Addisons Disease Made Simple - Primary Adrenal Faliure
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Addisons Disease Made Simple
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Addison’s disease, also known as primary adrenal insufficiency, is a long-term endocrine disorder in which the adrenal glands do not produce enough steroid hormones.[1] Symptoms generally come on slowly and may include abdominal pain, weakness, and weight loss. Darkening of the skin in certain areas may also occur. Under certain circumstances, an adrenal crisis may occur with low blood pressure, vomiting, lower back pain, and loss of consciousness. An adrenal crisis can be triggered by stress, such as from an injury, surgery, or infection.[1]
Addison's disease arises from problems with the adrenal gland such that not enough of the steroid hormone cortisol and possibly aldosterone are produced,[1] most often due to damage by the body's own immune system in the developed world and tuberculosis in the developing world.[2] Other causes include certain medications, sepsis, and bleeding into both adrenal glands.[1][2] Secondary adrenal insufficiency is caused by not enough adrenocorticotropic hormone (ACTH) (produced by the pituitary gland) or CRH (produced by the hypothalamus). Despite this distinction, adrenal crises can happen in all forms of adrenal insufficiency. Addison's disease is generally diagnosed by blood tests, urine tests, and medical imaging.[1]
Treatment involves replacing the absent hormones.[1] This involves taking a corticosteroid such as hydrocortisone and fludrocortisone.[1][3] These medications are usually taken by mouth.[1] Lifelong, continuous steroid replacement therapy is required, with regular follow-up treatment and monitoring for other health problems.[4] A high-salt diet may also be useful in some people. If symptoms worsen, an injection of corticosteroid is recommended and people should carry a dose with them. Often, large amounts of intravenous fluids with the sugar dextrose are also required. Without treatment, an adrenal crisis can result in death
The signs and symptoms include fatigue; lightheadedness upon standing or difficulty standing, muscle weakness, fever, weight loss, anxiety, nausea, vomiting, diarrhea, headache, sweating, changes in mood or personality, and joint and muscle pains. Some patients have cravings for salt or salty foods due to the loss of sodium through their urine.[8] Hyperpigmentation of the skin may be seen, particularly when the patient lives in a sunny area, as well as darkening of the palmar crease, sites of friction, recent scars, the vermilion border of the lips, and genital skin.[9] These skin changes are not encountered in secondary and tertiary hypoadrenalism.[10]
On physical examination, these clinical signs may be noticed:[8]
Low blood pressure with or without orthostatic hypotension (blood pressure that decreases with standing)
Darkening (hyperpigmentation) of the skin, including areas not exposed to the sun. Characteristic sites of darkening are skin creases (e.g. of the hands), nipple, and the inside of the cheek (buccal mucosa); also, old scars may darken. This occurs because melanocyte-stimulating hormone (MSH) and ACTH share the same precursor molecule, pro-opiomelanocortin (POMC). After production in the anterior pituitary gland, POMC gets cleaved into gamma-MSH, ACTH, and beta-lipotropin. The subunit ACTH undergoes further cleavage to produce alpha-MSH, the most important MSH for skin pigmentation. In secondary and tertiary forms of adrenal insufficiency, skin darkening does not occur, as ACTH is not overproduced.
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Excellent. ER Physicians need to watch this in the US. I know from experience they are clueless when Addison's Crisis presents.
I'm here because an *endocrinologist* just tried to take me off prednisone. I told her I'm pretty sick from being on only 6.5mg, and think I need more. She said I'm fine and don't even need a follow-up! Thing is.. she's my 6th endo and one of the best I've found. Why is it like this?
And yeah, in the ER they usually try to withhold steroids, disregard my Medicalert bracelet, it's a mess. I've had to sneak my own hydrocortisone out of my bag.
Realy I think they are excellents
@@howtomeetwomen- I understand completely! It's not only frustrating, but dangerous. I carry an article with me that I printed to try to open their eyes. Even my PCP said she knew practically nothing about Addison's. Very disheartening.
Doctors don't know everything, ffs. lol.
@@atheistleopard618 F U atheist idiot.
* Firstly, am sorry for my bad English because English isn't my primary language.
