Wow!! I am a nursing student and have watched several videos on this topic but this is the first one that I have understood with ease!! Thank you very much! :)
What if the mother has had 4 healthy pregnancies and the 5th has been found to have this disease? The mother is due January.. How would it have come about if the first 4 were healthy? Thank you
There are many example of persistent antibodies such as some vaccinations. Other times antibody levels can decline over time. I found this online regarding the persistence of RH(D) antibodies: "Anti‐D, which is induced by pregnancy in the majority of cases and can amount to high titres, consistently shows lower evanescence rates compared to other RBC antibody specificities and may persist for many years or even throughout life (Owen et al, 1954; Ward et al, 1957; Hutchison & McLennan, 1966)."
I believe it is IgM type antibody which does n cross the placental barrier. In contrast, the antibodies directed against Rh from the moms immune system are IgG which cross more easily. Google the structure of IgM versus IgG, they are quite different.
I have a lot of question, because my 1 year old baby has hemolytic anemia. His hemoglobin dropped to 5.0. We just found out last december And stayed at the hospital for 9 days, and also he got blood transfusion once. We are still waiting for the other result to find out if is it severe or not. Im just worried. I am willing to ask in a private message. Thank you.
Please explain.. i am a rhesus positive A and my husband is rhesus positive O, we have two children, first born with Rhesus Negative O and our second born with rhesus negative A. second baby had problems during delivery. now im pregnant with our third. what can i do to hinder possible problems?
According to StatPearls/Pubmed "Mild to Moderate Disease: Less severely affected infants typically present with the self-limited hemolytic disease which is manifested as hyperbilirubinemia within the first 24 hours of life (Jaundice). Hydrops Fetalis: Infants with severe, life-threatening anemia (e.g., hydrops fetalis) present with skin edema, pleural or pericardial effusion, or ascites. Infants with RhD and some minor blood group incompatibilities, such as Kell, are at risk for hydrops fetalis, especially pregnancies without antenatal care."
With my last baby I had this and couldn't breastfeed him and he had blood incompatible jaundice and had to stay in the hospital for 3 days and then had to have a bilie blanket and blood test everyday to check his jaundice . the nurse would come to our house to check his jaundice . he is now 26 and never had any problems after that first 2 weeks of life.
Great video explanation :)I think it is worth mentioning that the Antibody involved with this mechanism is very specific. In way that Immunoglobulin G is an antibody which is actually capable of crossing this Maternal/Placental barrier, due to the existence of the neonatal Fc receptor (FcRn).-Just an extra little fact :)
This video is so awesome! soothing, relaxed voice clear drawings hilarious anecdotes I died at the babys face when they injected the mom with antibodies. He's like o shit wtf?
In addition to Kristy's comment below-I am a medical student, and this disease has been a huge problem for me to understand for years!! thanks to this video I now FINALLY get it!! thank you so much! :D could have explained the different antigens (c/e etc.) but I guess thats in a lot more detail ! still brilliant! :D
With the first baby the antibodies may not be there yet in the mother's circulation… so the first baby is what triggers sensitisation of the mother's immune to produce anti-D which causes a risk for the next baby if it is Rh+
I think RhoGAM is an IgM antibody so it is less likely to cross the placental/fetal barrier. Compared to the anti-Rh antibodies from the mother which would be IgG. It's something like IgG and perhaps IgA cross and IgM less likely.
RhoGAM is actually an IgG form so my guess is that the levels of injected antibodies cannot do any significant harm to the fetus. It’s more about stopping immunization of the mother to Rh-D.
Wow!! I am a nursing student and have watched several videos on this topic but this is the first one that I have understood with ease!! Thank you very much! :)
LOL... baby thinking "WTF?!" xD
You made this really easy to understand, thank you!!
you made this topic really so easy. great. Thanks heaps
Wow... I just love this video...
Very clear. Thanks!
What if the mother has had 4 healthy pregnancies and the 5th has been found to have this disease? The mother is due January.. How would it have come about if the first 4 were healthy?
Thank you
What happen when mother is O_ve and father is AB+ ...?
Aren't antibodies short term? Would they not have deteriorated by the time of the 2nd pregnancy
There are many example of persistent antibodies such as some vaccinations. Other times antibody levels can decline over time. I found this online regarding the persistence of RH(D) antibodies:
"Anti‐D, which is induced by pregnancy in the majority of cases and can amount to high titres, consistently shows lower evanescence rates compared to other RBC antibody specificities and may persist for many years or even throughout life (Owen et al, 1954; Ward et al, 1957; Hutchison & McLennan, 1966)."
Why the Rhogram or anti Rh antibody that we injected not cross placenta?????
I believe it is IgM type antibody which does n cross the placental barrier. In contrast, the antibodies directed against Rh from the moms immune system are IgG which cross more easily. Google the structure of IgM versus IgG, they are quite different.
