it's amazing how Mark uses the nerf gun to hook u into watching and then secretly makes u learn all about scientists who actually deserve the exposure ❤
my students deserve a lot of credit! Lauren, Amanda, Jocelyn, Ryan and Barry were all amazing and helped make this happen! Mark was super down to earth and spent a lot of time talking to all of them - it was really a collaborative effort and so much fun to work together on this project!
@@pallavkosuri5606 It's truly heartwarming to hear that you appreciate the efforts of everyone involved. We're all thrilled by this project and are eagerly looking forward to your next endeavor.❤
@@pallavkosuri5606 So is the plan to inject DNA bullets into cells using DNA structures? I love how passionate you are about your work, you have become a great inspiration for me. I can't believe things like this exist, people like you change the world. Thank you for what you do 👍
Im a physicist in Nanofabrication. This is impressive on another level. You made a video that children can watch that has more science inside than most lecture courses at university
Great comment from the Nanophysicist guy! Exactly what I wish I could have said. And done so credibly and concisely. This video seemed a whole new level for Mr. Rober. It was technical enough that it allowed me to finally realize Mark Rober is currently one of the nearest this era can offer to Richard Feynman or Steven Hawking or the like. Or at least working at or near their level in his field of mechanical engineering.
@@hamza-chaudhry University courses goes wide, not deep. Unless it's a course specifically designed around this subject/thematic, you don't get too much details about the content. For instance, I don't think you see how carbon nanotube are created (9:40) . Or how you can build stuff with DNA (not from DNA)
It's not that visible light can't reflect off the object, it's that it won't carry the density of information we're looking for. The whole object would look like a single blur with no detail.
I wonder if there's a way of using some kind of micro shifting of the object to increase resolution - similar to some cameras or apps, that use device/sensor motion to increase the resolution, by multi exposure. @@JWQweqOPDH
Probably build a couple strands then amplified each component via PCR - polymerase chain reaction, which uses a special DNA building molecule "taq polymerase" from a very heat resistant organism. Could be wrong though.
This guy pulls off something that is clearly extremely difficult to achieve and compresses it in a 20 minute video coupled with happy music. Well done.
Another incredibly well made video. Thank you so much Mark for being an absolute inspiration for millions of people. I’ve had so much fun watching your videos in the last several years, and now my 9yo son is following the steps and is developing a more and more engineering mindset everyday. Thank you truly.
This might be one of the best explanations of DNA manipulation I have ever seen. Well done just for that. Using the Nerf project as a vehicle to explain such complex science in a way that people can understand is extremely clever. Gives me hope for the future knowing there are absolute geniuses like Pallav and all his colleagues out there doing this kind of work.
As a recent graduate in the engineering field and 3D printing experience now working with semiconductors, this video has been one of the most interesting videos Mark has ever put out. I would love to work on something like this with Mark one day.
I think this is probably his best video yet. Every time I was amazed, he went even further. Each step was beyond what I thought was possible. That's a rare feeling to get as an adult, and it makes you feel young again. Thanks Mark
I completely agree!! I am passionate about learning and science so I tend to try and keep up on what ever is happening but there are industries where I don’t even know where to start! I was learning more about Crispr the other day and this was so fun to come across! Who knew you could form DNA into actual shapes! And I loved learning about the tiny useful machines! It was astonishing to me that he covered so much information in such little time all while making it impossibly easy to understand.
So unreal... If there were videos like this being made when I was little, it would have probably inspired me to pursue engineering. I'm happy it's here for today's kids to see. Doubt you'll see this Mark, but if you do, just know I'm glad there are people like you out there. You're doing great work.
Mark you're a treasure to humanity. Seriously, thank you for doing what you do. Ive been feeling dejected lately over the online discourse talking about how the public school teachers are reporting their students being very behind and lacking motivation to want to engage at all. But your content I truly believe is the spark that absolutely will be the start of so many kids today becoming adults in the future who pursue STEM for the betterment of mankind. Your content is the exact kind of content that we should be celebrating as a society. You can tell that you truly care for this world and you want to do what you can to encourage and inspire people around you. I hope you continue to keep doing what you are doing, it is truly a great service to the world.
1:53 What a heartwarming display of affection between student and teacher! Mark hugging his professor so enthusiastically really shows the wonderful bond they share!
One lockdown 3AM night couple years ago I stumbled across a video of a dude playing with squirrels in his backyard I enjoyed it so much and decided to watch more, since then I have bookmarked and saved each and every one of these, they went from being just entertainment to fully immersive learning experiences. This is the kind of thing I want to do with my life. Currently a junior engineering students and these videos are really fuel for the work. One day ...🙏🏽🙏🏽
Thank you Mark! You filled us with hope about the future. It's really inspiring that so many great scientists around the world are working tirelessly for a better future. Thank you so much for showing us that!
Mark, Lately as an engineer and a teacher I feel kind of low about what we are doing and where we are going as a people. Then I watched this video and I have come away feeling hopeful. Thank you! This was very cool.
