Sickle Cell Disease by V. Tran, N. Archer | OPENPediatrics

By the end of this video, the learner will be able to describe the fundamental elements of sickle cell disease, including pathophysiology, potential complications, and management strategies.
0:00 Introduction
3:18 Pathophysiology
5:06 Complications
9:13 Management
15:13 Summary
LEARNING OBJECTIVES
By the end of this video, the learner will be able to:
• Describe the fundamental elements of sickle cell disease
• Discuss the pathophysiology of sickle cell disease
• Identify the common complications seen in this condition
• Describe the management options for sickle cell disease and its complications
AUTHORS
Virginia Tran, BS
Harvard Medical School
Natasha Archer, MD
Physician
Dana Farber/Boston Children's Cancer and Blood Disorders Center
Assistant Professor of Pediatrics
Harvard Medical School
DATES
Initial publication: June 9, 2023
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CITATION
Tran V, Callas C, Moulton H, Fantasia K, McFee AM, Wolbrink TA, Archer N. Sickle Cell Disease. 06/2023. OPENPediatrics. • Sickle Cell Disease by... .

[@DrMohamedAyyedi]

Very common in Tunisia 🇹🇳🇹🇳🌶️🌶️

[@Rene-uz3eb]

6:45 a higher calcium diet in rats delayed hypertrophy. Bp medication made it worse.
Careful though: large intake will result in more urinary calcium, effected by calcitonin, and the precalcitonin levels are used to diagnose serious infections. So calcium intake right before a blood test should be avoided

[@teanikahoffman1189]

Please stop telling providers the genotype HbSC is “ milder” by the time a person reaches adulthood it all becomes severe

[@Praise_ye_Yahweh]

I find the video very helpful, but the mutation occurs on the 11th chromosome, not the 6th chromosome.

[@rukayarasheed5421]

Its 6 chromosome not 11

[@Praise_ye_Yahweh]

​@@rukayarasheed5421I don't know everything, but I see the 11th in what I have read, if it would be easy for you, could you please provide me a source to check?
Here are some sources that state the 11th: www.genome.gov/Genetic-Disorders/Sickle-Cell-Disease#:~:text=Sickle%20cell%20disease%20is%20caused,and%20glide%20through%20blood%20vessels.
www.cdc.gov/genomics/about/basics.htm