Synthesis of Methamphetamine
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- เผยแพร่เมื่อ 14 มิ.ย. 2024
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This video shows the synthesis of Methamphetamine and the chemistry behind it. ONLY use this video for educational purposes as it only meant to be for the class Organic Chemistry II.
LinkedIn: / kevan-j-english-91b9b11b7
Snapchat: / kravono
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![Fc ครับ ขอแนะนำให้รู้จักกับ "น้องเปียโน" l [Nickynachat]](http://i.ytimg.com/vi/HQU6Q_IYTLo/mqdefault.jpg)
Thank you so much, I got diagnosed with lung cancer and because of you I was able to provide for my family before I checked out
Say my name 😆😆😆
@@johnrobert385mm Mataj Bosnjak?
He's a fucken angel!!
@@ChickenSaveThe you’re goddamn right.
@snickers katze he is referencing walter white from the netflix series “Breaking Bad”
Greetings, fellow DEA watchlisters!
man ngl, I read this comment in Half-Life's scientists voice.
@@ryujinayato1623 do you know who ate all the donuts
f' the DEA
i didnt even mean to click this video now im fucked
howdy
Thanks for motivating me to study for chemistry
us 🗿
i am influenced by water white from breaking bad.
so far done with, iupac naming 🤓.
I have a degree in chemistry.
You want to become good a synthesis?
Take a target molecule and do a retro synthesis! Buy a book about retro synthesis and use it to look up solutions if do not know further.
I took part in chemistry olympiad competitions in school. Actually there were problem sheets with synthesis of cocain and roofie and amphetamine as a problem set lol.
Also in the beginning neglect chirality and stay away from biomolecules.
Water white💀
@@zakytherandomguy6469 Water weight is evil man
He’s always wet
What about the chilly powder?
Cuz it kicks like a twelve gauge when you hit it
Gotta love that chili p dope
Nah man chilli p is my signature
Lol
Capsaicin is the bomb yo
A practical Demo would be quite helpful
Saale haramkhorr😂
Agreed
nice try fed boi
I'm sure it could help me do this complicated reaction
Vice just uploaded a video of it, too. @@kainhall
I have a PhD in chemistry, but made my millions making this one sweet sweet molecule. Cooked for the Mexicans for 3 months, made 12M and got out. Living the good life now baby!!
Really could u drop ur address down pls.. i would like meet u to learn something
@@subasharunagiri7034 no figure it out yourself, I'm not a charity.
Well done them man...i dont even know why i am watching this video i am supposed to be learning chemistry 😂
Your homepage told me that you may not be able to afford the rent now
Are you serious? I'd like to learn but not to sell it, I just want to, for the beauty of the art. Could you explain the proccess you used to do?
DEA if you're here: I'm not trying to cook meth, I'm just trying to watch this epic breaking bad reference
Same
Same
"Your Honor, it was all just a Breaking Bad reference."
They didnt cook meth from chloroacetone in the show.
DEA, if you're here: f' you! :-)
FYI: Alpha Chloroacetone is an extremely powerful lachrymator. It makes regular old 'tear gas' take a dirt road, and if ANY of it gets away from you, you'll wish to God it hadn't. Handling that stuff in an 'informal' setting is almost a guarantee that you will have a problem that will advertise your presence to anyone nearby. When he said, "for educational purposes only" he meant it.
why did u try to do it? lol
Jesse! What is that sme-
@@wheatlycrab4868 😭😭😭😭
can attest, did a chemistry thing at home (not drugs) after lots of research, knew it could generate a very little tiny bit of chloroacetone as a side product (couldn't use any other acid than HCl for the catalyst to a reaction), as soon as I smelled it when I was drying it I had my gas mask, smell is comparable (at least when it is extremely low concentration) to a mix between a very pungent acidic smell and organics, even at very low concentrations, you can feel it have it's effects.
Why call it alpha chloroacetone? Chloroacetone is already non-ambiguous.
