Vincent, I am a member of the general public. I found you and your Virology course in March 2020. I’ve been a TWiV listener since. I appreciate all of the science and the information you and the TWiV team provide.
My formal education ended with high school, but I’m intelligent and eager to learn. The knowledge you share is absolutely fascinating. The world would be a better place if mainstream media shared shows like this.
I’m blood group, O+, Long Tail COVID-19, 7 months so far, symptoms started 3/22/2020. Risk, co-morbidities, female age 72. Have had genetic, autosomal done, uploaded to genetic analysis company related to National Geographic. I have been identified with ancient DNA designated as Neanderthal origins from a cave in Siberia and other other ancient skeletal remains found around the world. My female line origins are Bosnia Herzegovina, Croatia, Slovenia, Hungary, Eastern European. This heritage is from my mother born California is 50% (other 50% Irish), her mother, my grandmother born in California is100%, and her parents, my great grandparents both 100% immigrated from Slovenia, Austria in 1876-1880. Many of my DNA cousins, from this area in Slovenia, now live here in US. The multi surnames from Semić, Slovenia (Austria) related family groups came to Tulare County, California to settle in that valley in the mid to later 1880s. A Catholic Cemetery there is full of these early pioneers, al, related from the old country.
All Eurasians have some Neanderthal DNA; it matters if you inherited the Neanderthal version of a specific stretch of DNA. Two of the risk SNPs are in Ancestry DNA and one of them in 23andMe and Family Tree DNA raw data. They are typically inherited together. Linkage disequilibrium is something like .99. Extremely high. Neanderthals lost almost all of their genetic variation as the result of the Toba eruption. They were extinct and just didn't know it yet. Of three skeletons examined, two had some of the risk SNPs and one had all of them. It matters not at all where your people lived recently but who they mated with as they were migrating out of Africa. As a rule people migrated eastward and then northward and eventually into Europe between the ice ages. Modern humans kept the parts of Neanderthal DNA that were advantageous.
A friend works in a homeless shelter and she said similar. We think it’s related to Vitamin D. People who are outside a lot get more vitamin D than those inside. Vitamin is important in the immune response.
I am hailing from Canada. Try to pass along to my less scientific friends what all of this is about. Oh if I were only younger (73) and could get really deep into the topic but I absorb what I can. Please tell me what is aisle 6.Patricia Harford retired X-ray tech.
Hi Pat - greetings from the UK. My partner and son have the same surname as you. Harford is quite an unusual name and they hail from the North East of the UK (Sunderland) and before that, Ireland. Related perhaps?
It's so weird, I started listening at the end of March when the temps were low, then got to listen all through the summer when it was super hot, and now we're circling right back around to the cold temps again!
Methamphetamines raise body temperature so the Psychiatrist may be onto something. 1:13. Love TWIV! Its keeping me intellectually stimulated while I take a year off teaching to help raise baby grandson. How much Raffi can any grandma take?
Interesting as the same types of English medication that affected the medulla obbligato and Olfactory that had a type of stimulating effect was showing great promises ! Further my study besides the locust and viral influenza connections with those sane parts of the brain from autopsy reports show those areas being affected Oh factory and medulla obbligato temperature and mucus regulating effects.using the same bio chemical in locust to start locust mating cycle during the times of droughts . Anyway my interest in hemp types that can affect patients who prefer stimulant or drowsiness as types of escapes from a loss or identified hole in ones happiness in ones life that removed the loss of personal perfection in performance ! And the use of selected types and species of hemp allow a safer alternative with a wise doctor who understands the human addiction cycle . And other adverse mental issues. Besides the loss of human need to perform or override the pain with occasional use of hemp at appropriate clinical effect , and a clinical approach to help keep the road map of treatment at the highest effect Even the hardest drugs can have return to a self awareness and return of pride and direction ! This has shown pain patients even reduce 25 percent of real pain patients ! Further Methamphetamine with correct species of hemp easily found . Can also produce a stimulant and mental excitement to work on complex subjects ! While others allow deep sleep or mild relax Or laughing well-being in tines of Sorrow and deep loss that can help remove pain to express ones issues, as needed to become real and allow self actuality. That is much more affective than the weeks of medication needed to achieve antidepressants levels ! That sadly had been way to long for many . I can not say Hemp has all the solutions ! However over many years of study I have seen results in humans that bribe less domestic violence and amazing changes to creative healthy and direction changes ! That no other ways of reaching those specifically hard to see change ! Have with a good health provider find a much healthier lifestyle that the power over the slavery of drug addiction , that the patients and clinical support have found in both understanding the reason for that loss of ones ability to function . Often found more profoundly with drugs . But the key is the way and amount and species of hemp , with the understanding of drug addiction and the street wise personality’s to find the reasons and replace and then implant the proper uses of this medical plant that had been used from before recorded history ! But we are continuing to find the blessing of moderate use at times of need , as wine was written about in biblical texts . We need to help others not create blank scripts of care that even doctors have no real treatment when addiction is presented and failure is expected more often than true patient willingness to try as he has not the tools given him to discover and change what is the hardest thing for a human to do ! Is change in mist things !hope this helps in your efforts to bring joy in the human mind. And. spirit a gift from God to help guide us in life as well as draw us closer to a spiritual walk in peace and joy and love .
