Frederick Sanger: The Quest for DNA Sequencing
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- เผยแพร่เมื่อ 26 ก.ค. 2024
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Credits:
Host - Simon Whistler
Author - Chase Kiddy
Producer - Jennifer Da Silva
Executive Producer - Shell Harris
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Check out Brilliant: brilliant.org/biographics
But again he believed his lacking comic delivery bring it back home please....
I am studying tatter totts 23 years soon I will give more then Simon fakes and b feeding less than imaged. OK think I've made my pointed critical observation
Please talk about Jules Brunett, Saigo Takamori, Yasuke or Newton Knight :)
would you consider doing a Bio on Huey Long. the Bernie Sanders of the 1930's.
Can we get Deborah Sampson on Biographics?
I genuinely felt your admiration for him.
This is one of those rare Biographics where I am personally thankful to the man in question. A number of medical conditions I suffer have been made a great deal less burdensome, indeed survivable, thanks to Dr. Sanger and his work. There's something truly humbling about someone who's saved your life a few times over, and yet declines the offer of a knighthood.
Man, this is why I watch this channel. Great video, really showcases what an excellent person Sanger was. He's the best of us.
Your voice has a musical quality to it when you talk like this. I just tuned my guitar to it!
What an amazing life, belonging to an amazing man.
Scientific research is one of the most exciting and rewarding of occupations.
-Frederick Sanger
Too bad in modern academia researchers (especially ph.ds and post docs) are used for slave labor to push poorly peer reviewed and straight up unfinished papers in order to please publishers and to be able to secure the grants they need. Oh and my condolences if you are a lab assistant. Hope you dont mind doing barely minimum wage after years of higher education
We had our lego sets... Sanger had his proteins and nucleotides...
Also Simon it's Sanger's REAGENT, it very much sounded like you said 'Sanger's regent'.
Well dont worry....im sure your sharp as a tack at whatever it is YOU do....(not my words)
In the 1990's I worked as a secretary in the human resources department of a biopharmaceutical corporation that used the human DNA sequence to develop protein and antibody drugs. While I wasn't working in any of the labs, I had the opportunity to learn about the history of the work and how these discoveries meant new, innovative treatments for diseases. Thanks for rekindling those wonderful memories!
That sounds like a cool job
Well this video was basically my entire first semester of molecular biology (my degree is in biochemistry)
@Biographics, I’d love to see a video about Roslind Franklin, the scientist whose data Watson and Crick stole and used in their discovery of the structure of DNA.
Exactly! Love her!
Rosalind Franklin is my hero and she was screwed over! Simon had better do a bio on her as Sanger wouldn't have been known without her work.
"If we all sat down with a goal in mind and messed about till we got it right, what might we accomplish?"
I don't know about the rest of you, but I'm making great progress on my dream to be a full-time writer, so there's that.
Please do videos about the following people:
1. Dennis Rader
2. Jack London
3. Upton Sinclair
4. Jack Ketchum
5. Jane Austen
6. Anton LaVey
Jane Austen?
That's Mercury's ex, right?
When I first read Dennis I thought it would say Dennis Prager
Full-time? Who will go for groceries? Scrub the bathtub? Separate the recyclables and compostibles? I recommend no more than 13 hours a day. Writers write, therefore can say, accurately, "I am a writer" - you are allowed to say that out loud to other humans. The first time I made that very statement put loud I realized that I had "crossed the border". The secret to writing (besides pens, pencils, paper, keyboards grammar, spelling, making up better words) is, hold on to something - write every day. Ten minutes, ten hours, it doesn't matter. What matters is the "everyday no matter what" mindset manifest in the physical act of writing...everyday. Also find a platform that allows for feedback (for contemplation, not arguments) and keep on growing. I know some writers who keep going back to their favorite works over and over. Living death to a writer. I have, literally seventeen hundred songs (one-third very good) as a reference source, in a cardboard box. I also like William Burrough's "cut-and-paste technique" just to keep things hopping, especially if you are a John Lennon fan. I am a writer. Get used to saying that bit with authority. Some folk may disagree, that's not a problem. Be well and fer crissakes have fun.
Impressive, good on ya sir!
Its videos like these that i just eat up. I knew of Sanger and heard his name but knew basically nothing about him, and this obviously taught me everything i needed to know about him.
Honestly, calling him a Titan of Science doesnt do him justice, maybe Father of the Human Genome does but man, this man was a legend.
Love the puns in your show. Dude is a Quaker so things quake 😭
At around 17:15
I learn more from this channel than doing online school
This is one of the most inspiring stories ever told.