Same! Whenever I'm feeling pessimistic about the world, I come to watch Mark's videos to remind myself that heroes don't always have the loudest microphones. There are people like Mark doing incredible work everyday.
As someone who has worked in a DNA origami lab and sat at a computer for countless hours designing staples (just to build a rectangle mind you), thanks for highlighting this technology. It’s pretty cool stuff!
This video had me wondering, and I'm hoping that you might be able to provide some insight here, how are the staples actually made? Design aside (I would still love to learn about the design) but physically, once you know which bases belong in the staple, what tools are used to actually construct the staple?
These videos are the highlight of the month whenever Mark releases them. They're entertaining, educating, and so exciting to watch. Thank you Mark, for these wonderful videos
He loaded and cocked all the DNA nerf guns with a flash of blue light. A slight tap of the test tube on the lab bench discharged them all - and leveled the Salk Insitute.
Just a clarification: no friction doesn't mean no wear. Unless you use a material that is ideally elastic, your compliant mechanism is gonna suffer some fatigue with use
Como ingeniero debo admitir que la explicación de los mecanismos flexibles me encanto!!! Es increíble el mundo que tenemos delante si solo abrimos los ojos y usamos el ingenio!
What I love most about this video is 19:25. Give people like these a fun yet seemingley rediciulous project and you never know what kind of idea it sparks in their head.
I preferred 8:49 if you listen to what he says in between the censoring it is very clear he wasn't saying the actual build instructions (listen very carefully next time you are here or just use subtitles)
@@ItsAllApsyop As you are - genuinley - curious, 1. I'm surprised myself. Sorry I can't answer any better as I don't know how I made it this long. And 2. It's one of those words I have a hard time to memorize the spelling. Or maybe it's the same reason you mixed three words into one and you wrote "four" instead of for.
If they are considered nerf guns, I believe that Mark is now the owner of the largest collection of nerf guns, assuming he got to keep the little ones.
The size of a collection, for world record purposes, is typically determined by the number of *unique* items. Many copies of the same item wouldn't contribute to the size of the collection.
This is genuinely one of the best videos I've seen in a long time, just incredible what people can achieve. And the Nerf guns were cool and all.. but the atomic force microscope was the craziest thing I've ever seen. The fact that humans have gone from banging rocks together in a cave to using machines to measure the distance of one atom, is mind-boggling.
Humans never collectively sat around in caves banging rocks together. We started as farmers with tools. The first metalworker was one of Adam's sons. First textile manufacturer was one of Adam's sons. On and on. Pretty arrogant to think we can do all this on our own.
@@TehButterflyEffect LOL I just realized ur comment says people just had these skills and tools and that's where it began XD bro definitely trolling, please go back to school if you aren't.
Imagine growing up in the 70's, 80's, 90's when all the nerds and geeks were being bullied and ridiculed and called losers for being nerds and geeks. Yet they are the only people changing the world and showing what humanity is really capable of. If only the nerds and geeks of the world are looked up to as the amazing people they are.
Mark, you and your team outdid yourselves! Thanks for mentioning the names of the students and staff not just dept heads. It’s great to see the credit get spread around
A lot of work with DNA is done using chance. Notice how they had to use electrophoresis to separate out the bits of DNA that didn’t form nerf guns. It’s because they knew that if they put in the proper structures and let the DNA bind to itself as they knew it would, that chances of it creating nerf guns was pretty high, but chances are there were a LOT more of the failed pieces that didn’t bind correctly, which they separated out.
DNA is a polymer and each single strand of DNA is a sequence of monomers called nucleotides that come in 4 major types: A, T, C, G. When two DNA strands come together to form a double-stranded form, they normally must follow the rule of complementary: A must be opposite to T, and C to G. In DNA origami, each staple DNA sequence is typically long enough to be close to a unique sequence inside the test tube, therefore it is designed to be complementary to specific counterparts in the scaffold DNA. If two complementary DNA strands are placed in solution, they spontaneously would bind into the double-stranded form, reasons for that arise from the laws of thermodynamics. Here, given enough time and preferably a temperature ramp, the staples will eventually "find" their complementary places in the scaffold. The whole process is governed by DNA self-assembly properties, there are CAD tools that can generate the sequences for staples based on your scaffold sequence and the design of DNA origami nanostructure you make. Then its just mixing scaffold and staples
@@volmyk6196 Thanks! How do they keep all of the strands near enough to their complementary strands to bind? With so many in use, wouldn’t they get jumbled up? Is it that each piece in each gun is unique so that they will each find their unique compliment? How do they make each strand?
That part is helped by the temperature they are incubated at in the little "oven". The pairing up of those nucleotide sequences have different energy requirements, heating up paired up DNA is how we normally unzip the strands and get single stranded DNA. You start off at this high temp where nothing can pair up, then you cool it down and hold it at ideal temps that favor particular sequence pairings. In this way you can help direct the assembly of the finale product. As annealing temperatures are easily calculated and used all the time in DNA amplification.
Every single time they made it smaller I was like "well this is it they can't possibly get any smaller than that." and by the end I was just totally in awe.
