Roundtable #6 - Human Model Systems w/ Don Ingber @ Wyss Institute & Hans Clevers @ Roche | BIOS

Guests: Don Ingber - Founding Director @ Wyss Institute / Professor @ Harvard & Hans Clevers - Head of Pharma Research & Development (pRED) @ Roche
Don Ingber is the Founding Director of the Wyss Institute for Biologically Inspired Engineering at Harvard University, Judah Folkman Professor of Vascular Biology at Harvard Medical School and Vascular Biology Program at Boston Children’s Hospital, and Professor of Hansjörg Wyss Professor of Bioinspired Engineering, Harvard School of Engineering and Applied Sciences. He received his B.A., M.A., M.Phil., M.D. & Ph.D. from Yale University.
Ingber is a pioneer in the field of biologically inspired engineering, and at the Wyss Institute, he currently leads scientific and engineering teams that cross a broad range of disciplines to develop breakthrough bio-inspired technologies to advance healthcare and to improve sustainability. His work has led to major advances in mechanobiology, cell structure, tumor angiogenesis, tissue engineering, systems biology, nanobiotechnology and translational medicine. Through his work, Ingber also has helped to break down boundaries between science, art and design.Ingber has authored more than 500 publications and 170 patents, founded 7 companies, and has presented 550 plenary presentations and invited lectures world-wide.
Ingber has made great strides in translating his innovations into commercial products and many are now either in clinical trials or currently being sold. Examples of technologies Ingber has developed include therapeutics for cancer and pandemic viruses; micropatterned culture substrate research tools; a dialysis-like sepsis therapeutic device that clears blood of pathogens and inflammatory toxins along with a companion diagnostic; an anticoagulant surface coating for medical devices that replaces the need for dangerous blood-thinning drugs; a shear stress-activated nanotherapeutic that targets clot-busting drugs and vasodilators to sites of vascular occlusion; low cost nasopharyngeal swabs and highly sensitive multiplexed electrochemical sensors for COVID-19 diagnostics; and Human Organ Chips lined by living human cells that are being used to replace animal testing for drug development and personalized medicine. Ingber’s Organ Chip technology was named one of the Top 10 Emerging Technologies by the World Economic Forum and Design of the Year by the London Design Museum. It was also acquired by the Museum of Modern Art (MoMA) in New York City for its permanent design collection.
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Hans Clevers is Head of pharma Research and Early Development (pRED) of Roche, Basel Switzerland, since March 2022. He has led his research groups in Utrecht, the Netherlands since 1989. He currently still advises his labs. Hans Clevers holds a University Professor at the University Utrecht.
Clevers is one of the world’s leading researchers on stem cells and their potential for regenerative therapy. Over the past decade, his lab has produced vital studies on stem cells and the nature of self-renewal pathways controlling stem cells. Clevers was the first researcher to demonstrate the existence of long-lived stem cells in many tissues, including the intestine and stomach. Starting from the discovery that the TCF gene is the transcriptional endpoint of the WNT pathway, a pathway that is implicated in stem cell control, Clevers demonstrated that one of the TCF genes is essential for the stem cell compartment in the intestine.
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[@justjanexxx]

So grateful for the work Don Ingber is doing on behalf of the animals.
And if I had cancer and needed treatment, I would be even more grateful

[@kochnnl]

Awesome