It has been suggested that the vampire myth originated from people infected with rabies. Since rabies causes light hypersensitivity, hydrophobia, aggression, and occasional biting, it fits the narrative of a typical vampire who goes out at night, is scared of holy water, and sometimes bites people. It’s interesting to think about anyway!
That also explains why the myth of vampires includes creating other vampires through biting sometimes! That’s cool, I honestly never drew that connection
I'm surprised that they didn't go into how serious the Hydrophobia is. It's so weird how it literally triggers intense dread and fear when exposed to water.
@@reina4969 they have videos explaining how vaccines work, and since this is about the virus not vaccine im guessing why thats why they didnt go in depth
When I was 19, an erratic bat that crashed with almost every object around entered in my house, and when I tried to grab the creature to throw it back outside, it bit me. My mother was highly concerned about what just happened, she seemed almost hysteric and I of course thought she was overreacting. She took me to a clinic that same night and made me take the anti-rabies vaccine, the first shot of many that I had to take in order complete the treatment. Reading afterwards about the awful and agonizing death that rabies patients suffer when they are left unattended, I am very grateful to my mother for her urgency and don't wanna think too much about what would have happened if she hadn't been around to act so quickly and decidedly. Most probably I would have forgotten about the bite the next day and would have died in the next few months. She saved my life.
@@adventureinlife7700 It seems like when they were bit they did not know of rabies or it being very serious which probably lead to them thinking that their Mom panicking so much was overreacting because, “it was just a bite” Uh, just realized I put hitch instead of which, oops.
My cousin-in-law died from rabies. It was an horrible sight. He lived in a rural communitu far away from the Tropical Medicine Foundation, so it was too late for him to be vaccinated. He got there already symptomatic. Died furious and suffering, trying to bite my mother-in-law, afraid of water, foaming in the mouth.
I’m so sorry you had to go through that. Feel free to ignore this, I’m just curious. I thought that the virus spreading through bites was just a clever way of using what most animals have as their natural mechanism of aggression to spread the disease. Humans don’t usually show aggression through biting. I thought that the ‘furious’ part of the virus was just general aggression/agitation of the victim. Is that not the case?
My Enemy died of rabies,I’m kinda happy about it he was my enemy, But I got horrified because he was trying to bite my best friend my best friend and my teacher-in-law
@@breetopkuschi9657 during the final stages of rabies, your brain is so disoriented and confused that you basically "devolve" into a half-animal. It depends on the person
Lyssa is basically running the optimal Pandemic/Plague Inc. strategy. Super stealthy until the target is fully infected, then rapidly turn extremely lethal
problem is if you see a human with full on rabies, you fear this and start quickly researching how to cure it, and since the actual infection to death time is long, with a cure this is easily taken care of
true but unlike in plague inc, rabies is incurable after symptoms show and also zoonotic making it extemely difficult to eradicate. also in plague inc u can trigger the mutation to become super lethal which affects every contagion immediately which is unrealistic
I remember reading that one of the most-affected parts of the brain by rabies is actually the amygdala, which controls a person's fear response. It essentially gets permanently switched on, so not only are you in agony as your brain expands and your muscles spasm uncontrollably, but you are trapped in a permanent state of terror where everything and everyone seems like a threat to you.
Oh man, I saw a video years ago when a young man that was infected with rabies acted violently so they tied him to his bed, but he struggled and escaped just to jump from the hospital's window. It's literally the most fked up way to go..
I found the video again, it's really bad. The title is "Rabies info campaign part 1.mpg" at 5:25 mark. It's in Filipino though but you can get the point..
I'm a doctor and I remember a case of a little girl who died of Rabies after being bitten by her pet dog while grooming it. It was so sad because we watched her die and couldn't do anything about it. The Lyssa virus is really deadly. Go to the hospital immediately after being bitten by any animal to get vaccinated against Rabies and tetanus.
Hi doc. Can I inject booster even if I hadnt bitten? You know it comes from the saliva and were not aware that saliva can go inside us. Why its aways have to be bitten since its the saliva that go inside us.
@Yummy Spaghetti Noodles Mainly causing muscle cramps that will kill you at some point. When they Start effecting the muscels you need for breathing you suffocate.
Or get vaccinated preemptively like many people where I live. (Not sure about rabies, but tetanus is a standard vaccine and it might even be required but I'm not sure)
@@drekson23 Saliva is usually transmitted through bites, since saliva is created in the salivary glands located in the mouth. And yes, you can and should get inoculated against rabies, even if you haven't been bitten.
Got bitten by a possibly rabied cat a day before my birthday. Got a vaccine for rabies within 24 hours, and then had two other doses in day 3 and day 7. within that week, i found out from witnesses that the cat died after the bite and i thought to myself, damn. a month in and had another does. docs told me to go back 7 months after that
I remember hearing that the first known person to survive an infection of rabies that reached the brain was kept in a particularly deep induced coma for the duration of their infection, which seemed to suppress the encephalitis and also gave the immune system a chance to fight back. And even then, they barely made it and had months of rehab to get over the coma.
yes and it's a wonder that kurtz didn't include this extremely vital information, or also the fact you need to get the shot the day you're bitten bc rabies ISN'T slow, it kills humans in under a week.
@@hoihoipoipoi This isn't true. Rabies is definitely slow with an incubation period of 2 - 3 months according to the WHO and "weeks to months" according to the CDC. You can get the vaccine any time within that incubation period. The full vaccination course (with 5 doses) takes 14 days, and while a few people have survived without the full 5 doses (take this part with a grain of salt because I don't fully remember it), it's generally best to get all the shots. Rabies may kill people quickly after symptoms present, but it's more likely than not that they were actually exposed to the virus months in advance. Secondly, if we're referring to the same person, they were using an experimental treatment called the Milwaukee Protocol to try to treat rabies. While that procedure worked on the patient, it has only worked that single time, while failing on 25 other patients it was attempted on. Due to this low success rate and high cost, it's more likely that the success was a fluke due to outside factors, and so it's generally not recommended now if I remember correctly.
Was talking to my mom a few weeks ago when she casually mentioned my grandpa was bitten by a bat. I freaked out, especially when she said he hadn't been to the hospital and wasn't going to go until he felt sick. I made her hang up with me and call him to tell him to go to the hospital. I've always been a bit 'morbid' and rabies has been a fascination/ fear of mine since I was a kid. I thought my grandpa knew about rabies because he was a firefighter and therefore had first responder training and had done rabies vaccination drives (for dogs) at firehouses. Turns out he didn't know how bad it was. He hated the vaccine regimen, but I'm glad he listened and went and got it.
Fun fact: opossums usually don't get rabies, because their body temperature is too low for the virus to survive in them. They're literally too cool for rabies!
@@user-eh2jk6mf9s they're too cute for this world, we couldn't handle having too many of them. We'd get nothing done! Just spend time petting and feeding them fruits and bug snacks
As someone who has been saved by the post-exposure vaccine for rabies, I can barely explain how thankful I am for this invention! It is really unpleasant, yes, but not getting that treatment after being bit by a rabid animal will result in one of the most horrible deaths known to mankind, therefore praise the science!
Yes, however not when it isn't throughoulgy thested and rushed out on the martket for a virus that has a death rate equal or lower than a regular flu. I'm talking about covid.
Do you mind donating to the scientists who invented the vaccine ? I believe we must all be grateful of scientific inventions and do the least to boost its progress if science has saved your life even once . ( it has saved mine twice lol in fact my entire family would have been dead right now if it weren't for science )
The most interesting and also haunting part about rabies to me is the strong hydrophobia people display. Its such a specific and scary symptom that by chance also helps you spread the virus better because you wont dilute your saliva with anything else.
"Lyssa is a patient monster until it goes for your brain." Literally chilling to hear! So glad I was taught about rabies when I was a kid. Also, the only known human to human transmission of rabies has been through infected organ transplants.
dying like that must feel horrible, you managed to survive another condition because of the transplant, but then it ends up killing you in an even worse way
I was exposed to rabies a few years ago when I tried to rescue an injured bat. The shots were expensive, viscous, and painful, but I'm SOOOO glad I got them... Don't mess with Rabies.