Great video. I've been suffering with all the addison's symptoms (Not fully diagnosed yet) for quite a long time. I'm craving salt, losing a lot of my weight, hypotension problem and more... Well, I also have Type 1 Diabetes (currently using an Insulin Pump) and Thyroid Disease. So, this video has opened my eyes about other autoimmune disease that probably manifest in my body. Thanks for the video because it's gonna save my life.
Brief and straight to the point. Well explained. Thank you.
Good information. My wife was diagnosed about 6 months and we are still researching and learning about Addison's Disease. It would be nice to find a place to print out what was in the video for our research.
Thank you so much! I love how easy this was to follow. 💕
Fantastic explanation. This was very helpful. Thank you so much.
youve made it so easy to understand, thank you!
APPRECIATE. Precise but to the point. And tests required.. thanks
Great video. Made it very simple to understand without wasting too much time. Great explanation skills too. Well done and thank you again.
You have a beautiful voice and clear enunciation. Thank you for a clear presentation at a good pace. 🙏🏻
Thank you so much. This has helped me greatly. I appreciate
amazing. Great help. Thanks
thank you! very well explained and organised video :D
Very helpful and informative, thank you
Brilliant!! explanation, well describe and clear, thanks.
Thank you so much.. You made it so simple to learn
My teacher has this, I will send this to her when she feels better.
Can you do a video on hydrocephalus?
Thank you so much! It helps
really helpfull for medicos thanks sir
Very helpful. Thank you!
thanks, wonderful talk!
Great video!
Thank you - great over view!
+Sarah Louise u r welcome sarah
This video is very helpful tq
Good job explains the subject
Excellent work! Although is a very rare disease it’s important to know about it. Thanks
Thanks so much it s very helpful😊
Very helpful, dude thank you
Great information thank you
Super video! You are very good at explaining! This really helped, thank you.
This is so interesting - THANKYOU
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Thank you. I'm sharing this with my adrenal insufficiency support group. It answers many of the questions that are posed by members of the group with PAI on a fairly regular basis.
This was two years ago but my two year old just got diagnosed. I’m looking for a support group but can’t find one for children
Good explanation.
for the causes... one was left out. Failure of the pituitary. It creates a secondary adrenal failure. Great video!
This video is tituled Primary adrenal deficiency.
I couldn't focus while watching this cuz I was wondering, is this your hand writing or did you use an application/program to make this .. I loved it.
great vid, thank you.
+SajoOo92 Sir, all the material in this video is first hand made with a digital pen and tablet. And then converted to necessary formats for an animation software. Thank you for ur kind words btw
Thank you
thank you sir
Thank You sir ✨️
very nice, simplified, to the point for quick review, good job well done
Good description sir but I d like to point out one minor mistake if u don't mind...U said androgen deficiency produces loss of libido in both sexes but actually it affects only females because males have other sources of androgens like testes so they are not affected... Thanks
Thanx
thank you sir ; its very useful video
+Rasha Tariq U r Welcome Rasha
Great video. Thanks for the upload. I've had Addison's for over 20 years. I believe the dosages for medication is different for every patient. My dosage is not as shown in this video. And I do very well.
It is also important. To take more fludrocortisone before any medical procedure even dental work
Pw.
thnx
Thank u sir ❤️
Most times 1.5 tab of Hydrocortisone is not enough. Summer time is increased to 4 TAB a day or during high stress.
My question is how many patients have a DEFIB or what is the standard?
Hi, my father has low cortisol but normal level of ACTH. What does that mean?
Plz make more videos on medicine
Beside short synacthen test what other test should be done to diagnose addison disease.
great video guys ..keeep it up ....also made videos on cardio diseases
tqq u
Good explanation though I would Suggest correcting the spelling errors. E.g. Failure not faliure.
I was diagnosed with Addison's about 7 years ago and wasnt suffering one of those symptoms. I was told by the Dr is was a stress management condition and I was having a few panic attacks at the time so just believed it. I have been taking hydrocortisone and fludrocortisone for the past 7 years every day. I think im going to get a second opinion.
Check out Pam Popper. She can help clear up the medical hype, so you don't get sucked into the medical mill again.
Can you please share about the dose ? And your age?
