Great work and another reminder of the Goldilocks principle - not too much, not too little (of beta cryptoxanthine in this case). And every gastrointestinal doctor I know says that the upper limit of normal should be in the mid to low 20s for both AST and ALT. The fact that labs have expanded their “normal” range up to the 40s is not consistent with good health. To get AST and AL T down to healthy ranges, in addition to lowering intake of processed carbs, one should also try to eliminate alcohol and Tylenol/acetaminophen which all put extra burden on the liver.
Just a quick mention - upper range for AST used to be 25, not 40, like 30-40 years ago. That range changed based on the current population average numbers which is a new “healthy” benchmark now, as I understand, but critically speaking it should be at/below 25
Awesome content! A close family member of mine recently came back with elevated AST ~50 and their doctor didn’t even mention it! My best guess is it’s probably related to their high sugar intake not so much b-cryptocanthin - I’m left recommending diet/exercise changes + seeing a new doctor. It is crazy how many doctors don’t focus on prevention/longevity, sometimes all it takes is simple lifestyle changes - hopefully content like yours changes things. I’m curious if fructose was correlated with your AST/ALT at all? It would be surprising seeing as nearly all your fructose comes from whole food sources. Cheers
Thanks Tom! What impacts AST may not be the same for everyone. For me, it's not strongly correlated with glucose levels (r=0.36). The correlation for AST with my total fructose intake was even weaker, r=0.19.
@@conqueragingordietrying123 How about total carbohydrate intake and daily calories? Or maybe even better, fructose/total calories. As we know the liver is the master processor for most higher level nutrients, I would also look at these. Your micronutrient analysis is very cool, although I can't stop thinking it could only be an association caused by some other ratio in your diet. For me AST plummeted during my keto period.
@@tonipieleanu Total calories wasn't significantly associated with AST (r=0.00). My total carb intake is weakly, but significantly correlated (r=0.41, p=0.008) with higher AST, but note the stronger correlation for B-cryptoxanthin (r=0.70), which is why I focused on that in the video. For this blood test, my total carb intake is a bit lower than my average intake over the past 6 years, so it will be interesting if its weak correlation with AST gets stronger or not.
I think its better to use good evidence-based medicine to make health decisions rather than a single case report on megadose beta crypto... there are dozens of RCTs that show effective interventions to reduce AST that I have in my AST/ALT/ALP/GGT optimisation guidelines.
@@droliverzolman If you mean testing at the individual level, then I obviously agree. Note that what works in interventional trials may not work at the individual level-at least that's my experience.
Not sure how relevant it might be, but there seems to be an interesting link between Natural Flavonoids like Apigenin, Quercetin, Luteolin, Chrysin and cholesterol in increasing free testosterone in the body, especially as something that decreases during aging, being able to avoid having to use TRT would be a huge bonus in order to preserve muscle mass.
Ah. I suggested butternut squash several times. Now, I see why you are not eating it. How were you preparing the butternut squash? My AST is 22, and it came down to that while I was eating butternut squash regularly. I slice it lengthwise and put a light dusting of Ceylon cinnamon and a very small amount of brown sugar on it (it is mixed into the cinnamon, maybe 3 parts cinnamon and 1 part brown sugar), seal it in something and cook it in the microwave. Nothing burned or singed. Nothing dried out. Not boiled where flavor would be lost, not blended where AGEs might be formed, and not with butter which is full of AGEs. I also cook it so all of it is soft. And I generally eat the skin. I don't know if that is brilliant or not. Just saying what I am doing. Steaming would probably accomplish the same result, if you are anti-microwave, or just don't have one. I suspect, if your prep method is not ideal, you may be miss-attributing the problems to the squash and the beta-cryptoxanthin. Carotenoids have the best effects on methylation of anything. I don't know. It contributes to me feeling better, so I can't help thinking it has gotten a bad rap. People can also be different, I suppose. And farms can do different things.
I had elevated AST when I had my newest blood test and all data in the past were in good range. After watching your video I realize I consumed too much beta crytpxanthin from taking a cayenne pepper supplement lately (to increase brown fat supposedly)!! So another piece of evidence to support your theory!
You cut out the supplement and AST went down? To evaluate that link further, you need to know your dietary intake, and compare it with/without the supplement. Other things may affect my AST, too, including too much niacin (> 40 mg/d) and/or fructose (from FV).
