Oral Submucous Fibrosis (OSMF) Introduction
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- เผยแพร่เมื่อ 6 ต.ค. 2024
- Oral submucous fibrosis (OSF) is a chronic, progressive, scarring disease, that predominantly affects the people of South-East Asian origin. This condition was described first by Schwartz (1952) while examining five Indian women from Kenya, to which he ascribed the descriptive term "atrophia idiopathica (tropica) mucosae oris". Later in 1953, Joshi from Bombay (Mumbai) redesignated the condition as oral submucous fibrosis, implying predominantly its histological nature. The WHO definition for an oral precancerous condition - "a generalized pathological state of the oral mucosa associated with a significantly increased risk of' cancer," accords well with the characteristics of OSF.
Clinical features:
The onset is insidious over a 2-5 year period.
The Prodromal Symptoms (early OSF)
This includes a burning sensation in the mouth when consuming spicy food, appearance of blisters especially on the palate, ulcerations or recurrent generalized inflammation of the oral mucosa, excessive salivation, defective gustatory sensation and dryness of' the mouth. There are periods of exacerbation manifested by the appearance of small vesicles in the check and palate. The intervals between such exacerbations vary from three months to one year. Focal vascular dilatations manifest clinically as petechiae in the early stages of the disease. This may be part of a vascular response due to hypersensitivity of the oral mucosa towards some external irritant like arena nut products. Petechiae are observed in about 22% of OSF cases , mostly on the tongue followed by the labial and buccal mucosa with no sign of blood dyscrasias or systemic disorders. Pain in areas where submucosal fibrotic bands are developing when palpated, is a useful clinical test.
Histologically, they revealed a slightly hyperplastic epithelium, sometimes atrophic with numerous dilated and blood-filled capillaries juxta-epithelially. The inflammatory cells seen are mainly lymphocytes, plasma cells and occasional eosinophils. The presence together of large numbers of lymphocytes and fibroblasts as well as plasma cells in moderate numbers, suggests the importance of' a sustained lymphocytic infiltration in the maintenance of the tissue reaction in OSF,
The advanced OSF
As the disease progresses, the oral mucosa becomes blanched and slightly opaque and white fibrous bands appear. The buccal mucosa and lips may be affected at an early stage although it was thought that the palate and the facial pillars are the areas involved first. The oral mucosa is involved symmetrically (with possible exception) and the fibrous hands in the buccal mucosa run in a vertical direction. The density of the fibrous deposit varies from a slight whitish area on the soft palate causing no symptoms to a dense fibrosis causing fixation and shortening or even deviation of the uvula and soft palate. The fibrous tissue in the facial pillars varies from a slight submucosal accumulation in both pillars to a dense fibrosis extending deep into the pillars with strangulation of the tonsils. It is this dense fibrosis involving the tissue around the pterygomandibular raphae that causes varying degrees of difficulty in mouth opening.
A factor, which seems to be overlooked by many investigators while recording the extent of mouth opening, is the acuteness of oral symptoms (persistent recurrent glossitis and stomatitis) at the time of recording. Sometimes the fibrosis spreads to the pharynx and down to the pyriform fossae. Upon palpation, a circular band can be felt around the entire rima oris (mouth orifice), and these changes are quite marked in the lower lip. All observers have noted impairment of tongue movement in patients with advanced OSF with significant atrophy of the tongue papillae. With progressing fibrosis stiffening of certain areas of the mucosa occurs leading to difficulty in opening the mouth, inability to whistle or blow and difficulty in swallowing. When the fibrosis involves the nasopharynx, the patient may experience referred pain to the ear and a nasal voice as one of the later signs in some patients.
Simply superb
Pls explain the grading sir
It is very helpful to understand the topic and easy to learn😊😊 thanku
Short & Sweet !!
thank you
amazing work
What's juxta epithelial hyalinization?
Sir ye thik konse medicine ya tablet se honga bataeye sir plzz
I think lycopene and eveon400mg
Mujay bhi hai osmf .par kya osmf honay say throat irritation bhi hota hai or tonsil par bhi asar karta hai.?swallowing problem bhi hota hai sir? Yeh kitnay tym lagta hey recover honay may?
Bhai ese hi kuchh bhi assumptions mt kr..... In yr case just have b complex capsule. Or capsule khol ke sirf powder khana without water... For 10 days
Pakka theek ho jayega
I think lycopene tab and eveon 400mg cap
Do you eat tobacco? How did you get this?
Pls tell me that which software u use?
Plzzz upload the other parts also
Liked and sunscribed. Hello sir i have tiny lumps or you can say tiny balls type in my inner lips, both top and bottom. Its scatterd around. Its bearely visible but i can feel when i roll my tounge around my inner lips. Its been for years and not painly but discomfortable. I dont know what exactly it is and whats the treatment. Is there any laser treatment for that.
It might be a mucocele or small fibroma/lipoma..Visit your nearby dentist..They can solve your problem
Does it lead to cancer of mouth?
Yes risk is 1 to 15%
Superb
thank you..:)
Where are the other parts?
Medicine batye sir
Lycopene tab eveo 400mg cap
Sir i have an assignment on this topic can you prescribe some.book plzzz
Oral medicine by Anil Ghom
Burket's Oral medicine
Bro hindi main video dalo
Aapni Bangali na?