Yeah science!
Haha😂
science Bithc
i was thinking for Jesse when reading of this
Yeah Mr.White !!
YEAH SCIENCE BITCHES
So can you do another video on the distribution of the product? (asking for a friend)
Slinging crystal ain't rocket science.
why? do you have the product in hand? I can sling it for you for 20% commission on each sell in bulk. pm me
You could try and be an independent dealer lol
@@duck508 Nah i'd rather not get colombian necktied
@@duck508 too risky imo
how fascinating. At least now I know why they needed aluminum in the process of making the blue stuff, even though the molecule doesn't contain it
it's a catalyst, AlCl3. It isn't per say, "used" in the reaction; just there to make it happen. Like a divorce lawyer.
@@stevegremory3849 Divorce lawyers I shaved my head
@@s3xyn0sfera2 JESSIE!! WHERE IS OUR METHE I WANT TO SELL METHE!!! GUS WILL FIRE US JESSAE!!!
@@stevegremory3849 So the aluminum can be reused? Is the strips shown on the TV show accurate?
@@technophant :trollface: hey maybe the show is accurate, I mean, I don't know like mmmmm
Thank you so much, this got me through college!
The video or…? 🤨
Wait wha-? 🤨
The fees or the exams?🤨
Heisenberg College?
writing in pen because we feel confident until we realize we get the mechanism wrong and can't erase....but i love the feel of that ball point
The large scale synthesis normally starts with phenylacetic acid + acetic acid using a tube furnace (This is in series 1 of breaking bad, but they say it’s for making methylamine) to give phenylacetone. The imine is made using anhydrous methylamine and a dehydrating agent, which is reduced in situ using sodium borohydride (or using hydrogen and Nickel catalyst).
If the imine is not completely formed the product will be a pale purple/lilac, not blue.
Meth is a horrible drug. I’d advise people to stick to coffee.
@lilou zekabyle if you know how to make meth tell me what chemicals and how to make it
LOL these dudes in the replies seem like they searched up "how to make meth" on youtube and desperately want to try it
@lilou zekabyle asking for a friend*
Weed
@lilou zekabyle you can't reliably methylate amines. You'd end up with the tertiary amine probably.
I guess you can call me Walter BLACK 😁
🤣you need ur own series seriously
"Good job Gale"
- Heisenberg
I just had a chemistry mock paper a few days ago and this was one of the questions. Didn't know how to answer it so you've been an absolute lifesaver for when it comes up in the actual test 😅
LOL. You are going to fail if you use this. I know, I have taught Organic chemistry AND Organic synthesis.
Why?
All in all, methamphetamine is pretty easy to synthesise once you've got the methylamine for it. For methylamine however, and this is purely for educational purposes, you just need to add methanol and ammonia in the presence of an aluminosilicate catalyst [ CH3OH + NH3 -> CH3NH2 + H2O ].
king
Wow, i was just about to mention that it can be made by acetic acid + ammonia and do a hoffmann bromamide but yeah bromine is also hard to get lol.
Again, only for educational purposes.
Its actually not that simple cause the methylamine will React with more Methanol to [(CH3)4N]+, you need to do it with phtalimide as nitrogen origin and H4N2. Its called Gabriel synthesis
With Ammonia it works too but its difficult to stop the Reaktion at the primär Amine, as they get more reaktiv the more methyle groups bond with the nitrogen
For educational purposes where may one find an aluminosilicate catalyst?
@o_sch As with many things in chemistry, if you need to ask you probably shouldn't be doing it.
Congrats! You're now on a list.
The first step of the synthesis is alpha halogenation, not Friedel-Crafts alkylation. As such, you will need to use a Bronsted-Lowry acid as the catalyst (such as acetic acid) instead of AlCl3. Other than that great job.
For Alpha halogenation we can use Hell- Vollhard Zeliensky reaction
It's not a Bronsted-Lowry acid, it's a Lewis acid.