I’m type 0 but also have 2-3% Neanderthal DNA. I Currently have COVID-19 but moderate symptoms for now. I’m rooting for my blood type to keep it that way.
If more research was done, bloodtyping would reveal timelines which would align with some randomized phenotype. So it may be that A type Actually has more Neanderthal as a later allele, where O type has had more time to evolve. B would be the unique new blood that seems to be more in mark with the time period of the OCA2, which is scary correlation of Biblical New Man and heavens eye. Although none of this is declarative of causation. I also think the supraorbital brow ridge of modern man may actually be more effective at matching dna samples. Then cross examine studies in blood Allele in relation. Come on!! Why did they continue cancer treatments of a covid positive while immunal suppressed... From the data you present this scenario is clearly Medical Malpractice; They sure did bleed that case for every dime. And their real chaching is ventilate while in a medically induced coma, till your lungs colapse. Dont put lungs on your organ donation, lol; You may not get resusc. So we can just snip and delete the Neanderthal? Who needs to throw spears anyway, wait where'd my thumbs go?🤔 Summary: If you are cave man, its time to hold the reapers hand.
So glad to have stumbled upon you this morning, thanks for your sharing of scientific info 🇨🇦😷, raining & 13C or 55F here, in my part of Canada where every day begins with checking the weather, a Canadian obsession 🍁😉
Ipothetical If some IgM covid19 induced globulin induce some sort of hemagglutination IT explain some clinical features like low level of periferial oximetry by capillaires obstruction
My highly valued TWiV crew, I watched Dr.Vivek Murthy host a discussion with Dr. Nicholas Christakis who just published Apollo’s Arrow about the Enduring Impact of the COVID-19. I highly recommend having Nick Christakis on TWiV. He’s an excellent science communicator. Please check out his credentials. You won’t be disappointed.
Good God, we've got the comment after mine thinking the fact she's from Eastern Europe should mean something! Pieces of Neanderthal DNA stuck around if they carried some adaptive advantage. Usually things related to metabolism and immune function, skin and hair color, that sort of thing. Different groups have different histories over time so at some time maybe it was an advantage in Bangladesh to have this haplotype. Clearly there is immune response or disease susceptibility of some sort in this piece of DNA. At some time in the past it was an advantage or we wouldn't still carry it. Another possibility is it was previously a disadvantage that selectively didn't hurt the people of Bangladesh.
I would like "This week in Gardening" as scientists you would provide an interesting perspective on the subject even if it is not your area of expertise.
I had noticed that we don't hear much about the homeless population. Since you asked for input, my theory is that they spend so much time outdoors that they may have adequate vitamin D levels. I had seen a lecture regarding Vitamin D and Upper Respiratory Infections (on utube) last year and noticed that the 3 groups most at risk of vit d deficiency corresponded with the 3 groups suffering highest chance of covid19 morbidity: elderly, african-american, obese. That led me to strongly believe in a vit d hypothesis for covid19 outcomes
Does this at all explain in part why northern Italy were more susceptible? It’s been a while since Anthro 101. I have a memory…..but it’s been 30+ years since. Fascinating correlation.
There is one SNP on the abo blood group gene strongly associated with severe covid. I don't have it in front of me. However it is in my 23andMe raw data. I'm blood group O- - and heterozygous for that SNP. In theory that ought to be impossible, because I'm homozygous for the genes for major blood group. In theory. It is possible something is going on with blood group; I have border lined von Willebrand level and the question is is it because I' m blood group O or something is wrong with me? If I have a deep wound it clots normally but doesn't stick. This is protective against strokes and probably against microclots in my lungs. But it looks more like something is going on with that SNP that is loosely associated with major blood group.
They can also look at African genomes to determine if the DNA at Chromosome three is common to African Homo sapiens and Euroasian Homo sapiens and Neanderthals. If common to all three, then origin is likely from a common ancestor. If only found in Eurasian Homo sapiens and Neanderthals, then it likely arose in Neanderthal and was transferred to Homo sapien during admixture.