Iwant know more medication about addissones.alsohow toprotect repeat.fenideslone raising bp
@@d.indira7548 when I am ill and by body of fighting an infection then I am required to double my daily dose of hydrocortisone. This drives my blood sugar levels up so it is very difficult to manage my type 1 diabetes when I am doubling my steroid dosage.
Best👌👌
Do video on congenital adrenal hyperplasia, cushing syndrome, liddles, bartter and gitelmann and gordons syndrome pls... Sorry for longlist😳
your video is really helpful! one thing i noticed, though - for the ACTH stimulation test, you should give 250 micrograms (0.25mg) of ACTH, not 250mg, that's so much! also, i believe cortisol is usually measured in micrograms/deciliter.
U r absolutely right Kelly. It was 250 micrograms. MY mistake
Lol huge correction. Difference between life or death in a patient due to malpractice
I had a blood test that shows I have anti adrenal anti bodies with a titer of 1.10. I was tested since I have a lot of the symptoms minus the skin stuff. My cortisol was actually high at 23.1... could I still be feeling symptomatic of Addisons? It’s very confusing
Opoids can also cause adrenal fatigue. Wish my doctors explained this!!
if it's autoimmune, take immunosuppressants and/or immunomodulators.
sry ...i think the dose of exogenously acth should be 250 micro gram....not milligram.....thanku...if m wrong plz inform me...
Sucks !! It’s taking a long time to get better .
Please more information in Spanish 🙏
Hi can i make a question
can you please upload some cardiac videos? Also diabetes. thx
+Freny Vaghela Sure. We will try our best
what is the treatment for addisons w/defective adrenals vs adrenals that have been removed
Adrenal hormones given artificially
Indeed, I actually have this disease and I need to take hydrocortisol as a medine 3 times a day. Since I have started taking the hormones, starting 3 weeks ago, I have felt healthier than ever. Of course, I cannot say yet how it will develop.
Hi, Thank you for the great video! Just wondering how does cortisol deficiency (less gluconeogenesis, ^ insulin activity) lead to weight loss. Thank you
First maybe bc of loss of fluid
Second bc cortisol causes high glucose level in blood >high insulin > target adipocyte to accumulate more fat molecules with time this will cause glucose intolerance >insulin resistance
No Gluconeogenesis means no glucose in blood no insulin
I was diagnosed with addisons disease when i was 4
So sorry to hear this. How are you doing? Does medicine control it pretty good
very clear presentation. thank you.. am on hidrocortisone replacement. since i got this illness so late in life, am hoping it will be temporary.. this disease is awful and is affecting many of my systems and has caused weight gain. still not sure if cause was over use of steroid injection or severe head trauma, perhaps affecting pituitary.
Thank u so much for the appreciation
Can you get Adrenal fatigue from head trauma? And have weight gain? Because this has been my experience but no diagnosis. In fact, the endocrinologist told me there’s no way I could have adrenal fatigue or failure because I was overweight. I think I was overweight because I couldn’t move for years and ate to feel better. (Which didn’t work )
Now I take adaptagenic herbs,Cordyseps mushrooms, vitamins and freeze dried cow Adrenals (found at the health food store) and I can at least function on some level. But without these I can’t function at all.
The Video was very helpful though.
Thanks
@@shaek6820 No such thing as Adrenal "Fatigue". Ask your Endocrinologist to perform a morning ACTH Stimulation test. Have an Addison's antibody test done. Get imaging done of your Pituitary & Adrenal Glands. Yes, u can develop Adrenal Insufficiency if your Pituitary or Adrenals were damaged by trauma/hemorrhage/infection. These tests will confirm whether u have Adrenal Insufficiency (AI) or not and need lifelong steroids. It will also differentiate whether u have Primary or Secondary AI.
The loss of adrenaline is very important. How could you miss that?
clinical features 3:09
My Father passed away from Addison's in 1975
Font is too small
I take medications constantly twice a day. Yet sometimes like now im on my way to a hospital. I can very little keep food down.
+Hidden-Pride-Gaming i m really sorry about your condition sir. I hope u get well
Check out Pam Popper.
