung. (2012). Association between serum thymosin β4 levels of rheumatoid arthritis patients and disease activity and response to therapy. Clinical rheumatology. 31. 1253-8. 10.1007/s10067-012-2011-7. [Research Gate]
Anyone know where I can get tb-500 I want to stack with my bpc 157
If I take any of these does my natty card get revoked?
Natty generally refers to anabolic steroids. These peptides are not anabolic steroids, so I would say no. But I'm not the one who determines who is natty and who isn't lol
Both are prohibited by USADA, WADA, UFC, and a number of other sports organizations. They will NOT grant a medical exemption for prescribed treatments since there is no FDA approval. 🙄
SO, if you’re competing in drug tested leagues you cannot use these.
Quick question, hoping someone can help.
How much of the bacteriostatic water do I need to mix into the BPC-157 (5mg) and the TB500 (5mg).
I'm going to be taking these on separate days but need to make sure I get the right amount of water solution into them both.
Help?
We normally create a concentration of 2mg/mL for the BPC-157 and 3mg/mL for the T500. So this would be 2.5mL BAC into the BPC vial and 1.67mL into the TB500 vial.
If you want to make it easy, you can just make the TB500 2mg/mL (so 2.5mL BAC) as well. You just have to adjust your iu dosing to get the proper mcg dose.
Drew Timmermann is great thank you! Is this for a once daily injection protocol of both?
I’ve seen nasal tb500, is that any good?
I don't believe so
So Doctor is one wasting their money buying the oral supplement, is there any benefit because when I've taken it I see results and feel differently
You absolutely do get results from tablets... It's ridiculous to think that they don't work, I've no idea why he says that because they do, some of the tablet will be absorbed differently but it still goes systemic...
Would it help to heal a slipping rib syndrome?
unlikely not, but it may help with the pain and inflammation associated with it
How can i fix the slipping rib syndrome?
Surgery, or potentially PRP injections. Not everyone who has SRS is a candidate for the PRP injections though. I would need to see you in my office to see if you're a candidate
@@DrewTimmermansND
Where is your office?
Gilbert Arizona. You can learn more about us here - regenerativeperformance.com
Tb_500 is something you must mix. How much of the water should I put in? I will be taking it with Bp-157. How much water for bp-157
you could do 1mL or you could do 5mL. The amount of water doesn't matter, because there will always be the same amount of peptide in the total amount of liquid.
Most people make their BPC-157 2mg/mL and TB500 3mg/mL
Is it okay to inject it with no water?
@@neiledward533 it is powder. You Must mix it with the water that comes with it
Hi, do you know any doctors in India who has good knowledge about peptides or specialized in such stuff?
Can you take 10iu of each per week for shins splints
I have BCP-157 10mg and TB-500 10mg cocktail.
So if docage is 3mg, then how many units is need to inject whit insulin suringe?
use a peptide dosage calculator. Search the term online.
Why can’t Tb500 be from a lab?
I just undergone pannus removal/tummy tuck. Im looking to have a speedy recovery. Anyone have some advice on what peptides and dosing for this?
Thanks Doc! I qas doing TB500 daily at about 3mg a week total. If your daily dose of TB500 equals 3mg for the week, does your recommendation of 2 or 3 times a week still hold?
Thanks!!
We have moved to daily dosing, no longer 2-3x a week
@DrewTimmermansND so if I have a 5 mg bottle. I can spread that out over two weeks? Or use it up in one week? Take about 350 iu a day?
whats the dailys dosing amount@@DrewTimmermansND
Doing 1000mcg a day bpc157 and 500mcg of tb500 twice a week for low back SI joint issues and disc buldge. I was hoping that would be enough? Can somone give me some clarity.
Yea that dose should be sufficient. If you don't notice improvements after 4 weeks, let's hop on a call and see if you're a candidate for working one on one with me in Arizona regenerativeperformance.com/contact
Can bpc 157 oral help With ED? If so what site would be the best to buy from?
Yes it can help some patients with EDS, but our approach is typically much more targeted with PRP or stem cell injections. We use the InfiniWell brand as they use the arginate salt. We specifically use the Rapid Pro capsules. We have a 20% patient discount code on our website regenerativeperformance.com/supplements
So are you saying that taking tb500 orally is ineffective??
Correct
@@DrewTimmermansNDthat's horseshit... 100%
So is 500mcg bpc157 and 500mcg tb500 daily good?
