The sugar coating on your cells is trying to tell you something | Carolyn Bertozzi | TEDxStanford
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- เผยแพร่เมื่อ 28 พ.ค. 2024
- In her talk about sugar and cancer, Stanford Chemistry Professor Carolyn Bertozzi tells us why the sugar coating on our cells is crucial to our health and well-being. Unlike the sugar coating on a peanut M&M, she explains, human cells are covered with complex sugars Bertozzi shows us are, “like foliage swaying in the breeze.” The language these sugars are speaking can tell us everything from what blood type we are to whether we have cancer.
Carolyn Bertozzi is the Anne T. and Robert M. Bass Professor of Chemistry and Professor of Chemical & Systems Biology and Radiology (by courtesy) at Stanford, and an investigator of the Howard Hughes Medical Institute. She completed her undergraduate degree at Harvard and her doctorate at UC Berkeley. After postdoctoral work at UCSF and a professorship at UC Berkeley, she joined the faculty at Stanford coincident with the launch of Stanford ChEM-H.
This talk was given at a TEDx event using the TED conference format but independently organized by a local community. Learn more at ted.com/tedx
She just won the 2022 Nobel prize for chemistry.
She is not sweet! No... wait ✋️ .. 😶
Her explanation literally visualize what's going on about our cells! It was great
She must have put sugar around her presentation! Just like an immune cell, I am completely put to ease with her style of presentation. My weakest subject is chemistry, yet her articulation with the help of the demonstration on slides made the material very easy to understand. She is so articulate that I just like listening to her talking.
Min Cao for the first half of your post I could not for my life tell if you were celebrating or roasting her presentation 🤣😂😅
she sounds so hopeful, yet no cures come, ever
ÀÀÀŽ
Yep, and she must've sprinkled some leftover sugar on her vocal cords too because her voice was so soothing throughout.
Love it! Amazing talk! All science teachers should learn from her!
These deep observations has made her a Nobel Laureate! Great Prof.
wow, even the comments are above my head, and i so appreciate that i understand this field so much more after viewing this speaker.
Ahhh Carolyn Bertozzi is my new hero. I watched her seminar on ibioseminar about glycobiology and it was absolutely amazing. Let alone the fact that she has a very good way to explain complex concepts, her studies on sugar is brilliant. Her work on bioorthogonal chemistry and using this chemistry to tag and visualise sugar on the cell surface is a masterpiece. She may just well be the winner of this year Nobel Prize in Chemistry (but of course, CRISPR-cas is a huge thing to consider too).
Omg she actually won it!
You well deserved the 2022 Nobel !!!
This just opened my mind with ideas and a waterfall of questions.
Great news ! It would support the claim that to heal cancer avoid sugar consumption, in fact it is one of the main factors sustaining cancer growth it seems. Now we know why and maybe we don't need to find complicated possibly costly medicines to "scrape" off sugar of our cells...
Congrats on the noble prize Dr Carolyn
I would like to add that I believe sugar's we consumed as a child were precursor to the addiction epidemic of today! Sugar consumed, lack, desire consumed gratify repeat!
Do u notice how many addicts in recovery consume large amounts of sugars... ? Its crazy. I see my brother eating 5 candybars a sitting.. Add coffee to his sugar.
He now tries mot to and cant get 10 days without it to change the craving.. Says it is worse than the drugs he was on..
@@corrinnegarfield2460 I think you can only work on the thing that will kill you first...
So, get rid of the drugs and alcohol. Back off on the coffee. Like maybe use a cold home made tea for one cup of coffee and alternate, backing down the dose...
Maybe half sugar or maple syrup and half Stevia?
Try eating well before sugar. Like vegetables. Sometimes, you get full.
Maybe a small cup for ice cream. Not the carton and a spoon. Bad idea.
Don't keep it in the house. Jmo
They do have OA for food addicts, which many or even most addicts are. They have phone meetings and such. Pre-recorded ones, too.
