This is the comment and thread I came for but we’re the only ones that get it because we saw that video of the ex waiting affiliate that did the ween stage dive off his balcony but he still has a nice shaft even though they didn’t replace the rest right. That’s the joke right yinz aren’t actually talking to the cutlery again right? 😅
@@gonelucid having done pcp and datura, i can confirm that datura creates horror delirium and voices. pcp is a perfectly good drug when used responsibly, but demonised due to prohibitionist racism of the 70s and 80s.
The voiceover of you saying: "It wasn't an issue and the condenser kept everything inside" while we can see a column of liquid rising in the liebig condenser was extremely funny. We really like to play down near-misses on accidents.
@@gutschke if the reaction doesn't include any acidic workup you don't produce it (luckily 😂) I'm really surprised he just mentioned the production of HCN without saying anything more 😂😂
I can still remember watching myself, from the street corner, riding a bike, while riding a bike and watching myself on the street corner..... Don't smoke angel dust, kids..
I remember lifting my knee up to my ear to step up on a sidewalk, because I'm it felt like I was only 6 inches tall. Then somewhere before my foot touched the sidewalk, I became 50 feet tall and almost fell down from dropping my foot that far. Angel dust is definitely a terrible drug. And I generally love drugs.
@@RevShifty I found it quite pleasurable, I experienced a similar "scaling" effect. I would reach out with my hand and it would suddenly be like 50ft long, and bring it back to my side and it would almost feel like it was gone. The feeling was very "buzzy", there is a quote from someone I don't remember, describing the experience of a newborn as "blooming buzzing confusion", and this is quite apt to the experience of PCP.
This is some groundbreaking shit in terms of youtube chemistry, love to see it and also that you explain your mistakes so us chemists can learn from them and not make them ourselves
Nah, I'm still waiting for the Hexanitrobenzene or even an Octanitrocubane synth (yes, I know heptanitrocubane is believed to be more practical, but it's all about the symmetry). That's where the real watchers of lists lie...
it doesn't matter to me what losers are watch, then again I don't jerk off, watch porn or do anything bad, or to be embarrassed of. they can put cams in every room even my bathroom.
Eh, it's not currently scheduled, and is sold as a designer drug, or research chemical as it's actually known in the scene of people who buy these chemicals(including me). So it's in a sort of legal gray area, and is only illegal if sold for human consumption. So legal if being produced, and marketed for research and analytical purposes only.
I typically use the "dissolve the NaOH in H2O first" trick exactly because of situations like this. Even finely-prilled NaOH takes forever to dissolve and change the pH of a solution.
It's the only way a lot of the time, but when you're doing a liquid-liquid extraction after it really sucks to double the volume. Especially when the freebase is freely soluble in water
I know when mixing insoluble powders with liquids (cocoa powder + soy milk) I add a very small amount of liquid to the powder initially to wet it so it does not clump up (then I add the rest of the liquid). In your case I say use a pre-made solution of base since the base is soluble. I assume your base clumped up and got coated with something that prevented mixing.
When I (didn't) do it, I used potassium cyanide to form the nitrile intermediate instead of the sulfate. I'm guessing using morpholine, you have to form the sulfate first? The phenyl grignard reacts directly with the nitrile to give you your product arylcyclohexylamine, if you use piperidine. The first sulfonation step wasn't necessary for that.
Going through the bisulfite adduct allows you to avoid generating stoichiometric HCN with strong acid during cyanohydrin formation, which is a major hazard since HCN boils at 26 °C and would be fuming invisibly from the reaction mixture. The bisulfite adduct forms a small amount of the ketone through its equilibrium and the bisulfite ion acts as a mild acid to form small amounts of HCN over time and/or protonate the final cyanohydrin. Small amounts of carbonyl and HCN means few side reactions and minimal poisonous gas generation.
@@geordifrere with piperidine, you don't use a solvent. You add cyclohenanone and piperidine neat, then add stoichometric KCN. The entire thing solidifies into the nitrite intermediate.
You've not seen the high explosives and the primaries being synthesized, yet? Brother... You've SO many watch lists to add yourself to, these days! It's fukn amazing! 🤓
awesome video, this was informative and quite funny that you could skirt regulations just enough to post this. I am just curious why you chose this route? as opposed to higher yielding cyanide free methods using para toluene sulfonic acid and azeotropic separation of water, do you not own a dean stark trap?
@Ren-xl1sq I wouldn't worry about it too, too much, if I were you. He's still just as strongly outclassed in the talent department. *edit for clarification* When I say outclassed, I'm talking about Lewis, of course, not Morris.
Yeah I'd assume most people don't even know how many and how popular analogues of PCP are. I get the click bait but somehow only with all the 3-meo-pcp, pco, o-pce 3-ho-pcp etc. The claims of "crazy powder never came back" Still it's great people learn about this, a shocking amount of people have never heard of a dissociative drug in their life.
@@billyhendry8369 yeah fs, pcp (and most dissociative hallucinogens) have this huge myth status of making you violent and insane, when most people who have gotten into states of delerium are mainly overdoses. Hell even ket i see people freak out about because its used as horse tranq. Dissos are such an interesting class of drug and arylcyclohexanone chemistry content is kind of obscure to come by and its pretty neat seeing them be brought out like this
@@bigboi9856 O-PCE is the best. But It wasn't as strong as you describe (at least for me). It did last for up to 10 hours though. And 10mg was a nice dose that made me slightly manic (or rather unnaturally happy and extraverted). It also doesn't really impair my motor control as much as other arylcyclohexylamines so thats convenient aswell. Deschloroketamine fucks with your motor control on an insane level for example.
I happen to run a shop that has a lot of ex-convicts, and I get to see all their criminal records. Though PCP may not be nearly as prevalent as meth which causes many more problems due to how common it is, PCP easily takes first place for "most likely to cause a violent crime". It's disproportionate, really. Terrible drug.
From an average person's perspective, it simultaneously looks like suffering and like some sort of dark magic. I actually appreciate that you post videos even though it's not a complete success.
How many legal amphetamine-like substances exist? Unfortunately where I live they have created blanket laws that ban substances the lawmakers have never even seen or heard of. The drug analogue act. It is draconian and hinders more than it helps. Of course.
@@Brice23 It's actually only been employed here in the US less than 5 times. The federal analogue act does not ban as many substances as you would imagine. I am not going to name the chemicals, but oh boy are they there. It is not illegal as long as it is for research purposes. homologous to Phenmetrazine is all I'll say.
