Prion Disease - Susan Lindquist (MIT/HHMI)
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- เผยแพร่เมื่อ 15 พ.ย. 2013
- www.ibiology.org/archive/surp...
Proteins are folded into intricate, complicated shapes and misfolding often results in disease. Lindquist describes how prions catalyze protein misfolding resulting in diseases such as Mad Cow Disease. She also gives a great explanation of why budding yeast (S. cerevisiae) is such a wonderful lab tool. - วิทยาศาสตร์และเทคโนโลยี
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You know someone is insanely smart when they say "DNA itself isn't that interesting." WOW LOL
Nothing is. Everyone and everything is an accident.
Just a bunch of ABBAGABBA.
@@furonwarrior I didn't mean to will myself into existence, i'm sorry it was an honest mistake I swear
@@andreaberryman5354 ABBA however, or at least the 1970s Swedish Pop band by that name, is that interesting - GABBA? Yet to be determined
Yeah intelligence has nothing to do with a statement like that- DNA is absolutely fascinating.
This talk by Dr. Lindquist is fantastic, I love how she has a clear enthusiasm for the subject and clearly explains and provides mental models for these intricate cell processes.
This is incredibly interesting story, and I was disappointed when it stopped on the 14th minute. So I followed the link and downloaded a whole video.
Smartest person I have heard so far in this area. I hope you win the Nobel Prize one day!
FASCINATING! Bravo lecture!
Interesting and clear explanation. God bless.
This is the oldest comment
@@grn-xx ahah, I just won myself a lamboghinni
I had a genetic test done for research and it came back with 35 variants linked to Prion Disease, including 2 mutations of the Prion protein gene (one is PRP129Homozygote). I can't convince my doctors to take the test seriously! I was possibly exposed to BSE in England 1988-1991. I'm already diagnosed with Ehlers-Danlos Syndrome. How can I get help if my doctor won't order a test to confirm my mutations for a diagnosis?
StarDeSoul What are your symptoms apart from EDS?
If you have any known form of prion disease, you'd have died decades ago. And some PrP mutations are actually protective against prions. One at 127 is very protective, and 129 can be protective depending on what amino acid has changed. But the 129 may only be protective when heterozygous.
Doctors not taking things seriously seems incredibly common in Britain and I'm sorry you have such a battle on your hands. You often have to get through lots of doctors, have a private consultation, or play things up in order to not get dismissed I'm afraid. There are many great doctors but also many ignorant know-it-alls and also ones who dismiss you as a hypochondriac etc before giving you a chance.
Maybe a researcher would be interested enough to do a test (I don't know of any prion tests but there are ways it might be possible) on the extremely outside chance you have a totally new manifestation of prion disease that would be one of the biggest discoveries in the entire field.
But it's far more likely you have something else causing whatever symptoms are worrying you - prions are probably the least likely cause out of everything. That's according to current knowledge of prions, which is really controversial early-stages stuff and could be very wrong. But the fact you're alive means you don't have any known prion disease. And BSE doesn't pass to humans (well it does, but incredibly rarely) according to what is currently known about these incredibly weird proteins. Pursue another possible cause and you stand much better chance of finding an answer.
I hope you find or have found some answers!
+RedButtonProductions Disagree with you on several points. BSE is transmissible to humans; and even more so when Scrapie is involved. On the farm, it is considered so transmissible that a strict environmental decontamination is required after a positive case is confirmed. US Doctors are not testing humans, so the statistics appear artificially low. The farms keep the statistics low by only testing downer cows. A largely uninsured population and lack of statistics reporting hide a lot of data. Neither the Health Department, nor the CDC, are taking statistics. It has been verified to be in approx 13% of dementia autopsies. But the question is how many autopsies were performed compared to the general population. Some sources estimate that the majority of the US population is hosting prion diseases due to mass farming techniques, which allow a single burger to contain meat from thousands of cows; increasing the odds greatly. I suspect the imported meats from China, and all over the world, would add risk. The prions can be in other parts of the body besides the brain. Prion based diseases can have very long incubation periods, spanning many years, depending on host health, level of exposure, and entry point on the body.
I would try to contact the US national center for surveillance of Prion Diseases (not the formal name I forget it).
Edit: Correct name is NPDPSC, National Prion Disease Pathology Surveillance Center. I would contact them or related people.
rarediseases.org/organizations/national-prion-disease-pathology-surveillance-center/
Being outside of the US affects this in a way unknown to me. I'm not sure how much they could help, but my guess is that you guys have a similar center (centre huh?).
The late Luc montagnier Nobel winner
Talked about the chance of prions
Aka/ mad cow disease spongiform encephalopathy from the spike protein going amiss. by letting linger it is in ur system it may take 3- 5 years for the spike to unraveling to then show up as prions if it happened
@@DaFinkingOrk The late Luc montagnier Nobel winner
Talked about the chance of prions
Aka/ mad cow disease spongiform encephalopathy from the spike protein going amiss. by letting linger it is in ur system it may take 3- 5 years for the spike to unraveling to then show up as prions if it happened
What part of Alpha fold 2 have in the events of 2020 and 2021?
thanks madam for new information about biopolymer..................
