Understanding The Role Of Polynucleotides In Aesthetic Medicine
ฝัง
- เผยแพร่เมื่อ 20 ต.ค. 2024
- Polynucleotides have been used as a medical device since 2004 but around the year 2015 they just started exploding in popularity. Here I pick apart some of the scientific studies available on the benefits of using polynucleotides in aesthetic medicine from simple fibroblast stimulation to using them as amazing wound-healing accelerators.
So what are polynucleotides? How do they compare to hyaluronic acid dermal fillers and who would benefit the most from trying them? Let's go!! 🤓💉🧬✨
#nucleofill #biostimulator #polynucleotides
👩🏼⚕️ Dr Sarah Tonks @drsarahtonks (say 👋 hello to me on Instagram I'm at a medical conference in Japan at the mo 🎌 and back to London next week!)
@thelovelyclinic 😊
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This video contains no sponsored content. Products in these videos have been either purchased myself or are PR samples. I regularly am sent products to test out, and I am under no obligation to give them a positive review. Any paid-for content will be disclosed in description boxes and blog posts.
Please note that any references to prescription-only medicines are for information and education only, this is not an advertisement for any product, prescription-only medicine, treatment or clinic. You must seek medical advice before embarking on any course of treatment. The views expressed on this channel are the author's own and provided for informational purposes only. The author makes no warranties about the suitability of any product or treatment referenced or reviewed here for any person other than herself and any reliance placed on these reviews or references by you is done solely at your own risk. Nothing on this channel shall be construed as providing dermatological, medical or other such advice.
👩🏼💻 JOURNAL ARTICLES / REFERENCES 👩🏼💻
pubmed.ncbi.nl...
Long-chain polynucleotide filler for skin rejuvenation: efficacy and complications in five patients
www.ncbi.nlm.n...
Consensus report on the use of PN‐HPT™ (polynucleotides highly purified technology) in aesthetic medicine
www.ncbi.nlm.n...
Trophic effects of polynucleotides and hyaluronic acid in the healing of venous ulcers of the lower limbs: a clinical study
pubmed.ncbi.nl...
Striae distensae (stretch marks) and different modalities of therapy: an update
www.scivisionp...
PN HPT™ and Striae Albae-Exploratory Interim Analysis of a Randomised Prospective Study
pubmed.ncbi.nl...
Polynucleotide biogel enhances tissue repair, matrix deposition and organization
www.sciencedir...
Polydeoxyribonucleotide: A promising skin anti-aging agent
DJ4LTOXKMMXVRQ4 - All in the end - Moments - (Music license 🎶)
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Finally a video that explains in depth about polynucleotides and not just trying to sell sell sell. Thank you!
Thank you! I’m going to do one on PDRN next time I think
Yes ! Love this ! Couldn’t agree more !
Very educational, thank you ! Having my first polynucleotide treatment in two weeks 🎉super excited
That’s great what are you having?
I am very scared that it would add volume to my face like something like sculptra would. I know they work differently but are we sure that polynucleotides don’t add volume?
Merciii ☺️
Never seen it happen!
Hi Dr. Tonks, i have seen both your videos on sculptra and polynucleotides, you mentioned that when it comes to volume, fillers are the answer. I wonder if both bio stims are diluted to promote collagen, is it possible for them to cause “overfill” look / puffy face from overly produced collagen after a year or so?
I’ve never seen it with polynucleotides, but I’ve seen with sculptra yes
Absolutely brilliant explanation!
does it help with scarring and skin tone? most of what i’ve seen says polynucleotides help with wrinkles/fine lines etc
Rejuran have a product specific for scars
Can Nucleofill strong be used under the eyes or do you have to use the eye version ?
You would be puffy for a long time
Thanks so much for explaining polynucleotides so well. New subscriber. Have you ever used Vitaran? I had one under-eye treatment with it 3 weeks ago. Next one due soon. I notice no difference in fine lines/crow's feet.(too early I know) I"ve tried PRP and Sunekos in the past with zero results. If anything they made things worse. When do most people notice a difference with this treatment (generally) as I don't want to waste more money on the latest treatment - it all works out really expensive, I"m not expecting miracles - a little improvement would be nice. Thanks.
