Does alpha fold use a similar concept as homology modeling? Does homology modeling outperform alpha fold for proteins with high sequence identity to known structures?
Old comment (sorry, not enough time), but it's a good question: Homology modeling always starts from sequence identity and structures thus being evolutionary related. Threading simply means we take a sequence and thread/put it in the shape of a backbone of an existing structure (or part of a structure) and try to evaluate how well it would fit.
Thanks, saved me from watching a 20 min video.
Does alpha fold use a similar concept as homology modeling? Does homology modeling outperform alpha fold for proteins with high sequence identity to known structures?
No, it's completely different. Check the separate lecture on AF2.
hello, what's the difference between homology modeling and protein threading?
Old comment (sorry, not enough time), but it's a good question: Homology modeling always starts from sequence identity and structures thus being evolutionary related. Threading simply means we take a sequence and thread/put it in the shape of a backbone of an existing structure (or part of a structure) and try to evaluate how well it would fit.