It's not surprising that you had the problem with the base not dissolving. It makes a basic solution immediately around it which causes the product to precipitate onto it. Next time, dissolve the base before adding it and you won't have that issue
"Coz it's trash" Yeah it really is. A very solid analogoue for ketamine in 4-MEO PCP. Same dissociative anesthetic effects, but has a much longer effect with greater chance of hallucinogenic effects. It is very difficult to be mobile once ingested, which isn't great if one has anything to do for about eight hours
I’ve never liked people referring to psychedelics or dissociatives as “psychotomimetic.” Veeery early on in their discovery, some scientists did kind of dismissively assume “Oh, LSD is altering your consciousness in this extremely complex & hard to characterize way… This must be what it’s like to experience psychosis!” But this is a profound mischaracterization, which is why (at least for most 5HT2a receptor agonists), it’s largely been dropped as we’ve come to understand both psychotic mental illness AND psychedelics better. The fact that people are still inclined to talk about PCP this way probably has more to do with media sensationalism than anything (though I’ve never done PCP & can’t say for sure)- from what I’ve heard it’s really just more stimulating than other dissociatives & therefore not suitable as a tranquilizer/anaesthetic. Beyond that difference… Like, sure, there are people who freak out & have mishaps on it, & I’m not saying people necessarily should be using it, but people freak out & have mishaps on too high a dose of all kinds of things. That doesn’t necessarily mean it was truly comparable to psychosis. I think psychotomimetic is a perfectly reasonable label for deliriants, & really that they’re the class which should’ve been labeled this way from the beginning… Completely hallucinating whole scenarios/people/conversations/animals/shadow people/etc. that aren’t there; hearing schizophrenia-like voices in your head; extreme fear/paranoia; extreme confusion & disorientation/disconnection from reality… These are the very psychosis-like symptoms of deliriant poisoning, or having intentionally taken Amanita Muscaria mushrooms, or diphenhydramine, or whatever- terrifying, awful, nightmarish stuff which I strongly suspect TRULY comes as close to simulating what a psychotic condition like schizophrenia as any chemical can induce… There’s not much else to it- those are the primary effects. You JUST feel like you’re losing your mind & living in a waking nightmare. On the other hand, dissociatives have considerably more interesting content to them, & far fewer of the truly psychosis-like symptoms. I’ve rarely heard or someone taking ketamine, or MXE, or DXM, or even PCP & legitimately hearing terrifying whispering or screaming in their head for hours they they just couldn’t shake off (whereas I’ve heard of people taking Amanita Muscaria extract 1 time in not that high of a dose & experiencing those kinds of symptoms for DAYS or WEEKS afterwards). You don’t have true hallucinations or dissociatives… You may have beautiful closed eye visuals, but that’s quite different from a nightmarish waking dream state where you literally don’t know what’s real & what’s not. I’d place dissociatives more as a middle-ground, because they do have a tendency to induce some delusions (usually just during the experience, which is why the issues mainly come about in cases of addiction/dependency, where someone is taking them all the time & never getting a breath of air from that state & assessing their experiences from a more lucid, rational perspective). Classical 5HT2a agonist psychedelics, IMO, are the farthest from “psychotomimetic” of any of these. I think it really was just ignorance that led to this labeling for LSD & psilocybin & the like early on; keep in mind that it was being applied so early on that we were only just even learning that serotonin had anything to do with mood/behavior- in the very earliest days of the discovery of LSD & it’s effects. It’s very much a vestige of an impoverished earlier state of psychopharmacological & psychiatric research. The effects induced by psychedelics like these may seem very chaotic & overwhelming, especially to the uninitiated, to someone who didn’t know what they were getting themselves into, or to someone who takes an excessive dose for their first time & plunges in deeper than they’re ready for… But upon the kind of deeper inspection that mystics & shamans have been giving these experiences/states for ages, & the kind that psychedelic scientists & “psychonauts” have more recently devoted themselves to, there’s actually a profound & beautiful order to that chaos; the fact that it’s unpredictable & too complex for our minds to easily put in a box, to reduce & identify with some very simple pattern or experience we’re familiar with, doesn’t mean that it’s actually untethered from reality or random or meaningless or in any way equivalent to symptoms of psychosis. And especially as classical psychedelic doses increase (besides n,n-DMT, which seems to go in exactly the opposite direction), you move towards boundary dissolution & ultimately full ego-death & mystical experience… Which is quite wildly different from any kind of psychosis. There’s really no comparison. If anything I think it romanticizes psychosis to compare it to something as favorable as psychedelic experience. Even in the fringe cases where someone has a predisposition to mental illness & psychedelics catalyzed the precipitation of a psychotic state, the psychosis it precipitates is going to be very different from the psychedelic state itself.
@@QuinazolinkingIt is an important distinction to be made, that most hallucinogens do not meet the classical definition of psychomimetic, "producing effects (as hallucinations or paranoid delusions) that resemble or are identical with psychotic symptoms," specifically the psychotic symptoms part.
Great info! I have schizoaffective disorder. Used to get real gnarly voices constantly. Very disturbing and bothersome. During IV ketamine therapy, no voices whatsoever. No more depression. Neurogenesis from activating glutamate is the way in my case. I also was put on an atypical antipsychotic that activates 5HT1a receptors and is a dopamine agonist. No voices for months now. The manufacturer doesn’t know exactly how it works, because from what my doctor step mom says, chemicals produced by the brain have so many roles that they are still discovering. Mushrooms are a joy. Never had a bad trip. I don’t do them often though. Not for everyone, of course. Some minds just can’t handle it, whereas mine relaxes.
Took a solid LSD dose one time and I genuinely thought I had triggered a psychotic episode because of the psychotomimetic misinformation. I was pretty familiar with hallucinogens to begin with so I just held on until it started wearing off.
The medicinal chemistry stuff is extremely interesting! Keep it up! Did you keep the aqueous layer from that neutral solution at the end? If so you easily could have remedied the error, and included the result in the video. All well. Is 5-MeO-MiPT controlled in the Netherlands? If not, that could be an interesting project. You could start from melatonin by conversion into 5-MeO-Tryptamine. Then reductive alkylation with one molar equivalent of acetone, and an excess of STAB-H (prepared ex-situ from borohydride, and 3 equivalents AcOH in THF, or DCE). Followed by the reductive alkylation with sodium hydroxymethylsulfinate, excess Et3N, and STAB-H under similar conditions. Both reductive alkylation reactions can be conducted in a one-pot operation. I think doing these reactions in that order is absolutely necessary to avoid formation of the dimethyl substituted product due to the steric bulk of the isopropyl group. For the same reason, the formation of the diisopropyl product by a second reductive alkylation is unlikely to occur. Furthermore, while this compound is certainly active, I don’t think 5-MeO-MiPT has much value recreationally. If I’m wrong the use of succinaldehyde to give 5-Methoxy-N,N-tetramethylenetryptamine (5-MeO-pyrrolidyltryptamine) would be an interesting alternative. The methoxy group could also be swapped for an ethoxy, or similar group by starting with 5-hydroxytryptophan. Thus, decarboxylation to serotonin, protection of the amino group as an amide (or carbamate), Williamson ether synthesis to give the desired alkoxy group, deprotection, and finally the reductive alkylation sequence would give the desired analog. This gives a large degree of freedom to design a compound that is certainly inactive. For example, 5-Propoxy-Pyrrolidyltryptamine; there’s no way that is active, so it could make for a cool project without legal worries.
Great video and synthesis! Love the content of making compounds of interest :) while casually making HCN as byproduct Just a few notes: - 4:55 Arrow to oxygen atom is redundant since lone el. pair moves to sulfur atom and is not conjugated with S-O pi bond system. - 5:06 Resonance not equilibrium (both structures describe the same molecule). Resonance arrow should be used instead. Congratz on 100k!!
A guy I went to HS with in the 1970's that never did anything but drink decided to try "drugs" by doing a big line of PCP. I remember being at that party but left before anything f ed up happened. Somehow he got home that night and was freaking out and his parents called the rescue, but two cops showed up also. He was trying to fight the cops and from what they said he tried to grab one's gun. (Back then the cops weren't psycho like they are now). He ended up in a locked ward in a mental hospital for about a week. He told me he went nuts when he was at home in his room and the giant mice attacked him
My cousin has a good friend from new orleans who did sherm for a little while...until a girl he did it with in his friend group while they hung out outside decided to climb a lightpole nude, and sat on the bulb part for so long it fused to her hoo-hah. Fire department had to uh...get kinda rough to unattach her. He never smoked sherm again after seeing that.