I was bitten by a semi-stray dog when I was maybe 10 or 12. They gave me a series of shots in the butt, including for rabies. I remember that the nurse took each needle by itself (not attached to a syringe) and, with one quick motion, "threw" it into my buttock almost like a dart. _Then_ she plugged the syringe to it and injected. I don't know if that's normal for buttock injections, but it seemed strange. She seemed to know what she was doing, though.
it isn't, because of the anti rabies campaign back in the early 80's... mostly... leave it to antivaxers and in a few years, no more wildlife (because they would simply kill the "vectors") and millions of infected peoples, because fluffy simply can't be infected, they are protected by their owners prayers... right?
Rabies and tetanus vaccines are so important. The risk was impressed on me a ridiculous amount as a kid, since I lived on a farm, but my mother was an ER nurse. She saw tetanus and rabies cases every year where some neighbor didn't get a child or older farmer the proper shots when bitten by bats, or when they got poked by a rusty piece of metal. I still remember her crying in the nurses lounge when I was a child because of a similar kid who died to rabies from a possum. (she would 'babysit' me there, aka the other nurses would')
Tetanus coming from rusty metal is a medical old-wives tale, you can get tetanus from anything unsanitary, it’s a bacterial infection. In fact much like copper oxide, iron oxide has antimicrobial properties, you’re much more likely to get tetanus from not washing up properly after the bathroom or scraping your knee.
Opossums don't carry rabies. Their base body temperature is too low for the virus to survive. They are one of the only mammals totally immune to the virus actually.
Actually, tetanus doesn't have much to do with rusty nails, the bacteria that causes it lives in a lot of places, almost everywhere. For example, if you cut yourself, and then smear dirt all over the cut, you might get tetanus. Rust is just usually an indicator that the nail itself probably has the bacteria on it, because it's been out for long and had a good chance to get infected, and nails are just... pretty good at poking you and getting the bacteria in your body, but the disease itself doesn't have much to do with rust.
A few points: 1) Up to 2004 no person had survived rabies after the onset of symptoms. However, since that time 29 people have survived through new techniques such as The Milwaukee Protocol. Still, when you consider that over 55,000 people die from rabies each year, 29 survivors in 18 years still means that rabies is almost 100% fatal after the onset of symptoms. 2) Birds have been found to carry rabies antibodies, showing that they’ve been infected. However they never become symptomatic. 3) At one point near the end, you imply (with a picture) that squirrels may be rabid. While this is possible since squirrels are mammals, it would be an extremely rare event, because any squirrel that’s bitten by a rabid animal will very likely die immediately. This is why rabies is more common in larger mammals, which can be bitten but survive long enough for the virus to incubate.
"The Milwaukee Protocol" sounds very scary haha (and I mean it is, considering you are put into a coma that you might not wake up from). But still, it's better than guaranteed death.
Two months ago, I thought I was going to die from rabies. I was on vacation in Morocco and attempted to pet a dog on the beach. It bit me and ran off. "Oh, that guy is angry, lol." - I thought. I had never heard that rabies was fatal, so I just ignored the subject, returned to my home country, and resumed my normal life. Ten days later, I was on my way to work and began to feel an itchy sensation in the area of the bite, accompanied by a strange headache. I searched for my symptoms online and discovered that rabies could be the cause. I then researched rabies further and watched a video that explained everything. That marked the beginning of the worst ten days of my life. Then, I immediately sought medical assistance. I went to the ER and described my symptoms. The doctors were concerned, as rabies rates in Morocco are high. Unfortunately, the rabies vaccine was only available at one hospital in the entire city, so I had to wait an entire day to receive it. That night, I didn't sleep, work, or eat I went to get my vaccine, fully aware that if rabies was the cause of my symptoms, it might be too late. The doctor who administered the vaccine appeared worried as well, though she tried to hide it. I received two doses of the vaccine and immunoglobulin to boost my immune system. Now, it was a matter of waiting. Unfortunately, my symptoms worsened. I started to feel dizzy and very anxious, both symptoms of rabies. However, I also experienced panic attacks. So I wasn't sure if I had rabies or if I was just having a panic attack. I was terrified, so I created my will online. I recorded a video for my mom, my girlfriend, and my two best friends, explaining why I thought I was going to die and wish them the best. The next day, I developed a fever (which I later learned was also a side effect of the vaccine). I couldn't help but cry. I wasn't afraid of dying; I was afraid of dying from rabies. The following day, I visited a rabies specialist in my city and described my symptoms. He assured me, "You don't have rabies. Go home and live your life." Of course, there was no way to verify his claim. Apparently, there's no such thing as a reliable rabies test. You can receive false negatives until you are literally in the ER being resuscitated. Luckily, rabies kills quickly, so I just had to endure ten days of agony. If I wasn't dead in ten days, I would be rabies-free. That's exactly what happened. I received my additional doses and now I am fine. I wouldn't wish this experience on anyone. It's mentally and psychologically exhausting. Even now, watching videos related to rabies makes me feel uncomfortable. It took me weeks to return to a normal sleep schedule and social life. Please, if you get bitten, seek vaccination immediately.
so glad to know that you're okay now rabies recently blown up in my country, not much cases, just because one case, but its going viral on internet cause someone upload it on tiktok. and now im terrified as hell after searching more and more about rabies. the 100% death rate when the symptoms appear is trully terrifiying
@@tukangeksperimen7844 yeah. No way to know you have it until you’re already dead. If you’re scared though, you can get the vaccine before being bitten and you’ll be fine. Just ask your doctor.
Rabies is truly terrifying. When you have it you may not know for months, but once you know your pretty much already dead. Lucky it’s not that common and hard to spread between people. I think only 1 person has ever survived so it’s maybe not deadly by amount of people, but by it’s effectiveness and death rate. Basically if you get bit by a mammal, immediately get a vaccine
In Finnish there are two words for rabies, the more popular one being "vesikauhu" which translates to "water horror" or more accurately "hydrophobia". The less popular one is "raivotauti" which means "rage disease".
Honestly, I thought rabies was just "Woah-ho! that dog is foamin' from the mouth! Don't go near it, they're aggressive!" but this video has actually shown me what happens, and I'm so happy that these videos exist
I'm a health inspector, and, in much of the United States, health inspectors are responsible for rabies management and tracking. In my state, rabies is still very much around and unfortunately a lot of people have to be vaccinated for it. Even more unfortunate, a full rabies treatment can cost anywhere from 5k to 10k+. It's disgraceful that a treatment, if you don't get you will 100% die, is so costly.
The majority of the Entire U.S. medical industry is a profiteering disgrace of greediness. As illness is involuntary, the prices charged are a national Shame. Simply a case of predatory capitalism.
@@chrysanthemumfire6456 south east united states. Rabies is rampant in all the states in the region. Though, to be fair, rabies is a problem in many states, not just the south east.
We are better in killing nature than nature is at killing us! We can destroy every living thing on this planet if we wanted to! But ofcourse that would also mean the end of us as well!
This is one of the craziest cellular biology animations ever, you really packed this one full of the amazing stuff, I didn't know any of these intricacies of the immune system and I feel like everyone should have a working model like this in their head of what's actually going on inside them.
Your generosity towards healing my Herpes is incomparable , DRETIKO you assured me of getting healed just within 21days and it was so . I will keep letting the world know about your good work ❤❤
Man watching these videos makes me realize... im really taking my body for granted. I mean we all act like were alone and nothing cares about us but there is always little creatures in you literally killing themselves to keep you alive . Really makes you think
They're not creatures, they are programmed to do that. If you feel alone, remember your instincts are your brain's certified way of protecting you, without the conscious you even realizing.
Did u know, ive been infected by lyssa once when i was like 3 in china. Im happy im alive now thanks to these people that decide to spend decades just to save maybe just one person even. It’s truly an example that everybody counts! ❤❤❤
I have been absolutely terrified of rabies for many years. It scares the absolute living crap out of me, even though it isn't something I really have any real need to fear - I don't spend an inordinate amount of time outside or near wild animals. It's not something I'll likely encounter, but as soon as rabies comes up in a conversation, I break out in a cold sweat. This was my first Kurzgesagt video that I've ever watched. Of _course_ it had to be about rabies.
My dad's a vet Every time he spoke of rabies (especially after an encounter with a sick animal - most often a cow) the little, bubbly, chatty 8 year old me would be like O.O in a corner
You could theoretically get it from food from infected animals, like cows. There have been panicks from raw milk used in sold in products and later discovered one of their cattle was infected from a wild animal. Though no one was infected there was panic and some had to get shots.