It's May (2021) now; when is "This Week in Gardening" coming out? Thank you for all these months of podcasts. Today the CDC (& the city I live in, Las Vegas) have reduced the call for vaccinated folks to wear masks. Let's see how this goes over the next few weeks.....
The number of cycles in the machine it takes to find the virus in PCR tests. I think it goes as high as 45 in the UK, which picks up those no longer infectious. From what I've read, around 35-37 is at the lower end of infectious. The higher the CT number the less virus in the body. The lower the number (teens, 20's) the more virus in the body, as it takes less cycles in the machine to find virus. One of the arguments for rapid saliva tests for screening is it will only pick up the infectious.
@@earthangel2524 they work the same way a pregnancy test works (except saliva, not urine). The paper strip would be imprinted with something that detects the virus, and as the saliva travels up the paper (there are articles and videos that can explain how that works), it'll probably leave a line (the test line to show it works) or two lines (second would be the positive pregnancy line in a pregnancy test). Also read about a blood prick test (similar to diabetes) that detects it the same way. It's technical to explain in detail, you'd need to check videos/articles that explain it better. Some rapid tests require a machine to process, which makes them less useful in schools, etc for screening. Also read about a breathalyser being adapted somewhere in Africa for detecting covid 19.
@@earthangel2524 That's my favourite way too. Imagine how quick that would be if each area had a squad of trained dogs screening at least weekly in schools, workplaces, etc.
I am 99% more Neanderthal than anyone who has ever submitted their DNA to 23& me. Today's TWIV title has me feeling a lil' bit o trepidation! I would like to win a copy of Principles of Virology. I've learned so much listening to the podcast.
I signed up with 23&me last dec. I was told that like you I had more Neandrthal DNA than 98-99% of 23&me participants. Then 6 months later it suddenly changed to 60%. Not sure what they are doing over there at 23&me
get the book, 'Old Ways' to care for your body/temple, and learn how to eat like our ancestors did - make all your food healing agents - i dont use the word 'medicine as its root is from Rome: Medici Love in Truth, Speis 💕💕💕💕💕💕💕
@@gabriellakadar🤣 ok, you keep believing the main stream narrative of the controllers who reign above you, and dont eat good food as your love for your own body, only temple worth giving to - you take your pharma like a 'good' girl whenever they deem it necessary, ok? And once you succumb to one of their shiest-driven diagnosis', and if you're wealthy enough, AND you have their prescribed affiliations, connections, they'll send their goons after me and give you MY good blood in one of their transfusion centers to revive you..nobody will ever know what really happened..house fires, so-called, 'disappearances', murders, supposed car accidents, organized institutionalizations for 'crazy people', and many more situational crimes aforementioned at their hands, all happen here on earth in increasing numbers - believe me, i went 'crazy' on purpose.🤣 💕💕💕💕💕💕💕
I love the weather chats ate the start. It's a topic I'm passionate about. What I'm not passionate about is hot dry sunny weather. I can feel Scotland calling.
One thing I would wonder about in the homeless community would be nicotine use and replacement therapy. Could that keep the cases mild enough they fly under the radar?
I for one was never worried about the homeless community. First off, in order to survive as a homeless person, you would need a really good immune system. Second, homeless people are exposed to all sorts of things to prime their immune system, including past coronaviruses (to make cross-reactive T-Cells) which in principle should give some resistance it's "new cousin". Basically, your cells chop them up to bits and T-Cells detect the body parts. You would presume that some body parts are shared across the family of coronaviruses. It's in one of Prof. Racaniello's Virology classes on Immunology if you want to look it up so it has been pretty obvious this happens if you learned that, despite various parties arguing there's no "proof" that it works, etc. etc. And if you had one of these co-morbidities in any serious fashion, you wouldn't make it long homeless to begin with. ;)
I have been listening to your podcasts regularly now..and learning so much every time. I really appreciate this new format of simpler explanations for noobs like me. Really great work and thank you!