@@conqueragingordietrying123 Before I started taking the cayenne supplement my AST and ALT were good in every blood test. It is only after I started supplementing (for about a month before the test) that they got elevated. I stopped and will get my test in about two months - let’s see if they come back to normal. By the way I refrain from fructose - no fruit and low sugar vegetables, and I don’t take niacin.
@@Blkpll Good liver function may be one of the most important organs for longevity-I'll have more on that on this channel and in a future academic publication, so optimizing AST and ALT is important (imo). Mine were double what they are now when I first started tracking in 2015, so they're definitely malleable via diet and/or supplements.
Awesome! So we covered the liver functions: Albumin, ALP and AST. We are missing the last one: ALT. I hope you find time for it! Thanks Edit: There is also Bilirubin I forgot, but I prefer the ALT if possible.
Thanks for the great content. Always interested in better understanding nutrition on aging and mortality. There are still 2 other major variables on aging which you have spent less time talking about: sleep and exercise. We all know that sleep is hugely important and they impact on your recovery, quality of life and potential for developing Alzheimer for example. Exercise is quite controversial because we all know we need some but how much. The more delicate question is how much and how intense. The intensity is a major variable that could play a positive role on your overall health but can we measure its impact on aging. There is also cardiac vs strength exercises which we both need but there are very few articles on aging and which one is better or in what ratios. Let us know your take and if you intend to review both subjects.
Thanks ccamire, and I have videos for both sleep and exercise: th-cam.com/video/XskTAUb6-ac/w-d-xo.html th-cam.com/video/oqkt_aWweK4/w-d-xo.html I'm still growing my channel, so I'd expect more of those videos in the future!
Just like you i am trying to optimize my aging thru better health. Currently at 65 yrs old, i am looking to be healthy until at least 90 by biking, strength exercise, high sleep score on fitbit and optimal nutrition without any drugs except for very few supplements like magnesium and electrolytes. Obviously optimal nutrition is such a debatable discussion. Hopefully artificial intelligence might help in the future to analyze all the data that you are compiling for helping people. Thanks again.
N=1 result. I'm in my 50s, my AST =24 (1 month ago). Carnivorish diet. I don't eat vegetables or fruits (unless I'm lost in the woods and I can't hunt things that move.)
Nice AST. Have you had a look at this video from Michael, a case study on blood markers on a carnivore diet? th-cam.com/video/6Rc9xLvD2PU/w-d-xo.html It might be useful for you to get some context and see how you’re doing with other important markers.
I love the content. However, one weakness in the general public trying to apply the information in your videos to themselves is that your correlation findings are often based upon a sample size of one person. It could be that these correlations only apply to you and no one else. It also could be that the correlations that you report are just correlations and not causations. These are some of the disadvantages of using a sample size of one.
That's exactly right, and I would never tell someone to eat this way based on my data. What I do support is everyone rigorously testing themselves to identify the diet pattern that best optimizes the sum of of their biomarkers. In terms of using a larger samples size, one would still need to do the experiment on themselves to see if the population-based average works on them. So there are strengths and limitations to each approach.
A complex thing to measure... but have you considered the synergistic effect that combining different plant foods could be having on the impact on your health. E.g. the benefits of cruciferous vegetables when combined with mustard seeds is enhanced. There are many examples of this in nature. I wonder if this could play a part in the effects you get on your biomarkers as your charts look at how x is affected by plant y rather than how x is affected by combining y and z or y and u
@@conqueragingordietrying123 oo no I am sorry if you misunderstand. I don't mean plant vs animal. I mean that some beneficial compounds in food items can be enhanced or hindered based on how they are prepared and what they are combined with. Some reduce bioavailability in the body whereas others enhance them.
@@littlevoice_11 I'm not into food combining-I just eat, and I try to focus on foods that I enjoy and that are a net positive on the composite of my biomarkers. It's too technical for me to try to combine foods for different potential effects.
Thanks Christopher L. That's further down on my list, as it's not usually included on the standard chemistry panel and I haven't measured it in my data yet. I try to go over the most frequently measured biomarkers first.
Bell pepper is an excellent choice not only for carotenoids but also is highly concentrated in vitamin C, ascorbic acid ( Albert Szentgyörgyi, Nobel Prize 1937).
Dr, what’s your take on ALT, and the ALT:AST ratio? My understanding is that a ratio of >2 is indicative of liver disease. On my last blood work, my ALT was 40, and my AST was 23. That’s just about 2:1. Any thoughts?
Dr, how in this video you found that 21-23 is optimal but in one of your articles on the website you presented a meta analysis that shows 10-15 may be optimal?