You have no idea what you are.... Another synthesis and it would be Beta chlorinated. Betachloroephedrine. Here it's dehydrochlorination with Lewis Acid AlCl3
@@user-xb5qt2qn6i the acid used here is a lewis acid, but this guy is saying they should use a Bronsted-Lowry acid instead
@@047mithutalom8 umm i am preety sure hell vorad zelensky is used for alpha halogenation of carboxylic acid not a ketone
As a brazilian, this video was very helpful in my job of chemistry
Friedel-Crafts acylation is really a game-changer in organic syntesis. On my org. chemistry exam I had to creative similar synthesis paths. That's good fun!
1) During the chlorination of acetone you can have different chlorinated products and you need to avoid the Friedel Craft reaction (aluminium chloride is your catalyst).
2) In the reaction between benzene and chloroacetone you must avoid a multiple alkylation by cinetic control.
3) So try to use a tube furnace reaction: Ar-CH2-COOH + CH3COOH --> Ar-CH2-CO-CH3 + CH3COCH3 + Ar-CH2-CO-CH2-Ar + CO2 + H2O.
By fractionated distillation you can separate the products.
4) The ammonia can react with alcohols by dehydration with allumina and alluminium phosphate. In this case: CH3OH + NH3 --> CH3NH2 + H2O .
However there's another way: cyanide ion reacts with aldehydes and ketones to form cyanidrines.
The bond can be C-N or C-C, (50% of probabilities) and there is 50% of probabilities the bond is over or under the plane of -C=O.
yes
@@eepp Just "Yes" or "Ohhhhh yeaaaah"?
Mate you should watch your back from the feds with that comment lmao
@@Stupedomin Then will they burn every chemistry book? It's knowledge of first level organic chemistry.
@@phantomzone2571 You got a point
I mean when youtube recommends me videos like these, I have no choice but to click. I hope the DEA and NSA understand. I hope this comment, that they are most definitely going to be made aware of explains this.
It's weird how easy it is to synthesize methamphetamine on paper using high school organic chemistry
"high school organic chemistry"? what? in what high school is that taught
@@Supercatzsmy old high school had us make flashbangs (Australia)
Thanks! Definitely recommend this tutorial.
Thank you WW for teaching us! I love your class
Nice Explanation 👍👍
yeah I hate the chemistry class, but can't ignore all the things chemistry has done for us 🥰
this is very educational thank you
I start watching just a few chemistry videos last night and TH-cam shoves this in my face, very cool
Thanks for the guide!
God it’s been ages since I last did ochem synthesis. Rly loved these stuff, should have done it in college
College is the time for experimenting
@@ryana7313oh yea bby
Inspired by Breaking Bad
that's definitely true
As a person who is working 2 jobs to support my family and recently got diagnosed with lung cancer, this really helped me live my life like a free man and make millions.
That propiophenone addition-elimination with primary amine is actually slow and also yields multiple products.
I would have used NaBH4 in the reduction of the imine because i guess is safer, greener and cheaper. Also you confused an acylation instead of an alkylation at some point but overall is a straight good synthesis and a classic example of retrosynthesis good job!
i was taught NaBH4 didn't reduce imines so i don't blame him for using Li
@@hello-rq8kf I was taught that they do... They turn Aldehyde/Ketone/Acid Halide/Imine groups into alcohol
Using a lewis acid Alcl3/Cl2 to halogenate a ketone? Would alpha ketone halogenation not be better carried out under basic, or acidic conditions? If you haven't removed a hydrogen from the alpha postition of the ketone, or otherwise protonated the oxygen, how is the reaction ever going to proceed in the manner described? Would it not therefore be better to use H3O/Cl2?
Thank you for the guide!
Beautiful crystals!
Methylamine comes from camping stove tablets(Hexamine) that have undergone acid hydrolysis(HCL). Almost 100
% pure.
