Folate antagonists | Type 1 and 2

Folate antagonists can be categorized into type 1 and 2 antifolates based on their effect on folic acid. Type 1 antifolates inhibit folic acid synthesis in bacteria whereas type 2 inhibit reduction of folic acid which is essential for utilization of folic acid. In this video, we will see folate antagonists and how they act.
#antifolates
#sulfonamides
#trimethoprim

[@muhammadhuzaifa8649]

Sir you have made antibiotics super easy now plz make a video about their indication and side effects .

[@egpat]

Definitely I will try to upload a video on indications.

[@mahsashirmard2760]

You make a big difference thank you

[@rekochan_7747]

جزاك الله خيرا

[@roseamongin3159]

Beyond special, thank alot

[@muhammadhuzaifa8649]

great work sir . thank you for uploading this

[@egpat]

It's my pleasure

[@mawulatonny8577]

Thanks sir, amazing

[@rambabuneelapala4832]

Great sir wonderful explanation

[@egpat]

Thanks and welcome

[@vijaykumar-up9fm]

you really made it easy to understand. thank you sir.

[@egpat]

You are welcome!

[@souvikhajra4213]

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[@learninglearning1262]

💕💕💕

[@Bageera63]

What about Imuran/Azathioprine?

[@akalyaselvaraj5014]

Trimethoprim also prevent the utilization of follic acid in human.

[@egpat]

Yes, that's why it produces megaloblastic anemia as side effect which can be prevented by giving folinic acid supplements. But it requires high dose to act as anticancer agent because of its low affinity to mammalian DHFR.