Taking my midterm on monday and boy the epinephrine and glycogen phosphorylation and synthesis of glucose is super new though all this energy of g6p and ATP energy... All in all thanks for posting insulin inhibits opposite of glucagon and epinephrine works
Great video lecture!!. Performing phosphoproteomics research on biopsy material from cancer patients. Its good to back to the basics for a good understanding. Especially the historic context is very interesting. Has someone ever written a book about the history of molecular biology ??
A search at amazon for "history of molecular biology" www.amazon.com/s?k=history+of+molecular+biology&ref=nb_sb_noss picked up the book: The Eighth Day of Creation: Makers of the Revolution in Biology, Commemorative Edition Expanded Edition by Horace Freeland Judson www.amazon.com/Eighth-Day-Creation-Revolution-Commemorative/dp/0879694785/ref=sr_1_13?keywords=history+of+molecular+biology&qid=1559402613&s=gateway&sr=8-13 It's a bit old (1996) but huge (720 pages) - well known but I have not read it.
IκBs are a family of related proteins that have an N-terminal regulatory domain, followed by six or more ankyrin repeats and a PEST domain near their C terminus. IκBα is the best-studied and major IκB protein.
#Kinases transfer the γ-phosphate of ATP to other biological molecules, serving as chemical messengers that make the tight regulation of cell-signaling pathways possible. For example, non-receptor tyrosine kinases are found in the cytoplasm (not membrane-bound) and transfer the γ-phosphate of ATP to tyrosine residues of other proteins, often turning these proteins “on” or “off” in the context of their respective signaling pathway. This notion of “on” or “off” can be useful to holistically conceptualize these pathways but is a gross oversimplification; in reality, many of these enzymes are multi-domain proteins that can exist in multiple conformational states, participate in multiple protein-protein interactions, and experience a gradient of variable activity levels depending on these states. The molecular mechanisms that govern the activity of these kinases is extraordinarily complex, and though much has been discovered in recent years, much remains to be understood, especially for the Tec family of non-receptor tyrosine kinases.
Thanks DR. Taylor for your great present :)
Taking my midterm on monday and boy the epinephrine and glycogen phosphorylation and synthesis of glucose is super new though all this energy of g6p and ATP energy...
All in all thanks for posting insulin inhibits opposite of glucagon and epinephrine works
These cascades are quite a theme in biology! Thanks
What a superb lecture. Love the history info too. Thank you
these lectures are awesome. This whole channel is awesome. Thanks for the content!
Dr. Taylor, Thank you for posting this well-organized and interesting lecture!
Beautiful lecture
Great video lecture!!. Performing phosphoproteomics research on biopsy material from cancer patients. Its good to back to the basics for a good understanding.
Especially the historic context is very interesting.
Has someone ever written a book about the history of molecular biology ??
A search at amazon for "history of molecular biology"
www.amazon.com/s?k=history+of+molecular+biology&ref=nb_sb_noss
picked up the book:
The Eighth Day of Creation: Makers of the Revolution in Biology,
Commemorative Edition Expanded Edition
by Horace Freeland Judson
www.amazon.com/Eighth-Day-Creation-Revolution-Commemorative/dp/0879694785/ref=sr_1_13?keywords=history+of+molecular+biology&qid=1559402613&s=gateway&sr=8-13
It's a bit old (1996) but huge (720 pages) - well known but I have not read it.
Awesome, great content and context!
This video is Great!! Thank you so much for this piece of information!
IκBs are a family of related proteins that have an N-terminal regulatory domain, followed by six or more ankyrin repeats and a PEST domain near their C terminus. IκBα is the best-studied and major IκB protein.
Great video worth viewing
Extremely interesting and enlightening Thank you.
great video! zillions of thumbs ups!
#Kinases transfer the γ-phosphate of ATP to other biological molecules, serving as chemical messengers that make the tight regulation of cell-signaling pathways possible. For example, non-receptor tyrosine kinases are found in the cytoplasm (not membrane-bound) and transfer the γ-phosphate of ATP to tyrosine residues of other proteins, often turning these proteins “on” or “off” in the context of their respective signaling pathway. This notion of “on” or “off” can be useful to holistically conceptualize these pathways but is a gross oversimplification; in reality, many of these enzymes are multi-domain proteins that can exist in multiple conformational states, participate in multiple protein-protein interactions, and experience a gradient of variable activity levels depending on these states. The molecular mechanisms that govern the activity of these kinases is extraordinarily complex, and though much has been discovered in recent years, much remains to be understood, especially for the Tec family of non-receptor tyrosine kinases.
Thanks Susan!
thanks! I understand this part now.
Thanks for the class!!!
thank you! i found this very informative and helpful! :)
Very helpful video!
Thanks, great video
So much diversity!
This is brilliant. Thanks Prof. Taylor
Fantastic, thank you.
Thank You so much!!!
Thank you
80 dalton mass for phosphate group, not 80 kilodaltons :)
Funny she said an average 70 kDa person turns over 40 kg of ATP per day
4:07 the year should be 1987. See www.ncbi.nlm.nih.gov/pubmed/2434996
I found it great but couldn't focus much because of so much swaying back and forth.
Dat comic sans. Love it
this is fabulously interesting = 7 likes