Very good TED talk. Thank you.
Phenomenal presentation! Thank you!
Such an insightful presentation. I love the way Dr. Carolyn explaining about sugar in our body !
wow! what an amazing teacher!!! great talk
Fabulous awesome presentation,and made easy to understand!🙏🙏
I still think that sugar, The Standard American Diet and the FDA is to blame
Added sugars are a big risk to get cancer, but not the only one.
It's not even the sugars we can see, like what people might add to coffee, which is a minor amount of our daily sugar intake ,that is key to the sugar. It's the sugar we can not see, added to everything from soup, sauces, soda drinks, salad dressings and gravy packets we have to worry about. It suppresses leptin which tells the body "I'm full" and that is a good business model. Consumers are being fattened up like feedlot animals, for corporate profits.
When it comes to drinks I stick to water, tea and coffee (without sugar) with the caveat that some forms tea and coffee are more sugarated than most people realise. Looking at you iced coffee.
The research studies I have seen do not link increased sugar in the diet with cancer incidence. People who eat lots of sugar dont get any more cancer than those who stay away from sugar.....except where the sugar causes significant weight gain.
@@tnvol5331 ok I'll rephrase it, the SAD diet+Big Food+Big Pharma are killing us.
@@davidahart2476 Agree
fantastic presentation !!! Just say "Wow" after seeing !
Very informative. Thank you.
Very interesting & nice conclusion.
Thanks for the info D.r Bertozzi ... good lecture and info and new area for research ... since metabolism is a "Response Mechanism" it would be good to know root causes and how cancer hides from our immune response system ... Have to look up any other lectures you have ...
70 going On 100
I really must watch this again. I don't consume any form of sugars and this hasn't changed my mind about my diet.
Another terrific speaker.
Where do I begin - # 1 Clean out your gut with "oxy-powder" this is where all your problems begin - toxins leach out into the tissue of intestines , then it enter the blood causing cancer, and everything else. Clean out your liver - liver flush. # 2 Switch to plant based foods. # 3 clean water # 4 Apricot seeds (B-17) - apricots from God .com #5 FLOOD the body with nutrients (plant based) #6 Up your Ph level to 8 "off and on" #7 Hydrogen peroxide therapy (do your home work) #8 Drink 8-10 glasses of water a day - if you can NOT defecate drink 10 glasses of water "one after the other" with out stopping, this will force your system to evacuate FAST without chemicals. # 9 Use Green Vibrance 8 x a day - first thing in the morning / before and after each meal and once 2 hours before bed time - in the morning drink your water mixture then go back to bed, and massage your right side, than do the same to the left side - this will stimulate the movement of toxins through the system # 10 Go for a short walk 3 x a day. Doing this will change your life - Oh one other thing DO NOT EAT SUGAR - NO DRINKING WHAT EVER - EXCEPT FOR A "NO SUGAR ADDED" PRODUCT CALL "NAKED" ALL NATURAL "NON SUGARD ADDED PRODUCT" FOUND IN WHERE YOU FIND THE REAL RAW FOOD - YOU WILL LOVE THE NATURAL PLANT BASES SUGAR - YES YOU NEED SURAR - "NOT ADDAED SUGAR" - I CURED MY CANCER IN JUST A FEW DAYS - YOU READ IT RIGHT, IN ONLY A FEW DAYS DOING WHAT I JUST SUGGESTED - DOING ALL OF THESE THINGS SIMULTANEOUSLY. God Bless
Wow - this speaker has such a deliciously smooth voice. She is very easy to listen to. Add that to the wonderful way she explains a super complex topic so that it is completely understandable. The result is a really beautiful and enjoyable presentation. Thanks for helping me spend my time well. Cheers!
Good talk.
Thanks.
Feels good to know this!!
This much appreciated!
Thank you for the presentation, & your work in this field.
Question: What knowledge have you gained regarding how diet, particularly a high sugar / high carb diet, relates to the bad cells' ability to cloak themselves in sialic acid? Have you found a person in ketosis to also have sialic acid on bad cells?
