PSM 185 Tuberculosis Treatment Drug Sensitive Resistant MDR TB XDR Bedaquiline NTEP latest 2021 2022

0:45 TPT TB Preventive Treatment Isoniazid Rifapentin
2:20 TB Treatment Algorithm Flowcart
8:35 Drug Sensitive TB Regimen 2HRZE/4HRE
---H Isoniazid
---R Rifampicin - Hepatotoxic
---Z Pyrazinamide
---E Ethambutol
9:22 H Mono/ Poly DR TB Regimen (6 or 9 ) Lfx RZE
10:40 Shorter Oral Bedaquiline containing MDR/RR-TB Regimen (4-6m) Bdq Lfx Cfz Eto HZE (5m) Lfx Cfz Z E
---Bdq Bedaquilline inhibit ATP synthase, Cardiotoxic
---Lfx LevoFloxacin
---Cfz clofazimine also used for leprosy
---Eto Ethionamide
---Z Pyrazinamide
---E Ethambutol
14:14 Longer Oral M/XDR-TB Regimen (18-20) Lfx Bdq (6 month or longer) Lzd(taper after 6m) Cfz Cs
---Lfx LevoFloxacin
---Bdq Bedaquilline inhibit ATP synthase, Cardiotoxic
---Lzd Linezolid
---Cfz clofazimine also used for leprosy
---Cs cycloserine
Communiity Medicine latest new
preventive treatment TPT Shorter oral bedaquiline containing MDR regimen XDR containing longer RR rifampicin regimen isoniazid first line resistance second line
PSM 185 XDR TB Extended drug resistant Tuberculosis treatment Mnemonic how to remember duration new
PSM 185 RRTB MDRTB new drugs bedaquiline delamanid Treat tuberculosis multi drug resistant MDR
guidelines
injectable

[@MBBSVPASS]

0:45 TPT TB Preventive Treatment Isoniazid Rifapentin
2:20 TB Treatment Algorithm Flowcart
8:35 Drug Sensitive TB Regimen 2HRZE/4HRE
---H Isoniazid - MOA inhibition of synthesis of mycolic acids for cell wall, ADR - Hepatotoxic, Peripheral neuritis hence add Vit B6 if older patient
---R Rifampicin - MOA Inhibit RNA synthesis, ADR - Hepatotoxic, Orange Secretions
---Z Pyrazinamide - MOA Inhibits Mycolic Acid synthesis, ADR - MOST HepatoToxic, HyperUrecemia
---E Ethambutol - MOA Inhibits Arabinosyl transferases.. Cell wall , ADR Optic Neuritis, HyperUrecemia
9:22 If Rifampicin Sensitive but Isoniazid resistant - H Mono/ Poly DR TB Regimen (6 or 9 ) Lfx RZE
---Lfx LevoFloxacin MOA inhibiting DNA gyrase ADR QT prolongation, Peripheral neuropathy, GI symptoms, Arthralgia, Seizure, Psychotic symptoms, Tendonitis etc
---R Rifampicin - MOA Inhibit RNA synthesis, ADR - Hepatotoxic, Orange Secretions
---Z Pyrazinamide - MOA Inhibits Mycolic Acid synthesis, ADR - MOST HepatoToxic, HyperUrecemia
---E Ethambutol - MOA Inhibits Arabinosyl transferases.. Cell wall , ADR Optic Neuritis, HyperUrecemia
10:40 Shorter Oral Bedaquiline containing MDR/RR-TB Regimen (4-6m) Bdq Lfx Cfz Eto HZE (5m) Lfx Cfz Z E
---Bdq Bedaquilline MOA inhibit ATP synthase, ADR - Cardiotoxic
---Lfx LevoFloxacin MOA inhibiting DNA gyrase, ADR QT prolongation, Peripheral neuropathy, GI symptoms, Arthralgia, Seizure, Psychotic symptoms, Tendonitis etc
---Cfz Clofazimine - MOA binding to the guanine bases of bacterial DNA, thereby blocking the template function of the DNA and inhibiting bacterial proliferation, ADR - cardiotoxicity, dark brown discoloration of the skin.
---Eto Ethionamide - MOA disruption of mycolic acid, ADR - Hepatitis, Depression, HypoThyroidism, Vestibular toxicity, Optic Neuritis, Gynecomastia , GI symptoms etc
---H Isoniazid - MOA inhibition of synthesis of mycolic acids for cell wall, ADR - Hepatotoxic, Peripheral neuritis hence add Vit B6 if older patient
---Z Pyrazinamide - MOA Inhibits Mycolic Acid synthesis, ADR - MOST HepatoToxic, HyperUrecemia
---E Ethambutol - MOA Inhibits Arabinosyl transferases.. Cell wall, ADR Optic Neuritis, HyperUrecemia
14:14 Longer Oral M/XDR-TB Regimen (18-20) Lfx Bdq (6 month or longer) Lzd(taper after 6m) Cfz Cs
---Lfx LevoFloxacin MOA inhibiting DNA gyrase ADR QT prolongation, Peripheral neuropathy, GI symptoms, Arthralgia, Seizure, Psychotic symptoms, Tendonitis etc
---Bdq Bedaquilline MOA inhibit ATP synthase, ADR - Cardiotoxic
---Lzd Linezolid - MOA inhibit bacterial protein synthesis by interfering with translation ADR - Anaemia, thrombocytopenia, peripheral neuritis and optic neuritis
---Cfz Clofazimine - MOA binding to the guanine bases of bacterial DNA, thereby blocking the template function of the DNA and inhibiting bacterial proliferation, ADR - cardiotoxicity, dark brown discoloration of the skin.
---Cs Cycloserine - MOA inhibiting cell-wall biosynthesis in bacteria, ADR - seizure, depression, suicidal tendency
Others
---Dlm Delamanid - MOA blocks the synthesis of mycolic acids, poison the bacilli with nitric oxide, ADR - GI Symptoms, Headache