You say, “What I tell people is: You are smart, you can figure it out, if there is no data, go look for it, and if there is not, just don’t believe it, right? Listen to the crickets man.” and “As Rich said, there is no data in the declaration”. I do enjoy and learn immensely from your discussions of virology and genetics. But when you stray outside your field, into epidemiology and public health policy, where is your data? Your strong opinion, but lack of relevant data reminds me of something… some guy who said “if there is not [no data], just don’t believe it, right? Listen to the crickets man.” 😊 The lead authors of the GBD are, unlike you, some of the worlds lead epidemiologists (Stanford, Harvard, Oxford, even a Noble prize). The GBD is not their academic/scientific work, and yes the short few paragraphs of the declaration do not in itself contain the vast amount of data and analysis that form the backbone of their science in the field of epidemiology. (Of course not!)) The GBD text is a short summary of the consensus among these leading epidemiologists about what policy recommendations they feel one can make based on all the data and the world’s best epidemiological science. It is not the data itself, for that you need to familiarize yourself with the scientific work of the authors. Ironically, the GBD scientists are exactly the camp within epidemiology that put an emphasis on the collection and analysis of data, as opposed to alarmist modelling and projections. Unlike anybody on this podcast, the authors of the GBD have been instrumental in motivating, organizing, and even conducting large population level data gathering and analysis on COVID-19. They are an order of magnitude more schooled in the relevant data and data science than anyone on this podcast. You, our podcast collection of virologists and infectious disease clinicians, are stepping into their territory, which is fine. But do it with truth, humility, and real scientific arguments. Ironically, the person suggesting “they have no data” have no data (on this issue). Ironically, the people he accuses is the relevant data experts. ----- Footnote: The nonsense about the Koch brothers is the opposite of scientific reasoning. It turns out a libertarian organization provided a conference venue. It turns out I lean libertarian, and the Koch brothers lean libertarian too. Many people lean libertarian, as opposed to the alternative which is authoritarian. It also turns out I am very liberal and the Koch’s are apparently conservative. None of this has anything to do with the science or data behind the GBD. Please, refrain from Koch brother nonsense when the discussion should indeed be about science and data with great import to the wellbeing of our nation, and our fellow man.
I found another who shares my maiden name, except it is her married name. My married name was her maiden name to make things even stranger. (1:46:00 ish)
You may have brought this out but I read that climate change will seriously influence viruses to thrive , not just cold or hot but the whole imbalance allowing viruses to go dormant then lasting longer in humans?? What do you think?
@Jack Torrance For gender neutrality, if applicable, i.e. they/them (when addressing a single individual) or gendered third-person pronouns, i.e. he/him or she/her.
@@InternetOfGames Jack asked a question; so I thought I'd answer it. I didn't opine on the matter or speak on behalf of a broader community. I know their first names, too. Perhaps the commenter is new around here, or didn't listen carefully during the introductions.
Vincent, I am a member of the general public. I found you and your Virology course in March 2020. I’ve been a TWiV listener since. I appreciate all of the science and the information you and the TWiV team provide.
My formal education ended with high school, but I’m intelligent and eager to learn. The knowledge you share is absolutely fascinating. The world would be a better place if mainstream media shared shows like this.
They ROCK, huh?! TH-cam 'college' ROCKS !!💕
Did the quality of the videos improved ? Looks better. Thanks for the great information
I’m blood group, O+, Long Tail COVID-19, 7 months so far, symptoms started 3/22/2020. Risk, co-morbidities, female age 72. Have had genetic, autosomal done, uploaded to genetic analysis company related to National Geographic. I have been identified with ancient DNA designated as Neanderthal origins from a cave in Siberia and other other ancient skeletal remains found around the world. My female line origins are Bosnia Herzegovina, Croatia, Slovenia, Hungary, Eastern European. This heritage is from my mother born California is 50% (other 50% Irish), her mother, my grandmother born in California is100%, and her parents, my great grandparents both 100% immigrated from Slovenia, Austria in 1876-1880. Many of my DNA cousins, from this area in Slovenia, now live here in US. The multi surnames from Semić, Slovenia (Austria) related family groups came to Tulare County, California to settle in that valley in the mid to later 1880s. A Catholic Cemetery there is full of these early pioneers, al, related from the old country.
Thank you for sharing the info.
All Eurasians have some Neanderthal DNA; it matters if you inherited the Neanderthal version of a specific stretch of DNA. Two of the risk SNPs are in Ancestry DNA and one of them in 23andMe and Family Tree DNA raw data. They are typically inherited together. Linkage disequilibrium is something like .99. Extremely high.
Neanderthals lost almost all of their genetic variation as the result of the Toba eruption. They were extinct and just didn't know it yet. Of three skeletons examined, two had some of the risk SNPs and one had all of them. It matters not at all where your people lived recently but who they mated with as they were migrating out of Africa. As a rule people migrated eastward and then northward and eventually into Europe between the ice ages. Modern humans kept the parts of Neanderthal DNA that were advantageous.
Vitamin D levels? Taking zinc and quercetin?
My Grandmothers parents were From Slovenia and came about 1890.