Hey Obi z, great catch. The AST video is based on more recent data in a larger study (n=16.6 million subjects). I'll have more on evaluating what's optimal for AST in an upcoming video-, as 15 - 23 may not be optimal for me, based on correlations for AST with other blood biomarkers.
Hey Obi Z, I see your recent comment in my email, but not on TH-cam. "I'm not sure it's correct to look for optimal AST quartiles in a study that split people to quartiles based on their GGT levels ("Implication of liver enzymes on incident cardiovascular diseases and mortality: A nationwide population-based cohort study"). In this way, AST quartiles are not isolated, and GGT can be a confounding variable, isn't it?" AST may be one of the trickiest biomarkers to pick an optimal range. Sure, based on large epi studies, somewhere close to 20 may be optimal. But, it increases during aging, and falls towards the end of life. I'm considering using the ratio for AST/ALT as a more informative index, relative to AST or ALT alone. Assuredly, though (based on the published studies), AST values approaching 40 is not optimal. But, is 15 better than 20 or 25? That's a very tough question, based on my reading of the literature.
It may be there as SGOT, which is the same thing. AST is on the standard chemistry panel in the US, it may be different elsewhere, but is usually included as a part of a yearly physical.
I take niacin. It increases my ast. It really helps keeping my cholesterol low and Lpa low. Also, triglycerides low. Would like to know how niacin affects you. Thanks for video
@@conqueragingordietrying123 Thanks for sharing. My TC is 106, my LDL 54, my triglycerides 26, Lp(a) @70 my ast 47! I'm going to try find other foods to improve my ast. Lemons are good for liver. Also beets are blood cleanser. Also i get those results from 1k mg or less. Best wishes on your continued health journey 🙏😊 just got in my Lpa score from test done on 6/28 results 51!! Thank God! I may tweak my niacin just a tad lower but with these results i going to continue with it. I wouldn't throw the baby out with the bathwater. 🥑
Perhaps this video demonstrates that when we try to fix one biomarker we often break another. This may be nature's way of checkmating us into a timely death.
That's why monitoring the effect on multiple biomarkers, and determining whether the overall correlation is net positive, neutral, or negative, is important.
Interesting. Due to one of your previous videos, I increased my betacrytoxanthin intake through one red pepper approx five days a week. Now I wonder whether that was a good idea.
A higher intake of b-cryptoxanthin is associated with a younger biological age, but the issue is dose. How much is too high? It's doubtful that 1 red pepper 5d/wk would be too much. 1lb of butternut squash/day, on the other hand, and based on my data, may be too much.
For me, figuring out the diet, exercise, and targeted supplementation approach to optimize as many biomarkers as possible is the approach. If that stops working, then maybe I'd use some drugs.
I didn't look specifically at beta-cryptoxanthin, but all of my dietary nutrients, including macros and micros. Of those, b-cryptoxanthin had the strongest correlation with AST.
@@conqueragingordietrying123 There are reasons that puzzels me. First cancers bypass the mitochondria using sugars as fuel to avoid apoptosis, so the ketone produced by aat should help turn on mitochondrial apoptosis killing cancers. But the reaction might be too slow. And then again the brain needs aspartate to produce myelin so perhaps excess aat could harm the brain. Perhaps published data would tell you that. But also I don't grasp why foods that upreglate sirtuins and logically kill cancers would be anti productive unless related to neuro degeneration. Something important is missing.
Great work and another reminder of the Goldilocks principle - not too much, not too little (of beta cryptoxanthine in this case). And every gastrointestinal doctor I know says that the upper limit of normal should be in the mid to low 20s for both AST and ALT. The fact that labs have expanded their “normal” range up to the 40s is not consistent with good health. To get AST and AL T down to healthy ranges, in addition to lowering intake of processed carbs, one should also try to eliminate alcohol and Tylenol/acetaminophen which all put extra burden on the liver.
This channel will go far.
Thanks Think&Grow Healthy! Even if it grows slowly (which it hasn't so far), I'm gonna make biohacking aging videos for at least the next 75 years!
This video makes me feel good that my AST was 20 on my recent blood panel at 49 years old.
20 is good news!
Just a quick mention - upper range for AST used to be 25, not 40, like 30-40 years ago. That range changed based on the current population average numbers which is a new “healthy” benchmark now, as I understand, but critically speaking it should be at/below 25
Nicotinic Acid increases ALT & AST so this is interesting.
Awesome content!