I love how Mark helps share what is the bleeding edge of the new science, but putting them together in a fun format and interesting projects. When you think its an impossible idea, there is someone out there that is able to help with this.
Jocelyn, you are the real MVP. Spoken like a true scientist "although there is no label on it." Put a label on your stuff. When in doubt, throw it out. That is the motto of my lab. 18:09
-ну что потомки, как вы там в 2024? Покоряете космос, вышли в 4ое измерение, летаете со скоростью света? -сегодня мы собрали микроскопический пистолет из которого застрелили муравья.
This was like those 3D rendering videos that show scale of how big/small things are but it was 3D printing. This technology is mind boggling. Also I live in Provo lol
@somebody3271 what are they really doing at that lab with DNA? Lol probably medicine. But the anime nerd in me imagines they are creating new lifeforms lol
19:03 - 19:17 Literally had my jaw on the floor for a solid minute Mark. As in the fine words of Bill Cypher, "Reality is an illusion..." and after seeing someone *BUILD WITH DNA* I think this statement is true. Never fail to shock and entertain us Mark, amazing! ❤😁❤
Even small ideas can give rise to big things. :D Much respect to the teams out at BYU. They all seemed so passionate about their field, it's contagious even through a screen!
It's to bad I can't hear about BYU not think of its discrimination to the LGBTQIA+ community that still happens to today, its archaic honour code and connection to LDS church.
This is absolutely incredible. I had no idea this was even POSSSIBLE. Great job on this one. I clicked to see a world record, and what I got was something 3,000,000x cooler. I never knew technology like this EXISTED! This is absolutely incredible.
I love that these young people are so imaginative, creative and intelligent and that they have such resources. Like Mark, it gives me hope for humanity.
Ilmu pengetahuan sangatlah luas. Meski pengetahuan ku sangat lah sedikit Tetapi bersyukur kepada Tuhan telah memberi karunia kepada kami umat manusia.Terima kasih banyak Mr mark Rober telah berbagi ilmu pengetahuan 🙏🙏🙏
Mr. Beast can actually still win. The same technology can be used as "A Boy And His Atom: The World's Smallest Movie" to make a Nerf Gun that is even smaller than DNA. And there even might be a way to "fire" it
This was actually amazing!! It made a ton of sense, it was easy to understand, and I genuinely learned something new today. Thanks Mark, this is incredible!! Keep being greater and more inspiring everyday!
Having actual students working on this problem is so cool. You could've gone to the top scientists or physicists with this problem, but no, you went to the school and got the students to use their head and work out a solution for this. I really respect that.
This episode is peak mark rober. 100s of combined hours of effort, on top of a century or more of combined expert experience, delivered in a tasty 20 minutes.
I LOVE compliant mechanisms. I remember Derek's video on the subject and was fascinated by it ever since. The ingenuity is mind-blowing...and applications like the lens cleaner are so clever.
I really appreciate that you covered aspects of what's involved in nanotechnology. I feel like it is easier to show off on TH-cam a mechanical or electrical engineering project, as the overhead costs for micro and nanoscale implementations are often very high. As someone who works in the field, it's great to see what nanotechnology can do, and I hope this inspires others to enter into the field!
Your move MrBeast. Get your CrunchLabs Build Box for the holidays!! crunchlabs.com
okay!
mebeast?
Yes!
wait its been a minute hi mark
make the nerf gun atom size you wont
it's amazing how Mark uses the nerf gun to hook u into watching and then secretly makes u learn all about scientists who actually deserve the exposure ❤
my students deserve a lot of credit! Lauren, Amanda, Jocelyn, Ryan and Barry were all amazing and helped make this happen! Mark was super down to earth and spent a lot of time talking to all of them - it was really a collaborative effort and so much fun to work together on this project!
@@pallavkosuri5606 Incredible work you guys are doing!!
@@pallavkosuri5606 y'all's micro nerf guns were so cool! Absolutely blows my mind how y'all figured out how to make structures with DNA.
@@pallavkosuri5606 It's truly heartwarming to hear that you appreciate the efforts of everyone involved. We're all thrilled by this project and are eagerly looking forward to your next endeavor.❤
@@pallavkosuri5606 So is the plan to inject DNA bullets into cells using DNA structures? I love how passionate you are about your work, you have become a great inspiration for me. I can't believe things like this exist, people like you change the world. Thank you for what you do 👍
Im a physicist in Nanofabrication. This is impressive on another level. You made a video that children can watch that has more science inside than most lecture courses at university
Cool
Cool
Great comment from the Nanophysicist guy! Exactly what I wish I could have said. And done so credibly and concisely.
This video seemed a whole new level for Mr. Rober. It was technical enough that it allowed me to finally realize Mark Rober is currently one of the nearest this era can offer to Richard Feynman or Steven Hawking or the like. Or at least working at or near their level in his field of mechanical engineering.
@@hamza-chaudhry University courses goes wide, not deep. Unless it's a course specifically designed around this subject/thematic, you don't get too much details about the content.