I note all the many deserving contenders suggested/submitted below that quite rightly definitely deserve some kind of merit . Though I reckon Sir Peter Mansfield English Physicist, winner of Nobel peace prize and amongst many other things inventor of the MRI machine (my father in-law did some work for him when he was designing and constructing this innovative machine, he said he was such an unassuming and humble guy), I think he definitely deserves some kind of accolade and acknowledgment from your many viewers and subscribers, at least for what he has also contributed to the wellbeing of others, just to think of how many peoples lives that Peter must have been instrumental in saving over the years is simply quite staggering.
This was so inspiring. Thank you!
I really enjoyed this. Really felt joy because of it. Thank you!
Do a biographics on Leonhard Euler please.
Simon seems an easy go
This was a great one. I thoroughly enjoyed watching this video. Keep up the great work guys💖👍
As a biotech student, I loved this video! If you decide to do more videos about 20th century biologists (you should!) I suggest Linus Pauling, Kary Mullis (who said that he had the idea for PCR while tripping on acid), Esther Lederberg, or Salvador Luria.
Isn't it amazing what a person can accomplish by devoting what time they want at a steady pace.
This is the kind of work model that works for a number of people
Excellent finish.
Could you please cover Kary mullis a very interesting and eccentric scientist
Thank you
Thank you for presenting the life of such an inspirational man.
Hey i love your stuff could u do an episode on the Pinkerton's
Love your videos!! Can you do more videos on women or ancient people?
How does this video not have more views. It’s awesome
Great channel! You should do videos on:
Hannah Szenes, a poet and Jewish SOE member who parachuted into Yugoslavia during WWII
Irena Sendler, a Righteous Gentile who worked with the Polish Underground Resistance in WWII in German-occupied Poland and who saved hundreds of children
Henrietta Swan Leavitt, the woman who figured out the Period-Luminosity Relationship and essentially how we can measure distances in space
I'm so excited to see a Biographics episode on a great scientist like Sanger! Sanger Sequencing is so important in the bio industry! p.s. Would love to maybe see the human genome project on Megaprojects in the future ;D
Hello I appreciate your efforts and I followed this channel more than 6 months and especially in this tough time
So can you please talk about Le Chevalier D'eon soon I want to know more about him and good job as always and good luck
I generally like your video's a lot, you just missed the mark with the explanation of sanger sequencing. The ddNTP does not peal anything off. A ddNTP hinders a DNA strain from being replicated further by blocking the DNA polymerase at that site. By mixing normal dNTP's and ddNTP's (one for each aminoacid A, T, C, G) the reaction is stopped randomly. By then analysing the length of each DNA string and arranging them it can be descerned for each position if a A, T, G, or C is incoorperated
You really sold the beauty of sanger sequencing short. The rest of the video was great though.
Very nice
Wow. So interesting
Could you please do Shaka Zulu!
Justice for Rosalind Franklin!!!😂😂😂
Liking the recent science focus on this channel
1:25 - Chapter 1 - Meet the fredericks
4:05 - Chapter 2 - Books, bombs and biochemistry
10:50 - Mid roll ads
12:10 - Chapter 3 - The 1st Nobel
17:15 - Chapter 4 - The molecular revolution
23:00 - Chapter 5 - Messing about
Could you please do a bio on Ip Man? Thank you :)
Simon - hello, I have also suffered the name of Simon my whole life, didn’t chose it, wanted to be a Brian really on reflection - but hey - why not a BIO of Simon - you not me
You should do some of those novel prize winners
Would love to see a biography video on - Stanley Kubrick
Werhner Von Braun, next video plz Simon
How about a vid about Joseph Needham?
Nice
They are solving decades old murders now thanks to his work. Good video. D
Wow! I wish he could see the progress of DNA now.
the war music was so damn dramatic holy wow
Emphasizes that monetary freedom is very important for Discovery.. the other side of the spectrum is Douglas Prasher.. he was deserted by the system and was overlooked for the 2008 Noble prize.. he did chauffeuring for his everyday survival while others worked on his foundation and won the Nobel for green fluorescent protein.. no, not everyone can be as lucky to be playing around in a lab
That sucks!!
@@danielhogan6255 yup.. was lucky to get in touch with Dr.Prasher.. he had a word of wisdom.. "work smart"
Upgrade advice: at the end of the episode do a quick recap, so we can remember the person better
As a nurse, this video has genuinely inspired me to push the boundary to contribute more to society.
Be a whistleblower 😉
Please do one on the Puertorican Revolutionary figure, Pedro Albizu campos!
Could you please do Linus Pauling.
Excellent video. Richard Feynman (Physics Nobel Laureate 1965) would be a very interesting video.
I think a video on James Watson/Francis Crick should come next.
How about an episode about Howard Stern?
Could you do Enver Hoxha?
This dude and I have very similar approaches to things. Pick it up. Play with it. See what you can do with it.
