I don't think I can exaggerate how much Psilocybin has helped me since I started using it for self treatment about 5-6 years ago. My anxiety is completely gone after more than 20 years of constantly being anxious, irritated and easy to anger. Microdosing psilocybin is also really good for lifting the mood, but mega dosing (3-5 gram) is where the magic happens. It's hard to describe the changes that goes on during and after a trip. The first time I mega dosed I felt like I've been to 100 hours of therapy - it was simply amazing and so much stuff in my life just fell into place. I''ve only tried Ayahuasca once and it wasn't a strong trip, but it was still impactful. But for me personally it's much easier and more pleasant to consume mushrooms so I don't think I'll try Auahuasca again.
When I first started tripping I thought I'd be cured from my lifelong depression immediately. But it didn't work like that. After many many trips I think I have changed, my views are changing, my personality is changing. And now I am planning to do a lot larger doses. Now I have zero fear of side effects. All trips are great, independent of dosage, and even "bad" trips are very useful.
Quick question about the DMT brain scans you mention towards the end. Wouldn't more entropic mean more chaotic? How does it translate to more information rich? Isn't more order when it comes to neuron connection correlated with more pattern formation? I was taught two terms in Physics class (I am Greek so I will share the terms in Greek and then the English translation could be slightly off) Ενθαλπία-Enthalpia means the concentrated dynamic (or potential) energy between the chemical bonds of molecules and also systems like springs under tension. Εντροπία-Entropy the inverse correlation of enthalpia, meaning the lack of potential energy within a system (in terms of physics that would translate to a chamber of gas with uniform temperature throughout, as opposed to a chamber where the starting condition has an imbalance of temperature leading to a breeze and an exchange of energy) In the system where the most disorder has not been reached we can say the system has enthalpia, or latent potential energy. In any case, by those definitions I would expect a more information dense brain to appear more enthalpic rather than more entropic. 😝😝 Sorry for the long tangent.
@@TheSheekeyScienceShow my guess is that it is described as more entropic from the perspective of the brain scan itself, meaning that to map it with a computer it would take more information to simulate the more chaotic neurons firing patterns. However that doesn't necessarily translate to more stable neuron connections, it could be that it breaks the weak neuron connections that have not formed a strong bond yet and quite literally clearing the head from too much worries about uncertain things 😝
using the serotonin transporter mutation to prove activity inside the call causes dendrite growth is a game changer, it was thought that raising mTor or BDNF levels was responsible for it, it may still be part of it but this shows that activity inside the cell should be the focus rather than what binds to receptor walls after crossing the synapse.
an interesting aspect of the action of psychedelics is the heterodimerization of HT2A with glutamate receptors. Glu-.receptor knockout mice do not show psychedelic symptoms
I hope they will do more study in the use for spine density …. spinal problem are one of the largest in the human race. Would be stupid to let this study to waist.
Apparently we're all already producing DMT endogenously and there might be some link between it and dreaming states, it might have something to do with melatonin metabolism, but I don't know all the details. Do you think you might do a video on AI in rejuvenation medicine soon? 😆
A wonderful intro to this area, but please, slow down a little! You blew through this rather information-rich material so fast, and skipped between graphics/text so quickly, that even with rewindings it was tricky to follow. Your work and comprehensive mastery of subject are awesome, but it may find greater penetrance if you dial back the pace of cognitive demand on your audience a tad.
70 year old guy here..... i remember Timothy Leary trying to convince LA drivers that I-5 thru town had disappeared. 🤪🤪🤪 the concept of playing with brain chemistry has 2 edges. progress and destruction. i think Durk and Sandy had it correct when they stated the best condition in a brain is BALANCE
Beware of spam comments! i'll try and block/delete as much as i can. Otherwise hope you're having a nice weekend!