For instance, I don't think you see how carbon nanotube are created (9:40) . Or how you can build stuff with DNA (not from DNA)
J'ai vu qu'on pouvait déplacer sous microscope atome par atome et même fabriquer des minis outils. Est-ce comparable avec l'utilisation de l'Adn ?.
I love how mark’s just like “this is so small, light cant even reflect off of it”. Just so casually as well.
lol fr
That's what she said
Technically only visible light can't reflect off it I believe.
It's not that visible light can't reflect off the object, it's that it won't carry the density of information we're looking for. The whole object would look like a single blur with no detail.
I wonder if there's a way of using some kind of micro shifting of the object to increase resolution - similar to some cameras or apps, that use device/sensor motion to increase the resolution, by multi exposure. @@JWQweqOPDH
Danke!
Mark Rober is a storytelling genius. His ability to trick my kids into loving science, math and engineering is nothing short of a miracle.
Bruh he makes me love that, and Im 26 LMAO. Its so interesting!
We need new generations of scientists, math geniuses, and engineers; otherwise AI will just control everything!
And salesman.. cough cough crunch labs
Jokes on him. I was already interested before the channel started.
Mark is the best!!!!! 👍👍👍👍
There are now more of the world’s smallest nerf guns in existence than there will ever be just regular nerf guns.
Oh no. That's a great point!
legend
Does that turn all the small ones regular size and the new ones now ‘giant’ size???
@logananderson9834 I suppose technically, since the small ones are now closer to the average size of all nerf guns they would be considered normal.
🤯
Mark is the guy that will literally remake all of his childhood toys into something insane.
ture
lol true
ur dum
I love it
mark be like " I enjoyed this a while ago, time to make it ridiculous"
Bro really said "I'm bored lol" and decided to make a nerf gun out of DNA, truly a masterpiece
bro was really that bored he almost made a new was of injecting medicine into certain cells
Love more detail on how the DNA was self building.
what do you want to know?
@@pallavkosuri5606he replied!! You're a rockstar Pallav!!
Probably build a couple strands then amplified each component via PCR - polymerase chain reaction, which uses a special DNA building molecule "taq polymerase" from a very heat resistant organism. Could be wrong though.
Google this, "Enzymes Involved in DNA Replication"
👍
This guy pulls off something that is clearly extremely difficult to achieve and compresses it in a 20 minute video coupled with happy music.
Well done.
E
It's so amazing that they even make something like this
His videos take months and months, some even years, and every time they’re worth it
No he didn't.. prove it
@taap.on.my.pic790 hey.. I thought you were my friend! What are you doing talking to this guy??
Another incredibly well made video. Thank you so much Mark for being an absolute inspiration for millions of people. I’ve had so much fun watching your videos in the last several years, and now my 9yo son is following the steps and is developing a more and more engineering mindset everyday. Thank you truly.
Thanks for putting your two cents in on our behalf. I mean, two dollars. Almost.
shouldve been pinned😔
8:30 Is no one really talking about how Mark Roger just casually tried to show us how to break in other dorm rooms!?😂😂
Sounds like a homemade under door tool. Deviant Ollam here on YT has videas about them, and he collaborated with LockpickingLawyer on one.
This might be one of the best explanations of DNA manipulation I have ever seen. Well done just for that. Using the Nerf project as a vehicle to explain such complex science in a way that people can understand is extremely clever. Gives me hope for the future knowing there are absolute geniuses like Pallav and all his colleagues out there doing this kind of work.
As a recent graduate in the engineering field and 3D printing experience now working with semiconductors, this video has been one of the most interesting videos Mark has ever put out. I would love to work on something like this with Mark one day.
.
Bring that enthusiasm to your work and be the person that others want to work with!
I think this is probably his best video yet. Every time I was amazed, he went even further. Each step was beyond what I thought was possible. That's a rare feeling to get as an adult, and it makes you feel young again. Thanks Mark
Mark liked ur comment
I know, he made it so small.
I completely agree!! I am passionate about learning and science so I tend to try and keep up on what ever is happening but there are industries where I don’t even know where to start! I was learning more about Crispr the other day and this was so fun to come across! Who knew you could form DNA into actual shapes! And I loved learning about the tiny useful machines! It was astonishing to me that he covered so much information in such little time all while making it impossibly easy to understand.
20:15 Proud to be an engineer too🥺🥺
Absolute joy seeing Pallav Kosuri on this channel. We had the pleasure of hearing him give a talk at our university, his enthusiasm is contagious.
Honestly I could listen to him ramble on for hours. Are there any videos out there of any lectures he's given?
Wasn't expecting to learn how cool DNA is during a video about Nerf guns but I am so incredibly here for it.
What are you doing here ????
HOW ARE YOU HERE! GET OVER HERE!
get back to crashing minecraft 😤
Thank you. I do my best.
Why are you here?
So unreal... If there were videos like this being made when I was little, it would have probably inspired me to pursue engineering. I'm happy it's here for today's kids to see.
Doubt you'll see this Mark, but if you do, just know I'm glad there are people like you out there. You're doing great work.