As someone who was exposed to a rabid animal when I was younger, I am very glad this vaccine exists. I might not be typing this comment today if it didn’t.
@@crazykiller001schannel5 *correction. Might not be. There has been a handful of people who survived rabies. All through the Wisconsin protocol I believe.
Props to the storyboard artist or concepter or whomever in production who decided the person in the animation to be infected should be a child rather than one of the birbs, adds a real oomph emphasizing the scary reality of rabies
but, I'm not sure what the point of scaring anyone would be. They mention in the very next moments how effective the vaccine is. I think it's more important to scare people about the ideology of anti-vaxers. There's much less reason to scare people about rabies otherwise.
@@squirlmy People dont get rabies vaccines. Animals do. You assume if you get bit they will then give you a bad series of shots and hopefully catch and test the animal. BUT in many states in USA it is not required to rabies vax. In my state, it is not only required, but MUST be administered and tracked by a vet. For dogs, anyway. We also have a guy in my city who captures stray and feral cats to get them vaxed, spay/neuter then releases.
@@sophiesmith5922 People DO get the rabies vaccine, but only if there's a chance they've been exposed to infected animals. Cats and dogs get it as a preventative measure.
@@sophiesmith5922 people absolutely can get a rabies vaccine? Usually after an infection, though I think if you’re going to a high risk area you’ll get one too
@@sophiesmith5922 Actually, there is a rabies vaccine for people, and as the video explains, due to the slow speed of progression of the rabies virus, it can be given after you have become infected as long as it is given quickly.
@@axehead45 Raccoons are friendly and sometimes walk up to people for food. But if a raccoon's alone and acts weirdly, then I wouldn't come close. Although, you should be cautious of any unfamiliar animal. Especially dogs, they are the most common cause of human deaths of rabies. Many people think that it's usual for stray dogs to be aggresive and don't take it seriously. Sometimes I see children playing with stray dogs.
So glad that content like this exists, spreading completely honest direct information and THEN explaining how you can fix the problem rather than just leaving viewers helpless
I find illnesses where your mind fails before your body, considerably more terrifying than the other way round. Not only rabies, but diseases like dementia, or heavy metal poisoning. The thought of my humanity dying while my body lingers, and what effect that would have on my loved ones horrifies me.
I find the opposite more terrifying. Something like ALS where your body just stops working while your mind is entirely there and you have nothing to do but contemplate your doom
One of the things that really stuck with me from my teenage years, was reading of the first Neolithic cities in human history and how we found them. Entire cities of tens of thousands of people, sitting like they were waiting for someone to come back home, and nobody knows where the original inhabitants went. Disease is the number 1 suspect, as tribes later on said they were cursed lands where all the people died mysteriously or vanished. Pretty interesting how easily we forget that stuff.
Scary thought. Bacterial infections were also far more deadly back them do to no antibiotics. The two cities that were both destroyed the same way in the same era are frightening as well. It's assumed they were destroyed by an asteroid air burst overhead because the only other known thing that can cause that much heat and send out a similar shockwave is a nuke. At least two cities 4000 miles apart in the time time frame.
Humans have been living through outbreaks of Bubonic Plague for thousands of years by the time the Black Death returned to Europe. Imagine being the first city to experience it when absolutely no one had it before; the 1/3rd death rate from the Black Death would've been child's play in comparison. And even if you survive, well, every single skill is critical for your town and no plague will ever kill equal rates of each skill, you might have enough coopers but none of the smiths survived, or you have enough smiths but no millers, the complete loss of any one skillset could simply doom your town. It's really surprising we've been able to get as advanced as we have without being taken out by disease.
4:03 Minor correction here: when the apoptotic signals are high enough to induce apoptosis into a cell, the affair isn't nearly so violent and explosive (that would be very bad and end up causing massive inflammation and necrosis in the local area). Rather, the cell "blebbs" and shrivels as it self digsets, with nearby macrophages consuming the little blebs in a very clean and contained way.
Yeah its true but there is no distinct apoptosis to be in reality but it happens with a mix of both necrosis and apoptosis called necroptosis. There is also ferroptosis and other stuff..
@@65nidheeshkumarprabakaramo68 The extrinsic pathway for apoptosis induced by CD8 cytotoxic T cells involves FAS signaling and utilizes caspase 3 to activate apoptotic effectors, thereby inducing DNA and protein digestion within the cell and ultimately leading to blebbing from the membrane while containing the viral particles within those discrete membrane pieces. While recent literature have identified alternative routes such as necroptosis, it would appear that mechanism may be involved in the lysis of tumor cells. Furthermore, from an evolutionary approach, it would appear counterproductive for the immune system to utilize necrosis in the case of viral infection due to how the rupture of infected cells results in the explosion of infectious particles into the surrounding matrix, thereby further propagating the infection.
It was actually incredible. I watched a couple videos of people who had rabies and one of the guys didn’t have the aggressiveness that’s associated with it. At least when he was being recorded, he was kind and polite the entire time, and was even willing to show how his throat denied him drinking water and how sensitive his skin got by letting the guy recording him open the window to his hospital room. I have *no* idea how he managed to keep his cool and was even willing to show how rabies was impacting him.
RANDOM COMMENT FOR THE ALGORITHM Apple is the bes of the only thing missing in this case was a great sense of the only news channel in a relationship with a lovely man and the Juice media
I had absolutely no idea rabies was almost certainly lethal once symptoms began showing. What a horrendous monster this virus is. Thanks for making this video. It will most definitely help raise awareness among people like me, who are still ignorant about the deadlines of this condition. Vaccination is ever so important.
the thing with rabies is that getting vaccinated is optional, not mandatory unless you get bitten by a random animal, so many people just don't get vaccinated aheas for it.
Once the bite location starts to tingle it is all over. It can be weeks, months or even years before the virus starts it's journey from your muscle (where it has been multiplying) to your nervous system, but when that happens the site of where you were bitten will start to tingle. You'll feel pins and needles as the virus hitches a ride on your nervous system and when that happens you are now officially too late to be vaccinated and you best start making plans for your funeral.
in germany we lern in elemenatary school stay away from wild animals that dont avoid u an wild animal no matter waht it is that does not is cautious about u can be asign of rabies (Tollwut in german) wich is a leathal virus especialy the children on the edges of the citys the small towns and villages get that taught there might be areas where this is not the case or it changed over time but when i entered school 21 years ago that was standard we also get told to imedietly go to an aduld and tell if w where bit or scatched even if it was a stray cat and that there are other deseases too
It's amazing how much your animations evolved over the past couple of years. Just the Killer T-Cell model alone in this video is incredibly more detailed and accurate compared to your first Immune System video. Of course, the simpler animations will have a special place in my heart, but it's also great that you guys have been keeping up the quality to the channel's massive growth in every video!
This channel is a large team, there is not one person who makes this LOL, you know how much effort is required to make just this video? There most likely are several animators, colourists, 3D artists and so on.
My wife, a public health veterinarian, told me that you can reduce the chance of getting rabies from an animal bite by 50% if you scrub the bite site well with soap and water. The initial replication of the virus happens at the bite, not in the neurons. As for dogs, in the US, we have pretty much eradicated canine rabies. Dogs, foxes, etc can get it, but almost always from another species.
"When you reach this stage, you are going to die." I hope I'm not the only one who is horrified by that sentence. No other Kurzgesagt video involving infections has ever had such a mundane certainty of death stated like this. Even with Cytokine Storms, they say it's "very likely", but here, it's treated like a certainty of death, because it is. Honestly, the most chilling thing ever said on this channel.
It's not an absolute certainty but very very close to that. As far as I could find, there are only 29 reported cases of rabies survivors worldwide (1st entrance in the list is from 1970) and only 4 of those made a complete recovery without long term consequences. Using Kurzgesagt's provided 60'000 deaths per year (8:30) that makes around 3 million deaths since 1970. So the survival rate is 29/3'000'000 = 0.00096% and the rate of complete recovery is 4/3'000'000 = 0.00013%
There are few things in life that scare me the exact and powerful way that rabies does. My sister and I were coming home from the zoo once, when we saw a young raccoon in broad daylight, acting strangely, and noticeably unwell. Staggering up toward any person that came by. It should immediately set off alarm bells for you to see a raccoon acting that unafraid of humans. That little guy caught sight of me, and a chase ensued. It would not leave me alone no matter where I went. First and only time I’ve been that viscerally afraid before. At that point I was weaving between cars, shouting “Help me” several times. I had to make a few laps around some vehicles and frantically yell for my sister to unlock the door to our car, and then race back around and scramble inside before it could crawl under the car and get to me. We were sure to warn others around the parking lot not to go near that poor thing, some unsuspecting folks were *walking towards the raccoon with their children.* Do not fuck around with sick animals. Rabies will fuck you up slowly and irreparably. As soon as you show symptoms, it’s all over.
