I started watching last night around 10 pm. You’re hickkups gave me the giggles. You handled it all so well. I thought you were great. I had to turn it off so I could go to sleep. I’m watching twiv this evening.
Great mini lecture this evening! Wow~so interesting I never knew when my kids were very young in the 90s and had bronchiolitis that it was RSV. These are very exciting developments! We are age 65 now and got our vaccines last Fall (2023).
By the way I am watching some hours after the broadcast, for hiccups my Mom always gave us a spoon of sugar with red wine vinegar. On a recent car trip I got them and had a sugar packet, then got a lemon wedge at a McDonald's with my unweet tea, and used lemon juice w sugar and it worked!
*Summary* ## Micro TV Office Hours: Hiccups and RSV Vaccine Development (August 7, 2024) *Host:* Vincent Racaniello *Moderators:* Les, Steph, Tom, Vanity, Nutrition *Topic:* Hiccups and a mini-lecture on Respiratory Syncytial Virus (RSV) with a focus on vaccine development. *Highlights:* * *00:00:17* The host struggles with hiccups throughout the episode. * *00:03:23* Viewers share their locations and current weather conditions. * *00:05:32* The host discusses the history of RSV control strategies, including: * *00:55:12* Initial attempts to develop inactivated vaccines, which failed and led to enhanced disease in infants. * *01:01:40* Development of passive immune strategies, such as polyclonal intravenous immunoglobulins and hyperimmune immunoglobulins, which provided limited protection. * *01:02:08* The development of monoclonal antibodies, specifically palivizumab (Synagis), which have been successful in preventing severe RSV disease. * *01:06:54* Recent advancements in vaccine development, including mRNA vaccines and pre-fusion stabilized F protein vaccines. * *01:02:15* The host discusses the importance of toll-like receptors in the immune response and how formalin treatment of RSV vaccines disrupted their ability to stimulate these receptors. * *01:14:30* The host answers viewer questions about topics such as: * *01:14:30* The current status of HIV vaccine development. * *01:16:24* The increase in tuberculosis cases after the COVID-19 pandemic. * *01:20:18* The timing of infant vaccination in relation to breastfeeding. * *01:32:48* The efficacy of flu vaccines and the process of selecting strains for annual vaccines. * *01:03:06* The role of monoclonal antibodies in treating diseases. * *01:26:16* The development of a personalized mRNA vaccine for pancreatic cancer. * *01:57:37* The importance of communicating accurate information about vaccines to combat hesitancy. * *02:00:56* The host mentions a previous Twiv episode about a case of brainworm acquired from eating bear burgers. * *01:06:29* The host shares his experience attending a Twiv at MedImmune, the company that developed palivizumab. * *01:54:41* The host discusses the importance of science communication and encourages viewers to support Micro TV. * *02:07:01* The host thanks the moderators and viewers for their participation. *Upcoming Office Hours:* * *Date:* August 14, 2024 * *Time:* 8:00 PM Eastern * *Potential Guests:* Dixon and Dr. De Pomier I used Google Gemini 1.5 Flash to summarize the transcript. Cost (if I didn't use the free tier): $0.0172 Time: 180.88 seconds I added a 60 second delay to prevent a rate limit of the free tier. Input tokens: 224875 Output tokens: 1162
RE: my question about the role of interferon, I'm still quite confused. Medcram did a video on it on 2024-02-24. High levels good during acute phase but bad long term. Defies logic!!!
No need to be sorry Vincent, I learn so much from you and your colleagues. We usually have success with using a paper bag for eliminating hiccups. Try it the next time.
laughing used to make an ex hiccup or if she got nervous she would hiccup so she had a hell of a time not telling truth cuz she would hiccup upon interrogation , go figure she has a really square honest life.
All the best from Brampton Ontario Canada.
I started watching last night around 10 pm. You’re hickkups gave me the giggles. You handled it all so well. I thought you were great. I had to turn it off so I could go to sleep. I’m watching twiv this evening.