@@lysy-zn2gg I know, WTF was he thinking? He didn't even smoke weed. He did drink a lot of beer though. He must have been drunk as Sh*t and figured YOLO or something. I do remember him doing some crazy impulsive stuff though. One time we were in his Camaro and he was doing like 60 and threw it in reverse. F ed shit up bad, I had to tow him home with my pickup. I asked him why he did it, and he just said "To see what would happen"
ive smoked loads of PCP, and ive never had what is called a "whack attack" but ive seen people freak the fuck out, strip naked, get hit with stun guns with no effect, ive seen people walk into traffic. they were indeed having a "whack attack" but every time ive had it i just felt really good, really high. kind of like a mixture of THC, nitrus oxide, and opiates. thats probably why its so addictive and why people keep doing it regardless of how crazy it makes them act. i think some people dont have the brain chemistry to handle the stuff because some people dont act any different and some people loose their minds.
Yeah I never had these crazy hallucinations people described when I smoked dippers. Worst thing I did was call my mom and asked her to pick me up when I was in a blackout. Perhaps having experience with psychedelics helps.
@@ZoruaZorroark Yeah I would be. But I am also really asking you. What do you mean with those messages exactly. How and where do they appear? And what do they say? Because you even mentions Google, do you mean in the search engine Google or something else? There is a lot of things "Google". For him it seems he would go on unhinged rants so bad, that he claimed staff of TH-cam would contact him by sending him emails to talk to him about getting help. And considering how TH-cams "moderation" seem to be just an AI bot censoring things. Up until straight up banning your whole life as in Google accounts, if you go too far of the rails. This whole "getting contacted" and it does not happen to anyone else. Seem to me to very possible be connected to schizo delusions in his case. But if it really does in happen in reality, I am very curious how and where it happens and after what kind of interaction you did? And just to be clear, me saying that it does not happen to anyone else. Does not mean it is not happening. I can not know that, but I just know about one other case, and now two with you, reported instance of something like that happening. And you know about the other guys problem. And you are saying this on a video about dissociative substances, so am sure you get why I could suspect and have a reasonable suspicion that it could be that it is a delusion in your case also. We all know how wonky things can get for people who have an affinity for dissociatives. Because most seem to have the reverse problem, that getting any sort of interaction or "support" from TH-cam or Google seems to be impossible. Even many channels with millions of subs can't get a any support from a human for example. I just comment a lot and have been in lots of discussions on this plattform about various intricacies on how the limitations works on the comment system we have here. Personally I would find it kind of nice if there really is humans that care enough, to ask us to get help if we need it. But I am afraid reality does not work like that. Just because it seem to be reported so exceedingly rare. And I also don't want to go around and claiming that it does not happen if it really does happen. So it would be great if you could give me more details to figure out if this mysterious contacts, from the staff overlords on TH-cam/Google really is a thing they do and how it manifests.
yes, the google search engine, and the message that i had pop up was very much a bot generated message. maybe next time i see a message like what i got on this video, i should take a snapshot and send it to you or post it on on of the myriad of message boards. chances are, i would just not bother mentioning such a message in the comments the future. sorry if i am coming off as a bumbling idiot who somehow cruised through school in this conversation on where you are legitimately attempting to understand what i have said
@@ZoruaZorroark If it is a message you get that pop up in the browser when you are just using Google to search and it happened after you clicked on some link. It is very likely some kind of spam ad for some kind of health services, the Web is filled with such things. And not Google the company trying to send you a message. Because they really don't do it like that. Although the very recently introduced a notification icon where they can send us updates in the Google search just like we have a on the TH-cam app and site. If they where to send some kind of a message I bet it would be either thorough email or to the notification thing. I had a friend who was diagnosed with schizo affective disorder. And he would see patterns and get messages from powerful people, celebrities, intuitions and companies all the time. It was all his delusions who made him think that though, he misinterpreted regular things as something much more significant than they really was and saw patterns and connections where they really was non. And he was quite disturbed. I am not saying you are that. Just that it is very unlikely that Google are sending you messages like that. But them again that have some disturbing privacy implications. If Google would be follow and spying on some of us like that. You know what the paranoid say, it is not paranoid if they actually are after you :) The closest I know they do is if you are acting to unhinged is they send you a message in TH-cam, telling you can't post messages in some time like 24 hours or a week or something. I don't remember exactly because it have never happened to me. But in some of those discussions I spoke about TH-cam comments limitations. There was a bunch who reported having gotten such messages. But no one besides that one guy said anything about get help messages. And because he said he got them to his email and you said you got them in the search site in the browser, that makes it even less likely that it is even the same thing, if it is a thing that originates from Google the company. Anyway if it happen again take a video of it with your phone and ask someone else about it to get a second opinion. Maybe it does happen....
Last extraction you could perform with dcm It nicely dissolve organic bromides But not toluene Then drying, turning back to bromide and recrystallization from EtOH That should work
KCN is well enough behaved, and acutely toxic, but not in a microscopic amount. It's not likely a chronic toxin or carcinogen, so a chemist is probably more likely to be casual handling it (with gloves) than a lot of other things. If you had a small exposure, you could just leave the room and wash up and it would clear from your body very quicklly.
This synthesis is gonna kill you before you can make it to the end, if not properly trained. Great video and great demonstration of frequent chemistry issues in a life of a synthetic chemist.
I know right actually PCP is super smooth and on top of it they were going to use PCP as a therapy drug for depression but there hasn't been enough studies on it for its long-term effects so that's why they switched to ketamine
@@Rexwizord I believe that it highly depends on the way it is administered for that to happen for what you said and it also depends on the person's genetics because everybody is different and it will affect everybody different.... Smoking it is very smooth
You're doing gods work my friend. Someone has to, that lazy A-hole must be sitting at home all day watching "The Honeymooner's," because he been MIA forever now. Or maybe he just doesn't exist. Either way good job brother, keep up the good work...✌️
"ALRIGHT TH-cam SUGGESTIONS FFS" I've given in and watched now leave me alone 😂 ah it's PCP makes sense 😆 and thanks for the info mate it was quite a decent upload 👊
Oh and I edit to say Team Ketamine all the way 😂😂.. Don't get me wrong I don't advice going crazy with it , but for real introspective insights or PTSD therapy etc it's Amazing stuff
Pcp is fun, peyote is better though, .... but you want to know a secret. You can either golden orb spiders and eat them for a strong hallucinogenic effect. I also hear some snake venom does the same If you could isolate what ever compound that it, it might be 100% legal. But as a person with schizophrenia myself please understand schizophrenia is not just hyper mania, I mean yes that's a part of it, but schizophrenia is so much more. It's a huge spectrum.
@@dmtwizard Dissociatives and traditional Psychedelics for me feel like they are on the opposite ends of the same spectrum. They are similar in a weird way but very different in general.
@@Mulmgott I agree. DXM and Ketamine for me had a lot less visuals than Psilocybin, LSD or DMT. Dissociatives are more in your head. Granted Ketamine was the most visual one
@@dmtwizard For me the most visual dissociative I have tried was Deschloroketamine. Psychedelics are hyper visual for me though. I can take 5mg of 2-CB and see fractals on my walls, hands, etc.