Hey buddy slow your roll
That doesn't work. The carbons in hexamine are in a different oxidation state than methylamine. Hexamine just gets hydrolyzed to NH3 and formaldehyde
you can go with the leuckart reaction. That imine looks super unstable under moisture
I want to explain why I'm here again. I didn't watch the full video last night. So I need to watch it fully now.
I understand that very well, keep it up man.!
I think methylamine can be synthesized with methanol and ammonia by removing the OH from methanol and a proton H from ammonia and finally binding them together in the same stequiometric proportion although ammonia is hard to find but it can be done with the haber-bosch method or just using NH4+ from urine or an aquarium and using OH- to take a proton out of the first ion. I'm not a chemist nor have a degree in chemistry but am I thinking right here?
There are two main problems.
1. You cannot displace hydroxyl from methanol by NH3. OH- is a very bad leaving group.
2. Suppose you nevertheless were able to do this. The methylamine you obtained would react with methanol as well resulting in the formation of dimethylamine. This is called overalkylation.
And there is no problem preparing ammonia in the lab. Take ammonium chloride and mix it with some strong base like sodium hydroxide.
@Bedanta Bytes Um Meth doesn't have oxygen, the whole point of using pseudoephedrine is because all you have to do is reduce the alpha carbon that has a hydroxyl group stuck to it, by convincing the oxygen to leave. OILRIG, reduction is the opposite of oxidation and what atom is oxidation named after?
Thank you Mr.White
Haha jokes on you he’s Mr Black now
@@limgiazhun LMAOOOO
Have my last final today in a few hours. This seriously helps me study thank you so much!
Thank you, really useful knowledge
Jesse, we need to cook!!!!!
in the beginning of the video: This video is only for educational purposes,
half way through the video: the chlorine is basically a bleach, you can buy it in store😂😂
Good Video works 👍👍👍👍
great tutorial, thanks!
This was an interesting video, but I'm just confused about the alpha-chloroacetone formation. I see that the alpha carbon would act as a nucleophile, but I don't understand how that would happen in real life unless you made the acetone into an enol first. Would appreciate if anyone could clarify.
Thanks for the interesting video though!
Potato Patate this needs to be in acidic conditions. H30+ forms Enol and the Cl2 can do the rest
@@juanmadrid2300 Thank you!
Boy o boy would I have loved to have this kind of info back in the day, I had to figure out how to with bits and pieces of info ...now I am to old ....good luck meth-la-mites
Don't know why the algorithm suggested me this, but I feel welcomed in this watchlist all of our names are on
This is THE reason why I study chemistry tbh
I love the substances
Nice... Hol' up..
@@amaan8688 thanks
Quick note after making the alpha-choloacetone you will need to perform a distillation to remove the byproduct of HCL.
Tell me about the stereo chemistry involved here because there are D and L isomers and only one is the desired product. What steps would you take to reduce the quanity of undesirable L isomer?
Start with pseudofed which is already stereoselected for you.
@@numberpirateyou’re a damn genius
This just appeared on my recommended I did not search for this
Thank you your recipe worked!
3:50 will result in overalkylation. Very impractical unless you have some good separation method.
Good one
in chloracetone synthesis u don´t need AlCl3 as a catalyst, just heat or light.
I believe the AlCl3 is the Lewis acid for the fridels crafts acetylation between the benzene and chloroacetone. Also for the synthesis of chloroacetone you don’t heat the solution or expose it to light, chloroacetone would decompose if heated too much or if exposed to light
Many why is illegal chemical tutorials showing up in my feed today. First explosives and now this? I’m definitely on a watchlist.
I really like this video and recommend
I wish my test had this problem
it's walter black
Wow. This straight landed into my recommended.
As someone who still studying synthesising aspirin and soap and this lame stuff, I found this video every helpful and fruitful also very interesting
Thanks mate helps me with my organic chemistry lab. For strictly educational purposes. How would one do a recrystallization?
maybe cool it down at low temp? 😂
People whatch this because of breaking bad
I whatched braeking bad because of this. I really whatched it whith mcmurry on knees
Breaking bad like, totally invented meth bruh.
