Swiss Target Prediction | Drug Target Prediction | CADD Step 2 | Lecture 34 | Dr. Muhammad Naveed

แชร์
ฝัง
  • เผยแพร่เมื่อ 29 ต.ค. 2024

ความคิดเห็น • 58

  • @RizvanAshraf-lp9xx
    @RizvanAshraf-lp9xx 2 หลายเดือนก่อน

    AOA. Sir Swiss target is showing this messege . Please guide.
    Checking the validity of the query molecule. This takes about 2 seconds. Please, wait.
    You are submitting molecules that are too large. Please, respect a limit of 200 characters per SMILES.

  • @AliRaza-ip9ev
    @AliRaza-ip9ev 3 หลายเดือนก่อน

    Dear Professor,
    I want to know that my ligand has a Vina docking score of around -7.00 using CB-Dock2.
    Can I consider it a potential drug target and go further towards wet lab experiments?

  • @johirislam8174
    @johirislam8174 3 ปีที่แล้ว +1

    did you use discovery studio for visualization in CADD?

  • @mariaansari3833
    @mariaansari3833 3 ปีที่แล้ว +1

    hello sir,
    why is there a need for further target prediction as the target was already selected in the previous lecture. I am a little confused here. It would be really helpful if you solve this doubt.
    thanks.

    • @Prof.Dr.MuhammadNaveed
      @Prof.Dr.MuhammadNaveed  3 ปีที่แล้ว +1

      because we predicted on the base of literature and might be possible some other target is more compatible to studied one

    • @mariaansari3833
      @mariaansari3833 3 ปีที่แล้ว

      @@Prof.Dr.MuhammadNaveed thanks a lot sir, really appreciate your help and the lectures you are putting out for us students.

  • @Biogirlgunaliii5454
    @Biogirlgunaliii5454 8 หลายเดือนก่อน

    Sir , please can you tell which file you import for Swiss Target prediction?... because dsv file format is not supported.

  • @AliRaza-ip9ev
    @AliRaza-ip9ev 3 หลายเดือนก่อน

    Dear Professor,
    I hope you are doing good. I am very thankful to you for sharing such a nice scientific information.
    I have a question. Can you please guide me in this respect.
    I want to know that my ligand has a Vina docking score of around -7.00 using CB-Dock2.
    Can I consider it a potential drug target and go further on wet lab experiments?

  • @BioinformaticsWANA
    @BioinformaticsWANA 2 ปีที่แล้ว

    Sir i am looking for cisplatin but it's failed what's the possible reason and how to resolve? Thanks

  • @johirislam8174
    @johirislam8174 3 ปีที่แล้ว

    Sir you already select the target in your first lecture which was ACE2.So i donot understand in this lecture target prediction called protease.In your 1st lecture you told that you design drug against ACE2.Plz clear the problem sir.Thanks in advance

    • @Prof.Dr.MuhammadNaveed
      @Prof.Dr.MuhammadNaveed  3 ปีที่แล้ว

      Yes dear as some time its delayed in our result so shared protease but later lecture got that

  • @zubairalamkhan
    @zubairalamkhan 2 ปีที่แล้ว

    Aoa sir, any others tools or website which can do target prediction because this website is not working right now.

  • @lifesciencedecoded
    @lifesciencedecoded 3 ปีที่แล้ว

    Sir today i have dock between receptor and ligand with the help of autodock vina , after command prompt i have the the result of docking like that -9.8 affinity kcal/mol.... Sir but maine ek hi ligand ko select kiya , but result main aesa aara hai..
    -9.8
    -9.7
    -9.2
    -8.5
    -8.1
    Sir ye samaj nahi aaya....

    • @Prof.Dr.MuhammadNaveed
      @Prof.Dr.MuhammadNaveed  3 ปีที่แล้ว +1

      you select one ligand but it give you results in many site of active site of protein so you choose -9.8 for further analysis

    • @lifesciencedecoded
      @lifesciencedecoded 3 ปีที่แล้ว

      @@Prof.Dr.MuhammadNaveed thank you so much sir

  • @saimamalik8115
    @saimamalik8115 3 ปีที่แล้ว

    Great work... Thanks alot for helping us sir, sir please lecture on virtual screening, docking, simulation, pharmacophore finding... Means the whole process from protein to drug development ( m.d simulation).

