#35 - Nir Barzilai, M.D.: How to tame aging
ฝัง
- เผยแพร่เมื่อ 6 ก.พ. 2025
- Original release date: 1/7/19
In this episode, Nir Barzilai, director of the Institute for Aging Research and expert in the genetics of longevity, discusses the evidence that metformin and rapamycin have anti-aging properties and how his TAME study aims to support this hypothesis in humans. Additionally, he describes the role of genetics in lifespan/healthspan and how it might affect important pathways such as IGF and insulin sensitivity.
We discuss:
-Nir’s background and interest in aging and endocrinology [3:30];
-History of metformin, and understanding the mechanism [11:15];
-Attempting to define insulin resistance [21:15];
-Metformin as a possible anti-aging drug [48:45];
-The TAME trial: Targeting Aging with metformin [57:45];
-Why Nir believes metformin can slow aging [1:16:30];
-The genetic gift of centenarians [1:28:00];
-IGF/GH and its impact on aging and chronic diseases [1:34:15];
-Genetics/epigenetics of centenarians, gene sequencing, CETP-VV, Lp(a) [1:49:15];
-Should you be taking HGH? [2:05:30];
-NAD and NAD precursors (NR and NMN) [2:30:00];
-Parting thoughts on metformin [2:36:15];
-Possible blind spots in Nir and Peter’s thinking? [2:43:00]; and
-More.
Show notes page: peterattiamd.c...
About:
The Peter Attia Drive is a weekly, ultra-deep-dive podcast focusing on maximizing health, longevity, critical thinking…and a few other things. With over 10 million episodes downloaded, it features topics including fasting, ketosis, Alzheimer’s disease, cancer, mental health, and much more.
Peter is the founder of Attia Medical, PC, a medical practice with offices in San Diego and New York City, focusing on the applied science of longevity. The practice applies nutritional biochemistry, exercise physiology, sleep physiology, techniques to increase distress tolerance, lipidology, pharmacology, and four-system endocrinology to increase lifespan (delaying the onset of chronic disease), while simultaneously improving healthspan (quality of life).
Learn more: peterattiamd.com/
Subscribe to receive exclusive subscriber-only content: peterattiamd.c...
Sign up to receive Peter's email newsletter: peterattiamd.c...
Connect with Peter on:
Facebook: bit.ly/PeterAtt...
Twitter: bit.ly/PeterAtt...
Instagram: bit.ly/PeterAtt...
Subscribe to The Drive:
Apple Podcast: bit.ly/TheDrive...
Overcast: bit.ly/TheDrive...
Spotify: bit.ly/TheDrive...
Google Play: bit.ly/TheDrive...
Dr. Attia is master at cutting your communication. What a skill
Very interesting talk. I didn't honestly understand everything, but still!
Thanks a lot for posting this interview here
Dr. Attia is hitting a point on testing insulin during OGTT that is dear to my heart. I have a not so uncommon ailment of low insulin production, and as you get older it leads to all sorts of problems, and as they get serious, the medical profession is totally useless. My fasting glucose was 100, and fasting insulin below 3. Kraft has nailed it down ,as Dr. Attia alludes to, with insulin graphs over 3 hours. His charts make it clear that I have insulinopenia, and sure enough, exogenous insulin was a life saver. The Oxford HOMA2 model also completely supports this. I diagnosed this myself, and even when begged with six MD's to see this as Type-I diabetes, they all could not see it. So, not testing insulin with diabetics seems like a big problem.
You have a perfect blood work with regards to your fasting insulin and glucose. The lower insuline, the better is your metabolic future. Take easy doctors" comments on d1 probability... they are still in the stone age
On the book release... I think everytime I read good health information, it engrains a little more. Like being reminded to brush your teeth to the point where it's a no brainer. The point is, putting the information out there is only going to solidify the knowledge base, engrain better lifestyles, and add some reinforcement in the battle against the modern world's influence on our well being.
Dr. Attia, love your podcasts, however in this one you cut off your guest too much. I’m healthy very active at 54, taking metformin 1/2g x2 and Test Cyp 200mg weekly. I would have enjoyed more info about metformin. I say this with love and appreciation. Thanks again for your podcast
It's already quite difficult to keep up, the style of the interviewer that keep interrupting doesn't help but make it even more difficult.
TheENofficial ok thanks :)
Yes! This is pointed out to him on almost every podcast! But in one of them he says he doesn't bother reading you tube comments so he obviously doesn't care that his listeners find it so rude and annoying!
Although no clinical trials exploring transdermal delivery of metformin are published, my family and I (neither of us is diabetic) are using transdermal metformin (10% of the 1500 mg oral dose). We have left behind the first pass (liver) and benefit from the increased bioavailability of metformin.
Combined with training with total body electrostimulation (WB-EMS), 20 minutes 2 x week, we are zeroing out what visceral fat is left. The gain in muscle mass is sensational, as I am 73 years old. Before metformin (which we have been using for over 2 years) combined with WB-EMS, I had a hard time getting rid of my sarcopenia. Metformin + WB-EMS put an end to the sarcopenia.
Where do you get the transdermal metformin?
Which WB-EMS system are you using?
Thank you
Joseph
I really appreciate the depth and breadth of the sessions. Also, I am drawn to the conversational style.
The interviewer keeps interrupting because he has an innate desire to show how smart and how much he knows.
Top 2 podcasts on longevity💕
Guest starts to make a point and is interrupted. Guest beings to answer the question posed by said interruption and is once again interrupted. Guest starts to try and make his point and is once again interrupted. Host goes on to talk about useless non-sense for the next 3 minutes, uninterrupted by guest. Guest begins to speak again and is interrupted...
Yes! This is pointed out to him on almost every podcast! But in one of them he says he doesn't bother reading you tube comments so he obviously doesn't care that his listeners find it so rude and annoying!
Peter was interrupting way too much. The interviewer s style is very annoying.
Episodes are super-long, brevity is an art of a great value
There are lots of Nir Barzilai interviews out there, but very few will get to the gist of what's really happening. That's why Peter's interviews are so rare; they actually give you all the details rather than just summarize the information. I agree being concise is good-but not when you actually want to know the Why's and the How's :)
@@andreeanitescu9026 it is called a book, not an interview then
Getting a prescription for metformin is tough.
FWIW.....I tried to get a prescription was not successful.
Not to wast anymore time, I ordered from overseas.
I am from the NL. I am non diabetic and not getting a prescription for it even though my doctor knows about the advantages. Have to buy it in india, wich is a pain
how is metformin better than berberine?
For a channel with so few followers, why don't any comments get any responses??
Real Talker 101 My best guess is that you get it if you have a subscription. Lets be thankful that he shares these in depth sessions for free with us.
1.25 speed
+,3-$1,#
8!;"and) ]
+;$&in