You typed this out after making some, didn't you? 😂
Another to add to my list collection
Will it to be possible to do toluene from reduction of Benzyl chloride? Beacuse Toluene + Acetyl chloride (not that chloroacetone) is P2P?
Are you sure when doing an alpha halogenation of a carbonyl compound.......like adding chlorine to acetone to make chloroacetone........that you could use a lewis acid like FeCl3??????? Because you need enol formation for the reaction to work. And an acid that protonates can form these enols but HOW CAN A LEWIS ACID protonate the carbonyl on the acetone to make the enol????????? A lewis acid is an "electron accepter" and NOT a "proton donor". NOW I AM SO CURIOUS IF YOU COULD USE A LEWIS ACID. It would make the Cl2 more positive. But what would form the enol or enolate anion???????????
Friedel-Crafts acylation not alkylation. Just finished my organic chemistry 2 class on Thursday
Also you can’t just stick a carbonyl on a benzene you have to halogenate first to get a good leaving group. Other comments mentioned that.
Wish I saw this before my exam this is a great way to teach retro synthesis 😅
he did that right? assuming you mean halogenate the acetone because you don't need to do chlorobenzene leaving groups unless you're doing NAS
jesse you need to learn this
Epic!! :D ❤❤ *SUPER* helpful!!! :D 😊😊
can’t you just do the dehydration of pseudoephedrine to make the OH come off by adding a proton(H) to make H2O/water and methemphetamine?
Yes. Adding Triethylsilane would deoxygenize the OH group of the pseudoephedrine (thereotically)
Well if you take off the -OH now you have the alpha carbon without 4 paired electron groups that carbon becomes + due to the oxygen in the hydroxide leaving with the alpha carbons electron. So that -OH could combine with an acidic hydrogen/proton/hydronium which would yield water. But now you have +H in solution and the +C alpha carbon. how do you propose to get two electrophile to bond to each other? Also if this was possible pseudofed would be considered a prodrug of meth as don't you think stomach acid would yield the same result?
@@numberpirate Even with all the information you provided, there are still so many other reasons that this 'dehydration of pseudoephedrine' question is just absurdly unfeasible from any serious perspective.
Gus doing side mission after he faked his death
I feel like the youtube recommendations are trying to get me arrested
Lot thanks Gus!
Jesse, we need to cook
We had to know how to synthesise meth 😎
the compound you create just before you reduce it to methamphetamine with lialh4 is c10h13n is that
2-methyl-N-phenylpropan-1-imine
or is it called something else??
I'm definitely on a list now.
Always interesting to see what is and what isn't again the TH-cam TOS.
You can produce methlyamine on your own by the reaction of ammonia and methanol with an aluminosilicate catalyst
Thanks! so where can i sell it now?
You forgot to mention the temperature of 400°C and pressure of 20bar
@@hantrio4327 and how to prevent it from forming the secondary and tertiary amines
@@hantrio4327ah, that's how the labs explode
Grat werk bro respect wich I did school to know what to do RC chems tort me a lot miss megachems
I’m on some list for sure
Thanks for the help
Kevan: Said my name!!!
DEA : Kevan
Kevan: You're god damn right!!!
This video really open my eyes on how to start Business 😂
thank you now i will make them
Heisenberg cooks this 😂
People here are serious about making meth and stuff
I just needed it for a story I'm writing XD
I'm just curious after watching breaking bad
I have cancer so this will be for my family
The real organic chemistry
Thank you so much!
I feel like I’m on an fbi watchlist
Hey thanks Kevan! Ive made well over 1 million dollars from all the meth you taught me how to make from this video!
Lol XD
can you teach me how to make it
@@Bolangsamarinda just watch the video bro
does the lithium addition have to be isobaric? please mention the dimensions for the titration glass next time
Nilered needs to see this.