What Are the Treatment Options for BRAF Mutated Melanoma?

Melanoma is a type of skin cancer that develops in the cells that produce melanin, the pigment that gives skin its color. It is the most dangerous form of skin cancer, and if left untreated, it can spread to other parts of the body and become life-threatening. BRAF-mutated melanoma is a type of skin cancer that is caused by mutations in the BRAF gene.
BRAF (v-raf murine sarcoma viral oncogene homolog B) is a gene that plays a crucial role in cell growth and division. Mutations in this gene can cause cells to grow and divide uncontrollably, leading to the development of cancer.
BRAF mutations are present in approximately 50% of all melanoma cases, making it the most common genetic mutation in this type of cancer. These mutations are more prevalent in younger patients and those with a history of excessive sun exposure.
One of the most significant advancements in the treatment of melanoma has been the development of precision oncology, which involves using biomarker testing to identify specific genetic mutations in a patient's cancer cells. This allows doctors to tailor treatment plans to target specific mutations and improve outcomes for patients.
In this video, Melissa discusses the treatment options for BRAF-mutated melanoma and the role of precision oncology in improving patient outcomes.

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what are the reasons of bRAF mutation?

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A BRAF mutation in melanoma is a spontaneous change in the BRAF gene that causes it to function incorrectly. This can lead to uncontrolled cell growth, which can cause melanoma to grow faster. BRAF mutations can be caused by environmental factors or errors during cell division. Around 50% of melanomas have an acquired BRAF mutation, which means it develops after birth. Acquired changes are usually not passed down to children because they don't occur in sperm or egg cells. People can also inherit a BRAF mutation from their biological parents, but this is very rare and can cause serious health issues.