Your generosity towards healing my Herpes is incomparable , DRETIKO you assured me of getting healed just within 21days and it was so . I will keep letting the world know about your good work ❤❤
@@nils9853I believe I say rabid raccoon 🦝 when going thru the Taco Bell drive thru. I feel bad I should’ve called someone it was a while ago though... my friend seen a rabid rabbit literally run and drown itself in his pond...he said it messed him up.
It doesn't even need to be a raccoon. I saw a feral rabid cat once. It stumbled around and walked in a zig zag. It would then fall after a few steps and try to stand up only to fall down again. Clearly not right.
I've seen it somewhere that there was a patient who survived rabies after the symptoms arose. She went into a coma, woke up after years of treatment, and had to learn basic motor functions like walking and speaking again.
Once got accidentally bit by a squirrel while in law school feeding it nuts. I didn't think anything of it, it was an accidental nip that drew blood. But then I thought, what about rabies? Did some research, found out squirrels almost never have rabies, didn't think anything else of it. Until, two weeks later, when I got a pretty severe sore throat. Suffice to say, that was over 20 years ago, so obviously not rabies, but for about a day...
I feel that, only watching this video makes me feel anxious as hell because I thought back to when some random cat snapped at my hand like half a year ago. Like the chances of that animal having had rabies are basically zero (rabies-free country, domestic cat) but I still get so paranoid
I misread that as a squirrel bit your nuts. That raises another question. Can rabies be transmitted through reproduction? Like if you have children while having rabies (with no symptoms obviously) would they be born with it?
I was going to say you are supposed to call them neurodivergent, but yeah, twenty years ago it was OK to call them nuts. So I guess I'm only slightly triggered. Still, you probably need to get fired after a healthy doxing.
The Milwaukee Protocol was, at one point, theorized as our best chance to combat rabies once it entered the body in the event that it was too late for the vaccine but before advanced symptoms developed. The idea was to put the patient in a medically induced coma and being pumped with antivirals as well as other drugs such as Ketamine. The suppressed brain activity would essentially slow the spread of the virus which would provide the body with extra time to combat the viral infection. While it worked in one case which became the first known survival of rabies it also failed in over two-dozen other attempts and is only seen as a last resort.
it has worked in a handful of cases, but even for the people that survive, the recovery is brutal. they had to be kept in a coma so long, that they had to relearn how to eat, walk, talk, etc again.
@@jastrckl funny thing is that cryopreservation therapeutics have been shown to kill lyssa in post-symptomatic animals, when used in conjunction with a vaccine. And the same "cold sleep" techniques actually PREVENT mental degradation in humans. And yet the idea of dropping the core body temp of rabies patients to 80 degrees Fahrenheit, while keeping them comatose, to *save thier lives* is considered "cruel" by the AMA?! I'm suuuuuure it has NOTHING to do with said animal experiments showing that the cure rate was near 100%, and with only 8% of the vaccine material needed... Sigh, THIS is why we are so "distrustful of vaccines", the behavior of the people who make money BY KEEPING US SICK. Never cut a deal with someone who benefits more from breaking it than keeping it, and TRUST is part of a DEAL between the customer and producer. Once it is lost it is NEVER coming the hell BACK! Fraud-ci et all have DESTROYED that trust for one of the most important discoveries ever made by man, the vaccine, to such a horrific degree that even *>>I
I find one of the most interesting and mystifying things about rabies is its frightening ability to easily jump species. Most viruses require mutation to be effective in a different organism and then its mutated form is usually then not effective against the original host.
That's because it is so simple and it exploits basic mechanisms that are fundamental to the biology of all mammals and as such, are unlikely to ever be modified by evolution. Another example of how often less is more, the simplest the solution, the most resilient it is
@@raffaeledivora9517 it's actually not true, there are strains of the lyssavirus, that are associated with specific orders of animals. Rabies lyssavirus, most probably, started out with bats, but then later on shifted to Carnivora, that unfortunately encompasses all cats and dogs, and all of the descendants of their latest common ancestor - and that is fifth biggest group of mammals. Fun fact: there seems to be a correlation between species the person was bitten by and how likely they are to contract the lyssavirus, with lagomorphs [so hares, rabbits and pikas] and rodents being less likely to transfer the virus.
Also, your immune system evolves to become better and better, but so do your enemies. It's a race. And considering the fact that humans are not extinct, we are doing decently in this race. Show some respect for your immune system, you don't know how hard it's working.
@@minecrafting_il I think its also important to mention that we have modern technology to help the immune system defend against certain illnesses which it would otherwise struggle with.
Well nature has had billions of years of competition, trial and error to develop, so it'd be weird if it wasn't that complex. That even a very simple virus like Rabies can defeat this with brutal effect is rather unsettling though.
When I was camping as a young kid I wondered out loud if I could catch one of the thousands of tiny bats on the lake in a net. My parents didn't care because they obviously didn't expect a kid to catch a bat in the pitch black with a butterfly net. Sure enough, I did. I literally grabbed the thing out of the net with my bare hands and ran up to the camp site to show them. My dad right away told me to throw it away, and as I was holding it it started to try and chomp my finger. It thankfully didn't break skin and I never got rabies, but sheesh... seeing this video really made me realize how bad it would have been if I did.... (Only scary because bats are a more common carrier of rabies)
At least in the US, it’s recommended to get the rabies vaccine whether you think it broke skin or not. Better safe than sorry. Many doctors will even want you to get vaccinated if you notice a bat in your house, because it might have bit you in your sleep and the bites are basically invisible. If you don’t get the vaccine in the first week or so, you’re basically gonna die one of the most excruciating deaths.
This is why parents should pay attention when their kids muse about things. Similar story here. "I bet I could jump across that river!" "Sure ya could, kid. Haha." "Oh *beep*" I did make it across, by the way. Jumped across some stones and a wet soggy log - about 30-40 feet wide, 6 or 8 feet deep. I was an adventurous 6 year old.
My best friend died from rabies. A bat bit him. He didn’t tell anybody, and it took about a month till he started showing symptoms. He eventually slipped into a coma and died. I miss him. RIP buddy.
What's interesting is there's a village of natives in the Amazon, and they all carry rabies antibodies. They're trying to figure out why they seemingly are naturally resistant to it. It's speculated that a ancestor developed rabies but it was more mild at the time and lived and she passed on the naturally immunity to her child and that child got bitten and lived and eventually everyone had developed a natural immunity to it
@@skylerthompson8652 Apparently it’s because compared to the other mammals rabies prefers, they have a much lower body temperature making them a less ideal host to replicate or survive in.
Supposedly they are getting subclinically infected with small amounts from bats and they developed immunity to this. Resistance or survival from rabies is known from many other parts of the world. You could survive it too, but the risk is too high and so we never skip the vaccine.
Hello! So today I received my third rabies shot I’ve made just in case cos of your video . Just wanna let you know that the information was very convincing. And I have never heard that rabies is so dangerous before your video 🙏🏻
7:00 My mother knew someone who had rabies and bit another guy who got rabies. Although there are no "known" cases, we must not forget that in developing countries a lot of these cases are not registered in some central database.
@@darksoles1305 Precious Reynolds has two sisters and one brother so she could have shared a dark with them. They probably didn't drink from the same cup because she was sick.
I went down a rabies rabbit hole and while it's super scary, the disease isn't as widespread as it could be because it can only be transmitted once the virus has reached the saliva, at which point the animal is not only going to be symptomatic but will only have a few days to live. This makes it difficult to spread.
Rabies can be spread by a single individual more then once what do you mean? If a animal with rabies bites more then one person it will infect more then once.
@@MRblazedBEANS right but that's how all viruses work, but most of them have weeks or even months of viable contagious time, rabies only has a few days to work, and it can take months or even years for an infection to manifest. not exactly outbreak material unless you intentionally dumped a bucket of Rabies Saliva into a city water supply or something absurdly stupid.