I'm currently studying master's of science in mechanical engineering and Mark Rober as blown my mind away with this video.
2:26 that aint wreck-it-ralph that's destroy-it-greg 💀
Mark is the definition of quality over quantity
Hindu fascism is definition of quantity and mass hoarding over quality or rational logic
@@thedictationofallah Bro HUMBLED him
so true
@@Asher50 who humbled me and i didnt humble anyone. i'm just sharing my thought what i think this comment relates to
I dunno, he just made 3 trillion nerf guns that don't even work, definitely feels like quantity over quality to me
you know you’re screwed when you’re fighting against a guy with not only the biggest nerf gun, but also the smallest nerf gun
Nah you know youre screwed when he knows a guy that can build nerf guns with dna 😂
@@supersonic5024 you know you’re screwed when the guy can build over a trillion nerf guns out of you
@@poluefemusa trillion nerf guns out of a single drop of your blood*
bro why is noboady taalking about Josline's gyaatt at 18:48?
Nah I saw the same thing flabbergasted fr
Ikr
@maxxxgamer9578this kid
@maxxxgamer9578same
Did not expect Robers viewers to be talking about a gyatt
8:28 - Questionable Mark Rober lore.
Ye lol
It’s crazy how a project like this could potentially change medicine in the future. I’m so excited to see what this DNA technology could bring.
We’re working on it!
He hearted your comment
Here before it blows up
Same
@@pallavkosuri5606I look forward to seeing Kosuri's and Rober’s names on the paper!
Mark you're a treasure to humanity. Seriously, thank you for doing what you do. Ive been feeling dejected lately over the online discourse talking about how the public school teachers are reporting their students being very behind and lacking motivation to want to engage at all.
But your content I truly believe is the spark that absolutely will be the start of so many kids today becoming adults in the future who pursue STEM for the betterment of mankind. Your content is the exact kind of content that we should be celebrating as a society. You can tell that you truly care for this world and you want to do what you can to encourage and inspire people around you.
I hope you continue to keep doing what you are doing, it is truly a great service to the world.
1:53 What a heartwarming display of affection between student and teacher! Mark hugging his professor so enthusiastically really shows the wonderful bond they share!
Best engineer youtuber in the world🔥
One lockdown 3AM night couple years ago I stumbled across a video of a dude playing with squirrels in his backyard I enjoyed it so much and decided to watch more, since then I have bookmarked and saved each and every one of these, they went from being just entertainment to fully immersive learning experiences. This is the kind of thing I want to do with my life. Currently a junior engineering students and these videos are really fuel for the work. One day ...🙏🏽🙏🏽
Same brother, same!. ... well, the squirrel video part, not the becoming an engineer part. 😁
Thank you Mark! You filled us with hope about the future. It's really inspiring that so many great scientists around the world are working tirelessly for a better future. Thank you so much for showing us that!
u sure that this video relates to a better future?
He is literally proving to you that nanoweapons exist lol
you didnt even watch the video its only been out 1 hour you comments 54 mins ago lol
Yes
@@handlingitwellmedically maybe
Mark, Lately as an engineer and a teacher I feel kind of low about what we are doing and where we are going as a people. Then I watched this video and I have come away feeling hopeful. Thank you! This was very cool.
Same! Whenever I'm feeling pessimistic about the world, I come to watch Mark's videos to remind myself that heroes don't always have the loudest microphones. There are people like Mark doing incredible work everyday.
It's because of 76 million people, in the USA at least, that are trying to roll us back to the stone age.
@@jenkins5265 yep, ...those denouncing science and such gets depressing then i see this
I knew you went to BYU. This video was so entertaining. You’re a genius. Thanks for sharing.
As someone who has worked in a DNA origami lab and sat at a computer for countless hours designing staples (just to build a rectangle mind you), thanks for highlighting this technology. It’s pretty cool stuff!
This video had me wondering, and I'm hoping that you might be able to provide some insight here, how are the staples actually made? Design aside (I would still love to learn about the design) but physically, once you know which bases belong in the staple, what tools are used to actually construct the staple?
These videos are the highlight of the month whenever Mark releases them. They're entertaining, educating, and so exciting to watch. Thank you Mark, for these wonderful videos
I know!
He didn't only build the world's smallest Nerf gun, but he also built more Nerf guns than Nerf ever produced or will ever produce. 😱
i dont often literally laugh out loud but this comment got me
Oh wow dude that's an awesome point lol
Bro has 2000iq
He loaded and cocked all the DNA nerf guns with a flash of blue light.
A slight tap of the test tube on the lab bench discharged them all - and leveled the Salk Insitute.
until Mr Beast builds one out of quarks
Why did mark Tal about uranium while talking about how he was able to make something to Lockpick people’s doors?
Ant was having the time of his life
Do I know you from somewhere?
Yes
no
Here before this comment blows up
Indeed, ant force
In amongst all this incredible science and learning tools I'm beyond glad that Mark still uses Plants Vs. Zombies music lol
It’s epic music
bro I was about to say that exact same thing XD
Same
what part?