    • @Prof.Dr.MuhammadNaveed
      @Prof.Dr.MuhammadNaveed  3 ปีที่แล้ว +1

      keep watching as my next lectures will cover these contents

    • @saimamalik8115
      @saimamalik8115 3 ปีที่แล้ว

      Sir how can we contact you via FB or WhatsApp?? If we wanna clear some queries regarding to computional work???

    • @saimamalik8115
      @saimamalik8115 3 ปีที่แล้ว

      @@Prof.Dr.MuhammadNaveed how can we contact with you sir? For our queries?

  • @AmjadAli-zz1re
    @AmjadAli-zz1re ปีที่แล้ว

    @ Dr. Muhammad Naveed. If we want to target bacterial enzyme how can we select bacterial species because here is no option for bacteria or we can use other tool please name that tool, because I want to check phytochemical against bacteria as drug

    • @Prof.Dr.MuhammadNaveed
      @Prof.Dr.MuhammadNaveed  ปีที่แล้ว

      go with enzyme name directly or design it structure by smiles

    • @AmjadAli-zz1re
      @AmjadAli-zz1re ปีที่แล้ว

      @@Prof.Dr.MuhammadNaveed OK thanks a lot Dr sab

    • @AmjadAli-zz1re
      @AmjadAli-zz1re ปีที่แล้ว

      I checked with smiles it predicted human cell proteins or enzymes as it s is designed for human and mouse base algorithms. If you found online server that predict bacterial target please share with us.

  • @informationtechnologywithu3783
    @informationtechnologywithu3783 3 ปีที่แล้ว

    sir if we have probability of same percentages for all ,then what does it mean?

  • @ajabgul5289
    @ajabgul5289 3 ปีที่แล้ว

    Great work Dr Shab!
    I would like to request for some videos on SNP genotyping, exom sequencing and whole genome sequencing data (Next Generation Seq) analysis.

  • @ranvjsingh6663
    @ranvjsingh6663 3 ปีที่แล้ว

    can we use canonical smiles given in PUBCHEM for a compound

  • @lifesciencedecoded
    @lifesciencedecoded 3 ปีที่แล้ว

    Sir how to download and install autodock 4.2.6 software.... And please make a video on chimera tool in depth....

    • @Prof.Dr.MuhammadNaveed
      @Prof.Dr.MuhammadNaveed  3 ปีที่แล้ว

      link shared in autodock video and sure will do

    • @lifesciencedecoded
      @lifesciencedecoded 3 ปีที่แล้ว

      @@Prof.Dr.MuhammadNaveed
      Sir vina and autodock 4.2 both are different software naa

  • @jyotibala102
    @jyotibala102 3 ปีที่แล้ว

    Nice video

  • @shreyasdeshmukh8055
    @shreyasdeshmukh8055 3 ปีที่แล้ว

    Sir from which city you are?

  • @lifesciencedecoded
    @lifesciencedecoded 3 ปีที่แล้ว

    Sir pyrx virtual screening (multiple ligend selection) pe video hogi aapki koi

    • @Prof.Dr.MuhammadNaveed
      @Prof.Dr.MuhammadNaveed  3 ปีที่แล้ว

      will try to make on it

    • @lifesciencedecoded
      @lifesciencedecoded 3 ปีที่แล้ว

      @@Prof.Dr.MuhammadNaveed
      Sir please ek din apna busy schedule nikal kar iski help se docking btaiyega aap....

  • @user-cc3en6ev3e
    @user-cc3en6ev3e 9 หลายเดือนก่อน

    Sir kindly make a comprehensive video on cabx flex 2 and how to change protein id .please sir

  • @syedzaheerbukhari8473
    @syedzaheerbukhari8473 3 ปีที่แล้ว +1

    ❤️❤️❤️

  • @lifesciencedecoded
    @lifesciencedecoded 3 ปีที่แล้ว

    Thanku sir

  • @syedaadeen9273
    @syedaadeen9273 3 ปีที่แล้ว

    👍

  • @lifesciencedecoded
    @lifesciencedecoded 3 ปีที่แล้ว

    😊😊

  • @zartashiaafzal8514
    @zartashiaafzal8514 3 ปีที่แล้ว

    Waiting

  • @lifesciencedecoded
    @lifesciencedecoded 3 ปีที่แล้ว

    😊😊