Lyme Disease and Autoimmunity, Rob Lochhead, PhD - Lyme Summit 2023
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- เผยแพร่เมื่อ 5 ก.พ. 2025
- Lyme Disease and Autoimmunity, Rob Lochhead, PhD, Medical College of Wisconsin from Lyme Summit 2023 hosted by CNY Lyme & Tick-Borne Disease Alliance and SUNY Upstate Global Health Institute.
Thank you for a fascinating lecture. Very complex. I must admit though, speaking as one who actually has Lyme arthritis, I have to disagree in part. My father was an immunologist, so I am not entirely without knowledge. As a Lyme patient, I am driven by a desire to completely understand my condition. So, what I must say, is, I do not for one minute believe in the concept of auto immunity. I think that what you are witnessing is not a wayward immune system destroying it's host but rather the ongoing progression of the infestation. After many years with this disease, I still have all the symptoms you show in your slides. I think that this is due to the actions of the parasite, very much active within my tissues. So my body's 'auto immune' response is actually the normal response to inflammation. My cytokines are reacting to a needed demand to deal with the invaders, NOT fighting ghosts. In these long Lyme cases what you have to do is inspect the victim's spinal fluid for signs of spirochete activity. Not assume that the antibiotics have done their job and declare " why is the body eating itself " . No , it is still mounting a rear guard battle for homeostasis. Doing what it is supposed to do. One should investigate the work of Alan Mc Donald. He was a pathologist who had access to dead subjects. He found spirochetes everywhere ! Significantly in spinal fluid. They are to be found in synovial fluid too, I am sure. I am sure they are still wandering about my body. They have this ability to wander and to disguise themselves and to hide under a biofilm. Therefore I say, NO, not auto immunity but self survival.
NB I also have Neuro Lyme Disease . Not nice.
Is the implication that autoimmunity is always a misguided explanation driven by false negative tests? I'm not too familiar with how Lyme tests work, but don't they test for the presence of these spirochettes or you can only find them having taken many tissue samples and looking under a microscope, and that is impractical in a living human?
I too have neuro symptoms after doxy (but only 2 weeks in). Looking for answers, not finding much. Johns Hopkins is the one of the few pushing the research forward.
@@mountainair Autoimmunity is a descriiptor, issued iin the absense of any other sensible explanation for inflammation in the body. Oh the body's detector mechaniism has gone awray and is attacking itself ! Anyone who can appreciate the body's amazing autonmic nervous system and the amaziing way it protects us on an hourly basis can also recognise the crass stupidity in the concept of auto-immune disease.. It cannot be a thing.
In Lyme, we are being attacked in many ways. These microbes invade our tissues seeking out anerobic situations, like joints and the interior of our brain and spinal cord. This is where they head towards and do great damage. It is also why drugs have great difficulty in getting to them and thus healing. Many deaths arise from neuro lyme. Auto Immmunity is a concept which is promoted by idiots who are trying to make a name for themselves and muddy the water for the rest of us.
2 years after tick bite & Borrelia infection with 3 rounds of antibiotics (2 doxycycline & 1 amoxicillin), I feel Borrelia is still alive & causing joint/nerve damage. I've been dismissed by my infectious disease Dr. & neurology PA as being cured & referred to rheumatologist for followup who tested for autoimmune blood tests which came back all negative. . My recent MRI shows moderate to severe arthritis with effusions in hip/knee joints... ankles & shoulders also have bad arthritic symptoms but no images taken. Never had arthritis before tick. I am now at end of road for any Dr. assistance...i am on my own to have to deal with constant arthritis & nerve pain/weakness/twitching. Turning to TH-cam for help these past 2 years. Gone down so many rabbit holes trying to figure out what is happening to me & why my life changed practically overnight. Will now have to try to lower cholesterol to see if any relief.
@@sandrap6321 bee venom therapy
What an overwhelming amount of information. I have chronic lyme. I was diagnosed with a positive lyme two years after symptoms. I am still experiencing extreme fatigue after being on 29 to 30 different antibiotics.
My mom has been on treatment for about 8 months and been on 5-6 antibiotics so far. The fatigue is still the thing that affects her most.
How do we treat Lyme arthritis after we have exhausted antibiotic treatments? Do we use immunomodulators?
I love medical science, biology, anatomy, immunology, physiology etc…but it is extraordinarily difficult to think clinically when what you are seeing has been completely debilitating within you. It has contributed to years of my life being missed
The medical community is at least a decade behind on lyme research and treatments. There is a strain in the Midwest that they can't even test for.
Please have Dr Steven Phillips and Dr Joseph Jemsek share their findings.
Erythema can present after a short time.
Did you say 6 months??
Every one of these CNY lectures contains errors.
Can this include inducing diabetes as isn’t that an attack on pancreas? My mom never had any problem with blood sugar and then now a year after their Lyme symptoms started, she’s had to start on insulin after trying other medications to reduce her blood sugar that would not work.
This is fascinating. I wonder if anyone can answer the question of: When he talks about b.burgdoferi here in this talk, is he talking about in the strict sense, or in the broader sense? Do/would other genospecies of borrelia behave in the same way, or produce these same peptidoglycans?