A close family member of mine recently came back with elevated AST ~50 and their doctor didn’t even mention it! My best guess is it’s probably related to their high sugar intake not so much b-cryptocanthin - I’m left recommending diet/exercise changes + seeing a new doctor.
It is crazy how many doctors don’t focus on prevention/longevity, sometimes all it takes is simple lifestyle changes - hopefully content like yours changes things. I’m curious if fructose was correlated with your AST/ALT at all? It would be surprising seeing as nearly all your fructose comes from whole food sources.
Cheers
Thanks Tom! What impacts AST may not be the same for everyone. For me, it's not strongly correlated with glucose levels (r=0.36). The correlation for AST with my total fructose intake was even weaker, r=0.19.
@@conqueragingordietrying123 How about total carbohydrate intake and daily calories? Or maybe even better, fructose/total calories. As we know the liver is the master processor for most higher level nutrients, I would also look at these. Your micronutrient analysis is very cool, although I can't stop thinking it could only be an association caused by some other ratio in your diet. For me AST plummeted during my keto period.
@@tonipieleanu Total calories wasn't significantly associated with AST (r=0.00). My total carb intake is weakly, but significantly correlated (r=0.41, p=0.008) with higher AST, but note the stronger correlation for B-cryptoxanthin (r=0.70), which is why I focused on that in the video.
For this blood test, my total carb intake is a bit lower than my average intake over the past 6 years, so it will be interesting if its weak correlation with AST gets stronger or not.
I think its better to use good evidence-based medicine to make health decisions rather than a single case report on megadose beta crypto... there are dozens of RCTs that show effective interventions to reduce AST that I have in my AST/ALT/ALP/GGT optimisation guidelines.
@@droliverzolman If you mean testing at the individual level, then I obviously agree. Note that what works in interventional trials may not work at the individual level-at least that's my experience.
Not sure how relevant it might be, but there seems to be an interesting link between Natural Flavonoids like Apigenin, Quercetin, Luteolin, Chrysin and cholesterol in increasing free testosterone in the body, especially as something that decreases during aging, being able to avoid having to use TRT would be a huge bonus in order to preserve muscle mass.
Ah. I suggested butternut squash several times. Now, I see why you are not eating it. How were you preparing the butternut squash? My AST is 22, and it came down to that while I was eating butternut squash regularly. I slice it lengthwise and put a light dusting of Ceylon cinnamon and a very small amount of brown sugar on it (it is mixed into the cinnamon, maybe 3 parts cinnamon and 1 part brown sugar), seal it in something and cook it in the microwave. Nothing burned or singed. Nothing dried out. Not boiled where flavor would be lost, not blended where AGEs might be formed, and not with butter which is full of AGEs. I also cook it so all of it is soft. And I generally eat the skin. I don't know if that is brilliant or not. Just saying what I am doing. Steaming would probably accomplish the same result, if you are anti-microwave, or just don't have one.
I suspect, if your prep method is not ideal, you may be miss-attributing the problems to the squash and the beta-cryptoxanthin. Carotenoids have the best effects on methylation of anything. I don't know. It contributes to me feeling better, so I can't help thinking it has gotten a bad rap.
People can also be different, I suppose. And farms can do different things.
Just got my blood work. My AST was 16. How am I living, Doc?
I had elevated AST when I had my newest blood test and all data in the past were in good range. After watching your video I realize I consumed too much beta crytpxanthin from taking a cayenne pepper supplement lately (to increase brown fat supposedly)!! So another piece of evidence to support your theory!
You cut out the supplement and AST went down? To evaluate that link further, you need to know your dietary intake, and compare it with/without the supplement. Other things may affect my AST, too, including too much niacin (> 40 mg/d) and/or fructose (from FV).
@@conqueragingordietrying123 Before I started taking the cayenne supplement my AST and ALT were good in every blood test. It is only after I started supplementing (for about a month before the test) that they got elevated. I stopped and will get my test in about two months - let’s see if they come back to normal. By the way I refrain from fructose - no fruit and low sugar vegetables, and I don’t take niacin.
@@Blkpll Good liver function may be one of the most important organs for longevity-I'll have more on that on this channel and in a future academic publication, so optimizing AST and ALT is important (imo). Mine were double what they are now when I first started tracking in 2015, so they're definitely malleable via diet and/or supplements.
Awesome! So we covered the liver functions: Albumin, ALP and AST. We are missing the last one: ALT. I hope you find time for it! Thanks Edit: There is also Bilirubin I forgot, but I prefer the ALT if possible.
Also the AST/ALT ratio...
