⚠ CORRECTION!!! In this video, I said "this video is brought to you by the Diamond Mind Foundation." Well, as of December 2022, that is no longer the case. Sense of Mind is now 100% dependent on viewers like you. So if you value this content, please go to www.patreon.com/senseofmind. For less than $5 a month, you'll get exclusive content and the satisfaction of knowing you're helping to keep Sense of Mind alive! 🧠
Ur videos about serotonin are mind blowing, u re such great communicator , u know how to put informations very well , explaining such a messy topic with so much grace is something to applaud. Great work , ur videos are magnetic !
I have recently started following your videos. Thank you for all the time and research you have put in. I have been studying how my brain processes the world around me, having had the diagnosis of bipolar disorder, with delusional psychosis, and have spent half my life on various medications. Your videos have been invaluable to me in my own healing and research.
Hi! I am a Psychiatric Mental Health NP student ( and psychedelic assisted psychotherapist!!) and I just learned more about serotonin through your videos than I did reading Stahl's psychopharmacology textbook - thank you so much!!
Loving your videos! In terms of how we understand the distribution of serotonin receptor subtypes - what kind of imaging is being used? i.e. is that image at 4:59 a PET scan with a radioisotope of a 1A agonist molecule? I'm curious to know the resolution of the imaging used (is it a voxel, or 10 cubic mm).
Great videos, keep it up. I like the balance of detail and high level layman explanations. Too light on details and it’s boring, too heavy and it feels like I need to go to med school. This feels just right.
There is group of psychedelics that work mainly on 5-HT1A receptors. Excellent example is 5-MEO-DMT, that is 1000x more strong on 1A then 2A. And the experience is so much different, no so visual in small and normal dosages and with white light, not hyperspace. I think that this type of psychedelic should have some another name.
Thanks really great episode! from the video, it seemed like the 1A/2A receptors produced variations on internal change relative to stressors. Do they also influence external behaviour towards stressors? EG - does 2A activation lead to people pursuing their goals / values more proactively? If so, would this only be indirectly through the person being in a less depressed state / a higher level of wellbeing?
First of all, thanks so much for your contribution and ongoing support of the channel, George! That's a really insightful question. As far as Carhart-Harris and Nutt's original paper goes, it seems that the internal and external changes go hand in hand. In other words, the behaviors we enact follow from the thoughts and feelings we have. So if 5HT2A receptors do stimulate an active form of coping with stress, we should expect the behaviors that follow to be aligned. For example, if you were undergoing psychedelic psychotherapy and realized that many of the behaviors you had been engaging in were in fact self destructive, we should expect you to stop engaging in those behaviors in the future. However (and sorry for the long message), I also want to mention that more recent work by Martin Seligman and his colleagues suggests that, while passive coping with stress is indeed associated with serotonin, active coping with stress may have more to do with *blocking* release of serotonin from the dorsal raphe nuclei during a stressful experience. My video on resilience goes deeper into this idea: th-cam.com/video/I_9oIWXz6ds/w-d-xo.html
I would really like to understand the aggression due to social isolation..... meaning being in a group but pushed out to corner , or aggression due to isolation and non activity??
Good question! I think that the increased aggression would apply to both social isolation due to exclusion as well as isolation due to agreeing to remove oneself from interacting with other people (for research purposes). I have a video on the neuroscience of loneliness if you're interested (th-cam.com/video/8C3c0p6aADM/w-d-xo.html) Also, this review discusses the association between aggression and loneliness (resulting from social isolation) at several points: www.johncacioppo.com/s/toward-a-neurology-of-loneliness-916y.pdf
Hi, wonderfully explained serotonin subject🥳 Thank you for your videos, very well explained and design. Can you make a video (maybe you already have) about the connection and effects of music and mental health and also what are the effects of listening music that go in one loop- same rhythm on repeat. Thank you very much🙏🙏🙏
That sounds super interesting! Music and the brain is a fascinating topic that I'll try to cover in the future. In the meantime, a great book on the subject is "Musicophilia" by Oliver Sacks
Hi, Love these videos and have shared with other therapist that are actively doing ketamine therapy and interested in working with psychedelics when they are rescheduled. We always hear about the shutting down of the prefrontal cortex with these compounds and thus the quieting of the default mode network. I am curious how this fits into this theory. You mentioned the active/excitatory action on the cortex, but how does the prefrontal cortex get inhibited? Thanks
I wonder whether the greater activation of 5-HT1ARs (relative to 5-HT2ARs) by antidepressants (in the case of SSRIs, presumably simply because of the relative abundance of 5-HT1ARs) is the main reason that antidepressants decrease the intensity of the effects caused by classic psychedelics (5-HT2AR agonists). If so, for 5-HT1AR agonists like buspirone, it should be the case that those with a greater affinity for 5-HT1AR are more effective at decreasing the intensity of the effects caused by classic psychedelics. This could easily be tested in many ways. This also points out a possible reason that antidepressants are ineffective for some people suffering from depression. Some of these people are probably people with a pathologically high ratio of 5-HT1AR-to-5-HT2AR activity, so using SSRIs to flood their brains with serotonin simply fuels a broken system.