I'm a bit late to the party here, so apologies, but with the protein folding and the resulting conformation, are the "prions" a more energetically stable state? And in that sense, is that how the common protein conformation can be persauded (for want of a better term!) to adopt this other conformation and give rise to the problem-protein?
As i understand it, yes.
I need the full presentation. Please share the link
Very interesting :)
GREAT!
Thank God for creating an intelligent person like you!
Do you thank god for prions too? She probably worked really hard to get where she is -- ever thought of thanking her?
nah he's right thank God. She could have died at birth. She could have died on her way to school when she was a kid. Her parents could have died at a young age and she will never have come into existence....you see here? God spared her life
Sure sure. But do you thank god for prions too?
Thank you
I’m actually eating an apple right now as I clicked on your video. Thank you for the information.
Please can the spike proteins reacting with heparin became prions?
Yes,amino acids similar to those in prions were found,pretty scary
The spike protien has a portion on it called the S subunit that could supply enough energy to activate or cause misfolding of several other protiens. Most notably it can cause fibrin to polymerize in a way that is not easily degraded by plasminogen.
@@christopherleubner6633 dam scary.... more scary then cancer😮
Amazing
Do prions have potential for weapons?
Yes, infect a nations food and there you go
@Daniel Hendrik it’s been aerosolized already,so I think that’s a very big possibility
We are already dead
tq so much god bless you.......
Video cuts off right when it was getting good
Any one here in 2021?
Quite interesting, you touch on Spontaneous infections. Where could Spontaneous infections come from? Humans had very little defective prions 50 years ago, but today it most likely is going to go to an epidemic!
Take for instance corn that's been genetically Modified, how do they do it? In most cases they use a gene gun loaded with particles of gold that has bacteria and viruses to invade the cells with the desired genetically material. Since prions are protien the coating on the cell walls and now become damaged or misfolded in a way unknown. Misfolded prions are very dangerous as they can replicate themselves, and most likely move into the brain stem through the nervous system. Once there they slowly turn the brain into sponge like material, DEATH follows shortly after!
I wouldn't say that sporadic prion disease is, in any way, an epidemic. If you Google the figures, you'll discover that Sporadic CJD accounts for approximately eighty percent of all known Prion disease. Of course, there are a, as yet unknown, number of people with vCJD, but these cases are, currently, asymptomatic and the true number will not be known until they become symptomatic.
Growing aging population is why. Prion diseases are mostly an aging related disease. You see very few 20-30 year olds develop this disease, but a much larger portion of 60 and 70 year olds do.
@@ekaterinavalinakova2643 Prions disease can cause dementia, Alzheimer and other memory dysfunctions. We humans have been exposed to GMO's for the past 20 years and all these autoimmune diseases are on the rise. Prions disease is slow in progressing, will not show up right away in young people, because GMO's were not a major part of our food until 2007. In 2007 was the first year GMO's took over more than 90% of the corn and soy market share.
There is a new kid on the block that will accelerate prions disease, possibly killing half the world population in 3 years, which is the unnecessary Corona vaccine. This is a depopulation tool nothing to do with the virus. It is a fact that injecting mRNA into the body and getting the body to produce a protein that is supposed to be the virus spike, will cause the protein to misfold.
This is similar to scrapies in sheep where the new born lamb is exposed to the scrapies from mother at birth. The lamb grows just fine the first two years, usually in 3rd year symptoms develop, sheep goes mad and dies. Scrapies is caused from misfolded proteins and there is no cure! Likewise there will be no help or cure from dying from the vaccine! This is why eugenics Bill Gates was a big part in developing the vaccine.
You're right. One of the biggest problems with transgenic tech is that the gene insertion point can inadvertently turn on other genes causing novel protiens and peptides to be created. Debugging DNA switches would be a literal god level task to be sure. 🤔
10:28 If you have little patients.
Dont wear black against a black background....
.. for the record, this is probably the only time im ever going to outsmart you.
Great video.
That effect was very pleasing. She had a white glow on the silhouette outline. It's reminiscent of the 1982 Tron movie. Black on black was either a great idea, or it was serendipitous.
Floating head syndrome
I didn’t mind it all. Bunch of weirdos.
Background could have been grey and solved it all.
I liked the Fred Astaire and Ginger Rogers clip
9:30 minutes of introduction. great video tho. aprecciate that
That’s kinda cool
Mitocondrial
Is not the same sac
so prioms are like mister Smith from matrix
XD
Has anyone else heard about the Covid-19 vaccine/prion link?
To me, it is incredibly frightening and awful.
Possibly, and without hyperbole, it seems to me that it has the potential to literally be the worst thing ever.