😊
My mom was been treated pituitary adenoma by surgery and then radiotherapy. Several years later her pituitary gland seems to shrink in function , not able to secrete ACTH , and cortisol level is too low . She got the symptoms of heaviness in chest, sometimes stomach and is not feeling fresh and energetic . She was initially taking prednisone with dose of 5 mg in the morning and 2.5 mg in the evening . Since the symptoms does not subside, or increase more , doctor prescribed 20 mg in morning and 10 in morning for a week . And now she is having moon face and. Still not fresh and energetic. Please help those who knows
My mother also a Addison patient ... she has same problems...
is an Addinson disease a addernal disease ????
Thanks for the video it's great , but please change the intro, the chalk sound made me cringe so bad.
+rawan naj HaHa. Thank you raj for bringing it to notice..
Omg this is what's wrong with me...
Hindhi m dalo koi vdo
it can't be fully cured???
i mn rest of d life patient need to be under medication??
plz reply..its urgent
Atindrila Dey There is no known cure unfortunately and a patient can lead a relatively normal life but this is achieved with various medications it stops adrenal crisis from happening which can be fatal I hope this helps you with your question
there will be a cure SOMEDAY IVE HAD IT FOR ALMOST 19 YRS NOW
READ ALL KINDS OF STORYS ABOUT CURES
I THINK THERE WILL BE
@@ekop1778 thanks for sharing your story. What is your quality of life if you don’t mind me asking? Also has it affected your vision?
adrenal insufficiency presents with irregular or absent menstrual period in women
It depends upon the Severity of adrenal faliure.
Also different females have different response
@Margo Lockweeze Feelings about our health are subject to manipulation. Doctors are not scientists, and science has become politicized. Doctors probably use an arbitrary standard to make you a regular customer once you are a believer. It's not their fault... Good Will Hunting
nice... but speaking style is not consistently fast a bit as is the writing .. but thanks anyway
After 15 days of prednisolone corse...can the pt suffer from addison symptoms?
+opium latex i don't think so
I have addison's disease
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I have primary Addisons disease I've had it since I was 14 I am now 65
I have Addisons Disease since I was 9 years old and now I am 11
It was a hard time.
Are you recover and you have any disability
Mi ma mi vlogs there is no cure for Addisons disease but i am thankfull i have lived a normal life just in the last few years i have a few more problems but i still work full time at amost 66
@@barbarakoeppe2623 my son 18year old he is leg payralize .my son have last year fever and vomating and after 2days urine block .after 1month he is stable but both leg have no power and not walking plz any suggestions for my son
Mi ma mi the only thing we can do is pray and ask God to heal him if not ask God to help him through it or give him strengh. Im sorry to hear about your son
my boyfriend died of this... it was terrible
Very sorry for your loss
@@MEDSimplified thank you :)
Rip
in my country Norway we are 5 million people i read that there is only a little bit more than 1000 addison's damn yeah the sleep is true i sleep 4 to 6 hours and i struggle to fall asleep as quick as my parents : P they fall asleep within 1 hour i can spend up to 3 hours before i fall asleep
*failure
No sex hormone replacement?
Nuwanda usually sex hormones are not affected
Adrenal gland is not the primary source of sex hormones.Testes and ovaries are the main source.So even if adrenal gland is insufficient the ovaries and testes compensate the losses of sex hormones.
Packed with typos 😂😂
I have Addisons Disease and I got it when I was 9 years old...
Don't get too attached to labels, and don't be manipulated by so-called "authority figures". Do your own research, and heal yourself. You don't want to be a regular patient in the medical mill. Check out Pam Popper. I realize she's a little older, but oh well, think of her as a loving grandmother with a lot of wisdom. Good luck.
Hi, if you don’t mind me asking how old are you now? Do you lead a normal life? Has this affected your vision? Are you on a medication? Sorry I’m asking all these questions but thank you and wish you all the best
why did you say anorexia as a symptom. anorexia is a MENTAL disorder in which the patient doesn't want to eat to control food, to feel better about their bodies and keep control. I don't see how anorexia is related at all. you mean low appetite?
Medically anorexia just means loss of appetite. 'Anorexia nervosa' is the mental health condition where people dont eat due to perceived body image issues, but we have come to refer to that as just anorexia in daily life.
Please..read medical books...there are millions of causes or anorexyia and catchexia.....besides mental, physical
Some " anorexics" are suffering from a form of addisons disorder....try to keep up...the class is starting now