@@MRblazedBEANS I didn't understand. What I meant was that the animal has only a short time to spread the virus and is also going to display symptoms during the time it can infect. This makes transmission more difficult than say, a virus that can be spread through the air from a host that has no symptoms and can spread the virus for a long duration.
I remember as a child reading a Guinness world records book and the deadliest disease was listed as Rabies, to me it was a commonly known fact but it seems many never knew about how terrifying it is.
how high have you ever been, is this gods world or do the go pros, and barrel lens tell the truth here way ye, thanks for being such a great sharing spirit of a man, hurry back to terra firma , always stay as cool as you are wers my chute n my seat is it behind or a one man flier
I got super terrified in the middle of the video thinking "wow, I hope I never got near this virus", then I realize that I already was infected with it, but I didn't associate the name in my language with it in English! After trying to help a bat with rabies and getting bitten by it, I had to take almost one shot of vaccine/injection per day for 1 month... At the time I cursed to have to do that (I hate needles), but after this video, I'm glad I took them correctly.
my brother got bit by a stray dog and had to get vaccines too off course. till this day i am terrified of dogs when they get a little too close to me. the funny part is that i was the one who got traumatised by this incident not my brother. also i am glad that you survived.
@@PRubin-rh4sr oh what? That's weird, in my country the rabies vaccine is known to be 20+ needles or something as crazy as that, not entirely sure could be outdated rumor but that's what i heard
Really really nice video. As a molecular biologist who plans to study and specialise in Virology, I really apreatiate the simplicity and yet absolutely exact informations. Also, the detail of very beautiful animation is admirable
1:20, The primary transmission vector where I grew up, in the state of Maryland, USA, was raccoons, not dogs. We were constantly being told/warned/terrified into being aware of any raccoons that were out during the day, as they are mostly nocturnal...although they Do come out in the daytime for the rare opportunity to eat an unusual treat or play with a new shiny object; and they start their food hunting during twilight, before it becomes completely dark. So, yeah; There were countless false reports about rabid raccoons being Everywhere. From the way of things, it was easy to believe that stepping outside just for a moment, to call the family cat or dog, or do anything, really, was pretty much a guarantee of being bitten by a swarm of crazed raccoons, and then slowly and painfully turned into a rabid, hybrid, zombie raccoon person, like in a real life Stephen King book. At least it was if you were seven years old...
the thing is, not only are raccoons nocturnal, but as wild animals they have an instinct to stay away from humans. Dogs tend to be not afraid of humans. You might have fun reading Steven King's "Cujo"!
Besides this, quicksand and dinosaurs, which other things did we have a deep, deep fear of when we were younger that turned out to be completely misplaced?
this is the story of my heart. for more than half a year I am very sensitive to animals that transmit rabies. even when I pass by, or see a dog I break out in cold sweat, and immediately run away from it. I don't even want to step on the floor of the house, if there are guests who have dogs. Even holding money I wash my hands 😭. I also consult a doctor every time I see a dog, I ask if I catch rabies if the virus evaporates in the air. In fact, I always felt that my life would not be long, even though I had never been bitten or scratched by an animal. and every day I'm always in a panic. I don't know, because when I went to school I passed a dog. until I always buy handsanitazer and masks when leaving the house. oh god I'm tired of living in fear. every day there is something that makes me afraid of rabies. and today I met a bat when running the motorbike at high speed and the bat was right in front of me but fortunately after I checked my body no one was bitten. and I am currently haunted by what if bat saliva gets into my eyes. and it always gets past me. i hope nothing happens what i want . God bless
Remember God’s love. He will take care of you because he is your father. 1 John 4:18 reads, “There is no fear in love, but perfect love casts out fear. For fear has to do with punishment, and whoever fears has not been perfected in love.” No matter what happens, NOTHING gets past God. Whatever happens is God’s decision, so it will always be for the better. Jesus loves you, accept His peace through a prayer like this: God, I love you. Thank you for always taking care of me, please give me Your love because perfect love, the love only You can give, will eradicate fear from my life. Remember this: Jesus is the prince of peace. Accept His perfect love and His peace.
Also remember the end of the video: Nature isn’t always scary, it can be beautiful. God did say everything was good when He created the world. Nature is beautiful because God created it. Living in fear will only worsen it. Being afraid for your life and dying afraid will only waste life. Live life with peace and joy, because even IF (big IF) you die young, but you enjoy life, that will be more valuable than living 100 years in fear.
That's what happened to me, till I realized that it doesn't matter if we live long or short, there is a continuation for life, that's right, that's God.
I remember reading about a rabies case a few years ago, where a 5yo got bit by a bat, and since he hated needles so much, his dad didn’t want him to have to go through all the trauma and so didn’t take his son in to immediately get vaccinated. Kid died 2 weeks later.
I was reading a book yesterday that mentioned this exact disease and how deadly it was, that was the first time I heard about it so this video couldn’t come at a better time. Thanks Kurzgesagt!
A few months ago I spent hours searching in TH-cam for how rabies works and got literally nothing. All videos just tell basic things like how symptoms look like, how it transmits through saliva, that it is deadly blah blah... You know, stuffs that everybody know since kindergarten. But, your channel is truly one of a kind. I couldn't say how much appreciated I am. Deeply, Really Thank you. Thank you for everything.
Just wanted to point out that while the animation at 8:40 shows a squirrel foaming at the mouth, squirrels and small rodents are almost never found to be infected with rabies. The leading hypothesis as to why is that in order to be infected the small animal has to get bit, but when the animal is that tiny they usually just die from the mauling before becoming infectious. That's why if you get bit by a squirrel, rat, mouse, rabbit, etc. doctors will usually brush it off unless you specifically saw the animal showing symptoms (foaming, erratic/aggressive behavior, averse to water)
I don't think Doctor should brush it off just because _it isn't likely_ to have Rabies, if it does, then you're dead. (What I meant was doctors should still check if you are infected so that if you are, you can go get the vaccines)
i'd probably still push to have that person get a rabies shot. We don't mess around with cuts/pokes from rusty objects do we? Nope, we get tetinus shots
The fact that rabies is so good at avoiding and hiding from your bodies defences for years, invisible from the outside, and when it makes it to the brain stem and the symptoms start showing it is too late is scary as hell.
@@zxcv97 prions for me are more scary because you cant really prevent their destruction once they enter your body (i might be wrong but last time i checked, there wasnt really anything we could do)
yeah reminds of Robbie Williams illness development. it starts out as behavioral issues, which lead to isolation and then there's no turning back as the person is incapable of understanding, seeking help etc.
I always thought HIV was the sneakiest and scariest of viruses bc its "life" cycle is the equivalent of a swarm of deadly ninjas sneaking up on the most crucial parts of your immune system "army", going undetected right under their nose, and then taking them out with a single deadly punch to the throat. But then I saw this and realized that Rabies does all that but with the twist of torturing you to death 😳
And rabies has a 100% mortality rate except for a handful of people who’ve been treated with extremely intensive medical interventions and had to recover from serious brain damage. With the newer drugs, HIV is still incurable (it will come back if you stop taking the drugs), but it’s no longer a death sentence.
This last Coronavirus killed well over a million Americans and will kill a few million more before it fizzles out, and has permanently disabled two of my three siblings who’ve had it with “long COVID.” Pneumonic viruses are the only ones to be truly fearful of, since people can do everything perfectly and then lose their entire families to death.
its my favorite and subsequently the most horrifying disease! its strange how this specific virus family either virtually does nothing, or puts you in the dirt so fast.
I've always found it hard to explain MHC class proteins so being able to display it is quite useful. I know it doesn't cover the class II's but I always find it incredibly useful to show these videos to people as my drawing ability is so horrible that I tend to mess up too much to get the point across. (also the motor proteins are borderline impossible to properly explain so that incredible drawing will help too) On a completely separate note, I find it intriguing that rabies maintains a lysogenic stage even while active, conventional knowledge is that if a virus is active it is always chewing through cells as well as creating plenty of MHCI markers so it is always impressive to find an exception to the rule. It also is puzzling to me as to how an infection that does not destroy a cell still ends up killing or at least disabling it. Perhaps the viral proteins simply oversaturate protein production making it impossible for crucial proteins to be made meaning it would simply disable the neurons rather than killing them.