Ketamine is extremely interesting when you research how it acts in the brain and how it acts on deleting trauma based memories causing instant depression relief
and dont give me the argu that it should be controled thats garbage as hell, old scientifics had the same conclusions, can you say why are you studying ketamine ? If you do chimic studies can you focus on other things that making drugs pls we have a lot of schyzo maker molecules, stay focus
That hcl salt may be moisture sensitive and also amount of solvent used was also more, hence yield was less Alternate method is that you can purge hcl gas to the solvent and take amine along with that solvent in another rbf, added hcl gas purged solvent at 0 to 5C, under nitrogen and filter it under nitrogen, dry it in vaccum oven
I would check the melting point of the final product, to confirm that the precipitate you obtained is indeed PCP HCl (m.p. 233-235°C). Or just take an NMR of it.
I would have skipped adding acid, filtered out the excess magnesium, then went streight to base. You would get the cyanide back and have a cleaner pull of your free base. ❤
@@Quinazolinking Okay wow how do you even know this? I can not find the article online, I even asked chatgpt and he wasn't able to help me, do you have the link/file by any chance? Thank youuu
@@humanplace1962 It’s government property, it is not available anywhere online or to the public. There are a few copies in university libraries but you have to get very lucky to find a copy
@@humanplace1962 Google only finds the 2020 edition (at www.dea.gov/sites/default/files/2020-04/Drugs%20of%20Abuse%202020-Web%20Version-508%20compliant-4-24-20_0.pdf)...
Interesting and thanks. I recall doing a Grinyard Rx in Organic Chem Lab II, at University. Them were the days. Eventually ended up in plastics and coatings. Even had a US Patent using surfactants to cause conformational nucleation of same. Predictably increase T(g).
The result have the same aspect of almost all PCP/PCE research chemical (or NPS) you can find on the market. First time i watch someone do the synthesis of a substance i used to take ^^
Always awesome stuff man but please, pleaseeeee, the iminium is in resonance with the carbocation, It is NOT an equilibrium, please❤ Edit: You even got It right the second time cmon😂
I think they should invent a kitchen knife that doesnt whisper
Don't tell them about me...
that's funny as fuck Lmfao
This is the comment and thread I came for but we’re the only ones that get it because we saw that video of the ex waiting affiliate that did the ween stage dive off his balcony but he still has a nice shaft even though they didn’t replace the rest right. That’s the joke right yinz aren’t actually talking to the cutlery again right? 😅
@@Mailmanzkidd masha allah brother
Always anoying when the couch tells you your penis is on fire
WE'RE MAKING IT INTO THE MENTAL HOSPITAL WITH THIS ONE
Gonna hit them with the hyper mania. You can fly!
Come on , voices , we're going home !
@@kaboom4679what if they are already home 😳. They never left the walls
Dissociatives suck.
My arm is numb 3 days 3 days 3 days
Three out of four wall voices agree that PCP is the best.
I wouldn't know.
None of mine speak English , and the one that did , just up and quit without any explanation .
The 4th prefers datura
The 4th is having a bad trip and wishes he had some MDMA.
@@gonelucid having done pcp and datura, i can confirm that datura creates horror delirium and voices.
pcp is a perfectly good drug when used responsibly, but demonised due to prohibitionist racism of the 70s and 80s.
Space!
The voiceover of you saying: "It wasn't an issue and the condenser kept everything inside" while we can see a column of liquid rising in the liebig condenser was extremely funny. We really like to play down near-misses on accidents.
Yeah that's how things went in my silver fulminate synthesis. Just don't worry about spillover on a hot surface. It's fine. Everything is fine.
I mean if it ain't exploding or on fire, then your probally doing it right. (unless you want it to explode or set on fire.)
i don't know what it is in other languages but that 'uhwowowooh' every english speaker half-says, half-chuckles on surviving a near-death incident. 😂
Anyone who has played around with O chem has had the fountain of reacting chemicals at least once. 😂
I’m too impatient for Grignards and always push it to near-disaster
I dont know why i expected a taste test at the end of this
Glad I'm not the only one who thought that.
I absolutely love how this guy casually makes HCN as a biproduct and doesnt bother putting any disclaimer. Btw love your content 😘
yeah, it just makes a bit of HCN as a side product, it'll just evaporate off so no need to separate it
When you start with KCN, don't be surprised if you are making HCN...
@@gutschke if the reaction doesn't include any acidic workup you don't produce it (luckily 😂)
I'm really surprised he just mentioned the production of HCN without saying anything more 😂😂
I'm pretty sure even the layperson knows "Potassium Cyanide" means "professional in controlled environment, do not attempt at home"
@JackFrawley101 never underestimate a stupid person's lust for money
Making [REDACTED] powder, only on TH-cam!
I can still remember watching myself, from the street corner, riding a bike, while riding a bike and watching myself on the street corner..... Don't smoke angel dust, kids..
or you will watch yourself riding bikes
I remember lifting my knee up to my ear to step up on a sidewalk, because I'm it felt like I was only 6 inches tall. Then somewhere before my foot touched the sidewalk, I became 50 feet tall and almost fell down from dropping my foot that far.
Angel dust is definitely a terrible drug. And I generally love drugs.
I have had similar experience with ketamine
@@RevShifty I found it quite pleasurable, I experienced a similar "scaling" effect. I would reach out with my hand and it would suddenly be like 50ft long, and bring it back to my side and it would almost feel like it was gone. The feeling was very "buzzy", there is a quote from someone I don't remember, describing the experience of a newborn as "blooming buzzing confusion", and this is quite apt to the experience of PCP.
I didn't smoke it, I used to sniff it.
This is some groundbreaking shit in terms of youtube chemistry, love to see it and also that you explain your mistakes so us chemists can learn from them and not make them ourselves
Just seeing 3 rings arranged like that screams “I will fuck you up”
Exactly what I was thinking
How so exactly? Just curious. Always interest in chemistry but failed miserably in math and couldn't really advance anywhere meaningful in it
Quite
@@douchebagginsmctalibancock2510triangles are angry
Can you explain? Is it cus the bonds look looser than a more stable molecule?
We making it on the watchlist with this one🎉🙂↕️🗣️❗️
Nah, I'm still waiting for the Hexanitrobenzene or even an Octanitrocubane synth (yes, I know heptanitrocubane is believed to be more practical, but it's all about the symmetry).
That's where the real watchers of lists lie...
Not funny getting old already
it doesn't matter to me what losers are watch, then again I don't jerk off, watch porn or do anything bad, or to be embarrassed of. they can put cams in every room even my bathroom.
@@mortlet5180there's that Australian youtuber chemist who's been trying to make some sort of cubane for a while
Eh, it's not currently scheduled, and is sold as a designer drug, or research chemical as it's actually known in the scene of people who buy these chemicals(including me). So it's in a sort of legal gray area, and is only illegal if sold for human consumption. So legal if being produced, and marketed for research and analytical purposes only.
I typically use the "dissolve the NaOH in H2O first" trick exactly because of situations like this. Even finely-prilled NaOH takes forever to dissolve and change the pH of a solution.
It's the only way a lot of the time, but when you're doing a liquid-liquid extraction after it really sucks to double the volume. Especially when the freebase is freely soluble in water
I know when mixing insoluble powders with liquids (cocoa powder + soy milk) I add a very small amount of liquid to the powder initially to wet it so it does not clump up (then I add the rest of the liquid). In your case I say use a pre-made solution of base since the base is soluble. I assume your base clumped up and got coated with something that prevented mixing.
this is actually how I make my hot chocolate, it mixes much nicer if you make up a paste with the powder first before mixing in the rest of the milk
I watch MRE videos and everyone says the exact same thing
@@dvdossbsvskfbdvavI was concerned that you guys used soy sauce for like a solid 10 minutes because I misread the top comment.