I don't think I can exaggerate how much Psilocybin has helped me since I started using it for self treatment about 5-6 years ago. My anxiety is completely gone after more than 20 years of constantly being anxious, irritated and easy to anger. Microdosing psilocybin is also really good for lifting the mood, but mega dosing (3-5 gram) is where the magic happens. It's hard to describe the changes that goes on during and after a trip. The first time I mega dosed I felt like I've been to 100 hours of therapy - it was simply amazing and so much stuff in my life just fell into place.
I''ve only tried Ayahuasca once and it wasn't a strong trip, but it was still impactful. But for me personally it's much easier and more pleasant to consume mushrooms so I don't think I'll try Auahuasca again.
When I first started tripping I thought I'd be cured from my lifelong depression immediately. But it didn't work like that. After many many trips I think I have changed, my views are changing, my personality is changing. And now I am planning to do a lot larger doses. Now I have zero fear of side effects. All trips are great, independent of dosage, and even "bad" trips are very useful.
Quick question about the DMT brain scans you mention towards the end. Wouldn't more entropic mean more chaotic? How does it translate to more information rich? Isn't more order when it comes to neuron connection correlated with more pattern formation? I was taught two terms in Physics class (I am Greek so I will share the terms in Greek and then the English translation could be slightly off) Ενθαλπία-Enthalpia means the concentrated dynamic (or potential) energy between the chemical bonds of molecules and also systems like springs under tension. Εντροπία-Entropy the inverse correlation of enthalpia, meaning the lack of potential energy within a system (in terms of physics that would translate to a chamber of gas with uniform temperature throughout, as opposed to a chamber where the starting condition has an imbalance of temperature leading to a breeze and an exchange of energy) In the system where the most disorder has not been reached we can say the system has enthalpia, or latent potential energy. In any case, by those definitions I would expect a more information dense brain to appear more enthalpic rather than more entropic. 😝😝 Sorry for the long tangent.
I haven't had time to read the new paper fully yet!
@@TheSheekeyScienceShow my guess is that it is described as more entropic from the perspective of the brain scan itself, meaning that to map it with a computer it would take more information to simulate the more chaotic neurons firing patterns. However that doesn't necessarily translate to more stable neuron connections, it could be that it breaks the weak neuron connections that have not formed a strong bond yet and quite literally clearing the head from too much worries about uncertain things 😝
I really do think there is great promise here!
using the serotonin transporter mutation to prove activity inside the call causes dendrite growth is a game changer, it was thought that raising mTor or BDNF levels was responsible for it, it may still be part of it but this shows that activity inside the cell should be the focus rather than what binds to receptor walls after crossing the synapse.
Yeah, mtor is likely still a downstream response to whatever happens following 5-ht2a r activation intracellularly
an interesting aspect of the action of psychedelics is the heterodimerization of HT2A with glutamate receptors. Glu-.receptor knockout mice do not show psychedelic symptoms
The increased spine density is what interests me... above all .. Thanks
Wow ... I am now glowing ..Thanks
I hope they will do more study in the use for spine density …. spinal problem are one of the largest in the human race. Would be stupid to let this study to waist.
👍💯🔥
Apparently we're all already producing DMT endogenously and there might be some link between it and dreaming states, it might have something to do with melatonin metabolism, but I don't know all the details.
Do you think you might do a video on AI in rejuvenation medicine soon? 😆
DMT is endogenously synthesized in mammals from the essential amino acid l-tryptophan
i also don't know all the details, but is interesting
A wonderful intro to this area, but please, slow down a little! You blew through this rather information-rich material so fast, and skipped between graphics/text so quickly, that even with rewindings it was tricky to follow. Your work and comprehensive mastery of subject are awesome, but it may find greater penetrance if you dial back the pace of cognitive demand on your audience a tad.
Psychoplastogenicity is a good name for a concept album
70 year old guy here.....
i remember Timothy Leary trying to convince LA drivers that I-5 thru town had disappeared.
🤪🤪🤪
the concept of playing with brain chemistry has 2 edges. progress and destruction.
i think Durk and Sandy had it correct when they stated the best condition in a brain is BALANCE