Sorry I have never tried Vitaran. Surprised to hear that about Sunekos it’s one of my favourites! Maybe try seventy hyal
Hi Doc. Thanks for the video. I’ve got a bit of hollow under my eyes. Had filler injection in the past and had to dissolve it recently as developed puffiness where I don’t need it (a bit lower in my cheek area). Is there’s a way to correct hollowness under eyes by fillers without creating puffiness? Or only option is fat transfer,please?
Take it out and replace it- could be in the wrong place (too superficial) or a product which holds too much water… or could just be older filler which can look more waterlogged as it breaks down. I would try again if there is a lot of hollowness. Alternatively try fibrin clot with PRP if there is a lot of hollowness. If more crepy skin then can try Sunekos, polynucleotides…
@@DrSarahTonks Many thanks for the advice. I was thinking the same but wasn’t sure as I’m not in a beauty industry. I also think another option could be to get a few treatments of polynucleotide despite of having hollowness. Since it’s a minor hollow it could be that by thickening the skin in that area the hollowness will improve as well. Would be great to hear your opinion on this one if possible, please..
You can get a little bit of volume from polynucleotides yes but you have to be persistent
Hey Doc, i’ve tried the treatment and with the BAP injections technique of 5 spots per side, is there any article or discussion on how the product will spread evenly distributed on all the face? Especially does this technique ensure nucleofill to reach forehead area? I found it weird compared to papoule injections like rejuran?
No discussion no! I agree that is weird. No wont go to forehead with that technique
Thanks Dr Tonks. Love that you present fact based data. Have you seen good resulta with pdrn like rejuran under eyes?
Yes I like rejuran a lot
Thankyou very much..Ive spent over $10 grand just in fillers.Had profhlio done to neck .I can see some results but no where near what I was told.
Tbh it is an expensive sport and not uncommon to spend quite a bit of money especially if you are going to someone well known. But I guess a facelift can be $70-250k depending on the surgeon
Very interesting video, I had my first ever consultation today where I was recommended a polynucleotides procedure for my under eyes as it apparently will stimulate collagen production and could help make the skin thicker again. After seeing this video I´m not sure if this is true and will solve my issue which are dark circles and a more sunken in look, which I assume is from volume loss. I did state though that I did not want filler as I´m very scared of the over filled look especially after long term usage.
Tbh it will probably make a bit of a difference yes and it’s pretty much risk free
Hello. Can i have hyaron and pn together? Can i both inject them at 90 degrees angle using 4mm needle? Or will they cause occlusion? Thank you @dr.tonks
In theory you can yes but there would be a lot of swelling
Such a educational down to earth presentation. Thank you. Do you more commonly use cannula or needles to administer your polynucleotide. Regards Dr Peter Lawson
Thank you!! I mainly use a needle
Thanks Dr. A slight sagging of the face would require a filler? or polynucleotides would be enough?
Depends how much we are talking about if it’s just a little bit then try the polynucleotides in the pattern in the new video where the ligaments are
Thanks for a great video. Very informative.
@dr Tonks can you have these on the upper eyelid?
You can yes
How interesting! Which one is best for under the eyes of a person who tends to get puffy eyes ? I know that HA has a tendency to draw water from the tissues and can puff . Does PDRN do that too ? My eyes have the beginnings of bags at 46 . This causes a tired and puffy look . It also makes my tear trough more apparent. I was told that HA fillers wouldn’t be the best idea for me due to me being prone to puffiness . I want to try having a microneedling or meso treatment with PDRN . But I’d hate to look more puffy . I have quite crepey skin under the. Eyes and the upper eyelid. Thank you ❤
Puffy eyes and crepy skin is quite the combo. Even if you get puffy it eventually goes away when using a polynucleotide or uncrosslinked hyaluronic acid. You could combine doing this with micro needling with exosomes or RF micro needling with exosomes or CO2 laser
Which brand of exosome do you recommend? @@DrSarahTonks
I am using ASCE at the moment
Hi hun so is this correct they won’t help with sunken tear trough or lifting areas in tear trough were filler cannot be injected? As I have practioner who swears that polynucleotides will help lift please reply
I really want to know this too! I've had Profhilo and Ellanse for my skin (both great) but my under eyes are sunken and I've heard lots of horror stories of HA puffing years later...