Thanks for the great content. Always interested in better understanding nutrition on aging and mortality. There are still 2 other major variables on aging which you have spent less time talking about: sleep and exercise. We all know that sleep is hugely important and they impact on your recovery, quality of life and potential for developing Alzheimer for example. Exercise is quite controversial because we all know we need some but how much. The more delicate question is how much and how intense. The intensity is a major variable that could play a positive role on your overall health but can we measure its impact on aging. There is also cardiac vs strength exercises which we both need but there are very few articles on aging and which one is better or in what ratios. Let us know your take and if you intend to review both subjects.
Thanks ccamire, and I have videos for both sleep and exercise:
th-cam.com/video/XskTAUb6-ac/w-d-xo.html
th-cam.com/video/oqkt_aWweK4/w-d-xo.html
I'm still growing my channel, so I'd expect more of those videos in the future!
Just like you i am trying to optimize my aging thru better health. Currently at 65 yrs old, i am looking to be healthy until at least 90 by biking, strength exercise, high sleep score on fitbit and optimal nutrition without any drugs except for very few supplements like magnesium and electrolytes. Obviously optimal nutrition is such a debatable discussion. Hopefully artificial intelligence might help in the future to analyze all the data that you are compiling for helping people. Thanks again.
Great information. Thank you Michael.
Thanks @vegasallen1!
N=1 result. I'm in my 50s, my AST =24 (1 month ago). Carnivorish diet. I don't eat vegetables or fruits (unless I'm lost in the woods and I can't hunt things that move.)
Nice AST. Have you had a look at this video from Michael, a case study on blood markers on a carnivore diet?
th-cam.com/video/6Rc9xLvD2PU/w-d-xo.html
It might be useful for you to get some context and see how you’re doing with other important markers.
I love the content. However, one weakness in the general public trying to apply the information in your videos to themselves is that your correlation findings are often based upon a sample size of one person. It could be that these correlations only apply to you and no one else. It also could be that the correlations that you report are just correlations and not causations. These are some of the disadvantages of using a sample size of one.
That's exactly right, and I would never tell someone to eat this way based on my data. What I do support is everyone rigorously testing themselves to identify the diet pattern that best optimizes the sum of of their biomarkers.
In terms of using a larger samples size, one would still need to do the experiment on themselves to see if the population-based average works on them. So there are strengths and limitations to each approach.
There are also dozens of randomised controlled trials that show you how to reduce ALT, AST, GGT, ALP....
Thank you for the video my numbers at 34 years ...AST 16, ALT 14 , GGT 18, Alkaline Phos. 70 on Keto Carnivorish paleo style diet
A complex thing to measure... but have you considered the synergistic effect that combining different plant foods could be having on the impact on your health. E.g. the benefits of cruciferous vegetables when combined with mustard seeds is enhanced. There are many examples of this in nature. I wonder if this could play a part in the effects you get on your biomarkers as your charts look at how x is affected by plant y rather than how x is affected by combining y and z or y and u
I don't specify plant vs animal intake for my biomarkers-I let the data dictate what is strongly correlated or not, without any pre-existing bias.
@@conqueragingordietrying123 oo no I am sorry if you misunderstand. I don't mean plant vs animal. I mean that some beneficial compounds in food items can be enhanced or hindered based on how they are prepared and what they are combined with. Some reduce bioavailability in the body whereas others enhance them.
@@littlevoice_11 I'm not into food combining-I just eat, and I try to focus on foods that I enjoy and that are a net positive on the composite of my biomarkers. It's too technical for me to try to combine foods for different potential effects.
@@conqueragingordietrying123 I respect your decision and find your work very interesting. Your commitment to sharing health research is wonderful
Great content! Any chance ferritin will be discussed? Thanks!
Thanks Christopher L. That's further down on my list, as it's not usually included on the standard chemistry panel and I haven't measured it in my data yet. I try to go over the most frequently measured biomarkers first.
Bell pepper is an excellent choice not only for carotenoids but also is highly concentrated in vitamin C, ascorbic acid ( Albert Szentgyörgyi, Nobel Prize 1937).
That's right, and I have a video about Red Bell Peppers being an All-Star for Vitamin C, too:
th-cam.com/video/MNcfDzhXuRw/w-d-xo.html
Good video. My recent AST came out 14. Any idea how can I improve it?
Thanks amstvm. Regular exercise can increase it by a bit, as published in the 1st paper in the video's description.
All my life I have had around 20/21. I guess it's ok.