Thank you for your very informative
I keep my immune system as healthy as possible by eating right... a plant based diet with plenty of leafy greens, beans, purple sweet potatoes, etc. But I know genetics play a role in cancer, so I appreciate this research. Unfortunately, I think the cost of these drugs is going to be out of reach of anyone with poor or no health insurance, so once again, the large pharmaceutical companies can watch their stocks gain price at the expense of many people.
Those medicines are needed. The prices and insurances are a different problem, which could be solved on political level.
@@bluejanis5317 What is the actual success rate for chemotherapy drugs? What do they do to the immune system and to what extent?
Fabulous - thank you for your amazing work. Yours in gratitude
I can't help but wonder how fasting, both intermittent and long term, might affect these sugars and the immune response.
Dry fasting cures everything
@@deadlyassasin714 Nonsense. Depriving yourself of water for an extended period is harmful to the body. I used to believe dry fasting was a cure all, but after more education, I have woken up.
Well when your fasting at least your not throwing more poison in your body and your body gets the necessary time needed to combat diseases. But its only futile if your not eating healthy nutrional foods.
Same reason why most diets dont work. Find a lifestyle that works not a diet.
@@jgfergus Well have you tried it?
Yes, and appropriate diet. Our bodies reveal by response indicators,…. and as you know it doesn't require 'science' in the majority of cases. Our bodies reveal. Keep vital. Body Integrity is the key term.
Very interesting talk
Is there a way we can lessen the layer of Sialic acid on our cells ? What specifically causes the build up of it ?
I’m not sure about the build-up of sialic acids. But here’s a “fun fact”: the influenza virus expresses a neuraminidase/sialidase (the N for example in H1N1), which cuts sialic acids to set free its offspring from the cell surface. So maybe we could use sialidase to reduce the sialic acid coating on cells. But still the problem remains, how to specifically target the Tumor cells.
Fascinating.
High dose vitamins , all of them, boost the immune system, I helped a 70 old lady w / lymphoma get over it with high dose broad spectrum vitamins. And it didn't take as long as I thought. She was on toxic chemo too, and I thought that would prevent the vitamins from working, but it didn't, without the vitamins, on just chemo, she got down to 85 lbs and lost her hair and hearing and wouldn't eat, but on the vitamins, she gained an appetite, and improved much faster than I thought.
Hi I've heard of Gerson Therapy (mainling vegetable juices full of vits and minerals every hour) and believe that if you are disciplined it will work some of the time depending on variables. Giving oral vitamins is a similiar approach but not the same I wonder at the quantity you gave to your friend? Nobel prize winner Linus Pauling recomended Vit C as a cure and also sustainer of health. Please let me know what you gave and amounts? I'm intrigued.. Thank you
whisperingsage see people don't realise humans can eat raw meat which is extremely high in b vitamins and also something that people don't realise is vitamin c is in raw meat (the vitamins in the water and water evaporates with heat). My favourite raw meats are liver; massive dose of vitamin A and b vitamins, caviar ; fish eggs really high in nutrients its what the native Americans gave to pregnant women high in vit D and omegas they knew the importance of omegas without knowing, this is why I believe humans need silence.
77 Yy i think Ill stick to all foods, barring grain, as Im an OMNIvore, with the ability to cook also, not a carnivorous animal.
I have Lynphoma, my Dr says cut sugar, but NO supplements?! They help feed cancer maybe?
@@stevecoscia123 sugar and oxygen feed every cell in you body. I wouldn't stop either!
Interesting - learned something about my blood type.
Congratulations doc ❣️
Any ideas how we can help our bodies to retain the balance? What triggers the growth of thick layer of sugar?
Sam Alex exactly my question and no holistic advice was given in that Avenue-
Heidi Verna Thorbjørnsen of course not, the medico-pharma-research complex shes in doesnt go that way lol
Shes a salesman for Big Harma, if only inadvertently and unwittingly, altho she appears to be able to grasp this so...