Great insight! I'm not sure if studies looking at the relative affinities of antidepressants vs the intensity of effects from psychedelics have been done, but the reduced intensity of psychedelics (in people who take SSRIs) could also be due to a general upregulation of serotonin in the brain, making the effects of psychedelics relatively less intense for these individuals. Thanks for your extremely thoughtful comment!
That’s a really good question. I’ll admit that I don’t know the answer off the top of my head. But here’s a summary of a relatively recent study that looked into a related question: brain.harvard.edu/hbi_news/exploring-how-serotonin-and-dopamine-interact/
Hey man, enjoying the videos.um question, how do we mimic the anti anxiety effects of SSRI without taking SSRIS. The risk for permanent sexual dysfunction is too high.
Thanks so much for your question. First I have to preface this with the disclaimer that I'm not a doctor or mental health professional, so this is not medical advice. From my limited reading, it seems that exercise may raise levels of serotonin, and that several other activities may also have a beneficial effect. Here's a non-technical article that lists some of those activities (and provides references): www.verywellmind.com/how-to-increase-serotonin-5248440 I also found this older review article from 2007 that addresses the question of how to raise serotonin levels without drugs (given the age of this article, be careful to cross-check the information with other sources if you can): www.ncbi.nlm.nih.gov/pmc/articles/PMC2077351/ This episode of the Huberman Lab podcast is an excellent resource for the related question of how to maintain healthy brain chemistry in general: th-cam.com/video/T65RDBiB5Hs/w-d-xo.html
I am a big migraine sufferer, and the only tablets that I take (Pitzotifen) that work have something to do with the serotonin in my brain. Maybe you can do a video on how seritonin coukd have a cause to migraines
⚠ CORRECTION!!! In this video, I said "this video is brought to you by the Diamond Mind Foundation." Well, as of December 2022, that is no longer the case.
Sense of Mind is now 100% dependent on viewers like you. So if you value this content, please go to www.patreon.com/senseofmind.
For less than $5 a month, you'll get exclusive content and the satisfaction of knowing you're helping to keep Sense of Mind alive! 🧠
Ur videos about serotonin are mind blowing, u re such great communicator , u know how to put informations very well , explaining such a messy topic with so much grace is something to applaud. Great work , ur videos are magnetic !
That's so nice of you! Thanks for watching the videos!
Hi friend. Psychiatrist here. Stopped by to learn something new about 5HT1A and 2A receptors. Very interesting stuff. Thanks!
Thanks so much for stopping by! And for checking it out!
I have recently started following your videos. Thank you for all the time and research you have put in. I have been studying how my brain processes the world around me, having had the diagnosis of bipolar disorder, with delusional psychosis, and have spent half my life on various medications. Your videos have been invaluable to me in my own healing and research.
Great video!!!best luck you will have millions of subscribers soon🤜🏻🤛🏻🎉
Thank you so much!
Wow! I just learned quite a bit. Thank you!
That’s fantastic! Thanks for watching!!
Hi! I am a Psychiatric Mental Health NP student ( and psychedelic assisted psychotherapist!!) and I just learned more about serotonin through your videos than I did reading Stahl's psychopharmacology textbook - thank you so much!!
Thank you.
Thank you for watching!
Excellent explanation
Thank you...great video
Glad you liked it!
Really great video dude
Thanks, I really appreciate that!
Loving your videos! In terms of how we understand the distribution of serotonin receptor subtypes - what kind of imaging is being used? i.e. is that image at 4:59 a PET scan with a radioisotope of a 1A agonist molecule? I'm curious to know the resolution of the imaging used (is it a voxel, or 10 cubic mm).
Great videos, keep it up. I like the balance of detail and high level layman explanations. Too light on details and it’s boring, too heavy and it feels like I need to go to med school. This feels just right.
There is group of psychedelics that work mainly on 5-HT1A receptors. Excellent example is 5-MEO-DMT, that is 1000x more strong on 1A then 2A. And the experience is so much different, no so visual in small and normal dosages and with white light, not hyperspace. I think that this type of psychedelic should have some another name.
Thanks really great episode! from the video, it seemed like the 1A/2A receptors produced variations on internal change relative to stressors.
Do they also influence external behaviour towards stressors? EG - does 2A activation lead to people pursuing their goals / values more proactively? If so, would this only be indirectly through the person being in a less depressed state / a higher level of wellbeing?
