Lysosome | NMDCAT 2022 | Cell Biology

Lysosome | NMDCAT 2022 | Cell Biology
About This Video ........................
In This Video Lecture You Will Learn Basic Concept Of Lysosomes
Lysosomes are cytoplasmic organelles and are different from others due to their morphology.
those animal cells which exhibit phagocytic activity. They are bounded by a single membrane and synthesized on RER and are further processed in the Golgi apparatus. The processed enzymes are These were isolated as a separate component for the irst time by De Duve (1949). Lysosomes (Lyso
= splitting; soma = body) are found in most eukaryotic cells. Any foreign object that gains entry into
the cell is immediately engulfed by the lysosome and is completely broken into simple digestible
pieces. The process is known as phagocytosis (eating process of a cell). They are most abundant in
are simple sacs rich in acid phosphatase and several other hydrolytic enzymes. These enzymes are budded of as Golgi vesicles and are called as primary lysosomes. Lysosomes contain those enzymes which can digest the phagocytosed food particles.
components of the vacuole. Some times, under abnormal circumstances, e.g. starvation, or as a glucose, is absent. About twenty such diseases are known these days, which are because of absence such as glycogen or various glycolipids. These are also called storage diseases and are produced of a particular enzyme. For example Tay-Sach’s disease is because of absence of an enzyme that is of cell, such as old mitochondria are digested. In this way, materials of cell may be recycled and cell Several congenital diseases have been found to be due to accumulation within the cell of substances
They are also involved in the autophagy (self eating). During this process some old, worn out parts
developmental processes. Lysosomes also release enzymes for extra cellular digestion.
glycogen within membrane bound organelles. In this disease, an enzyme that degrades glycogen to
by a mutation that effect one of the lysosomal enzymes involved in the catabolism of a certain
normal physiological process the parts of the cell are engulfed by primary lysosomes and digested
substance. For example, in glycogenosis type II disease, the liver and muscle appear filled with
involved in the catabolism of lipids. Accumulation of lipids in brain cells lead to mental retardation
The digestive vacuoles and autophagosomes are also known as Secondary Lysosomes.
may be renewed. Their enzymes can also result in degeneration of cell, as may occur during some
to generate energy. The lysosomes which eat parts of their own cell are known as autophagosomes.
and even death.
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Lysosomal pH is kept at 4.5-5 ?

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no difference, all primary lysosomes can be called Golgi vesicles but not all Golgi vesicles can be called primary lysosomes because there are also some other types of vesicles produced by Golgi complex and those may not contain lysosomal enzymes therefore not all Golgi vesicles are primary lysosomes but all primary lysosomes can be called Golgi vesicles

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