@@dvdossbsvskfbdvavas a pastrychef , I can confirm adding 1/3 of the liquide to a powder or a thicker consistency makes it easier to emulsifiate/mix
When I (didn't) do it, I used potassium cyanide to form the nitrile intermediate instead of the sulfate. I'm guessing using morpholine, you have to form the sulfate first? The phenyl grignard reacts directly with the nitrile to give you your product arylcyclohexylamine, if you use piperidine. The first sulfonation step wasn't necessary for that.
"didn't" xD
Going through the bisulfite adduct allows you to avoid generating stoichiometric HCN with strong acid during cyanohydrin formation, which is a major hazard since HCN boils at 26 °C and would be fuming invisibly from the reaction mixture. The bisulfite adduct forms a small amount of the ketone through its equilibrium and the bisulfite ion acts as a mild acid to form small amounts of HCN over time and/or protonate the final cyanohydrin. Small amounts of carbonyl and HCN means few side reactions and minimal poisonous gas generation.
I was wondering this. Guess my comment is obsolete now
@@geordifrere with piperidine, you don't use a solvent. You add cyclohenanone and piperidine neat, then add stoichometric KCN. The entire thing solidifies into the nitrite intermediate.
Dissociative substance synthesis in a chemistry youtube channel? We're truly living a eventful decade
You've not seen the high explosives and the primaries being synthesized, yet?
Brother... You've SO many watch lists to add yourself to, these days! It's fukn amazing! 🤓
I really hope it never ends. But I'm not too sure about that. Better get them before they all get taken down 🐴
Chemiolis is truly #ourguy
@@remcovanvliet3018 u care to share any?😂
Genuinly, i dont think anyone understands him and nile red are the new wave
awesome video, this was informative and quite funny that you could skirt regulations just enough to post this. I am just curious why you chose this route? as opposed to higher yielding cyanide free methods using para toluene sulfonic acid and azeotropic separation of water, do you not own a dean stark trap?
Only because this was the original method, and to follow closest to Hamilton’s synth
@@Chemiolis Hamilton ended n7 on the quali today, Mercedes is strong now
@@Chemiolis ahh I see. what synthesis are you planning next?
@Ren-xl1sq I wouldn't worry about it too, too much, if I were you. He's still just as strongly outclassed in the talent department.
*edit for clarification* When I say outclassed, I'm talking about Lewis, of course, not Morris.
@@Chemiolisdude pls make other video of pcmo but with basic solution
You do not expect to see a full Arylcyclohexylamine synth every day on TH-cam, good shit
Yeah I'd assume most people don't even know how many and how popular analogues of PCP are.
I get the click bait but somehow only with all the 3-meo-pcp, pco, o-pce 3-ho-pcp etc. The claims of "crazy powder never came back"
Still it's great people learn about this, a shocking amount of people have never heard of a dissociative drug in their life.
@@billyhendry8369 pcplogs are absolutely the most popular rc dissos there are but personally I'll stick to k or klogs
@@billyhendry8369 yeah fs, pcp (and most dissociative hallucinogens) have this huge myth status of making you violent and insane, when most people who have gotten into states of delerium are mainly overdoses. Hell even ket i see people freak out about because its used as horse tranq. Dissos are such an interesting class of drug and arylcyclohexanone chemistry content is kind of obscure to come by and its pretty neat seeing them be brought out like this
@rockysable20 o- pce is crazy strong and lasts about 16 hours. a 10mg dose will send you to another dimension. Fun stuff
@@bigboi9856 O-PCE is the best. But It wasn't as strong as you describe (at least for me). It did last for up to 10 hours though. And 10mg was a nice dose that made me slightly manic (or rather unnaturally happy and extraverted). It also doesn't really impair my motor control as much as other arylcyclohexylamines so thats convenient aswell. Deschloroketamine fucks with your motor control on an insane level for example.
I happen to run a shop that has a lot of ex-convicts, and I get to see all their criminal records. Though PCP may not be nearly as prevalent as meth which causes many more problems due to how common it is, PCP easily takes first place for "most likely to cause a violent crime". It's disproportionate, really. Terrible drug.
Dissociatives suck, but I guess some people enjoy them
"Strength of 10 men"...
worse than meth?
I really don’t get the appeal of PCP. Everything I hear about PCP sounds like a nightmare. It’s somehow still popular in Washington, DC.
I suspect it produces an ever lasting high. They're never the same after.
From an average person's perspective, it simultaneously looks like suffering and like some sort of dark magic. I actually appreciate that you post videos even though it's not a complete success.
That succinctly describes chemistry studies :).
we all are waiting for you to make legal meth analogue
Meth is already legal and they put it in Vicks inhalers
How many legal amphetamine-like substances exist? Unfortunately where I live they have created blanket laws that ban substances the lawmakers have never even seen or heard of. The drug analogue act. It is draconian and hinders more than it helps. Of course.
Even better, pseudephrine.
idk why ppl so obesessed with meth or amph synth considering its been done to death and is boring af imo
@@Brice23 It's actually only been employed here in the US less than 5 times. The federal analogue act does not ban as many substances as you would imagine. I am not going to name the chemicals, but oh boy are they there. It is not illegal as long as it is for research purposes. homologous to Phenmetrazine is all I'll say.
Nothing quite like a good dissociative anaesthetic synthesis in the morning to begin an excellent day!!! Cheers for Chemiolis!! and for H Morris
It's not surprising that you had the problem with the base not dissolving. It makes a basic solution immediately around it which causes the product to precipitate onto it. Next time, dissolve the base before adding it and you won't have that issue
Congrats on 100k!
"Coz it's trash" Yeah it really is.
A very solid analogoue for ketamine in 4-MEO PCP. Same dissociative anesthetic effects, but has a much longer effect with greater chance of hallucinogenic effects. It is very difficult to be mobile once ingested, which isn't great if one has anything to do for about eight hours
Felt like I was on a raft in a river when really I was in a forest on solid ground. Still made it to the party but barely.
Can only find info on 3 and 4 meo PCP. Is 5 real or a typo?
@@hj-hh4gc No, you're correct. I meant to type 4. Thank you
@@deadlikedisco4726 thank God you replied cause that sounds like heaven
@@hj-hh4gc I mean, if you don't have anything to do for a day, turn off the lights, lay down, and get weird.
I’ve never liked people referring to psychedelics or dissociatives as “psychotomimetic.” Veeery early on in their discovery, some scientists did kind of dismissively assume “Oh, LSD is altering your consciousness in this extremely complex & hard to characterize way… This must be what it’s like to experience psychosis!” But this is a profound mischaracterization, which is why (at least for most 5HT2a receptor agonists), it’s largely been dropped as we’ve come to understand both psychotic mental illness AND psychedelics better. The fact that people are still inclined to talk about PCP this way probably has more to do with media sensationalism than anything (though I’ve never done PCP & can’t say for sure)- from what I’ve heard it’s really just more stimulating than other dissociatives & therefore not suitable as a tranquilizer/anaesthetic. Beyond that difference… Like, sure, there are people who freak out & have mishaps on it, & I’m not saying people necessarily should be using it, but people freak out & have mishaps on too high a dose of all kinds of things. That doesn’t necessarily mean it was truly comparable to psychosis.