Perfect. Start off with that for 3 weeks, then do that dose both morning and evening, for another 3 weeks before you cycle off. Do a Trucheck before starting.
Is. Tb500 safe to take after stem cell therapy 😊
We use it after cellular therapy yes!
@@DrewTimmermansND thanks doctors you da best
@@DrewTimmermansND one more question does it interact with marijuana?
Alongside bpc157
@@DP-jb4yofrom all I've researched and gathered, No it shouldn't have any interaction with Marijuana, but I'm not a doctor. Lol so don't take as an absolute.
I have tb500 and bpc157 orals… I would like to start these for hip/glute weakness strain and pain. Could you recommend a dose schedule? Thanks!
Starting TB500 dose is usually 500mcg once daily, and BPC-157 is 500mcg oral or 300mcg subQ. This is the standard dosing
@@DrewTimmermansND Hi! Thank you so much! Can I take them both at the same time? With a meal or empty stomach? Thanks again! Appreciate this!
Oral BPC-157 should be known empty stomach. We use the InfiniWell brand as they use the arginate salt. We have a 20% patient discount code on our website regenerativeperformance.com/supplements.
You can taken them at the same time
@@DrewTimmermansND thank you so much!
@@DrewTimmermansNDhi Doc, another question if you don’t mind. Is the bpc157 once a day also as with the tb500 or is bpc 2 times a day? Can I take oral bpc157 while using the injectable too? Is in the stomach ok or should I do my thigh if my knee is bothering me? Thanks again Doc!
If I have a 10mg vial of TB500 and I mix 3 ml ……. My needle is 100 units where would I be on my syringe for a daily dosage ….. sorry it gets confusing I already mixed my bpc 157 I have spinal injury 9 mo post op just trying to get off this last oxy daily
30 on the syringe =1mg of tb 500. 15 on the syringe would be .5mg
What about time of day? I saw the video that BPC inj doesn’t matter what about time of day for TB500
We don't think time of day really matters for TB500
@@DrewTimmermansND How about Sermorelin and Ipamorelin. Time of day, what if someone can only eat at 1030 at night. How long should I wait before taking sermorelin or Ipamorelin.
Can I do intramuscular injection in shoulders for TB 500 and BPC-157?
don't need to bother with IM injection as subQ works just as good, and then you don't have to worry about doing an IM injection!
Ok thank you. But does IM work the same? Bc depending on where it is I find sub Q to be more painful.
Can I draw the BPC and TB 500 into one syringe? Or does it need to be separate?
Yes IM works the same. Keep it separate
@@DrewTimmermansNDthank you! I really appreciate your advice and getting back to me so quickly.
Can anyone point me in the direction where to purchase this to Canada? Thank you!
We use the BPC-157 capsules from InfiniWell as they use the arginate salt and they ship to Canada. To help out, we have a 20% patient discount code on our website regenerativeperformance.com/supplements (code is RP20). Once on that website, click the InfiniWell link, and then choose the product labeled 'BPC-157 Original 250mcg'. This is the version that does not have SNAC, which we find works better.
As for TB500, I don't think they are compounding that in Canada. But you could research peptide docs in your area.
@@DrewTimmermansND you’re an absolute legend. Just ordered. Have been looking for quite some time. Appreciate the response very much and the discount helps to!! Take care 🙏 💪
Unfortunately for a lot of us, getting these compounds from a pharmacy is not viable.
Then not worth the risk IMO
@@DrewTimmermansND
Yeah, fair call mate. Under normal circumstances I'd not consider it but I've an upcoming hiking trip in the Himalayas, which I've been planning for for many months and have a mild calf strain I'm trying to overcome. I'm running a short cycle of tb-500, so far there's been no negative sides I've noticed but I accept there is a degree of risk to this approach.
If you're open to a few other suggestions that could help, here are a few things we would consider using in our clinic:
Vitamin C (we use vitality C) 1000mg 3x/day
SPM Active (by Metagenics) 3 softgels 3x/day for 2 weeks
Stem Regen Release 2 caps twice per day
Those are probably the top 3 supplements we find effective for muscle strains.
If you want discounts, you can find the first 2 supplements on our Fullscript account, and the 3rdis found directly from the Stem Regen Website. You can find discount codes here: regenerativeperformance.com/supplements
Mg?? You sure your not talking ius? Seems like a lot
Could you recommend a source to get capsules of BPC-157 in Europe?