A friend works in a homeless shelter and she said similar. We think it’s related to Vitamin D. People who are outside a lot get more vitamin D than those inside. Vitamin is important in the immune response.
I am hailing from Canada. Try to pass along to my less scientific friends what all of this is about. Oh if I were only younger (73) and could get really deep into the topic but I absorb what I can. Please tell me what is aisle 6.Patricia Harford retired X-ray tech.
Hi Pat - greetings from the UK. My partner and son have the same surname as you. Harford is quite an unusual name and they hail from the North East of the UK (Sunderland) and before that, Ireland. Related perhaps?
IL6, short for interleukin 6. A signaling molecule used by immune cells to communicate with each other in inflammation.
I would LOVE a book!!!
'Hello' from the warmth of N Zealand.
Would the anti-inflammatory effect of tumeric effect the course of the disease, in people in India; either way?
It's so weird, I started listening at the end of March when the temps were low, then got to listen all through the summer when it was super hot, and now we're circling right back around to the cold temps again!
You guys look like a bright rainbow today. Video quality is nice.
The covid mortality rate in Bangladesh is very low- 36/M while the world average is 152/M. This Neanderthal gene association is not panning out.
I wondered the same thing
@@notsogreen Is there data to surmise more such complications in Bangladesh or random conjecture?
I wonder abt data quality in Bangla
Methamphetamines raise body temperature so the Psychiatrist may be onto something. 1:13. Love TWIV! Its keeping me intellectually stimulated while I take a year off teaching to help raise baby grandson. How much Raffi can any grandma take?
Interesting as the same types of English medication that affected the medulla obbligato and Olfactory that had a type of stimulating effect was showing great promises !
Further my study besides the locust and viral influenza connections with those sane parts of the brain from autopsy reports show those areas being affected Oh factory and medulla obbligato temperature and mucus regulating effects.using the same bio chemical in locust to start locust mating cycle during the times of droughts .
Anyway my interest in hemp types that can affect patients who prefer stimulant or drowsiness as types of escapes from a loss or identified hole in ones happiness in ones life that removed the loss of personal perfection in performance ! And the use of selected types and species of hemp allow a safer alternative with a wise doctor who understands the human addiction cycle . And other adverse mental issues. Besides the loss of human need to perform or override the pain with occasional use of hemp at appropriate clinical effect , and a clinical approach to help keep the road map of treatment at the highest effect Even the hardest drugs can have return to a self awareness and return of pride and direction ! This has shown pain patients even reduce 25 percent of real pain patients ! Further Methamphetamine with correct species of hemp easily found . Can also produce a stimulant and mental excitement to work on complex subjects ! While others allow deep sleep or mild relax Or laughing well-being in tines of Sorrow and deep loss that can help remove pain to express ones issues, as needed to become real and allow self actuality. That is much more affective than the weeks of medication needed to achieve antidepressants levels ! That sadly had been way to long for many . I can not say Hemp has all the solutions ! However over many years of study I have seen results in humans that bribe less domestic violence and amazing changes to creative healthy and direction changes ! That no other ways of reaching those specifically hard to see change ! Have with a good health provider find a much healthier lifestyle that the power over the slavery of drug addiction , that the patients and clinical support have found in both understanding the reason for that loss of ones ability to function . Often found more profoundly with drugs . But the key is the way and amount and species of hemp , with the understanding of drug addiction and the street wise personality’s to find the reasons and replace and then implant the proper uses of this medical plant that had been used from before recorded history ! But we are continuing to find the blessing of moderate use at times of need , as wine was written about in biblical texts . We need to help others not create blank scripts of care that even doctors have no real treatment when addiction is presented and failure is expected more often than true patient willingness to try as he has not the tools given him to discover and change what is the hardest thing for a human to do ! Is change in mist things !hope this helps in your efforts to bring joy in the human mind. And. spirit a gift from God to help guide us in life as well as draw us closer to a spiritual walk in peace and joy and love .
Ah TWiG, the latest podcast in the stable (The week in gardening)
It is sad that the medical name for bloody nose doesn’t have ‘rhino’ in it. Runny nose is ‘rhinorrhea’- my fave med school vocabulary word
TWiV would totally be a driveway show, if people still drove anywhere
Those title illustrations are getting very fancy!❤️
The glass sealife link is amazing.
I’m type 0 but also have 2-3% Neanderthal DNA. I Currently have COVID-19 but moderate symptoms for now. I’m rooting for my blood type to keep it that way.