Dr, what’s your take on ALT, and the ALT:AST ratio? My understanding is that a ratio of >2 is indicative of liver disease. On my last blood work, my ALT was 40, and my AST was 23. That’s just about 2:1. Any thoughts?
Hi K J, AST, ALT, and their ratio data is presented here:
th-cam.com/video/du3pjIpoC8Q/w-d-xo.html
Dr, how in this video you found that 21-23 is optimal but in one of your articles on the website you presented a meta analysis that shows 10-15 may be optimal?
Hey Obi z, great catch. The AST video is based on more recent data in a larger study (n=16.6 million subjects). I'll have more on evaluating what's optimal for AST in an upcoming video-, as 15 - 23 may not be optimal for me, based on correlations for AST with other blood biomarkers.
Hey Obi Z, I see your recent comment in my email, but not on TH-cam.
"I'm not sure it's correct to look for optimal AST quartiles in a study that split people to quartiles based on their GGT levels ("Implication of liver enzymes on incident cardiovascular diseases and mortality: A nationwide population-based cohort study"). In this way, AST quartiles are not isolated, and GGT can be a confounding variable, isn't it?"
AST may be one of the trickiest biomarkers to pick an optimal range. Sure, based on large epi studies, somewhere close to 20 may be optimal. But, it increases during aging, and falls towards the end of life. I'm considering using the ratio for AST/ALT as a more informative index, relative to AST or ALT alone. Assuredly, though (based on the published studies), AST values approaching 40 is not optimal. But, is 15 better than 20 or 25? That's a very tough question, based on my reading of the literature.
I AST on a normal blood result taken by the GP? I can't seem to see it on my last test result.
It may be there as SGOT, which is the same thing. AST is on the standard chemistry panel in the US, it may be different elsewhere, but is usually included as a part of a yearly physical.
You should find it in any comprehensive metabolic panel. Not in a basic CBC, though.
I take niacin. It increases my ast. It really helps keeping my cholesterol low and Lpa low. Also, triglycerides low. Would like to know how niacin affects you. Thanks for video
I've taken high dose niacin in the past, too, and similarly, it reduced my LP(a), but doubled my AST, so I stopped taking it.
@@conqueragingordietrying123 Thanks for sharing. My TC is 106, my LDL 54, my triglycerides 26, Lp(a) @70 my ast 47! I'm going to try find other foods to improve my ast. Lemons are good for liver. Also beets are blood cleanser. Also i get those results from 1k mg or less. Best wishes on your continued health journey 🙏😊 just got in my Lpa score from test done on 6/28 results 51!! Thank God! I may tweak my niacin just a tad lower but with these results i going to continue with it. I wouldn't throw the baby out with the bathwater. 🥑
Perhaps this video demonstrates that when we try to fix one biomarker we often break another. This may be nature's way of checkmating us into a timely death.
That's why monitoring the effect on multiple biomarkers, and determining whether the overall correlation is net positive, neutral, or negative, is important.
Interesting. Due to one of your previous videos, I increased my betacrytoxanthin intake through one red pepper approx five days a week. Now I wonder whether that was a good idea.
A higher intake of b-cryptoxanthin is associated with a younger biological age, but the issue is dose. How much is too high? It's doubtful that 1 red pepper 5d/wk would be too much. 1lb of butternut squash/day, on the other hand, and based on my data, may be too much.
Can't you use some drugs to reduce those negatively affected biomarkers?
For me, figuring out the diet, exercise, and targeted supplementation approach to optimize as many biomarkers as possible is the approach. If that stops working, then maybe I'd use some drugs.
With all the carotenoids out there, what prompted you to look specifically at beta-cryptoxanthin for an AST relationship?
I didn't look specifically at beta-cryptoxanthin, but all of my dietary nutrients, including macros and micros. Of those, b-cryptoxanthin had the strongest correlation with AST.
Perhaps aat is upregulated to fight cancer?
If that was true, we'd expect to see a decreased cancer risk above 15 - 24. However, based on the data in the video, the opposite is true.
@@conqueragingordietrying123 There are reasons that puzzels me. First cancers bypass the mitochondria using sugars as fuel to avoid apoptosis, so the ketone produced by aat should help turn on mitochondrial apoptosis killing cancers. But the reaction might be too slow. And then again the brain needs aspartate to produce myelin so perhaps excess aat could harm the brain. Perhaps published data would tell you that. But also I don't grasp why foods that upreglate sirtuins and logically kill cancers would be anti productive unless related to neuro degeneration. Something important is missing.