I think psychotomimetic is a perfectly reasonable label for deliriants, & really that they’re the class which should’ve been labeled this way from the beginning… Completely hallucinating whole scenarios/people/conversations/animals/shadow people/etc. that aren’t there; hearing schizophrenia-like voices in your head; extreme fear/paranoia; extreme confusion & disorientation/disconnection from reality… These are the very psychosis-like symptoms of deliriant poisoning, or having intentionally taken Amanita Muscaria mushrooms, or diphenhydramine, or whatever- terrifying, awful, nightmarish stuff which I strongly suspect TRULY comes as close to simulating what a psychotic condition like schizophrenia as any chemical can induce… There’s not much else to it- those are the primary effects. You JUST feel like you’re losing your mind & living in a waking nightmare.
On the other hand, dissociatives have considerably more interesting content to them, & far fewer of the truly psychosis-like symptoms. I’ve rarely heard or someone taking ketamine, or MXE, or DXM, or even PCP & legitimately hearing terrifying whispering or screaming in their head for hours they they just couldn’t shake off (whereas I’ve heard of people taking Amanita Muscaria extract 1 time in not that high of a dose & experiencing those kinds of symptoms for DAYS or WEEKS afterwards). You don’t have true hallucinations or dissociatives… You may have beautiful closed eye visuals, but that’s quite different from a nightmarish waking dream state where you literally don’t know what’s real & what’s not. I’d place dissociatives more as a middle-ground, because they do have a tendency to induce some delusions (usually just during the experience, which is why the issues mainly come about in cases of addiction/dependency, where someone is taking them all the time & never getting a breath of air from that state & assessing their experiences from a more lucid, rational perspective). Classical 5HT2a agonist psychedelics, IMO, are the farthest from “psychotomimetic” of any of these. I think it really was just ignorance that led to this labeling for LSD & psilocybin & the like early on; keep in mind that it was being applied so early on that we were only just even learning that serotonin had anything to do with mood/behavior- in the very earliest days of the discovery of LSD & it’s effects. It’s very much a vestige of an impoverished earlier state of psychopharmacological & psychiatric research. The effects induced by psychedelics like these may seem very chaotic & overwhelming, especially to the uninitiated, to someone who didn’t know what they were getting themselves into, or to someone who takes an excessive dose for their first time & plunges in deeper than they’re ready for… But upon the kind of deeper inspection that mystics & shamans have been giving these experiences/states for ages, & the kind that psychedelic scientists & “psychonauts” have more recently devoted themselves to, there’s actually a profound & beautiful order to that chaos; the fact that it’s unpredictable & too complex for our minds to easily put in a box, to reduce & identify with some very simple pattern or experience we’re familiar with, doesn’t mean that it’s actually untethered from reality or random or meaningless or in any way equivalent to symptoms of psychosis. And especially as classical psychedelic doses increase (besides n,n-DMT, which seems to go in exactly the opposite direction), you move towards boundary dissolution & ultimately full ego-death & mystical experience… Which is quite wildly different from any kind of psychosis. There’s really no comparison. If anything I think it romanticizes psychosis to compare it to something as favorable as psychedelic experience. Even in the fringe cases where someone has a predisposition to mental illness & psychedelics catalyzed the precipitation of a psychotic state, the psychosis it precipitates is going to be very different from the psychedelic state itself.
Ok? So?
Bro wrote a whole bible page.
@@QuinazolinkingIt is an important distinction to be made, that most hallucinogens do not meet the classical definition of psychomimetic, "producing effects (as hallucinations or paranoid delusions) that resemble or are identical with psychotic symptoms," specifically the psychotic symptoms part.
Great info! I have schizoaffective disorder. Used to get real gnarly voices constantly. Very disturbing and bothersome.
During IV ketamine therapy, no voices whatsoever. No more depression. Neurogenesis from activating glutamate is the way in my case.
I also was put on an atypical antipsychotic that activates 5HT1a receptors and is a dopamine agonist. No voices for months now. The manufacturer doesn’t know exactly how it works, because from what my doctor step mom says, chemicals produced by the brain have so many roles that they are still discovering.
Mushrooms are a joy. Never had a bad trip. I don’t do them often though. Not for everyone, of course. Some minds just can’t handle it, whereas mine relaxes.
Took a solid LSD dose one time and I genuinely thought I had triggered a psychotic episode because of the psychotomimetic misinformation. I was pretty familiar with hallucinogens to begin with so I just held on until it started wearing off.
The medicinal chemistry stuff is extremely interesting! Keep it up! Did you keep the aqueous layer from that neutral solution at the end? If so you easily could have remedied the error, and included the result in the video. All well.
Is 5-MeO-MiPT controlled in the Netherlands? If not, that could be an interesting project. You could start from melatonin by conversion into 5-MeO-Tryptamine. Then reductive alkylation with one molar equivalent of acetone, and an excess of STAB-H (prepared ex-situ from borohydride, and 3 equivalents AcOH in THF, or DCE). Followed by the reductive alkylation with sodium hydroxymethylsulfinate, excess Et3N, and STAB-H under similar conditions. Both reductive alkylation reactions can be conducted in a one-pot operation. I think doing these reactions in that order is absolutely necessary to avoid formation of the dimethyl substituted product due to the steric bulk of the isopropyl group. For the same reason, the formation of the diisopropyl product by a second reductive alkylation is unlikely to occur.
Furthermore, while this compound is certainly active, I don’t think 5-MeO-MiPT has much value recreationally. If I’m wrong the use of succinaldehyde to give 5-Methoxy-N,N-tetramethylenetryptamine (5-MeO-pyrrolidyltryptamine) would be an interesting alternative. The methoxy group could also be swapped for an ethoxy, or similar group by starting with 5-hydroxytryptophan. Thus, decarboxylation to serotonin, protection of the amino group as an amide (or carbamate), Williamson ether synthesis to give the desired alkoxy group, deprotection, and finally the reductive alkylation sequence would give the desired analog. This gives a large degree of freedom to design a compound that is certainly inactive. For example, 5-Propoxy-Pyrrolidyltryptamine; there’s no way that is active, so it could make for a cool project without legal worries.
WHERE GETING ARESTED BY THE FEDS WITH THIS ONE 🗣🗣🗣🔥🔥🔥
Great video and synthesis! Love the content of making compounds of interest :) while casually making HCN as byproduct
Just a few notes:
- 4:55 Arrow to oxygen atom is redundant since lone el. pair moves to sulfur atom and is not conjugated with S-O pi bond system.
- 5:06 Resonance not equilibrium (both structures describe the same molecule). Resonance arrow should be used instead.
Congratz on 100k!!
A guy I went to HS with in the 1970's that never did anything but drink decided to try "drugs" by doing a big line of PCP. I remember being at that party but left before anything f ed up happened. Somehow he got home that night and was freaking out and his parents called the rescue, but two cops showed up also. He was trying to fight the cops and from what they said he tried to grab one's gun. (Back then the cops weren't psycho like they are now). He ended up in a locked ward in a mental hospital for about a week. He told me he went nuts when he was at home in his room and the giant mice attacked him
My cousin has a good friend from new orleans who did sherm for a little while...until a girl he did it with in his friend group while they hung out outside decided to climb a lightpole nude, and sat on the bulb part for so long it fused to her hoo-hah. Fire department had to uh...get kinda rough to unattach her. He never smoked sherm again after seeing that.