If more research was done, bloodtyping would reveal timelines which would align with some randomized phenotype. So it may be that A type Actually has more Neanderthal as a later allele, where O type has had more time to evolve. B would be the unique new blood that seems to be more in mark with the time period of the OCA2, which is scary correlation of Biblical New Man and heavens eye. Although none of this is declarative of causation. I also think the supraorbital brow ridge of modern man may actually be more effective at matching dna samples. Then cross examine studies in blood Allele in relation.
Come on!! Why did they continue cancer treatments of a covid positive while immunal suppressed... From the data you present this scenario is clearly Medical Malpractice; They sure did bleed that case for every dime. And their real chaching is ventilate while in a medically induced coma, till your lungs colapse. Dont put lungs on your organ donation, lol; You may not get resusc.
So we can just snip and delete the Neanderthal? Who needs to throw spears anyway, wait where'd my thumbs go?🤔
Summary: If you are cave man, its time to hold the reapers hand.
Neanderthals we’re not spear throwers. They had to spear the animals they hunted up close. Thrown spears were invented by Homo sapiens
If some sort of hemagglutination occur by cryoglobulins induced by covid19 IT can explain the corelation of blood group
Hemagglutination can be increased by low blood temperature
No complaints. Love the chats 😊
Yes, at this point, it would be wrong if they didn't chat. TWIV, don't worry about the complaining outlier!
So glad to have stumbled upon you this morning, thanks for your sharing of scientific info 🇨🇦😷, raining & 13C or 55F here, in my part of Canada where every day begins with checking the weather, a Canadian obsession 🍁😉
Ipothetical If some IgM covid19 induced globulin induce some sort of hemagglutination IT explain some clinical features like low level of periferial oximetry by capillaires obstruction
My highly valued TWiV crew, I watched Dr.Vivek Murthy host a discussion with Dr. Nicholas Christakis who just published Apollo’s Arrow about the Enduring Impact of the COVID-19. I highly recommend having Nick Christakis on TWiV. He’s an excellent science communicator. Please check out his credentials. You won’t be disappointed.
Good God, we've got the comment after mine thinking the fact she's from Eastern Europe should mean something!
Pieces of Neanderthal DNA stuck around if they carried some adaptive advantage. Usually things related to metabolism and immune function, skin and hair color, that sort of thing.
Different groups have different histories over time so at some time maybe it was an advantage in Bangladesh to have this haplotype. Clearly there is immune response or disease susceptibility of some sort in this piece of DNA. At some time in the past it was an advantage or we wouldn't still carry it.
Another possibility is it was previously a disadvantage that selectively didn't hurt the people of Bangladesh.
I would like "This week in Gardening" as scientists you would provide an interesting perspective on the subject even if it is not your area of expertise.
Sure.. grow 30 different herbs for your partners daily salads and your cooking. Its healthier than chocolate and wine
@@henkvandergaast3948 I'm a farmer, so, FOOD is my healing everything 'go to' Also, i forage a LOT of great food, most is DEEEElicious💕
I had noticed that we don't hear much about the homeless population. Since you asked for input, my theory is that they spend so much time outdoors that they may have adequate vitamin D levels. I had seen a lecture regarding Vitamin D and Upper Respiratory Infections (on utube) last year and noticed that the 3 groups most at risk of vit d deficiency corresponded with the 3 groups suffering highest chance of covid19 morbidity: elderly, african-american, obese. That led me to strongly believe in a vit d hypothesis for covid19 outcomes
Does this at all explain in part why northern Italy were more susceptible? It’s been a while since Anthro 101. I have a memory…..but it’s been 30+ years since. Fascinating correlation.
There is one SNP on the abo blood group gene strongly associated with severe covid. I don't have it in front of me. However it is in my 23andMe raw data. I'm blood group O- - and heterozygous for that SNP. In theory that ought to be impossible, because I'm homozygous for the genes for major blood group. In theory.
It is possible something is going on with blood group; I have border lined von Willebrand level and the question is is it because I' m blood group O or something is wrong with me? If I have a deep wound it clots normally but doesn't stick. This is protective against strokes and probably against microclots in my lungs.
But it looks more like something is going on with that SNP that is loosely associated with major blood group.
One question- Is uttering 'translation' instead of 'transcription' a Freudian slip?
They can also look at African genomes to determine if the DNA at Chromosome three is common to African Homo sapiens and Euroasian Homo sapiens and Neanderthals. If common to all three, then origin is likely from a common ancestor. If only found in Eurasian Homo sapiens and Neanderthals, then it likely arose in Neanderthal and was transferred to Homo sapien during admixture.
Yeah, but there was some gene flow back into Africa so not all will be identified.
What is the chair Breann has? These days a quality work chair is right there after TP!
It is a GT racing gaming chair.
