Rajiv Ratan: The Power of Challenging Brain Cells to Enhance Resilience and Stimulate Repair

The usual approach for developing treatments for brain disorders is to make a drug that acts on a specific molecular target. But this approach has largely failed. In this episode I talk with Professor Raj Ratan at Weill Cornell Medicine about ways to tap the intrinsic ability of brain cells to respond adaptively to challenges - metabolic, oxidative, and biosynthetic - in ways that protect them against pathological processes such as those occurring in stroke, traumatic brain injury, Alzheimer’s and Parkinson’s diseases. Raj and his colleagues have developed several different interventions that are highly effective in animal models of stroke and Alzheimer’s disease. Intermittent dosing with such treatments can activate evolutionarily conserved complex and integrated gene expression responses in brain cells that bolster stress resistance and enable recovery and repair.
LINKS
Dr. Ratan’s laboratory webpage: burke.weill.co...
Selenium protects against ferroptosis and stroke:
www.cell.com/a...
HIF prolyl hydroxylase inhibition for stroke ?:
www.ncbi.nlm.n...
2-deoxyglucose for experimental stroke and Alzheimer’s disease:
pdf.sciencedir...

[@krisvette5874]

Fascinating podcast. Eciting potential for near term translation and cost effective interventions.

[@studentaccount4354]

😍😎

[@NicholasWilliams-uk9xu]

Glutamate! The theory of neuronal pathology! The theory of consciousness, no algorithms required ;)

[@MS_Sabir]

Hi Mark P. Mattson, your podcast videos are very well. But your video has no Thumbnail. Thumbnail is very important for a TH-cam Video. I've created a thumbnail for you and already sent you.

[@eugeniebreida1583]

I love Mark’s truthy ‘thumbnails’ . . . as what could be better than a snap shot of two brilliant scientists, retired or otherwise, in the midst of an enthusiastic discussion of their fields of expertise?? ( Keep your good thang going, Dr. Mattson! )

[@eugeniebreida1583]

Afraid the level of discussion is above my pay grade - is there a two sentence summary as a practical take away? Should I be chelating iron, if so, how does one do so?

[@brainponderingswithmarkmat648]

Your body naturally chelates iron as it produces several different iron-binding proteins including the heme in hemoglobin and ferritin.

[@eugeniebreida1583]

@@brainponderingswithmarkmat648 Thank you so much Mark. I eat as broadly as I can for my inflammation, but include a bit more red meat than ‘most’ would recommend - as a source of higher calorie concentration (am way underweight at 65, look - and could be? - cachexic (ai psoriatic arthritis -NOT taking those black box warning drugs, do take aspirin w/meal).
Anyway, so I take what seems a decent quality multi that regrettably has ‘50% ‘ of rda iron . . . would you cease a good multi due to this undesirable ingredient. Keeping in mind the gen’l state of ongoing inflammation - ?
Just enjoyed two more of your in-depth interviews w/fascinating authorities… even if I DID have an academic background in biology I’d be rewatching several times ❤