Re: RFK Jr 'confession' of dumping a dead bear in the park: The best response comment I've seen from George Conway:
"Right to arm bears"
Virology starts at 42.45
My sure fire way to stop hiccups is holding your breath for about a minute. If you feel a spasm or two, it'll calm down the hiccups.
Another listener Yueqing from Changsha! I'm not alone haha!!!
Great mini lecture this evening! Wow~so interesting I never knew when my kids were very young in the 90s and had bronchiolitis that it was RSV. These are very exciting developments! We are age 65 now and got our vaccines last Fall (2023).
By the way I am watching some hours after the broadcast, for hiccups my Mom always gave us a spoon of sugar with red wine vinegar. On a recent car trip I got them and had a sugar packet, then got a lemon wedge at a McDonald's with my unweet tea, and used lemon juice w sugar and it worked!
*Summary*
## Micro TV Office Hours: Hiccups and RSV Vaccine Development (August 7, 2024)
*Host:* Vincent Racaniello
*Moderators:* Les, Steph, Tom, Vanity, Nutrition
*Topic:* Hiccups and a mini-lecture on Respiratory Syncytial Virus (RSV) with a focus on vaccine development.
*Highlights:*
* *00:00:17* The host struggles with hiccups throughout the episode.
* *00:03:23* Viewers share their locations and current weather conditions.
* *00:05:32* The host discusses the history of RSV control strategies, including:
* *00:55:12* Initial attempts to develop inactivated vaccines, which failed and led to enhanced disease in infants.
* *01:01:40* Development of passive immune strategies, such as polyclonal intravenous immunoglobulins and hyperimmune immunoglobulins, which provided limited protection.
* *01:02:08* The development of monoclonal antibodies, specifically palivizumab (Synagis), which have been successful in preventing severe RSV disease.
* *01:06:54* Recent advancements in vaccine development, including mRNA vaccines and pre-fusion stabilized F protein vaccines.
* *01:02:15* The host discusses the importance of toll-like receptors in the immune response and how formalin treatment of RSV vaccines disrupted their ability to stimulate these receptors.
* *01:14:30* The host answers viewer questions about topics such as:
* *01:14:30* The current status of HIV vaccine development.
* *01:16:24* The increase in tuberculosis cases after the COVID-19 pandemic.
* *01:20:18* The timing of infant vaccination in relation to breastfeeding.
* *01:32:48* The efficacy of flu vaccines and the process of selecting strains for annual vaccines.
* *01:03:06* The role of monoclonal antibodies in treating diseases.
* *01:26:16* The development of a personalized mRNA vaccine for pancreatic cancer.
* *01:57:37* The importance of communicating accurate information about vaccines to combat hesitancy.
* *02:00:56* The host mentions a previous Twiv episode about a case of brainworm acquired from eating bear burgers.
* *01:06:29* The host shares his experience attending a Twiv at MedImmune, the company that developed palivizumab.
* *01:54:41* The host discusses the importance of science communication and encourages viewers to support Micro TV.
* *02:07:01* The host thanks the moderators and viewers for their participation.
*Upcoming Office Hours:*
* *Date:* August 14, 2024
* *Time:* 8:00 PM Eastern
* *Potential Guests:* Dixon and Dr. De Pomier
I used Google Gemini 1.5 Flash to summarize the transcript.
Cost (if I didn't use the free tier): $0.0172
Time: 180.88 seconds
I added a 60 second delay to prevent a rate limit of the free tier.
Input tokens: 224875
Output tokens: 1162
Some live commenters should have given a drumroll and announced your next hiccup. It seldom fails to stop them!
RE: my question about the role of interferon, I'm still quite confused.
Medcram did a video on it on 2024-02-24.
High levels good during acute phase but bad long term. Defies logic!!!
No need to be sorry Vincent, I learn so much from you and your colleagues. We usually have success with using a paper bag for eliminating hiccups. Try it the next time.
laughing used to make an ex hiccup or if she got nervous she would hiccup so she had a hell of a time not telling truth cuz she would hiccup upon interrogation , go figure she has a really square honest life.
Wil LAM ette Valley
High levels good during acute phase but bad long term... very interesting comment....
Botulism is in honey