And the Sanger method is still in use today for schort sequences despite being very slow (compared with more modern methods) because its cheap, simple, and reliable good job fod a guy messing around in a lab😜
I love science!!
Friedman spent one year in Cambridge in a career spanning many years. If anyone can lay claim to him, it's University of Chicago. Hence why he is regarded as an influential member of the Chicago School.
Crick and Watson wrongly earned their prizes as they stole the discovery from Rosalind Franklin who had done a very large percentage of the work. They then went on to rubbish her after she died of cancer caused by her work with X-Rays.
"If we all sat down with a goal in mind and..... messed about - what could we accomplish?"
AW LAWD SAVE ME!!
Enjoyment = the basis of productivity
Will you all at Biographics do an episode on the Dalia Lama?
8:56 Talks about the outbreak of World War 2. Shows newspaper about the outbreak of World War 1...
Joe Exotic needs a biographic!
Ahh.. so he is responsible for a good part of my college misery and fun 😂😂.
I’m from South Africa. Would you please do a video on Shaka Zulu, that would be really great hey
If you haven't already then Dianne Fossey would be an amazing biography, also Jane Goodall. more scientists please! 👍
I don't think Simon Whistler sleeps. Or he is the most brilliant somnambulist entertainer ever.
Do Albert hofmann
I know science isn't as sexy as war but thanks for this
I think you used the wrong picture for GB declaration of war. It was WW1 instead of WW2
What about Sir Francis Collins?
You need to do captain Tom moore one day or Anton Chekhov
Double the helix, double the Nobel Prizes.😎
So weird to see Simon being 'touching' lolol
How exactly did you break down an amino acid with chromatography? I think you mean he separated a mixture of amino acids using chromatography. (I’m an analytical chemistry masters student who specializes in chromatography and mass spec)
Please Please Please Please! Do the following
-Leonid Brezhnev
-Emperor Meiji
-Kaiser Wilhelm I
-Karl Dönitz
-Carl Gustaf Emil Mannheim
Suggestions for Biographics, Stan Lee, Krishnamurti the astrologer creator of Krishnamurti Padhati Jyotish Sidereal Astrology , two people intrinsically linked to Eugenics Margaret Sanger founder of Planned parenthood , Sir Francis Galton who couined the term Eugenics and wrote the books that first inspired the Eugenics out of which came Genetics , Robert Malthus first major proponent of Population Control , Phil Jackson winningest coach of Championships in NBA history , the Koch brothers particularly the one who passed away recently. John Henrik Clarke the blind historian, And Ra Un Nefer Amen I prodigious author of many subjects ( probably the most prolific writer on occult practices in history. ) and founder of the Ausar Auset Society International whom many consider a Sage or Avatar. Also for your other channel Slave Breeding in western world. The documentary MAAFA 21 is good source to start for Eugenics movement. Goodbye Uncle Tom has sequence at the end of the Movie that gives a visual representation of what Slave Breeding plantations were like. There are alot of good resources for it all over the internet. Check out book on it by the name of Slave Breeding plantations. Also Slavery in Brazil and the United States book will help with that as well.
Stan Lee has been done already...a little more then a year ago.
Do mother teresa, padre pio
Some people are just smart
Geniuses always start out just messing about with things... :)
"Gloster"
Reagent - "RE- AGENT"
Its nice to hear of someone so persistent and globally affecting actually getting to live a full life. You know, unlike normal where they're either dying of some shitty disease or just offing themselves.
ATTENTION BIOGRAPHICS TEAM: Please do a show on Tupac Shakur. I think it would be great
Define "final" member of the multiple Nobel Club? Is that because no one else has earned a second or is that because they've decided to no longer award multiple Nobels?
I have a graduate degree in chemistry, but I almost never hear Sanger's name. Then again I do physical chemistry not biochemistry
Bro your information material is phenomenal, but Business Blaze has me conflicted. Both with the tone and seeing your face.
His idea made 73K experiments work? I bet he's the AI in this simulation. Also, Simon...... I hope you know Watson and Crick were copiers......
grace o malley.
Please tell Me Simon has stopped rifting his lacking banda bom bang boom keep it to the blaze
Watson and Crick stole the data from their aid, who wasn't credited because their aid was a woman. Watson and Crick wouldn't have gotten anywhere without her, and Sanger wouldn't have gotten anywhere without their stolen work. Rosalind Franklin deserves the credit she had stolen, and Watson and Crick need to be taken down a few pegs. Do a video on her - the true person behind the discovery of the structure of DNA, and who made much of Sanger's work possible.
Could you do your biography?
What part of no do you not understand you pathetic trolll?
Do Eva Braun she is a interesting theme
A sanger is a sandwich in Australia
Are we unpersoning James D. Watson?