Holy, PCP is like the worst possible drug to start with. Even if I'm pretty experienced I wouldn't take it. A small dosage atleast.
@@lysy-zn2gg I know, WTF was he thinking? He didn't even smoke weed. He did drink a lot of beer though. He must have been drunk as Sh*t and figured YOLO or something. I do remember him doing some crazy impulsive stuff though. One time we were in his Camaro and he was doing like 60 and threw it in reverse. F ed shit up bad, I had to tow him home with my pickup. I asked him why he did it, and he just said "To see what would happen"
@@joecummings1260 Maybe he wasnt aware of its effects and thought it would work like cocaine or something. Crazy dude nontheless
Back then, people didn't have cell phones to record cops only doing bad things so everybody thinks that cops are bad.
ive smoked loads of PCP, and ive never had what is called a "whack attack" but ive seen people freak the fuck out, strip naked, get hit with stun guns with no effect, ive seen people walk into traffic. they were indeed having a "whack attack" but every time ive had it i just felt really good, really high. kind of like a mixture of THC, nitrus oxide, and opiates. thats probably why its so addictive and why people keep doing it regardless of how crazy it makes them act. i think some people dont have the brain chemistry to handle the stuff because some people dont act any different and some people loose their minds.
Yeah I never had these crazy hallucinations people described when I smoked dippers. Worst thing I did was call my mom and asked her to pick me up when I was in a blackout. Perhaps having experience with psychedelics helps.
I’m no stranger to fun substances but never have I ever come across this fancy molecule available for exchange.
Hamilton Morris is definitely watching this
This is intresting as hell. Not because of the chemical being synthesized, but because the chemistry of it is fascinating.
Good, now make a gallon of it. I need for my work downtown at an investment firm, mostly land acquisitions.
How’s the family?
@@Michael-kp4bd well, candice died and I gotta pick up the kids from soccer practice
When do the 200mg samples drop @ the shop? ;)
PCP has newer been popular here in Europe.mainly because it produces relatively low euphoria and huge hallucinations
I don’t think pcp is popular by any means but at certain times it was common in the USA
The way you drew that ketamine structure made me angry. Liked and subscribed.
Wheres the taste test at????????
you know it might be good when youtube/google gives one a "please get help" type of message
What do you mean TH-cam gives you get help type of a message?
I have only heard one other person mention this and he was an admitted schizo.
hmmmm, that does gives me a concern too if that guy was the only other to get that message
@@ZoruaZorroark Yeah I would be.
But I am also really asking you. What do you mean with those messages exactly. How and where do they appear? And what do they say? Because you even mentions Google, do you mean in the search engine Google or something else? There is a lot of things "Google".
For him it seems he would go on unhinged rants so bad, that he claimed staff of TH-cam would contact him by sending him emails to talk to him about getting help.
And considering how TH-cams "moderation" seem to be just an AI bot censoring things. Up until straight up banning your whole life as in Google accounts, if you go too far of the rails.
This whole "getting contacted" and it does not happen to anyone else.
Seem to me to very possible be connected to schizo delusions in his case.
But if it really does in happen in reality, I am very curious how and where it happens and after what kind of interaction you did?
And just to be clear, me saying that it does not happen to anyone else. Does not mean it is not happening.
I can not know that, but I just know about one other case, and now two with you, reported instance of something like that happening. And you know about the other guys problem. And you are saying this on a video about dissociative substances, so am sure you get why I could suspect and have a reasonable suspicion that it could be that it is a delusion in your case also.
We all know how wonky things can get for people who have an affinity for dissociatives.
Because most seem to have the reverse problem, that getting any sort of interaction or "support" from TH-cam or Google seems to be impossible. Even many channels with millions of subs can't get a any support from a human for example.
I just comment a lot and have been in lots of discussions on this plattform about various intricacies on how the limitations works on the comment system we have here.
Personally I would find it kind of nice if there really is humans that care enough, to ask us to get help if we need it. But I am afraid reality does not work like that.
Just because it seem to be reported so exceedingly rare. And I also don't want to go around and claiming that it does not happen if it really does happen.
So it would be great if you could give me more details to figure out if this mysterious contacts, from the staff overlords on TH-cam/Google really is a thing they do and how it manifests.
yes, the google search engine, and the message that i had pop up was very much a bot generated message. maybe next time i see a message like what i got on this video, i should take a snapshot and send it to you or post it on on of the myriad of message boards. chances are, i would just not bother mentioning such a message in the comments the future.
sorry if i am coming off as a bumbling idiot who somehow cruised through school in this conversation on where you are legitimately attempting to understand what i have said
@@ZoruaZorroark If it is a message you get that pop up in the browser when you are just using Google to search and it happened after you clicked on some link. It is very likely some kind of spam ad for some kind of health services, the Web is filled with such things. And not Google the company trying to send you a message. Because they really don't do it like that. Although the very recently introduced a notification icon where they can send us updates in the Google search just like we have a on the TH-cam app and site. If they where to send some kind of a message I bet it would be either thorough email or to the notification thing.
I had a friend who was diagnosed with schizo affective disorder. And he would see patterns and get messages from powerful people, celebrities, intuitions and companies all the time. It was all his delusions who made him think that though, he misinterpreted regular things as something much more significant than they really was and saw patterns and connections where they really was non.
And he was quite disturbed.
I am not saying you are that.
Just that it is very unlikely that Google are sending you messages like that.
But them again that have some disturbing privacy implications.
If Google would be follow and spying on some of us like that.
You know what the paranoid say, it is not paranoid if they actually are after you :)
The closest I know they do is if you are acting to unhinged is they send you a message in TH-cam, telling you can't post messages in some time like 24 hours or a week or something. I don't remember exactly because it have never happened to me. But in some of those discussions I spoke about TH-cam comments limitations. There was a bunch who reported having gotten such messages.
But no one besides that one guy said anything about get help messages.
And because he said he got them to his email and you said you got them in the search site in the browser, that makes it even less likely that it is even the same thing, if it is a thing that originates from Google the company.
Anyway if it happen again take a video of it with your phone and ask someone else about it to get a second opinion. Maybe it does happen....
Whenever you're saying "phenyl" I hear "fennel" which is kinda funny and I can't unhear it, sorry ^^
Last extraction you could perform with dcm
It nicely dissolve organic bromides
But not toluene
Then drying, turning back to bromide and recrystallization from EtOH
That should work
Me: buys toluene
DEA and ATF: rock paper scissors shoot!
I hope you don't have a dog!
too real
Wait no way you are dutch too,
Nice edic : congrats on 100k subs
I really love PCP Analogs, especially O-PCE or 3-MeO-PCE
You know where to get some?!
I second that. I have not had a reliable vendor since 2019. Could really use one.
you're the only one that can use the s word without it being offensive, i love you chemiolis
4:03 *casually*
KCN is well enough behaved, and acutely toxic, but not in a microscopic amount. It's not likely a chronic toxin or carcinogen, so a chemist is probably more likely to be casual handling it (with gloves) than a lot of other things. If you had a small exposure, you could just leave the room and wash up and it would clear from your body very quicklly.
yummy good job. this is my first video but i enjoy it ,hypes me up for more chem classes in the fall.
nice video but why did you use HBr to hydrolize instead of HCl?
Only because of the literature I followed, it doesn’t really matter.
@@Chemiolisu Said diethyl ether can also be use but does the volume is still the same?? (400ml)
WE'RE GOING TO LOOSE OUR MINDS WITH THIS ONE🔥🔥
How are dealing with HCN fumes? Did you just connect the condensor to a NaOH containing scrubber?