@@konrad75923:00
Just a clarification: no friction doesn't mean no wear. Unless you use a material that is ideally elastic, your compliant mechanism is gonna suffer some fatigue with use
no se ingles🥲
@@tiffanyvngs3765 y el traductor de google esta de adorno o que?
@@tiffanyvngs3765 Then how did you enjoy the video? Forget the translator?
he said no wear between moving parts, which is correct.
@@jrwill58theres translated audio in the video, settings and change the audio track
Como ingeniero debo admitir que la explicación de los mecanismos flexibles me encanto!!! Es increíble el mundo que tenemos delante si solo abrimos los ojos y usamos el ingenio!
What I love most about this video is 19:25. Give people like these a fun yet seemingley rediciulous project and you never know what kind of idea it sparks in their head.
I preferred 8:49 if you listen to what he says in between the censoring it is very clear he wasn't saying the actual build instructions (listen very carefully next time you are here or just use subtitles)
I'm genuinely curious as 2 how you can be on this planetfouras long as you have been, and 2 not understand that you spelled ridiculous incorrectly..
@@ItsAllApsyop As you are - genuinley - curious, 1. I'm surprised myself. Sorry I can't answer any better as I don't know how I made it this long. And 2. It's one of those words I have a hard time to memorize the spelling. Or maybe it's the same reason you mixed three words into one and you wrote "four" instead of for.
@Kathlanus I use voice to text. I also use finger swipe, so they both make errors, but I clearly know the difference between 'for and four' lol
I prefer 18:48 😉
I'm pretty sure Mark's channel is the only channel that produces such incredibly interesting content for every single age.
Incredible video!
Not 1 year olds
Not 2 year olds
Not 3 year olds
Not the sperm that just gotten to the egg
Maybe 4 year-olds
As an engineer, watching this is like seeing art being created.
As a regular person who isn't an engineer, I too, can confirm that watching this was like seeing art being created.
1:34 ANIMATIC BATTLE REFERENCE?!
fr
I don’t think he knew what animatic battle was
*deep inhale*
NO
It’s time fr the intro!
*slowly points my thumb at myself* >:]
As an engineering student at BYU, this was so fun to watch. Definitely an inspiration when the classes are hard!
BYUI IS BETTER!!!
Is the engineering school there just for mormons? And/or is it a leading uni for engineering?
@@jacquesca 💀
@@jacquescatechnically no but you’d better be prepared!
@@jacquescait’s definitely not just for lds people, most people there are but everyone is welcome
If they are considered nerf guns, I believe that Mark is now the owner of the largest collection of nerf guns, assuming he got to keep the little ones.
The size of a collection, for world record purposes, is typically determined by the number of *unique* items. Many copies of the same item wouldn't contribute to the size of the collection.
@@bobbobert9379collecting the same item is still a collection
@@9BallBory not by official world records standards it isn't.
@@bobbobert9379but not every one is the exact same some have different shapes if you look closely so he does have the largest collection of nerf guns
@@bobbobert9379 mind showing me these standards? i dont care at all but where would you even find them lmao
This is genuinely one of the best videos I've seen in a long time, just incredible what people can achieve. And the Nerf guns were cool and all.. but the atomic force microscope was the craziest thing I've ever seen. The fact that humans have gone from banging rocks together in a cave to using machines to measure the distance of one atom, is mind-boggling.
Humans never collectively sat around in caves banging rocks together. We started as farmers with tools. The first metalworker was one of Adam's sons. First textile manufacturer was one of Adam's sons. On and on. Pretty arrogant to think we can do all this on our own.
@@TehButterflyEffect Of course you have proof of your words, don't you?
@@TehButterflyEffect somebody has never seen cave markings x.x HOWEVER, "cavemen" did not exist with the dinosaurs.
@@TehButterflyEffect LOL I just realized ur comment says people just had these skills and tools and that's where it began XD bro definitely trolling, please go back to school if you aren't.
Imagine growing up in the 70's, 80's, 90's when all the nerds and geeks were being bullied and ridiculed and called losers for being nerds and geeks. Yet they are the only people changing the world and showing what humanity is really capable of. If only the nerds and geeks of the world are looked up to as the amazing people they are.
18:48 HOLY GYATT
?? This is really rude
Mark, you and your team outdid yourselves! Thanks for mentioning the names of the students and staff not just dept heads. It’s great to see the credit get spread around
Mind blown. Most amazing thing you’ve done too date. I’d love more detail on how the DNA was self building.
A lot of work with DNA is done using chance. Notice how they had to use electrophoresis to separate out the bits of DNA that didn’t form nerf guns. It’s because they knew that if they put in the proper structures and let the DNA bind to itself as they knew it would, that chances of it creating nerf guns was pretty high, but chances are there were a LOT more of the failed pieces that didn’t bind correctly, which they separated out.