I use them if someone has crepy skin and it’s not wise to go straight in with a cross linked hyaluronic acid. They are also excellent for small lines under the eye which a traditional filler won’t reach. You might get a bit of volume from them but for the best results I recommend both
Under correct by 20% and use something to thicken the skin first like polynucleotides and you will be grand
great presentation
Hey guys. Considering rejuran is injected all over the face, would the effect be better even though nucleofill strong is said to be more potent? Especially for targeted treatment. Thanks a lot :)
Is it said to be more potent?
Dr. Tonks This is such an exciting product. Two questions. Can a patient get Nucleofill and ProPhilo. Would there be any benefit to that or is that just crazy. If so how would one stagger the treatments. Also, can two protocols be done at the same time? For instance the five point injections as well as the under chin or with that be flooding the cells with too much all at once? Thank you so much for all you do!
Yes and actually this is common. I personally refer to do a whole course of Profhilo followed by a course of nucleofill so you can assess the results for both individually
@@DrSarahTonksOMG‼️ I can’t believe you responded and I literally just fell out of my bed! Thank you so much! Is there a risk of over flooding by doing multiple protocols on the same day with the Nucleofill? For instance would it be too much to do the Bap technique and under chin and eyes on the same day with? You’re amazing and so knowledgeable and you communicate your knowledge so well. Thank you!
@@tonyaellerby4884 no this is super common as long as you don’t mind looking a bit puffy and swollen you can go for it
@@DrSarahTonks Thank you so much! Joyous Christmas to you!
loving the hair Sarah x
So for stretch marks is it injected with a cannula or little blebs?
Little blebs
Hi,
Can PN be used in a hypertrophic scar? Or will it lead to a further thickened scar due to more collagen formation?
I have never tried it in hypertrophic scar I would say you’re better with laser assisted steroid
Hi I really want this treatment in my neck but I read there is a risk of going blind! Is this true?
Not from polynucleotides in the neck
Aren’t PLLA and PCL treatments also good for building volume?
Yes PCL like Ellanse and PLLA like sculptra or lanluma give volume
what's better for anti-ageing, someone looking for a more youthful boost, skin booster or polynucleotides? Is there any benefit in maybe having both..
They do have both in Asia yes. Studies show parity in terms of collagen stimulation. I would say if the skin is dry and you want more of a sheen then do the hyaluronic acid. If it’s more a crepy skin issue then do the polynucleotides
@@DrSarahTonks thank you, enjoyed this video
Do polynucleotides deal with sunken and hollow eyes?
To a certain degree yes
@@DrSarahTonks How long does it take to see the full benefits of this treatment?
What do you think of renuva?
I have never tried it
Also filler Dosent dissolve that’s why I don’t want it it’s permanent according to new studies
Show me this study
I got boletero for my horizontal necklines and it gave me e me hypopigmentation 😱
which filler whould you suggest for someone with huge volume loss and hyperpigmenattion under the eyes
Skinboosters first like Sunekos or polynucleotides followed by Teosyal Redensity 2
@@DrSarahTonks i did polynucleotides from Geo eyes two times until now what do you think about them ? and are there cheaper options than Teosyal because I already spend a lot of money on Platelet rich plasma and fillers and they did not gave the results I needed is it really worth it because I am struggling for a long time because I have problems with breathing while sleeping so thats why I have volume loss in first place
I haven’t tried or heard of polynucleotides from Geo so not sure. The Teosyal redensity 2 isn’t that expensive to buy you’re paying for the person to inject it!
hi can it cause vascular occlussion?.
