Erythroblastosis fetalis | Rh Incompatibility

#hussainbiology #apbiology #csirnet
ABO Antigens : • Biochemistry of ABO An...
In this video we will be discussing about the Rh disease also termed as Erythroblastosis fetalis.
Hemolytic disease of the newborn, also known as hemolytic disease of the fetus and newborn, HDN, HDFN, or erythroblastosis fetalis,is an alloimmune condition that develops in a peripartum fetus, when the IgG molecules (one of the five main types of antibodies) produced by the mother pass through the placenta. Among these antibodies are some which attack antigens on the R.B.Cs in the fetal circulation, breaking down and destroying the cells (hemolysis). The fetus can develop reticulocytosis and anemia. This fetal disease ranges from mild to very severe, and fetal death from heart failure (hydrops fetalis) can occur. When the disease is moderate or severe, many erythroblasts (immature red blood cells) are present in the fetal blood, and so these forms of the disease can be called erythroblastosis fetalis (or erythroblastosis foetalis).
Antibodies are produced when the body is exposed to an antigen foreign to the make-up of the body. If a mother is exposed to a foreign antigen and produces IgG (as opposed to IgM which does not cross the placenta), the IgG will target the antigen, if present in the fetus, and may affect it in utero and persist after delivery. The three most common models in which a woman becomes sensitized toward (i.e., produces IgG antibodies against) a particular antigen are hemorrhage, blood transfusion, and ABO incompatibility.

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[@madhuryadhamija5151]

sir if we transfuse rh + blood to a rh negative person the person get ill
so in this case also the rh + blood ( from baby) is somehow entering the person who is rh - (mother ) why is it not affecting the mother at first

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.Doc

[@faizulrizwan]

I have a doubt sir_ The blood coming in the baby is from mother's body through umblical cord, then the blood of baby and mother is different then how can bay survive?👈👈👈👈👈👈👈👈👈👈👈👈👈👈👈👈👈👈👈👈👈👈👈

[@hussainbiology]

Blood doesnt mix up,,,,,
We see through the blood vessels in the umbilical cord, the fetus receives all the necessary nutrition, oxygen, and life support from the mother through the placenta.

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[@jyotismitaswain5461]

4:11 what if the child doesnt have d antigen? Will it still get affected??

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[@saltysco9829]

What happened for vice versa condition ? Mom is Rh + and fetus is Rh - ?

[@hussainbiology]

In that case problem would persist only if babies had fully fledged Immume system but they haven't...that is why thr Rh+ Mother and Rh- baby doesn't prove to be fatal.

[@saltysco9829]

I see, thank you for your response. I appriciate it

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Why IgG can cross plaxenta?

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Ihsan Bangash bcz igG molecules weight is very low so it cross the placenta

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Thank you sir

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[@azaleamannat3470]

sir confusion
o group has H antigen Or no antigen plzz reyy

[@hussainbiology]

Yes , O Group has H Antigen....
Watch this vidoe and clear your concept
th-cam.com/video/Kf4eb-CBF-s/w-d-xo.html

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Sir, upload( mns grouping) system and its mechanism in detail.

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What combination of Father and mother for Rh + or negative is dangerous

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Best explanation ....nw I understand it well

[@homo_spider5607]

Sir, one question . can baby's antigen enter into mother's body during 2nd pregnancy like in 1st pregnancy and cause harm to mother's also.

[@MSIVA-or8in]

Sir, why antiD antibodies are administered to the mother, by prevents the formation of anti D antibody in the mother blood.. please explain it! "Both are same "

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Same question

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Thanks for the explanation! Liked this video

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Sir, the first baby can also suffer from erythroblastosis foetalis as IgG can also enter into the neonate through the mother's milk?? 🤔🤔

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If mother is O+ve Father is O-ve
Is there any problem in pregnancy???

[@hussainbiology]

no

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sprrrb.......thnx lot

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