DNA is a polymer and each single strand of DNA is a sequence of monomers called nucleotides that come in 4 major types: A, T, C, G. When two DNA strands come together to form a double-stranded form, they normally must follow the rule of complementary: A must be opposite to T, and C to G. In DNA origami, each staple DNA sequence is typically long enough to be close to a unique sequence inside the test tube, therefore it is designed to be complementary to specific counterparts in the scaffold DNA. If two complementary DNA strands are placed in solution, they spontaneously would bind into the double-stranded form, reasons for that arise from the laws of thermodynamics. Here, given enough time and preferably a temperature ramp, the staples will eventually "find" their complementary places in the scaffold. The whole process is governed by DNA self-assembly properties, there are CAD tools that can generate the sequences for staples based on your scaffold sequence and the design of DNA origami nanostructure you make. Then its just mixing scaffold and staples
@@volmyk6196 Thanks! How do they keep all of the strands near enough to their complementary strands to bind? With so many in use, wouldn’t they get jumbled up? Is it that each piece in each gun is unique so that they will each find their unique compliment? How do they make each strand?
from one scientist to another, thanks for explaining in simple terms. @@volmyk6196
That part is helped by the temperature they are incubated at in the little "oven". The pairing up of those nucleotide sequences have different energy requirements, heating up paired up DNA is how we normally unzip the strands and get single stranded DNA. You start off at this high temp where nothing can pair up, then you cool it down and hold it at ideal temps that favor particular sequence pairings. In this way you can help direct the assembly of the finale product. As annealing temperatures are easily calculated and used all the time in DNA amplification.
Every single time they made it smaller I was like "well this is it they can't possibly get any smaller than that." and by the end I was just totally in awe.
normally such a scenario would make you progressively more disappointed
In this video we found another dead ant outside and this time we're building cybernetic limbs to reanimate this ant
"We found a dead ant outside"... Minutes before that: "The ant was not intimidated at all! It even took our gun!"
We see what you did there, Mark!
lol
I love how mark goes from talking about life-changing inventions than to talking about the most random stuff ever.
all with playing the pvz roof level music
Nobody does it like Mark!
True, great video! Just waiting for more of your weekday ones to keep me preoccupied through boredom
Same with you too Tom!
Oh hello, Tom!!
Nobody
Where's @ct5625
3:43 OMG DR HOWELLS GRANDSON IS MY BEST FRIEND!!!!!!!!
I used to be a fan of Mark Rober, but after watching this incredible video, I am a whole air conditioner.
😂
lmao
I had to read that twice to get it 😂
😆
😂😂😂😂😂😂😂😂😂😂😂😂😂
its crazy how far mark has come. 8 years ago, he was showing us how to make a watermelon smoothie and now he is breaking 4 records in one video!
I think it's even more amazing that an idea of a toy unexpectedly can be a potential solution to a complicated problem at the end.
Mark slowly becoming the Willy Wonka of engineering. Just incredible and inspiring on so many levels.
He is most likely doing more to get people into engineering than any other person who ever lived. Amazing work.
@@Studeb
.
@@Studeb
.
@@Studeb
.
@@Studeb
.
10:28 that "psheuuu" was wholesome
14:23 "Would you patent the Sun?" Dr. Jonas Salk... one of my idols too!
🗿
@@luis38265🗿
@@aditip6695🗿
I love how Mark helps share what is the bleeding edge of the new science, but putting them together in a fun format and interesting projects. When you think its an impossible idea, there is someone out there that is able to help with this.
Jocelyn, you are the real MVP. Spoken like a true scientist "although there is no label on it." Put a label on your stuff. When in doubt, throw it out. That is the motto of my lab. 18:09
@18:48 da REAL MVP
@@tycowpie only time i paused the vid.. GYATT
@@tycowpiesame mate same! 🥵
Jocelyn has the entire bakery.
-ну что потомки, как вы там в 2024? Покоряете космос, вышли в 4ое измерение, летаете со скоростью света?
-сегодня мы собрали микроскопический пистолет из которого застрелили муравья.
Русскоговорящий
This was like those 3D rendering videos that show scale of how big/small things are but it was 3D printing. This technology is mind boggling.
Also I live in Provo lol
Just imagine a water jet cut one :)
If only the DNA gun would work lol
@somebody3271 what are they really doing at that lab with DNA? Lol probably medicine. But the anime nerd in me imagines they are creating new lifeforms lol
You gotta make a video of a waterjet cut one
@WaterjetChannel same lmao! My first thought was “wait those mountains look familiar…wait so does that campus…OH MY GOSH THAT’S BYU PROVO!”
19:03 - 19:17
Literally had my jaw on the floor for a solid minute Mark.
As in the fine words of Bill Cypher, "Reality is an illusion..." and after seeing someone *BUILD WITH DNA* I think this statement is true.
Never fail to shock and entertain us Mark, amazing! ❤😁❤
Even small ideas can give rise to big things. :D Much respect to the teams out at BYU. They all seemed so passionate about their field, it's contagious even through a screen!
Yes sit
It's to bad I can't hear about BYU not think of its discrimination to the LGBTQIA+ community that still happens to today, its archaic honour code and connection to LDS church.