First of all, thanks so much for your contribution and ongoing support of the channel, George! That's a really insightful question. As far as Carhart-Harris and Nutt's original paper goes, it seems that the internal and external changes go hand in hand. In other words, the behaviors we enact follow from the thoughts and feelings we have. So if 5HT2A receptors do stimulate an active form of coping with stress, we should expect the behaviors that follow to be aligned. For example, if you were undergoing psychedelic psychotherapy and realized that many of the behaviors you had been engaging in were in fact self destructive, we should expect you to stop engaging in those behaviors in the future. However (and sorry for the long message), I also want to mention that more recent work by Martin Seligman and his colleagues suggests that, while passive coping with stress is indeed associated with serotonin, active coping with stress may have more to do with *blocking* release of serotonin from the dorsal raphe nuclei during a stressful experience. My video on resilience goes deeper into this idea: th-cam.com/video/I_9oIWXz6ds/w-d-xo.html
Awesome video!!!
I would really like to understand the aggression due to social isolation..... meaning being in a group but pushed out to corner , or aggression due to isolation and non activity??
Good question! I think that the increased aggression would apply to both social isolation due to exclusion as well as isolation due to agreeing to remove oneself from interacting with other people (for research purposes).
I have a video on the neuroscience of loneliness if you're interested (th-cam.com/video/8C3c0p6aADM/w-d-xo.html)
Also, this review discusses the association between aggression and loneliness (resulting from social isolation) at several points: www.johncacioppo.com/s/toward-a-neurology-of-loneliness-916y.pdf
Diamond in the rough.
Hi, wonderfully explained serotonin subject🥳
Thank you for your videos, very well explained and design.
Can you make a video (maybe you already have) about the connection and effects of music and mental health and also what are the effects of listening music that go in one loop- same rhythm on repeat.
Thank you very much🙏🙏🙏
That sounds super interesting! Music and the brain is a fascinating topic that I'll try to cover in the future. In the meantime, a great book on the subject is "Musicophilia" by Oliver Sacks
@@senseofmindshow Thank you for the answer and super appreciate the book reccomandation🙏
Great videos 15:14
Hi, Love these videos and have shared with other therapist that are actively doing ketamine therapy and interested in working with psychedelics when they are rescheduled. We always hear about the shutting down of the prefrontal cortex with these compounds and thus the quieting of the default mode network. I am curious how this fits into this theory. You mentioned the active/excitatory action on the cortex, but how does the prefrontal cortex get inhibited? Thanks
Genius
I wonder whether the greater activation of 5-HT1ARs (relative to 5-HT2ARs) by antidepressants (in the case of SSRIs, presumably simply because of the relative abundance of 5-HT1ARs) is the main reason that antidepressants decrease the intensity of the effects caused by classic psychedelics (5-HT2AR agonists). If so, for 5-HT1AR agonists like buspirone, it should be the case that those with a greater affinity for 5-HT1AR are more effective at decreasing the intensity of the effects caused by classic psychedelics. This could easily be tested in many ways.
This also points out a possible reason that antidepressants are ineffective for some people suffering from depression. Some of these people are probably people with a pathologically high ratio of 5-HT1AR-to-5-HT2AR activity, so using SSRIs to flood their brains with serotonin simply fuels a broken system.
Great insight! I'm not sure if studies looking at the relative affinities of antidepressants vs the intensity of effects from psychedelics have been done, but the reduced intensity of psychedelics (in people who take SSRIs) could also be due to a general upregulation of serotonin in the brain, making the effects of psychedelics relatively less intense for these individuals.
Thanks for your extremely thoughtful comment!
How do serotonin and dopamine interact? Is dopamine decreased by seretonin/ vice versa?
That’s a really good question. I’ll admit that I don’t know the answer off the top of my head. But here’s a summary of a relatively recent study that looked into a related question: brain.harvard.edu/hbi_news/exploring-how-serotonin-and-dopamine-interact/
@@senseofmindshow thank you sir!
Hey man, enjoying the videos.um question, how do we mimic the anti anxiety effects of SSRI without taking SSRIS. The risk for permanent sexual dysfunction is too high.
Thanks so much for your question. First I have to preface this with the disclaimer that I'm not a doctor or mental health professional, so this is not medical advice. From my limited reading, it seems that exercise may raise levels of serotonin, and that several other activities may also have a beneficial effect. Here's a non-technical article that lists some of those activities (and provides references): www.verywellmind.com/how-to-increase-serotonin-5248440
I also found this older review article from 2007 that addresses the question of how to raise serotonin levels without drugs (given the age of this article, be careful to cross-check the information with other sources if you can): www.ncbi.nlm.nih.gov/pmc/articles/PMC2077351/
This episode of the Huberman Lab podcast is an excellent resource for the related question of how to maintain healthy brain chemistry in general: th-cam.com/video/T65RDBiB5Hs/w-d-xo.html
I am a big migraine sufferer, and the only tablets that I take (Pitzotifen) that work have something to do with the serotonin in my brain. Maybe you can do a video on how seritonin coukd have a cause to migraines
2:50 "Brain stem does autonomic control of the body"
Plot twist: Brain stem does autonomic control of the rest of the brain too.
0:15