Muito bom!!!
This idea of immune modulation to treat cancer is all the rage in the medical research community nowadays. At 8:56, I think she's talking about ipilimumab and along with nivolumab is another nice example of "releasing the brakes" on white cells. Hopefully the drugs turn out to be an improvement over what is currently available.
+mdphdguy1 , her research and the research of many of her/our colleagues are benefiting our patients....This was her topic and it was a nice summary...However, other research has shown that preventing cancer cell formation is the most ideal ''treatment''....An important fact to decrease cancer formation at the earliest stage has been that higher levels of antioxidants and higher daily Vitamin-D (actually a cellular hormone) help these same immune cells ''mature'' and to find and remove the single abnormal ''cancer'' the day it forms...
Mathoma just drink some raw milk
Wudnt anything be an improvement?
Here after her winning Nobel in Chemistry 2022 :)
That was very interesting new information. I always thought my blood type was due to the antigen (proteins) on the cell surface and not "sugars"
Your blood group is determined that way. She has discovered additional info, which I am confident that by itself in a basic blood GROUP test, would not be evidenced. Your blood TYPE is determined by your rh factor. Perhaps she might care to comment in response? As she never mentioned any distinguishing of group vs type in regards to blood, nor the rh factor at all, my guess would be she has not done any 'drill down' research in this area.
I loved her presentation here and really look forward to hearing more from her regarding her discoveries. Let us hope and pray that she is 'safely allowed' to continue her research.
This reminds me of how the body fights off all disease.
Fabulous.
Superb 👍
"..i liked her xposition on the fact she talked about, very knowledgeable scientist for sure, namaste"
This is similar to Staphylococcus aureus cells, that they coat themselves in hyaluronic acid molecules, thus hyaluronic acid binding peptides (hyaladherins) can be used in therapy. I would be interested if silicic acid, hyaluronic acid, glycolic acid and other glycogens would signal various things such as angiogenesis in addition to immunological resistance.
Check out Gc MAFF
Educational, but how to you prevent the development of scialic acids to begin with?
reduce or eliminate our consumption of sugar would be a great start. there's more but that would be a start.
In Indian Ayurvedic medicine they recommend to boost our immunity to take little turmeric(half tea spoon, or little less than half ) powder with warm water every morning. It increases ur immunity.
So, immune cells cannot discern surface sugar density as an abnormality. How does such obliviousness related to autoimmune diseases?
Nobel laureate🙌🏻🙌🏻
Didn't talk about prevention.
So, should we cut down the amount of sugar we consume?
This is the whole concept behind the blood type diet by Dr. D’adamo going back in the 80s.
The question is, if we cut back on sugar does it decrease the sugar on the cell membrane? Do we need new drugs, or do we just need to stop eating sugar?
I don't consume any form sugars. This lecture isn't going to change the way I eat.
Surely drugs are not the answer. Most of our current chronic illness is because of food.
Good idea, but how the drug can do the difrence between the sialic acid of a cancer cell and the sialic acid of a healthy cell? Or only cancer cell have sialic acid in cell membrane?
There’s no difference between sialic acids of a cancer cell and of a healthy cell. But cancer cells sometimes have way higher levels of sialic acids on their surface. So we would need a drug, which only activates the immune system, when a certain threshold of sialic acid expression on the cell surface is reached.
HOLY COW!
*Who is here after she Awarded Noble prize* 👍
the wonderful offshoot of germ war fare, they had a bacteria that "tasted" like a nerve cell, when the body got done eating the bacteria it started to eat its own nerve cells.
Totally believe this
Any update on this ?
But what happens to the sialic acid once it is cut?
The cell tasting analogy is great and I wonder how this looks in a lupus patient
My classmate recovered from Lupus... See my comment above
Mr. Trump's Russia Advisor I would like more information
Is there a nutrutional way to encourage the immune cells to be more aggressive in destroying the cancer cells? Iow, without the use of pharmaciticals?