You should definitely check out the book they wrote, it's called "Immune: A Journey into the mysterious system that keeps you alive". It's basically like a dummy's guide to your immune system, but it also has all sorts of wonderful illustrations that make the complexity of the immune system a bit easier to understand. It's obviously not meant to be like an actual serious immunology book, and it oversimplifies a lot of things, but it's still something I recommend checking out. I'm a big science nerd so I always love learning something new about the hidden and unappreciated complexity of my body or the world around me.
@Merik When it comes to brain function, just slightly throwing things out of whack would, presumably, be enough to cause major problems. So the cells may be fine individually, and yet the overall effects would still be deadly, perhaps.
The only survivors of rabies that I know of were intentionally kept in a coma to deal with brain swelling (I understand that this was _not_ effective in all attempts), so it's possible that the fatal aspect of the disease is actually a side-effect rather than a direct result of viral action.
@@qwertydavid8070 I mean I've already done both beginner and intermediate levels of immunology on the university level so that one will at most help me to explain it to others. I mean no offence in that, it's just the difference between typical secondary education that everyone gets vs university level science is in an entire other realm when it comes to complexity. Most of what you learn will be 50-200 years out of date in high school and by the time you hit 3rd year (which is the intermediate immunology course) you're pretty much caught up to modern standards.
Well, it's true. You can literally count on one hand the amount of people in all of human history that have survived rabies without the vaccine. The odds are pretty much nil that you won't die, and even if you lived somehow, enjoy the severe brain damage
Listening to a rabies victim screaming uncontrollably while scratching the walls to get away from a glass of water is a sound that will haunt you for the rest of your life. Not even kidding...
@Thanks been on the internet since the wild old days of reality shock sites and gore sites and rabies is stil absolutely at the top of the heap for living terror shit.
@Thanks Imagine trying to gatekeep being scared by something. All you've done is make yourself sound like the type to go on the dark web and watch executions. Because normal internet use is actually pretty darn tame for most people who don't seek out violence and gore. Maybe try to fake just a bit of respect for the disease and the people it's affected and those who've experienced it first hand - not through their monitor - instead of just trying to one up everyone like a middleschooler who just found out about the tor browser.
That's not really how it works, though? Hydrophobia isn't like being afraid of spiders. It means your body will automatically reject any attempt to drink water or get near it. You're not "clawing at the walls" to get away from a glass of water. I think you made this up, or saw something that was a work of fiction because that's not how rabies infected humans behave. Signed, a biologist with a medical background.
@@OneFluffyKiriko since even covid almost made healthcare system collapse, I would give us 3 months before the end of the world unless it was still preventable.
Only 29 documented people have survived rabies. 18 of them had severe damage like complete paralysis. One of the 18 died five years later, anyway. 4 had moderate damage like partial paralysis. 3 had mild side effects likes weakness, poorer coordination, or involuntary movements. Only two made a complete recovery with no noticeable symptoms. Also, only 2 of the 29 people who recovered weren't vaccinated. Most of the 29 cases' vaccination failed. Out of the two complete recovery cases, one (17 yr old from Turkey) received one dose of a rabies vaccine post-exposure (you should get 4 doses plus immunoglobulin). The other case (6 yr old from USA) received a dose of a vaccine just two days before symptoms showed up (18 days after the bite), which is definitely too late. It's said that after 3 days, it's too late to get vaccinated and this is 6 times that, so it's unclear how much the vaccine helped. Neither of these patients were treated with the Milwaukee Protocol or Recife protocol since the American kid's case happened in 1970 (Milwaukee Protocol was first used in 2003) and the other kid's case was in Turkey in 2008, only 5 years after the Milwaukee protocol's first use in a different country. That said, it's not very common to use the Milwaukee protocol. Only 36 patients were treated with it, out which 5 survived, yielding it a 14% survival rate compared to 0% of people: 29 people including those who survived using the Milwaukee protocol out of so many people: 59,000 dead every year worldwide (that's every year, not total).
@@solar0wind it's a very complicated, 22-stage (at its current version) treatment protocol that involves a lot of different drugs, but the main point is keeping the person heavily sedated for a certain amount of time.
A man in my country, Chile, survived after the onset of symptoms. Like his case, there are very few survivors in the world. He is truly a legend to survive that.
@@kristijanoros7208 The neurological sequelae he suffers are: Impairment of movement (imbalance), color blindness, mild amnesia (he doesn't recognize old friends faces for example), imbalanced corporal temperature (sometimes high, sometimes low compared to the mean corporal temperature). And he got kinesiology treatment for almost 2 years to begin to walk again, because when he woke up, he couldn't walk. But if you ask me, he cheated death with 'mild' sequelae. It could have been worse.
The quality of these videos never fail to absolutely amaze me. Thinking of all the hundreds of hours that the Kurzegat team spent bringing us top quality and truly honest videos for the sake of science just refreshes us from the extremely toxic and useless ways this wonderful platform is being abused. I usually don’t comment on videos but I really had to express my thanks for the team and their dedication as well as remind everyone to like these videos as well as subscribe to the other language Channels so more people can see this. Have a nice day!
I agree. The videos are a brilliant hybridization of aesthetics, animation and knowledge, and I adore how engaging they are while still giving lots of information while being up-front when things are simplified.
Rabies is the single most thing that terrifies the hell out of me out of everything else Its just so scary to think about its effects almost like entire point of this disease was to kill someone in the worst possible way
If it counts for anything, diseases such as "Mad cow disease" (Bovine Spongiform Encephalopathy), or the similar condition in humans (Creutzfeldt-Jakob Disease) are FAR scarier. While they aren't common, they're 100% fatal, there is no treatment for them, there is no current diagnostic test that can be used to detect the disease before death, and usually symptoms don't appear until you're well into your 50's/60's, regardless of when you were exposed. It presents very similarly to dementia, so it can be difficult to diagnose, but unlike dementia, people suffering from CJD tend to not survive more than a year past the appearance of symptoms. Even more wild is the fact that it can be caused by a rare genetic mutation, and that mutation can be passed to your children, increasing their chances of developing CJD on their own without being infected. It is caused by a misfolded protein, called a prion, and these prions induce misfolding in normal proteins. And since it is just a protein, you cannot just "disinfect" contaminated surfaces, and it cannot be "killed", per se. Because it's not alive, it can stay on surfaces for upwards to two years, remaining infectious the entire time. CJD is the reason why most countries do not allow people to donate blood if they spent more than 3 months in the UK between 1980 and 1996. As a medical lab technologist, there is not a virus or bacteria that scare me more than prions. And not because they are common, or super infectious or anything like that, but rather because they're so insidious. Imagine rabies, except it cannot be detected until you die, it presents similarly to dementia and can be missed, it can potentially remain on surfaces for years infecting you long after the surface was contaminated, it doesn't present symptoms for 10-40 years after infection, and it's 100% fatal. At least you can be protected from rabies, and there are very successful treatments up until the final stage of infection. Id much rather take my chances with Ebola or Lissavirus. Nothing scarier than getting a call from a doctor that the CSF you just processed last week came from a patient who is now suspected of having CJD (or worse, now confirmed). You have no idea where those prions potentially have ended up, and the amount of cleaning of the lab that occurs because of them is mind boggling. @Kurzgesagt, you should totally do a video on prion diseases!!
@@marias1609 i think he means a RTS game and the battlegolround is inside the human body 😜, units are cells etc. It would be interesting since it can be made like RTS in space and you can move in 3D space and the campaign will be fighting off bacterial infections, fungus ones viruses etc and also play as the virus to defeat the human body😬🤔.
What’s interesting is that even the incredibly small percentage of ppl that have survived rabies show signs of mental deterioration and cognitive issues afterwards showing that truly no one leaves unscathed.
Hey Kurzgesagt, could you do a video on prion diseases/ the Mad Cow disease outbreaks? It would be very interesting and fit with the theme you have of extremely deadly brain diseases.
Just here to appreciate the subtle Wilhelm scream at 7:58, since no one else seems to have mentioned it. Enjoyed the video very much, also loved learning about the transparency trick!
I never had lyssa, but I did have encephalitis when I was young, my neurologist is pretty sure that's why I have brain damage now. I got it from a mosquito bite. Pretty scary stuff, I'm happy to be alive, but it definitely puts stuff in perspective and makes you realize how lucky we are to have access to medicine and hospitals
It has been suggested that the vampire myth originated from people infected with rabies. Since rabies causes light hypersensitivity, hydrophobia, aggression, and occasional biting, it fits the narrative of a typical vampire who goes out at night, is scared of holy water, and sometimes bites people. It’s interesting to think about anyway!