My office chair Aeron
I think Vincents mike cuts out at arond 1:40 in the podcast version. At least for me. It was strange to hear the others comment and laugh at nothing.
It's May (2021) now; when is "This Week in Gardening" coming out? Thank you for all these months of podcasts. Today the CDC (& the city I live in, Las Vegas) have reduced the call for vaccinated folks to wear masks. Let's see how this goes over the next few weeks.....
What is a "CT"value?
The number of cycles in the machine it takes to find the virus in PCR tests. I think it goes as high as 45 in the UK, which picks up those no longer infectious. From what I've read, around 35-37 is at the lower end of infectious. The higher the CT number the less virus in the body. The lower the number (teens, 20's) the more virus in the body, as it takes less cycles in the machine to find virus.
One of the arguments for rapid saliva tests for screening is it will only pick up the infectious.
@@sharonsloan Thank you so much! Are the saliva tests also measured in CT values?
@@earthangel2524 they work the same way a pregnancy test works (except saliva, not urine).
The paper strip would be imprinted with something that detects the virus, and as the saliva travels up the paper (there are articles and videos that can explain how that works), it'll probably leave a line (the test line to show it works) or two lines (second would be the positive pregnancy line in a pregnancy test).
Also read about a blood prick test (similar to diabetes) that detects it the same way.
It's technical to explain in detail, you'd need to check videos/articles that explain it better.
Some rapid tests require a machine to process, which makes them less useful in schools, etc for screening.
Also read about a breathalyser being adapted somewhere in Africa for detecting covid 19.
@@sharonsloan Thanks. Wow! So many ways. My personal favorite is the dogs sniffing infected travelers at Finnland's airport.
@@earthangel2524 That's my favourite way too. Imagine how quick that would be if each area had a squad of trained dogs screening at least weekly in schools, workplaces, etc.
I am 99% more Neanderthal than anyone who has ever submitted their DNA to 23& me. Today's TWIV title has me feeling a lil' bit o trepidation! I would like to win a copy of Principles of Virology. I've learned so much listening to the podcast.
How many Neanderthal SNPs have you got there, Dave? I have 400 or so and I' m high up.
I signed up with 23&me last dec. I was told that like you I had more Neandrthal DNA than 98-99% of 23&me participants. Then 6 months later it suddenly changed to 60%. Not sure what they are doing over there at 23&me
get the book, 'Old Ways' to care for your body/temple, and learn how to eat like our ancestors did - make all your food healing agents - i dont use the word 'medicine as its root is from Rome: Medici
Love in Truth, Speis
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@@elizabethharrison2947 But they went extinct from eating the old ways diet. The Neanderthals did.
@@gabriellakadar🤣 ok, you keep believing the main stream narrative of the controllers who reign above you, and dont eat good food as your love for your own body, only temple worth giving to - you take your pharma like a 'good' girl whenever they deem it necessary, ok? And once you succumb to one of their shiest-driven diagnosis', and if you're wealthy enough, AND you have their prescribed affiliations, connections, they'll send their goons after me and give you MY good blood in one of their transfusion centers to revive you..nobody will ever know what really happened..house fires, so-called, 'disappearances', murders, supposed car accidents, organized institutionalizations for 'crazy people', and many more situational crimes aforementioned at their hands, all happen here on earth in increasing numbers - believe me, i went 'crazy' on purpose.🤣
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First time listener, really enjoyed show
Subscribed
did you know that Elbert Einstein could have gotten his giftedness from Neanderthal genes
I love the weather chats ate the start. It's a topic I'm passionate about. What I'm not passionate about is hot dry sunny weather. I can feel Scotland calling.
One thing I would wonder about in the homeless community would be nicotine use and replacement therapy. Could that keep the cases mild enough they fly under the radar?
I for one was never worried about the homeless community. First off, in order to survive as a homeless person, you would need a really good immune system. Second, homeless people are exposed to all sorts of things to prime their immune system, including past coronaviruses (to make cross-reactive T-Cells) which in principle should give some resistance it's "new cousin". Basically, your cells chop them up to bits and T-Cells detect the body parts. You would presume that some body parts are shared across the family of coronaviruses. It's in one of Prof. Racaniello's Virology classes on Immunology if you want to look it up so it has been pretty obvious this happens if you learned that, despite various parties arguing there's no "proof" that it works, etc. etc. And if you had one of these co-morbidities in any serious fashion, you wouldn't make it long homeless to begin with. ;)
I have been listening to your podcasts regularly now..and learning so much every time. I really appreciate this new format of simpler explanations for noobs like me. Really great work and thank you!