Search snake diet on yt, dry fasting works great for killing diseases and other health issues.
@@deadlyassasin714 fasting mimicking diet - while in early research regarding its cancer impact - seems to be as effective as any other fasting while having no negative effects and being much easier to follow than water fasts or dry fasts.
@@GregVidua thanks for reminding about that diet, I want to help someone lose weight with the snake diet because I know how well I felt. But he is the type of person that can't go 6 hours without eating.
@@deadlyassasin714 Calorie restricting diets do not work. Very tiny piece of population can simply not eat or eat little.
Put the person on a whole foods plant based diet with no oils, nuts (but some seeds - preferably chia or flax as they aren't too tasty so won't be over consumed) with 12 hours window for eating ending 4 hours before bed time (6 to 6, 8 to 8 or 10 to 10) and weight loss will be natural with no calorie counting.
It's clinically researched to be the most efficient way for average person (who is unable to channel will power to limit calories) to drop weight and maintain it.
@@GregVidua That might be a better plan for this person in the long term. However he was confident enough to wager 200 on 1 month weightloss competion against his buddy, so I thought he wouldn't be a crybaby about doing omad with healthy keto into a longer salt water fast.
Is it sugar on the cells good or bad? I'm so confused!
Does hi fructose corn syrup affect cancer or more important immune cells??
how about telling us eating dietary sugar affects this process?
I just can't believe that even my immune cells are sugar addicts..
Great talk! let's not mention diet!
Lolzz
HyperColours raw meat activates your immune system without you even knowing. Natures gift to connect us to our environment
Shes not employed by the diet “industry”, but the medico complex.
I don't understand. Do you get sialic acid by eating sugar?
there is probably something from nature that already does that, find that!!
Laurie Davidson raw meat my dear, natural and wild of course so it's high in dopamine not factory farms high in cortisol, and that's one of the million bad things factory farms do. Be vegetarian if you can't buy organic meat don't support big business support little family farms they are the true doctors.
@@curtis7595 Actually you should get some info about your local farm first. They might do all the bad stuff too.
Apricot pits.
I wonder if it could be cannabis since our cells actually have cannabis receptors and there's evidence that some cancers are being cured with cannabis.
Prudent body management to optimize body integrity, with appropriate diet and dietary practices being key. How is your Body Integrity?
It would be wonderful if antibodies that detect sugar changes on the surface of cancer cells could be used in early detection of cancer. In addition, a poison could be attached to a cancer detecting antibody that might kill the cancer cell.
Reading these comments I think we have to accept that people require different approaches to cancer treatment. Some motivated people will do Gerson Therapy or Vit C therapy as per Nobel prizewinner Linus Pauling others want to take a pill as they don't want to be disciplined for some reason and so need to pop a pill. It's not simply big pharma it is also that people follow bad behaviours for emotional reasons that are cognitively very difficult to change. Some are shocked into change others are not. Do we deny treatment?
What causes the growth of sialic acid on cancer/abnormal cells?
The very question that should be answered. My guess is the glucose infused American diet is the problem
I 100% agree! Always trying to fix the symptoms instead of the underlying cause. We have been fed a great nutritional lie for the last 100 years and it has prematurely killed 100s of millions of people. I feel 80% of health and well-being is what goes in your mouth.
Maybe mutations? Or kind of a positive selection process? Cancer cells with higher expression levels rather stay undetected by the immune system than cancer cells with lower levels of sialic acids on their surface.
Are the sialic acids found in healthy cells?
Sialic acid is barely a footnote in biochemistry textbooks. Is it found widely across animal cells of different species?
Yes, it is. One figurative example: there are human and avian influenza strains. They most of the time can only infect human or bird cells. This is due to the receptors which they use to attach to and infect cells: with their surface protein they attach to sialic acids. Humans and birds express different kinds of sialic acids, that’s why normally an avian influenza strain cannot infect humans. But: pigs express both sialic acids which can be used for attachment of avian AND human influenza strains. So they can be infected by both at the same time, then recombine to completely new strains which can infect both birds and humans!