That also explains why the myth of vampires includes creating other vampires through biting sometimes! That’s cool, I honestly never drew that connection
I'm surprised that they didn't go into how serious the Hydrophobia is. It's so weird how it literally triggers intense dread and fear when exposed to water.
man what about garlic
Could also fit with werewolves
I always thought the same thing but with werewolves
Im a biologist and I’m always fascinated how you manage to explain complex mechanisms in an easily understandable manner. Great job once again!
I don't know if this is your field, but since you are a biologist, how accurate do you think their visualization of the dynein motor is? Just curious.
I wish they had shown us how the vaccine works....
@@reina4969 Exactly! Also why do the rabies patients fear water so much!!
Physician here. Ditto.
@@reina4969 they have videos explaining how vaccines work, and since this is about the virus not vaccine im guessing why thats why they didnt go in depth
When I was 19, an erratic bat that crashed with almost every object around entered in my house, and when I tried to grab the creature to throw it back outside, it bit me. My mother was highly concerned about what just happened, she seemed almost hysteric and I of course thought she was overreacting. She took me to a clinic that same night and made me take the anti-rabies vaccine, the first shot of many that I had to take in order complete the treatment.
Reading afterwards about the awful and agonizing death that rabies patients suffer when they are left unattended, I am very grateful to my mother for her urgency and don't wanna think too much about what would have happened if she hadn't been around to act so quickly and decidedly. Most probably I would have forgotten about the bite the next day and would have died in the next few months. She saved my life.
You should have been worried, treat any bite as it can be infected with rabies!
I'm confused as to how its possible that you thought your mom was overreacting.
@@adventureinlife7700 it seems that this person associates careful but expressive people as overreactive / overdramatic lol
@@adventureinlife7700 It seems like when they were bit they did not know of rabies or it being very serious which probably lead to them thinking that their Mom panicking so much was overreacting because, “it was just a bite”
Uh, just realized I put hitch instead of which, oops.
Your mother did the right thing
My cousin-in-law died from rabies. It was an horrible sight.
He lived in a rural communitu far away from the Tropical Medicine Foundation, so it was too late for him to be vaccinated. He got there already symptomatic. Died furious and suffering, trying to bite my mother-in-law, afraid of water, foaming in the mouth.
That's more than trauma, rabies is so cruel.
I’m so sorry you had to go through that. Feel free to ignore this, I’m just curious. I thought that the virus spreading through bites was just a clever way of using what most animals have as their natural mechanism of aggression to spread the disease. Humans don’t usually show aggression through biting. I thought that the ‘furious’ part of the virus was just general aggression/agitation of the victim. Is that not the case?
My Enemy died of rabies,I’m kinda happy about it he was my enemy,
But I got horrified because he was trying to bite my best friend my best friend and my teacher-in-law
@@Awesum_Pawsum teacher- in law??
@@breetopkuschi9657 during the final stages of rabies, your brain is so disoriented and confused that you basically "devolve" into a half-animal. It depends on the person
Lyssa is basically running the optimal Pandemic/Plague Inc. strategy. Super stealthy until the target is fully infected, then rapidly turn extremely lethal
problem is if you see a human with full on rabies, you fear this and start quickly researching how to cure it, and since the actual infection to death time is long, with a cure this is easily taken care of
hella fax
That's certainly one way to evade the Madagascar/Greenland problem.
The lethal skill does not seems a good one. How can a virus replicate if it kills its host. AIDS seems better to me.
true but unlike in plague inc, rabies is incurable after symptoms show and also zoonotic making it extemely difficult to eradicate. also in plague inc u can trigger the mutation to become super lethal which affects every contagion immediately which is unrealistic
I remember reading that one of the most-affected parts of the brain by rabies is actually the amygdala, which controls a person's fear response. It essentially gets permanently switched on, so not only are you in agony as your brain expands and your muscles spasm uncontrollably, but you are trapped in a permanent state of terror where everything and everyone seems like a threat to you.
This is actually probably what the series "all of us are dead" is based of, no joke, they bombed the entire city to stop the virus
That's the worst ways to go 😷😷
Oh man, I saw a video years ago when a young man that was infected with rabies acted violently so they tied him to his bed, but he struggled and escaped just to jump from the hospital's window. It's literally the most fked up way to go..
I found the video again, it's really bad. The title is "Rabies info campaign part 1.mpg" at 5:25 mark. It's in Filipino though but you can get the point..
Dang 666 Likes lol
I'm a doctor and I remember a case of a little girl who died of Rabies after being bitten by her pet dog while grooming it. It was so sad because we watched her die and couldn't do anything about it. The Lyssa virus is really deadly. Go to the hospital immediately after being bitten by any animal to get vaccinated against Rabies and tetanus.
Hi doc. Can I inject booster even if I hadnt bitten? You know it comes from the saliva and were not aware that saliva can go inside us. Why its aways have to be bitten since its the saliva that go inside us.
@Yummy Spaghetti Noodles Mainly causing muscle cramps that will kill you at some point. When they Start effecting the muscels you need for breathing you suffocate.
Or get vaccinated preemptively like many people where I live. (Not sure about rabies, but tetanus is a standard vaccine and it might even be required but I'm not sure)
Fake liberal bot...How much did they pay u?????
@@drekson23 Saliva is usually transmitted through bites, since saliva is created in the salivary glands located in the mouth. And yes, you can and should get inoculated against rabies, even if you haven't been bitten.
Got bitten by a possibly rabied cat a day before my birthday. Got a vaccine for rabies within 24 hours, and then had two other doses in day 3 and day 7. within that week, i found out from witnesses that the cat died after the bite and i thought to myself, damn. a month in and had another does. docs told me to go back 7 months after that
I remember hearing that the first known person to survive an infection of rabies that reached the brain was kept in a particularly deep induced coma for the duration of their infection, which seemed to suppress the encephalitis and also gave the immune system a chance to fight back. And even then, they barely made it and had months of rehab to get over the coma.
yes and it's a wonder that kurtz didn't include this extremely vital information, or also the fact you need to get the shot the day you're bitten bc rabies ISN'T slow, it kills humans in under a week.
You mean the Milwaukee protocol? It doesn't work.
@@hoihoipoipoi This isn't true. Rabies is definitely slow with an incubation period of 2 - 3 months according to the WHO and "weeks to months" according to the CDC. You can get the vaccine any time within that incubation period. The full vaccination course (with 5 doses) takes 14 days, and while a few people have survived without the full 5 doses (take this part with a grain of salt because I don't fully remember it), it's generally best to get all the shots. Rabies may kill people quickly after symptoms present, but it's more likely than not that they were actually exposed to the virus months in advance.
Secondly, if we're referring to the same person, they were using an experimental treatment called the Milwaukee Protocol to try to treat rabies. While that procedure worked on the patient, it has only worked that single time, while failing on 25 other patients it was attempted on. Due to this low success rate and high cost, it's more likely that the success was a fluke due to outside factors, and so it's generally not recommended now if I remember correctly.
@@AgentSmith911 14% survival rate instead of 0%
I would say it works.
@@lachieslan3970 Out of a few dozen samples, it has never been proven to work. Which why experts are avoiding the method. It's basically quackery.
Was talking to my mom a few weeks ago when she casually mentioned my grandpa was bitten by a bat. I freaked out, especially when she said he hadn't been to the hospital and wasn't going to go until he felt sick. I made her hang up with me and call him to tell him to go to the hospital. I've always been a bit 'morbid' and rabies has been a fascination/ fear of mine since I was a kid. I thought my grandpa knew about rabies because he was a firefighter and therefore had first responder training and had done rabies vaccination drives (for dogs) at firehouses. Turns out he didn't know how bad it was. He hated the vaccine regimen, but I'm glad he listened and went and got it.
Great job! You likely saved your grandpa's life.
Not all heroes wear capes.
Your grandpa is now a lizard person 🤔
@@anthonyfarias5076 yo ngl that was corny
@@watterson.darwin its true tho
Fun fact: opossums usually don't get rabies, because their body temperature is too low for the virus to survive in them.
They're literally too cool for rabies!