Caveat: I am not a medical professional nor a scientist, but I do have some university education in chemistry - which little knowledge of prions that gives me is enough to scare the hell out of me and make me very much want to learn more from qualified experts.
The following is from the video "International Covid Summit III - part 2 - European Parliament, Brussels."
At 2h 06m 31s, the segment with Neurologist, Rosanna Chifari, begins.
She details how the spike protein is metabolized by the body and is broken down to become prionic in its parts.
She cites a French research group's work that has studied 26 cases of a rapid-onset rapid-progress Creutzfeldt-Jakob-like
disease which kills in 2-4 months from first symptoms, and that the research group says is caused by the prionic action of a metabolized part of the spike protein from the vaccines.
A chilling quote from her speech is:
"Be prepared to see an epidemic of prion disease."
The worst part, though, is this quote of a statement she made in regard to Covid-19 vaccines:
"This is an amazing discovery, proof that *ALL* vaccines show a prion sequence." (Emphasis mine)
After seeing her speak, I read the abstract of a paper titled, "A Potential Role of the Spike Protein in Neurodegenerative Diseases: A Narrative Review" that goes into detail about all of this.
From the abstract, I learned that the metabolized component parts of the spike protein seem to also increase the incidences of Alzheimers, Multiple Sclerosis, and ALS, in addition to causing the rapid-onset rapid-progress Creutzfeldt-Jakob-like disease noted above.
Altogether, I find the implications of all of this to be maximally profoundly disturbing - as prion diseases such as Creutzfeldt-Jakob cannot be cured and are 100% fatal...
With the worst implication from all of the above being the possibility that every person who received an mRNA Covid-19 vaccine could now have prionic action at work in their bodies that could eventually kill them if it goes the same as it does with every other prion that infects mammals - and with there being no reason whatsoever to think that there should be any different outcome for humans (think Mad Cow disease or Chronic Wasting Disease in deer).
Finally, I do not know why this would not also apply to the virus:
Same spike protein.
Same automatic metabolic process that breaks it down and releases the S1 part (where there are multiple prion domain sequences to be found) into the body.
In addition to all of the above there is the extremely frightening lingering nature of prions in the environment, and that they uptake by plants into the food chain.
For instance, if grass is eaten that grew where deer with CWD died, then the animals eating it are affected.
It should be noted that not only the 'prion factory' bodies of the deceased infected are dangerous but also various body wastes might be.
To illustrate: feces from sheep with Scrapie (the sheep version of the PrPc/PrPsc infection) carries prions.
I have to wonder if it is similar for humans with prions from the spike protein.
And that makes me think about the waste water treatment facilities that would have no affect on prions.
K, I think you get the idea.
Also, I'm so sorry for passing this information along.
I found it devastating to learn.
I hope there are experts who can disabuse me of the notion that this seems like a doomsday scenario.
I've read about the spike proteins in the Covid19 vaccine. It's very alarming.
Oh yes, thanks for your completely unqualified analysis, I’m sure that failed intro to chemistry course was enough for you to grasp all of this
I am a biologist. This dna is too complex to explan by simple drowing. This is not even possible to model through commputer models. Life is very complex unlike communication skills.
S Pol This talk is obviously for the public(or some other general audience) and not for scientists, dearie.
lol this lady and her music
I thank you, without involving God :D
joel quinn Triggered? It's surprising to see the idiocracy of religious people, as I just lost my faith in Christianity.
joel quinn what made you come to that conclusion?
Donate to tge prion alliance!
She wasted most of the video on unnecessary background information. I wanted to hear a detailed explanation of how prions function.
in b4 the vaccine zombies
The laughing disease
Anyone else here from cyngulym?
Nope.
Who's here because of Scp-008?
What's that
The joker
It was never by ingestion.. it was always by injection.
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I BELIEVE HER EX-HUSBAND AND BECAUSE I CAUGHT LIE'S THAT WEREN'T CONSISTENT WITH PRINCESS DIANA'S EXPERIENCE'S COVERING THE ABUSES SHE RECEIVED FROM HER HUSBAND AND HIS SECOND WIFE, WHOM HAVE HAD A DIFFICULT MARRIAGE. SHE TURNED OUT TO BE AN ALCOHOLIC AND BEHAVED DISGRACEFULLY ON THE BALCONY OVER THE CENOTAPH. PRINCESS CATHERINE COMFORTED HER MAJESTY, WHEN THE OTHER WAS MORE CONCERNED ABOUT HARRY'S WIFE RATHER THAN BEHAVING LIKE A ROYAL. HER BEHAVIOUR CAUGHT BY A PHOTOGRAPHER WAS DISGRACEFUL AND IT WAS APPALLING.
Vaccine.
Also in supermarket foods, as meats lookout. These people know alot of people aren't taking their poison, they gonna poison us one way or the other
For all their learnedness they can not explain even why the sun rises!
Be more specific in your lecture
What is her point? Who's the audience? Kindergarden kids?
Very interesting about nothing.