Sorry I don't have any European sources. You can check to see if the InfiniWell brand ships there, but i don't think so. If they do, you can get 20% discount with code RP20
I thought dosages was in micro grams? If both are injected can you put both in the same one needle?
1000mcg = 1mg, so if we're doing 3mg each week with daily subQ injections then that's 3000mcg/7 which is just under 500mcg per day.
And no we don't recommened mixing in same syringe
@@DrewTimmermansND thanks. So typically you would do daily doses? For TB as well?
Yes
So what’s the ratio of each if we are doing 3ml a week or is it 3 ml of each
Hey, I have blend of TB500 and BPC157 with 2 ML bacteriostatic water. As it is a blend, what dosage would you recommend?
And instead of bacteriostatic water, Can I use sterile water?
Hi.
Ye bpc 157 ka kya scene hai???
Ye steroids hain kya???
TB500 kya hai joki iske sath mix ho rha hai???
@@SilentSound-oe9pg No brother, Its peptide.
@@rajivshonak2272 kya ye harmful hain steroids ki tarah?? Kya inhe normally le skte hain gym krte hue???? Kya bodybuilding me inka koi asar pdega body bnane me???
@@SilentSound-oe9pg Not harmful, but they are mostly used for treating an injury. It will not help in your bodybuilding goal. Use Only for injury.
I was thinking about the blend as well. How much did you end up doing?
Hi doc, in one of your lectures i hear you say thay u like to start a cycle of thymesin beta 4 / tb500 with a high dose to reach a peak fast and then slowly build it down.
Online i read some articles of suggested dosed between 5-20mg/weekly
So i was thinking of starting with 10-15mg tb500 first week and then slowly building down to 3 while doing 500mcg BPC/daily for 4 weeks.
But.. now i hear you recommend dosing 3-5mg weekly. So one vial (5mg) /weekly is more then enough u would say now?
Yea we have adjusted our thinking on that one, and commonly we are now doing daily dosing with anywhere between 3-5mg weekly (in divided doses, daily)
Hey doc,
Bpc 157
.2 ml daily, with tb 500 twice a week at . 5 ml twice a week.
Is that enough for injury muscle repair? That's what I'm doing atm but would love your advice. I'd be greatful.
Does body weight matter in regards to dosage?
TB 500 pointless orally then?
in my opinion, yes
What dosage and frequency would you recommend for TB-500/BPC-157 mg blend? Everyday or twice a week injections?
If it's a blend (which we never recommend), it's better to do daily injections because you'll want the BPC-157 daily. Dosing recommendations don't change, so you'll just have to do the math to figure out how to get the right amount with both in the blend
@@DrewTimmermansND Thanks for clarifying Dr. Timmermans.
my pleasure
@@rushenpatel5149 different half lifes, TB500 can be injected twice a week whereas BPC157 can be injected once or twice a day
@@thebigwilly123 yes, and I'm hearing people go up to 3 doses a day considering their situation. The argument is that the half life is at about 4-5 hours, and doses can go anywhere from 200- 800 mcg. Obviously only a dr. Can tell you that, but its a.. new trend, shall we say?
Hi
I’m unsure on the dosing. If I mix 5mg of TB 500 with sterile water around 2.5 ml is it still classed as 5 mg? So I would need that full bottle for one week?
Also how many units on the insulin syringe would I want for each injection going off a 5mg a week cycle?
Any help would be fantastic
Thanks 😊
5mg of TB500 in 2.5mL sterile water is 2mg/mL. 1mL is 100 units on an insulin syringe. If you are going to dose at 5mg/week for TB-500 (which is a high dose and you may not need that), then yes you would use a full vial each week. On the lower end, you could dose 3mg/week.
Easy math - if you need to inject 2.5mL over 7 days (for the 5mg dosing), you would be injected 250iu/7 which equals 35.7iu per day (so just round that to 35iu per day).
Hey Thanks for your reply. Although I partly understand I’m
Just wondering a couple more things.
How much water would you advice to mix with the 5mg bottle of TB 500?
How many units on the insulin syringe would you then draw from the bottle for each injection?
Sorry just not 100% on this
It’s for really bad tennis elbow.
Thanks
Hey sorry, I’ve read through your last comment again and understand it all much better now
I think I mite just got for a lower dose of maybe 2mg a week so I guess that would be around 30 units 4 days a week in the insulin syringe
Would you recommend pinching the skin on the elbow like you would for BPC 157 or putting in the stomach?