I just came back from the doctor and well I am 0- my husband is A+ .. so I have to have some special shots 😑😑 etc etc 😭
I have a lot of question, because my 1 year old baby has hemolytic anemia. His hemoglobin dropped to 5.0. We just found out last december And stayed at the hospital for 9 days, and also he got blood transfusion once. We are still waiting for the other result to find out if is it severe or not. Im just worried. I am willing to ask in a private message. Thank you.
Please explain.. i am a rhesus positive A and my husband is rhesus positive O, we have two children, first born with Rhesus Negative O and our second born with rhesus negative A. second baby had problems during delivery. now im pregnant with our third. what can i do to hinder possible problems?
Thanks man helped alot!
WHAT DOES IT DO TO THE BABY?
According to StatPearls/Pubmed "Mild to Moderate Disease: Less severely affected infants typically present with the self-limited hemolytic disease which is manifested as hyperbilirubinemia within the first 24 hours of life (Jaundice).
Hydrops Fetalis: Infants with severe, life-threatening anemia (e.g., hydrops fetalis) present with skin edema, pleural or pericardial effusion, or ascites. Infants with RhD and some minor blood group incompatibilities, such as Kell, are at risk for hydrops fetalis, especially pregnancies without antenatal care."
IM A+ WAS BORN TO A O- MOM VERY SICK AT BIRTH
With my last baby I had this and couldn't breastfeed him and he had blood incompatible jaundice and had to stay in the hospital for 3 days and then had to have a bilie blanket and blood test everyday to check his jaundice . the nurse would come to our house to check his jaundice . he is now 26 and never had any problems after that first 2 weeks of life.
Is the second oregnancy safe for a baby with sll injections abd renedirs given to mother?
Great video explanation :)I think it is worth mentioning that the Antibody involved with this mechanism is very specific. In way that Immunoglobulin G is an antibody which is actually capable of crossing this Maternal/Placental barrier, due to the existence of the neonatal Fc receptor (FcRn).-Just an extra little fact :)
Lewis Ashmore yeahhhh...U r information is very useful man!!!! i just needed this info and i gt it
Lewis Ashmore Are anti-Rh antibodies that were formed in the maternal blood upon initial exposure IgG type?
What is the relevance of igM type anti-D globulin in Rh incompatibility?
Coool
I died when the fetus said WTF?
This video is so awesome!
soothing, relaxed voice
clear drawings
hilarious anecdotes
I died at the babys face when they injected the mom with antibodies. He's like o shit wtf?
My. Professor. That. Taught. This. Sucked. Please take her salary
What if the mom is (suppose) A+ and the baby is A-? Is there any risk then?
In addition to Kristy's comment below-I am a medical student, and this disease has been a huge problem for me to understand for years!! thanks to this video I now FINALLY get it!! thank you so much! :D
could have explained the different antigens (c/e etc.) but I guess thats in a lot more detail ! still brilliant! :D
bio is amazing
FROM THE BOTTOM OF MY ❤️ PLEASE!! Make A&P VIDEOS!
th-cam.com/play/PLp_4xx9iulI_dZjc4tvblHexgSTiOu9QP.html
Fetus or baby. Just call it babies dude be a man!
excelent explination. Thank you
Brilliant. Flawlessly clear.
Thank you very much and very clearly explained and helped a lot to understand. Iam really appreciated to have your video and now its interesting.
Thanks alot .. I have been reading this many time and not understand it .. and now it’s easy .. 🌸🌸
1 like is not enough
amazing video ,thank you very very much
Nice video sir....how u grow ur channel..I need ur help..Easy2Learn
Sir can give me ur email id...#Easy2Learn
thanks it was very helpful
Thank you!
Can anyone tell me why HDN is concerning for the second baby that has rh+ but not the first?
With the first baby the antibodies may not be there yet in the mother's circulation… so the first baby is what triggers sensitisation of the mother's immune to produce anti-D which causes a risk for the next baby if it is Rh+
good job thanks for the easy lecture, you should make more videos.
I have a whole course of AP videos! Most of the videos are longer topics though
Where did RH positive come from, thats the real question!!!
Check this out: www.ncbi.nlm.nih.gov/pmc/articles/PMC1831834/
"evidence that the Rh blood group proteins belong to an ancient family of membrane proteins involved in ammonia transport."
won't RhoGAM injected enter the blood circulation of the fetus?
I think RhoGAM is an IgM antibody so it is less likely to cross the placental/fetal barrier. Compared to the anti-Rh antibodies from the mother which would be IgG. It's something like IgG and perhaps IgA cross and IgM less likely.
@@ChrisSullivanMCC-SCC thank you!
RhoGAM is actually an IgG form so my guess is that the levels of injected antibodies cannot do any significant harm to the fetus. It’s more about stopping immunization of the mother to Rh-D.