Often a splenectomy is part of the treatment as well. This is because myelofibrosis can also lead to splenomegaly, which will cause an massive anaemia.
Great video, thanks so much for your work!. It might be worth noting that Calreticulin gene mutations are responsible for a significant portion of primary myelofibrosis (since JAK2 is only responsible for ~50%).
Hello, I don't want to offend you. But I would like to find out more about the disease. On the Internet, life expectancy is reduced to around 15 years for non-risk patients. Did your doctor tell you anything more specific? Is the statement correct or is it not correct? I thank you in advance for your answer.
My mother’s spleen took over from the bone marrow she survived 15 years died with every organ in her body had cancer the brain was the last to be infected the inhibitors etc she was taking masked thesymptoms of the other cancers
FadeSkywards imatinib is used to treat conditions where there is over-activity of a tyrosine kinase receptor, e.g. in C-kit positive GI stromal tumors, or CML t(9,22) where you get the formation of the Philadelphia chromosome, and the BCR-ABL fusion protein as a result (constitutively active tyrosine kinase receptor). Myeloproliferative disorders (like myelofibrosis, essential thrombocytosis, polycythemia Vera, etc.) are caused by a JAK mutation, which is different, so it needs a different inhibitor (ruxolitinib) :)
Hi! Thanks for letting us know. The video quality seems great on our end, so this might a network connectivity issue. You might want to try playing the video using a different internet connection. 😊
Haematology is my least favourite subject and you guys make it so simple and logical. Keep it up!
HOW THE HELL CAN ANYONE LIKE HEMATOLOGY 😭😭😭😭
@@AhsanKhan1998 Do you drink coffee?
@@MBOsman Why??
Often a splenectomy is part of the treatment as well. This is because myelofibrosis can also lead to splenomegaly, which will cause an massive anaemia.
Great video, thanks so much for your work!. It might be worth noting that Calreticulin gene mutations are responsible for a significant portion of primary myelofibrosis (since JAK2 is only responsible for ~50%).
Thank you so much! Very useful to Learn it within a short period 👍
I have myleofibrosis i got diagnosed at 15 also I was born without a spleen
Hello, I don't want to offend you. But I would like to find out more about the disease. On the Internet, life expectancy is reduced to around 15 years for non-risk patients. Did your doctor tell you anything more specific? Is the statement correct or is it not correct? I thank you in advance for your answer.
@@HBoi-md7yrMaybe she forgot to answer.
Why are these so good?
great video. What causes the itching ?
Puritis is a histamine response.
Well done guys, thanks a lot😊
Any treatment?
Nice Conceptwise Animation !!! It'll help to learn myelofibrosis easily within short time !!
great summary.
Thank you for your help 😊
Happy to help! 💕
such good explanation!!
Thank you! 🙏🏼
Nice explanation Thankyou
Happy to help, Mitanshu! 🙌🏼
Thanks 😊
You're welcome! ❤️
🎉Thank you❤
thank u
Amazing!
Puede poner los subtítulos en español? Plis
"dry tap": on bone marrow aspiration attempt
Also need a video about Essential Thromnocythemia...😇
love u gys !
Thanks
Amazing 👏
Welcome! 😊
muito bom
Another treatment is interferon.
How did you get thee John Mulaney to do this? 🥰
Is it curable?
sadly not
I hate the fact that I'm here because my friend has myelofibrosis. She's currently at the hospital:
My mother’s spleen took over from the bone marrow she survived 15 years died with every organ in her body had cancer the brain was the last to be infected the inhibitors etc she was taking masked thesymptoms of the other cancers
My Deepest Condolences.
So sorry for your Loss.
So sorry for you. How old was she?
Sorry for your loss bro
What about imatinib?
FadeSkywards imatinib is used to treat conditions where there is over-activity of a tyrosine kinase receptor, e.g. in C-kit positive GI stromal tumors, or CML t(9,22) where you get the formation of the Philadelphia chromosome, and the BCR-ABL fusion protein as a result (constitutively active tyrosine kinase receptor). Myeloproliferative disorders (like myelofibrosis, essential thrombocytosis, polycythemia Vera, etc.) are caused by a JAK mutation, which is different, so it needs a different inhibitor (ruxolitinib) :)
the video image is too poor, you need to fix it more
Hi! Thanks for letting us know. The video quality seems great on our end, so this might a network connectivity issue. You might want to try playing the video using a different internet connection. 😊
Superrrrr
⚡️⚡️⚡️
👍🏻
❤❤❤❤❤❤
Doesn't really causes....
my father survived for 3 years, then came leukemia...
My his soul Rest In Peace , 3 years from discovering myelofibrosis?
😍
Look at em' cute immature wbc. hehehe...