Beth Stevens (Boston Children’s) 1: Microglia States in Health and Disease

www.ibiology.org/neuroscience...
Beth Stevens talks about her work on microglia cells in the brain and the role they play in brain development and neurodegenerative disease.
Microglia are the primary immune cells in the central nervous system. In the brain, they play central roles in proper development and function, as well as dysfunction and disease. In her first talk, Dr. Beth Stevens provides an overview of the many ways microglia cells operate, and how they can both harm and protect the brain. Fairly recent advances in the study of microglia through imaging have allowed researchers to identify different microglia states and study their dynamic roles at different stages of development.
In her second second talk, Dr. Stevens dives deeper into the mechanisms that allow microglia to shape the network of connections between neurons in the brain. She provides an introduction to the role of microglia in synaptic pruning, the process of eliminating extra synapses in healthy developing brains. She then goes on to explain how the reactivation of this process affects aging and diseased brains.
0:00 Start
1:17 What are microglia?
6:01 Microglia in healthy brains
8:55 Synaptic pruning
13:10 Microglia in health and disease
15:50 Heterogeneity in microglia
Speaker Biography:
Beth Stevens is a neurobiologist at Boston Children’s Hospital, the Broad Institute, and the Howard Hughes Medical Institute. Her lab studies neuro-immune interactions in developing and diseased brains. She has made notable discoveries about the role of microglia cells in developmental disorders and neurodegenerative disease.
Stevens earned her B.S. from Northwestern University, her Ph.D. from the University of Maryland, College Park, and completed a postdoctoral fellowship at Stanford University. She has received numerous awards for her work, including the MacArthur Fellowship and the Smith Family Award for Excellence in Biomedical Research, and she is an elected member of the National Academy of Medicine.
www.stevenslab.org
Credits:
Karen Dell (iBiology): Producer
Kevin McLean (iBiology): Producer
Eric Kornblum (iBiology): Video Editor
Chris Vargas (HHMI): Videographer

[@Plain_Wizard]

Wow, amazing presentation! I always wanted to learn more about Microglia, they are like a special unit of the immune system dedicated to protect neurons :)

[@larisabogdan4467]

This video helped me a lot to understand more about Microglia. Thank you!

[@poppetrurazvan3900]

Very complete and expplicit. Thank you.

[@patrickdezeeuw1594]

Listening to Dr. John Krystal on Tim Ferris’s podcast brought me here. Specifically the one on the effects of Ketamine and Rapamycin. How the microglia are gobbling up the new synapses after 72 hours. Rapamycin halted the microglia from gobbling up the new synapses for a longer period. Hopefully they will find why microglia go rogue.

[@heyheyheyhey282]

Nice presentation and interesting mechanisms .Thanks 😊

[@robertkopp873]

Fascinating. Thank you. ✅🌹

[@c.h.8754]

Mind-blowing presentation! I’m curious if you have any input about Hyperbaric Oxygen Therapy and the Glial cells?

[@maxwell3814]

Thank you very much Beth

[@henrylopez3014]

Question: is the gene expression during pruning of the axon pre-synaptic end different than the pruning of the dendritic post-synaptic end because it is a different part of neuron that the microglia is pruning?

[@mahuubao]

Excellent ... well done ... does silent inflammation in the Gut via Microglia influence Apoplexie ?

[@joeguy7690]

Awesome talk

[@rogerscottcathey]

I believe mast cell activation syndrome may be due to over prescribed lithium. Lithium seems to be necessary for wandering cell motility, but an over abundance induces them to seek to purge the glut and results in collection in the renal system. The neural network might realize a similar dysfunction due to overages in motility requirements.

[@yanhan9373]

thanks

[@josephd.4890]

Does fasting help increase their productivity? As in autophagy??

[@sharonjoy3197]

I recommend the book The Angel and the Assassin by Donna Jackson Nakazawa. Beth Stevens is interviewed extensively by the author and interment fasting and it’s benefits are also addressed in later chapters. 🙂

[@michaele.4702]

I find it interesting that their surveying pattern looks near identical to how Physarum polycephalum Plasmodium move searching for food.

[@michaele.4702]

It makes me think that when one gets a signal to trigger a state change it may be sending a signal to others to trigger a change, cascade effect.

[@mikemoss2275]

@@michaele.4702 you talk 2 much 2 urself

[@B.Mega.D]

@@michaele.4702 you mean slime mold? The Japan metro (Tokyo I believe) has been designed based on how slime mold would move. They put it on a mini outline of the city...and you're right! I can see similar motions in the neuralgia.

[@Oona707]

Wow ❤

[@antoniochirico9529]

Please more videos like this, newer videos are less informative

[@ApteraEV2024]

🔔 👍 🥪

[@cingocia2760]

I am an adopted. My mother left me in hospital

[@Mau365PP]

I wonder why.... 😮‍💨

[@cingocia2760]

@@Mau365PP ?

[@mihakavcic7237]

​@@cingocia2760 How old are you?

[@cingocia2760]

@@mihakavcic7237 39 why?

[@mihakavcic7237]

@@cingocia2760 Why are you commeting that you are apopted on a microglia subject?
Is there some missing feeling of love, within you?