Thanks
just put it in the stomach fat. even BPC, you don't need to put it anywhere special so just do the abdomen
Thanks 😊
Based on one of the mechanisms of BPC-157 I would also take Growth hormone, IGF-1. Their is a oral available form, Deer Antler Velvet Powder from Barlowes.
yes we find synergy when we also increase GH and IGF-1
Do I need BAC Water
Yes
I'm starting to suspect that if the patient has Mold Toxicity or living in a Moldy Home they should avoid BPC-157 because of the histamine Mast Cell Reaction. Also if they are taking high doses of Opiates for pain.
What is the histamine mast cell reaction
I believe I live in a moldy house hold and am interested in dosing bpc 157. What is this mast cell reax that you are referring to so I know to be safe
I also believe that bpc 157 helps calm a overactive immune system in my understanding mitigating a mast cell reaction and the release of histamines?
Why are you saying that TB-500 tsblets do not work? There are dozens of companies who have tablets out there, plus doctors advising that it will go systemic regardless of delivery method, i couldnt comment on potency, but to say its useless i believe is a lie..
Tablets are BPC157 not TB500
Can TB500 and BPC157 injected the same day?
Doctor recommended 5 units 5 days on 2 off.
But said nothing about TB-500
About to reconstitute a 5mg tb500 vial with 1ml bact water for a dose of 2500mcg, is this right?
no that's not correct. 5mg T500 in 1mL is 5mg/mL (same as 5000mcg/mL). This site may help you - peptidecalc.com/
@DrewTimmermansND forgot to mention I'd be pulling up to 50 iu that should give me 2500mcg or 2.5mg
How much mcg tb500 per week
depends on what's going on, but the range we use is 3-5mg per week, dosed daily. I think a good place for most to start at is about 3mg per week
I been taling 2mgs everyday
For how long?
I took a total dose of 6mg TB500, split into 10 doses. I had to stop due to the side effects.
Worthless video doesn’t specify what dose for what compound don’t waste your time.
Maybe you didn't get far enough into the video where I say that injectable dosing (which is for TB500) is 3-5mg per week?
@@DrewTimmermansND nah it states it as a combination worthless video
ohhh so the product you have is a combination product (which we don't recommend because of dosing issues), so because it doesn't answer your exact question it's a worthless video for everyone else. Got it 👌.
It's too bad you just didn't ask nicely in the comments how to navigate dosing when you have a combo product, as I most likely would have answered. But that time has passed because of your first comment. Best of luck to you
@@DrewTimmermansND clickbait title and your replying to a comment stating your video is worthless. The truth hurts that’s why you’re playing dumb and ignoring the fact that your video is worthless for the title advertised.
You recommend 3-5gs which is an insane spread. I would not take anything you say as credible seeing as your logic for medical recommendation you operate from is whether someone is “nice”. If you were a real dr not a phony you give medical advice that works or doesn’t. Sounds like you have some discriminatory contingencies in your medical advice. That’s pretty funny, you probably do TH-cam cause you can’t actually practice medicine due to your discriminatory behaviors.
I have a 10 mg bottle of TB 500 combined with Bpc 157 5 mg each,any suggestions on how much to take? I was thinking 1000 McG 5 days on 2 days off,thanks
standard (not individualized to you) dosing is 300mcg subQ BPC once daily and 500mcg TB500 subQ once daily. You don't need to cycle 5 on 2 off
@@DrewTimmermansND hello, I love all your information.
I have some questions , regarding Tb-500 & bpc-157 ?
I had a complete rupture of my left biceps tendon and had surgery last week that had to be allograft since my injury was of a sever impact that caused my tendon to retract 6cm with a 12cm hematoma. Had surgery and have been told to take the bpc-157 peptide and tb-500 peptides as they work very well in healing and recovery of then tendons and especially with my case of having a allograft done I need for it to completely heal and make a full recovery since I need to be 100% with the career I have.
I have been told to do bpc-157 every day and tb-500 twice a week.
I just need it for recovery and the recommended dosages for both? Any help woukd be extremely appreciated.
@@DrewTimmermansND would you do tb 500 every day or 2 times a week and what dosage for a tendon surgery recovery?
Where would you recommend inject it i search help for costochondritis
Subcutaneous in the abdomen. Self administered site specific injections are not superior to abdomen.
@@DrewTimmermansND Thank you 🙏🏻