Into the atmosphere
@@Chemiolis Nature's trash bin
He's leading all the gas into a modified shower
Cloud storage
Now we just need a proper trip report from Chemiolis. There is no way that you didn't test it, and we know it.
Your whole grignard set up just under a normal atmosphere and open to air before the sealing?
What a time to be alive they allowed how to basically make drugs on you tube before GTA 6 came out
How much would I need to make a gallon? Preferrably in liquid form
You had me at "subscribe for better yields"
Never tried the original PCP, but I had an intense relationship lasting a couple of years with its cousins 3meo-pcp and 3ho-pcp
i don't know what i watched but it was stimulating.
this is like an extractions and ire video
This synthesis is gonna kill you before you can make it to the end, if not properly trained.
Great video and great demonstration of frequent chemistry issues in a life of a synthetic chemist.
PCP's fine and gentle, try 3-MeO-PCPy and rewrite that intro ;)
You are a junkie
I know right actually PCP is super smooth and on top of it they were going to use PCP as a therapy drug for depression but there hasn't been enough studies on it for its long-term effects so that's why they switched to ketamine
@@iiiKingLongSwipeiiiand the people who thought they were taking it and instantly found themselves in Mad Max
@@Rexwizord I believe that it highly depends on the way it is administered for that to happen for what you said and it also depends on the person's genetics because everybody is different and it will affect everybody different.... Smoking it is very smooth
@@iiiKingLongSwipeiii the chemical itself it is almost impossible to stop redosing
i actually have that DEA drugs of abuse book from 1973 and i pulled it out so fast after your mention at 1:57
What chemists see: A threeneck flask. What I see: A glass bagpipe
Lol.
Me: That's a funny looking bong.
Three out of four voices in my head agree that PCP is the best.
I already subscribed years ago and the yields have not improved. I want my money back.
i was thinking the same thing lol
Plz dont expose me
You're doing gods work my friend. Someone has to, that lazy A-hole must be sitting at home all day watching "The Honeymooner's," because he been MIA forever now. Or maybe he just doesn't exist. Either way good job brother, keep up the good work...✌️
DISSOCIATIVE ANAESTHETIC GANG
Idk how i ended up here because i know nothing about chemistry, but this was very enjoyable.
I was here before his lab got raided
same
"ALRIGHT TH-cam SUGGESTIONS FFS" I've given in and watched now leave me alone 😂
ah it's PCP makes sense 😆
and thanks for the info mate it was quite a decent upload 👊
Oh and I edit to say Team Ketamine all the way 😂😂.. Don't get me wrong I don't advice going crazy with it , but for real introspective insights or PTSD therapy etc it's Amazing stuff
noice
Slow clap...
HCN - check,
grignard solution on the ceiling - check,
gaseous HCl without downstream trap - check,
PCP - maybe - probably not
thanks for the instructions
GG on 100k subs! Huge milestone!
Pcp is fun, peyote is better though, .... but you want to know a secret. You can either golden orb spiders and eat them for a strong hallucinogenic effect. I also hear some snake venom does the same
If you could isolate what ever compound that it, it might be 100% legal.
But as a person with schizophrenia myself please understand schizophrenia is not just hyper mania, I mean yes that's a part of it, but schizophrenia is so much more. It's a huge spectrum.
Of course Peyote is better. It comes from the earth. They aren’t even in the same hallucinogenic class lol
@@dmtwizard Dissociatives and traditional Psychedelics for me feel like they are on the opposite ends of the same spectrum. They are similar in a weird way but very different in general.
@@Mulmgott I agree. DXM and Ketamine for me had a lot less visuals than Psilocybin, LSD or DMT. Dissociatives are more in your head. Granted Ketamine was the most visual one
@@dmtwizard For me the most visual dissociative I have tried was Deschloroketamine. Psychedelics are hyper visual for me though. I can take 5mg of 2-CB and see fractals on my walls, hands, etc.
username checks out
Dissociatives make me feel like im not real.
Ketamine is extremely interesting when you research how it acts in the brain and how it acts on deleting trauma based memories causing instant depression relief
are you fckin serious ? ask that to all my friends in psychatric hospital bc of Ketamine
and dont give me the argu that it should be controled thats garbage as hell, old scientifics had the same conclusions, can you say why are you studying ketamine ? If you do chimic studies can you focus on other things that making drugs pls we have a lot of schyzo maker molecules, stay focus
@@ilis_5794 as a heavy ket addict i cant attest it does not just delete bad memories and instantly make everything better lol
@@ilis_5794Skill issue
That hcl salt may be moisture sensitive and also amount of solvent used was also more, hence yield was less
Alternate method is that you can purge hcl gas to the solvent and take amine along with that solvent in another rbf, added hcl gas purged solvent at 0 to 5C, under nitrogen and filter it under nitrogen, dry it in vaccum oven
6:53 *Forbidden Rootbeer*
I would check the melting point of the final product, to confirm that the precipitate you obtained is indeed PCP HCl (m.p. 233-235°C). Or just take an NMR of it.
Ok now make MXE
And send it to me
😂😂 I miss that stuff lol 😢
I have made it several times. It is fairly simple and easy. That is why it was so prevalent in the 70's..
More arylcyclohexylamines!
I would have skipped adding acid, filtered out the excess magnesium, then went streight to base. You would get the cyanide back and have a cleaner pull of your free base. ❤
Very educational film.
@chemiolis when will you be uploading the taste test? Can't wait to see that one 🎉😅
Can you try making some Benzo RC's. I would be so happy
No
what a junkie
😂😅
Oh you poor bastard, you're never going to break your brain with yields like that!
What is the 00:03 image from?
DEA drugs of abuse guide 1978
@@Quinazolinking Okay wow how do you even know this? I can not find the article online, I even asked chatgpt and he wasn't able to help me, do you have the link/file by any chance? Thank youuu
@@humanplace1962 It’s government property, it is not available anywhere online or to the public. There are a few copies in university libraries but you have to get very lucky to find a copy
@@humanplace1962 Google only finds the 2020 edition (at www.dea.gov/sites/default/files/2020-04/Drugs%20of%20Abuse%202020-Web%20Version-508%20compliant-4-24-20_0.pdf)...
@@Quinazolinking aaanddd?? where exactly?
The first reaction was very satisfying.
First!
That shit was some scary stuff and GE dumped a whole bunch of that shit into the Hudson River.
It just amazes me that peope figured out how to do all this stuff
The BEST Chanel orgánica chemistry
Ahh, brings me back to my wet lab days. Made a novel analogue of moramide once! Don't tell my supervisor :P
Interesting and thanks. I recall doing a Grinyard Rx in Organic Chem Lab II, at University. Them were the days. Eventually ended up in plastics and coatings. Even had a US Patent using surfactants to cause conformational nucleation of same. Predictably increase T(g).
Angel dust. The only medicine that keeps you alive after your dead. except your still dead.
Worst drug ever
2:43 That Morpholine jar was like "Uhm, what the..."
The result have the same aspect of almost all PCP/PCE research chemical (or NPS) you can find on the market.
First time i watch someone do the synthesis of a substance i used to take ^^
Chemiolis has completed his transformation into sketchy gas station rchem bro
Always awesome stuff man but please, pleaseeeee, the iminium is in resonance with the carbocation, It is NOT an equilibrium, please❤
Edit: You even got It right the second time cmon😂