Hi no not possible with Rejuran as not particulate I would assume it’s the same with the rest of the
Why does Dr Abs say that sunekos is better than PN ye says that sunekos generates the correct type of collagen which PN Dosent
I don’t know you’d have time ask him! There was a paper published in Nature which stated when comparing hyaluronic acid with polynucleotides the type 1 collagen production was greater in polynucleotides in comparison with hyaluronic acid but in any case it really is comparing apples to oranges as they are totally different and you will get something different from each. www.nature.com/articles/s41598-020-61952-w
You’re not going to get the lovely sheen with polynucleotides that you get with hyaluronic acid and I wouldn’t say that they have as much of an effect on hyperpigmentation in my experience although I would have to check for a paper on that
@@DrSarahTonks her more so talks about how suenkos specifically generates type 4 and type 7 which are the most important ones to anti ageing and the other types aren’t as important which is why sunekos is superior
@@amardaniellok so I wanted to watch the video before I responded. I think these are all great points but it’s not really an either/or decision - clinically there is a ceiling to the improvement you’re going to get if you only do one thing- I know because I’ve seen it! So it’s better to switch between different treatments that act in different ways for the best results. I know this doesn’t apply to everyone because let’s face it, it’s expensive, but if you’re at the limit of what you can get with one modality, switch to another
What is the difference between Rich PL and Nucleofill?
Rich PL is hyaluronic acid and poly lactic acid, Nucleofill is polynucleotides, totally different
Would rich pl help with volume and lifting then? It’s advertised to. Do you like it?
I have never tried it so can’t comment
Can you have this on forehead scars ?
Yes
Can this replace botox? With enough treatments can it remove all fine lines and wrinkles?
Nothing can replace Botox!
@@DrSarahTonks Botox is a waste! It doesn’t last. Looking for better alternative
There just isnt anything. About 15 years ago there was a device which could be used to freeze the muscle quite literally, it had some carbon dioxide thing cooling the needles but it was only ever meant to be used on the frontalis and nowhere else. I cant remember the name of it, it didnt take off
@@dennisguilder1Nothing lasts! You need to repeat every filler, biostimulator, treatment, whatever. I do microneedling at home with good results. Not costly at all if you do it yourself but you need to do lots of research before you start.
@@maxmustermann4772 I just don’t smile and stay inside. I use Tazarotene gel .1% and it works solid thanks though.
would polynucleotides cause occlusions?
Never been documented
Thank you
This isn't available in the U.S., correct?
Correct
I flew to the UK London for treatment. I loved my experience
@@jessewaronaging256 cheaper right?!
Because the USA have more sense than to license things that are ridiculous and don’t work.
Yes because that’s the reason
Not been here for a while but wow you look so much younger. You dissolved fillers or something has happened.
No I lost a lot of weight by taking ozempic
Hey @@DrSarahTonks ! You're beautiful. Fellow dentist turning medic here and you are an absolute inspiration, I love your attitude, way of talking, educating and sharing about aesthetics. I haven't seen you in a while (maybe a couple years) and seeing this today you are looking great! Is it weight loss like you say? If not, and treatment, it would be so wonderful to hear about anything you're doing to look after your lovely self. I'm very slim, but self-concious about my buccal fat, I know about surgical buccal pad fat removal but was wondering if there's anything else? I'm nervous about my filler along my zygoma that it might be shifting and will make me look bloated in years to come? What are your thoughts to a more chiseled look?
@@susannebosman1283 are you going to do omfs? Easier to do part time than when I did it which is why I left in a hurry
@@susannebosman1283 based on what you sag I would go for the submalar region and take it into the hairline it will give lift and recontouring
@@susannebosman1283I’ve been off the radar, had a baby and doing some work projects so haven’t had much time!
Just another waste of people’s money. Since I have stopped all these ridiculous procedures I have never had so many comments on how well I look, whereas no comments, only stares when I had Botox & fillers because they make you look ridiculous.
These kind of treatment is kind of sucking your money for something barely visible to none result. I am not surprised injectors become so rich in such a short amount of time.
I WISH I was rich
Ok, but why only your lips and eye lids move but nothing else does?
crétin
@@micheleparadis2808V a t e f a i r e f o u t r e
I superglued down my facial gill flaps for the video so I could pass as human
@@DrSarahTonks 😂
Hyaluronic acid injections are not bio stimulators
Why do you say that?
because they do not stimulate new collagen@@DrSarahTonks
www.ncbi.nlm.nih.gov/pmc/articles/PMC10082573/
she is so boring
Thanks for watching! I’ll be sure to include some special effects and satanic rituals next time
@@DrSarahTonks😂😂😂
Ahahaahhahaha legend 😂😂❤
@DrSarahTonk😂love it ❤
😂😂😂@@DrSarahTonks