2:25 Mark was wearing a prison jumpsuit 😆
18:49 stay focused brothers 💪
😑
😐
you are suppperrrr amazinggg Mark!!!
love all your video ❤️
Love from Indonesian Creator 🥰
yes
@@MartinAccelno😊
@@Theghos1 yes
@@Theghos1yes
@@Theghos1 yes
This is absolutely incredible. I had no idea this was even POSSSIBLE. Great job on this one. I clicked to see a world record, and what I got was something 3,000,000x cooler. I never knew technology like this EXISTED! This is absolutely incredible.
7:26 she was kinda quick determining that distance 🤔
I love that these young people are so imaginative, creative and intelligent and that they have such resources. Like Mark, it gives me hope for humanity.
84 likes and 0 comments? now its 1 wow
I mean he's deep into middle-age and he gets millions for doing this, guy.
@@hansolo631 i dont think he's talking abt mark in specific
We don’t deserve someone as incredible as Mark, he’s such an amazing person and his teaching of random engineering is so inspiring it’s insane
He is awesome! And a BYU grad!
10:59 great job, Mark! you've armed the ants and now we're doomed!
*O H N O*
Ill miss yall _😢_
*O H N O*
Ilmu pengetahuan sangatlah luas. Meski pengetahuan ku sangat lah sedikit Tetapi bersyukur kepada Tuhan telah memberi karunia kepada kami umat manusia.Terima kasih banyak Mr mark Rober telah berbagi ilmu pengetahuan 🙏🙏🙏
Kita salah server 😂😂
2:25 That looks like a mugshot💀💀💀💀💀💀
So true 😭
Mark rober jail card 💀
Especially with the orange shirt 💀
He looks like an angry bird
Frr
こういうワクワクする実験が未来のエンジニアを生み出すんですよね！是非未来の為に活動を続けて下さい！. 1:40I absolutely love the edit/cinematography here. It's so seamless!.
Mark is literally a really smart child and I love him so much for that
What are you an asian parent?
bro thinks adult is a child 💀
@@lexgameraftonI think he means that Mark still hasn't lost his inner child lol
I don't know why but this video is probably my favorite video on TH-cam now.
It's always just so marvelous to see people like Mark still geek out like a kid with conviction in an incredibly complex adult field...
Yeah.
“Umm guys I think I’m better than mark Rober” -🤓
Selam
He’s so hot! Smart, enthusiastic, optimistic, passionate, fun-loving, and so down to earth.
Yeah Mark thanks very much ❤❤❤❤
Mr. Beast can actually still win. The same technology can be used as "A Boy And His Atom: The World's Smallest Movie" to make a Nerf Gun that is even smaller than DNA. And there even might be a way to "fire" it
This was actually amazing!! It made a ton of sense, it was easy to understand, and I genuinely learned something new today. Thanks Mark, this is incredible!! Keep being greater and more inspiring everyday!
Happy diwali 🎇🪔
Tu yha bhi aa gya
i love this channel So much! iTs so Fun and stUff.
i can’t express how much i love mark using plants vs zombies music ❤❤
Dude I know, it was a welcome suprise.
It slaps, that’s why
dammit I KNEW I recognized it from somewhere! :D
Bro I immediately recognized it.
He didnt
Having actual students working on this problem is so cool. You could've gone to the top scientists or physicists with this problem, but no, you went to the school and got the students to use their head and work out a solution for this. I really respect that.
9:30 .. i`m more impressed with the clarity/precision of the Mark Rober logo on the gun .. than the gun itself XD
I just love how he uses Plants Vs Zombies music.
Forrel 🗿
This episode is peak mark rober. 100s of combined hours of effort, on top of a century or more of combined expert experience, delivered in a tasty 20 minutes.
I LOVE compliant mechanisms. I remember Derek's video on the subject and was fascinated by it ever since. The ingenuity is mind-blowing...and applications like the lens cleaner are so clever.
This was insane! The tiny nerf gun's beyond tiny and I'm just mind blown by the science behind the process. Amazing stuff Mark!
Hallo, is a stl out there with the hinge compliant mechanism showen at 4:20?
I really appreciate that you covered aspects of what's involved in nanotechnology. I feel like it is easier to show off on TH-cam a mechanical or electrical engineering project, as the overhead costs for micro and nanoscale implementations are often very high. As someone who works in the field, it's great to see what nanotechnology can do, and I hope this inspires others to enter into the field!
I hope Crunch Labs is still around once I have kids in a few years. I would have loved to have those boxes when I was a kid.
13:54 “At that scale, you would basically need to fold a DNA helix into the shape of a nerf gun. Which was precisely our plan.”
Bro watched the video
He crazy ☠️
Crazy
13:15 For those confused, this is a MALE carbon nanotube.
This is insanely incredible! I didn't even know DNA could be fragmented like that to form junctions!
Ivy was one of my statics TA while at BYU, she was awesome and it was great to see her on such a great video!
Ivy is the nicest person!
1:40
I absolutely love the edit/cinematography here. It's so seamless!
from the beatles isnt it