In your discussion of adverse selection reduction of fecundity was omitted. Wouldn't onset around childbearing age also play a potential role?
This Week In Gardening, would that be TWiG?
While it is nice to see your faces it would be very helpful to see your screens when you are discussing various graphs, etc
California-Blue v Arizona-Red. Both were in the highest infection list.
Lots of antivaxxers in CA
Loved the ice cream cone & drownings “connection” Rich mentioned 😉
Wear a mask please 😷🇨🇦
Ha!!! Driveway moment... it would be if I was driving anywhere... but it’s a little too long to keep someone in the driveway for the whole thing... :)
Love the Instagram!
5:55 Is this clickbait?
1.04.24 Great Barrington Declaration
Stay tough, you guys.
I want one of these books
1:04:24 Great Barrington Declaration & Data
You say, “What I tell people is: You are smart, you can figure it out, if there is no data, go look for it, and if there is not, just don’t believe it, right? Listen to the crickets man.” and “As Rich said, there is no data in the declaration”.
I do enjoy and learn immensely from your discussions of virology and genetics. But when you stray outside your field, into epidemiology and public health policy, where is your data? Your strong opinion, but lack of relevant data reminds me of something… some guy who said “if there is not [no data], just don’t believe it, right? Listen to the crickets man.” 😊
The lead authors of the GBD are, unlike you, some of the worlds lead epidemiologists (Stanford, Harvard, Oxford, even a Noble prize). The GBD is not their academic/scientific work, and yes the short few paragraphs of the declaration do not in itself contain the vast amount of data and analysis that form the backbone of their science in the field of epidemiology. (Of course not!)) The GBD text is a short summary of the consensus among these leading epidemiologists about what policy recommendations they feel one can make based on all the data and the world’s best epidemiological science. It is not the data itself, for that you need to familiarize yourself with the scientific work of the authors.
Ironically, the GBD scientists are exactly the camp within epidemiology that put an emphasis on the collection and analysis of data, as opposed to alarmist modelling and projections. Unlike anybody on this podcast, the authors of the GBD have been instrumental in motivating, organizing, and even conducting large population level data gathering and analysis on COVID-19. They are an order of magnitude more schooled in the relevant data and data science than anyone on this podcast. You, our podcast collection of virologists and infectious disease clinicians, are stepping into their territory, which is fine. But do it with truth, humility, and real scientific arguments.
Ironically, the person suggesting “they have no data” have no data (on this issue). Ironically, the people he accuses is the relevant data experts.
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Footnote:
The nonsense about the Koch brothers is the opposite of scientific reasoning. It turns out a libertarian organization provided a conference venue. It turns out I lean libertarian, and the Koch brothers lean libertarian too. Many people lean libertarian, as opposed to the alternative which is authoritarian. It also turns out I am very liberal and the Koch’s are apparently conservative. None of this has anything to do with the science or data behind the GBD. Please, refrain from Koch brother nonsense when the discussion should indeed be about science and data with great import to the wellbeing of our nation, and our fellow man.
I found another who shares my maiden name, except it is her married name.
My married name was her maiden name to make things even stranger.
(1:46:00 ish)
3:45, "Oh, man!"
TWiG! 😆
I can be a cutout from TWiV where they keep all the banter but none of the science news stuff.
If we dont now the real pathofiziological chain we can corelate with antypiretics use
You may have brought this out but I read that climate change will seriously influence viruses to thrive ,
not just cold or hot but the whole imbalance allowing viruses to go dormant then lasting longer in humans?? What do you think?
In a few days South Florida will see temperatures in the 70's. Great rational discussion on our party animal ancestors. Bless
Too much chitchat
more hobby chat requested...
I was jonesing.
lol
I’m the driveway watcher.
It's hot still here in Kuwait 85 F!
28:50 very unkind of you to say >:O
Please get on with it.
FASTINATING,, but I thought you originally taught you came from an omeba???? FASINATING....
I like the click bait. Lol
One thing that would be great is having your names and academic affiliations on your screens along with preferred pronouns.
@Jack Torrance Snow flake alert.
@Jack Torrance For gender neutrality, if applicable, i.e. they/them (when addressing a single individual) or gendered third-person pronouns, i.e. he/him or she/her.
Is this for real? I think I just became “woke” woke. If you want to protest my stance, you can. Just say your “woke woke” woke.
@@InternetOfGames Jack asked a question; so I thought I'd answer it. I didn't opine on the matter or speak on behalf of a broader community. I know their first names, too. Perhaps the commenter is new around here, or didn't listen carefully during the introductions.
@@InternetOfGames I wonder if the commenter meant titles, not pronouns.
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