[@harishlakshya3459]

Is bedaquiline effective and how much

[@DrThritia]

Very nicely explained 👌🏻👌🏻👌🏻.Thank you mam🙏🏻🙏🏻🙏🏻

[@dr.mohitkher7496]

Nice information

[@prj2871]

Big fan mam

[@soundararajanrajasekar8185]

Excellent session Mam thank you so much to make it very simplified

[@sz6234]

Ma’am what all questions they ask from tb in university exams.. could you please discuss it in a video I’m quite confused already in tb

[@sangamrai8230]

How many tablets in the treatment and how long we have take medicine

[@Lover9420]

Mam mera MDR ka treatment chal raha thaa, phir pata chala levoflaxacin resistance hai. Phir unhone mexofloxacin de di. Kya levoflaxacin ke sath Jo dawa khayi thi vo sab bhi resistance ho gayi hongi?????

[@rrns825]

🙏

[@sahilbaikar6264]

th-cam.com/video/BRuejDpwoUo/w-d-xo.html imp psm notes

[@arunagurung603]

Mneumonic for longer oral M/XDR TB regimen
Bahot= Bedaquilline
Lamba=levoflox, Linezolid
Course = Cycloserine,Clofazamine

[@mkshorts_75p]

hello bro help me

[@Vishn78]

@@mkshorts_75p thik ho jaoge bhai 12% to kar liya hai

[@khaldabegum2858]

​@@Vishn78 hii me pre xdr patient hu condition Boht kharab h or dlm nhi mil rha kya kru or kya xdr shi ho jata h

[@Vishn78]

@@khaldabegum2858 thik Ho jaoge aap medicine lete raho

[@lavetirajesh8322]

TB preventive drug regimen how many months will give???

[@SiSi-ju1xk]

1:50

[@shilpysingh6614]

Mera rifampcin resistance tb hai...aur 1st line and 2nd line drug test k reports negative aa rhe hai...mai kya Karu...mera shorter regimen chal rha hai..kya koi aur drug se resistance ho sakta hai kya

[@Lover9420]

Yes

[@bhavanamayekar3062]

Hi ma'am my tb is detected is pre xdr tb after delivery am having 1 month daughter what precaution should i take plz repply ...

[@yuveshragavendiran]

Precautions are to not to sneeze near the child that helps in preventing droplet transmissions.and for children, preventive tb treatment of isoniazid of 10/kg for 6 months (daily) with vitamin b6 (5mg/day) supplements are preferred.

[@khaldabegum2858]

Hi ma'am I am just 18yr old and suffering from pre xdr with no hope of cure as you will about govt hospital so can you help me by telling that how are you now and what mistakes u did in this situation plz

[@pradiprdaradecool]

Now no injection is given to the patient

[@MBBSVPASS]

Yes no injection for drug sensitive

[@preethipreethi4062]

Mam government tablet or private tablet which is best

[@harishlakshya3459]

Govt

[@harishlakshya3459]

Ab kesi h tabiyat apki

[@nehazahed2226]

Hello ma'am can I get all the videos of pathology

[@sahilbaikar6264]

th-cam.com/video/BRuejDpwoUo/w-d-xo.html imp psm notes

[@SiSi-ju1xk]

2022

[@mmeezan9658]

My sister started the course of longer oral m/xdr tb regimen from 1 August 2021, she has taken the badaquiline for approx 4 months and after that she skipped the bedaquiline.
And she was taking other medicine on and off sometime.
Today after 1 year we get to known about it.
Is there any other regimen after this.
Mam please tell, we are completely in shock.

[@harishlakshya3459]

Bhai ab kesi h apki sister

[@mmeezan9658]

@@harishlakshya3459 abhi tho theek h
Pr ek baar doc ko dikhana parega BHU me

[@mmeezan9658]

@@harishlakshya3459 aapko ko koon sa tb hua tha

[@harishlakshya3459]

@@mmeezan9658 lungs
Or aapki sister ko

[@harishlakshya3459]

Abhi report to negative aa gai hogi

[@Jackson-yn5xc]

Have been living with tuberculosis for years now,until I got in contact with Dr mason channel on TH-cam and got cured ,thank you Doctor,God bless you

[@harishlakshya3459]

How r you now bro
And who is Dr mason

[@amyaman9759]

Itna complicated bna diya yr 😂😂😂😂😂 simple treatment hai