Why isn't she my professor at college?!
Universities are rubbish.
Shes not a teacher, shes a researcher. Those that can, do. Those that cant...
I was wondering if people certain of blood group are more prone to cancer given the role of sialic acid.
If this has inspired anyone please take a moment and research the Polly pore mushroom - Turkey Tail.😏
Well if cancer is actually a coordinated response, then for the time being the immune system and cancer cell would want to have a handshake moment and that may be sialic acid. It’s been 6 years and that penicillin moment seems to have gone. Maybe we are closer to the point of recognizing killing cancer cells is not the solution. It’s also very strange that cancer tends to stay put for years, instead of growing out of control, like either the immune system is actually doing it’s job or the cancer knows not to grow out of bounds. I suppose the euphemism is ‘benign tumor’.
One of the best presentation ever came accross... 🤌🏻
I'm surprised this isn't about diabetes. Very interesting and breaking news.
and of course profit comes first !
Oh, oh. Problems for the cancer establishment. Cancer being connected to sugars but not dietary ones. It'll only spark interest if there is potential for profit through drug interventions.
I wonder if the cells normally eat some of the sugars found on the surfaces of other cells, as part of normal physiological processes. In addition, I wonder if having sugar on the surface of multicellular organisms is a key in understanding how multicellular organisms evolved. Maybe multicellular organisms share this food in this way?
I guess immune cells are eating some of the sugars on the surface? Maybe this "tasting" is done during other important cell processes like cell migration or blood circulation?
Maybe proteins are also shared food between cells? There are many receptor and cell surface proteins whose function is unknown, maybe they are cellular stores of protein?
❤
Well wait, the other tedtalk that I heard said it was oils and fats that caused cancer. Which is it? Or is it my thoughts about which one causes cancer?
Fats cause cancer??? Try using commonsense. Millennia of human history say otherwise.
Not only sugar, anything that you put in your mouth and you eat it, which is added with non food substances will cause health hazard in future.
Yeah, but other possible interventions Carter did, dietary ones, for example, may be part of his success. But the focus will always be on the drug.
Hmmm, I have AB positive
I don't understand, I asked the doctor , if sugar is really bad for cancer, they say cancer feeds on sugar? And she said , no, I don't understand, that there was no proof? Then I asked the PA, she said no too, that is not proven, so what do you think?
I wonder if such drugs with cause then major autoimmune diseases - not just “ help” ward off cancer?. It would be nice to give a more wholistic reason why this S. Acid Sugar coats cancer cells - and maybe, what we can do or not do naturally to try and avoid this cell problem- instead of just creating a drug- which grant it I am thankful for- especially surviving Melanoma myself 20 some years ago but, without the drug.
Does not mention how the cancer is created in a first place. Prevention is better than cure. Overall it's not a bad presentation very good.
Standard Care for Cancer is Chemo and radiation which kills the immune system uncologist and doctors need to get with the programme on the findings to prevent Cancer. But Cancer is a business and every one involved gets a kickback.
This is why I love science. It's an ever expanding adventure that anyone can and should participate in.
How does Rh- blood play into this? How do environmental problems play into it??? Like mold?
More of the same reductionistic view of the MDs.
Wouldn’t it be smarter to address the reason why cancer appeared to begin with?
Wouldn’t wiping those sugars from the cell membrane affect other systems in the body that MDs still don’t understand?
That's why we have research, to know what we don't know. She was clear what she was taking. As an MD, I can tell you we don't know a lot and what's good today may be proved as wrong tomorrow. We do our best to help people with the current information we have but will not be surprised when recommendations change. Also some times we don't use common sense as it should be used.
Have to wonder what consuming mass quantities of genetically-modified High Fructose Corn Syrup is doing to our cells...
My sugar craving are crazy ugh