And most die before the age of 2, so not much chance of getting it
@@user-eh2jk6mf9s they're too cute for this world, we couldn't handle having too many of them. We'd get nothing done! Just spend time petting and feeding them fruits and bug snacks
@@Bleats_Sinodai skill issue
It literally said 50,000 people a year die from it, yet it is the most deadly virus?
@@angelmainaccount2507 I'm sorry?
A cell: **got infected**
Immune system: you should sacrifice yourself, NOW!
imagine if that's what adults did when we got sick... Welp, time to die
Not really
HEYY THATS MY LINE!!
*lightning bolts*
Bureaucracy amirite?
As someone who has been saved by the post-exposure vaccine for rabies, I can barely explain how thankful I am for this invention! It is really unpleasant, yes, but not getting that treatment after being bit by a rabid animal will result in one of the most horrible deaths known to mankind, therefore praise the science!
Yes, however not when it isn't throughoulgy thested and rushed out on the martket for a virus that has a death rate equal or lower than a regular flu. I'm talking about covid.
Religious bots gonna swarm here
Do you mind donating to the scientists who invented the vaccine ? I believe we must all be grateful of scientific inventions and do the least to boost its progress if science has saved your life even once . ( it has saved mine twice lol in fact my entire family would have been dead right now if it weren't for science )
@@incognitoman3656 lol
@@incognitoman3656 As the video said. Praise the Science! Commit no blasphemous questioning! Amen!
i swear to god the microscopic world of the immune system is the most involved and elaborate RTS game in existence its actually insane.
Fun fact, my group and I created an immune system RTS game in a college game dev class. It was awesome, albeit not perfectly scientific lol
@@survivalizer wow, can I download this?
Id love to play it
@@survivalizer may I play it?
@@survivalizer what is it
The most interesting and also haunting part about rabies to me is the strong hydrophobia people display. Its such a specific and scary symptom that by chance also helps you spread the virus better because you wont dilute your saliva with anything else.
@@anonlf8398 dude are you having a stroke, or are you high?
@@anonlf8398 what are you on about my guy
@@anonlf8398 go to sleep bro
@@ABIADAB The drugs finally got to him
It's terrifying how microscopic life can alter our brain and make us do things
"Lyssa is a patient monster until it goes for your brain." Literally chilling to hear! So glad I was taught about rabies when I was a kid.
Also, the only known human to human transmission of rabies has been through infected organ transplants.
dying like that must feel horrible, you managed to survive another condition because of the transplant, but then it ends up killing you in an even worse way
I was exposed to rabies a few years ago when I tried to rescue an injured bat.
The shots were expensive, viscous, and painful, but I'm SOOOO glad I got them... Don't mess with Rabies.
Expensive? Are you American?
I was bitten by a semi-stray dog when I was maybe 10 or 12. They gave me a series of shots in the butt, including for rabies. I remember that the nurse took each needle by itself (not attached to a syringe) and, with one quick motion, "threw" it into my buttock almost like a dart. _Then_ she plugged the syringe to it and injected. I don't know if that's normal for buttock injections, but it seemed strange. She seemed to know what she was doing, though.
Don’t mess with injured bats!
Expensive? Where do you live?.
@@_._ajmal probably the USA
I knew of its fatality rate, but never knew rabies was this insidious with its process.
Glad it isn't _very_ widespread.
it isn't, because of the anti rabies campaign back in the early 80's... mostly...
leave it to antivaxers and in a few years, no more wildlife (because they would simply kill the "vectors") and millions of infected peoples, because fluffy simply can't be infected, they are protected by their owners prayers... right?
I’m sure as governments work to weaponize it by making it airborne we can come back to this comment and reminisce
Yes indeed. Because that crown belongs to ME!
Don't jinx it lmao
Has the world been bitten by faang companies
Rabies and tetanus vaccines are so important. The risk was impressed on me a ridiculous amount as a kid, since I lived on a farm, but my mother was an ER nurse. She saw tetanus and rabies cases every year where some neighbor didn't get a child or older farmer the proper shots when bitten by bats, or when they got poked by a rusty piece of metal. I still remember her crying in the nurses lounge when I was a child because of a similar kid who died to rabies from a possum. (she would 'babysit' me there, aka the other nurses would')
Tetanus coming from rusty metal is a medical old-wives tale, you can get tetanus from anything unsanitary, it’s a bacterial infection. In fact much like copper oxide, iron oxide has antimicrobial properties, you’re much more likely to get tetanus from not washing up properly after the bathroom or scraping your knee.
Opossums don't carry rabies. Their base body temperature is too low for the virus to survive. They are one of the only mammals totally immune to the virus actually.
I thought Possum’s internal body temperature was too low to carry rabies.
Actually, tetanus doesn't have much to do with rusty nails, the bacteria that causes it lives in a lot of places, almost everywhere. For example, if you cut yourself, and then smear dirt all over the cut, you might get tetanus. Rust is just usually an indicator that the nail itself probably has the bacteria on it, because it's been out for long and had a good chance to get infected, and nails are just... pretty good at poking you and getting the bacteria in your body, but the disease itself doesn't have much to do with rust.
rzbies was eradicated in the rich countries since 90's
You're tearing me apart Lyssa!
how could you break my quadcopter!?
Oh hi Mark
lol
This is an incredibly underrated comment Good job I see what you did there
OH HI MARK
A few points:
1) Up to 2004 no person had survived rabies after the onset of symptoms. However, since that time 29 people have survived through new techniques such as The Milwaukee Protocol. Still, when you consider that over 55,000 people die from rabies each year, 29 survivors in 18 years still means that rabies is almost 100% fatal after the onset of symptoms.
2) Birds have been found to carry rabies antibodies, showing that they’ve been infected. However they never become symptomatic.
3) At one point near the end, you imply (with a picture) that squirrels may be rabid. While this is possible since squirrels are mammals, it would be an extremely rare event, because any squirrel that’s bitten by a rabid animal will very likely die immediately. This is why rabies is more common in larger mammals, which can be bitten but survive long enough for the virus to incubate.
"The Milwaukee Protocol" sounds very scary haha (and I mean it is, considering you are put into a coma that you might not wake up from). But still, it's better than guaranteed death.
Thanks for the info👍
@@concrete_dog Exactamundo
Heyyyyyy
Nah I'm glad they didn't sit on it
Don't disrespect our homeboy the opossum. Deserves credit too. It's rare they get rabies. Better and safer wildlife friend than a raccoon.
yes
Two months ago, I thought I was going to die from rabies.
I was on vacation in Morocco and attempted to pet a dog on the beach. It bit me and ran off.
"Oh, that guy is angry, lol." - I thought.
I had never heard that rabies was fatal, so I just ignored the subject, returned to my home country, and resumed my normal life.
Ten days later, I was on my way to work and began to feel an itchy sensation in the area of the bite, accompanied by a strange headache.
I searched for my symptoms online and discovered that rabies could be the cause. I then researched rabies further and watched a video that explained everything.
That marked the beginning of the worst ten days of my life.
Then, I immediately sought medical assistance.
I went to the ER and described my symptoms. The doctors were concerned, as rabies rates in Morocco are high. Unfortunately, the rabies vaccine was only available at one hospital in the entire city, so I had to wait an entire day to receive it.
That night, I didn't sleep, work, or eat
I went to get my vaccine, fully aware that if rabies was the cause of my symptoms, it might be too late.
The doctor who administered the vaccine appeared worried as well, though she tried to hide it. I received two doses of the vaccine and immunoglobulin to boost my immune system.
Now, it was a matter of waiting.
Unfortunately, my symptoms worsened.
I started to feel dizzy and very anxious, both symptoms of rabies.
However, I also experienced panic attacks.
So I wasn't sure if I had rabies or if I was just having a panic attack.
I was terrified, so I created my will online. I recorded a video for my mom, my girlfriend, and my two best friends, explaining why I thought I was going to die and wish them the best.
The next day, I developed a fever (which I later learned was also a side effect of the vaccine).
I couldn't help but cry. I wasn't afraid of dying; I was afraid of dying from rabies.
The following day, I visited a rabies specialist in my city and described my symptoms. He assured me, "You don't have rabies. Go home and live your life."
Of course, there was no way to verify his claim. Apparently, there's no such thing as a reliable rabies test. You can receive false negatives until you are literally in the ER being resuscitated.
Luckily, rabies kills quickly, so I just had to endure ten days of agony. If I wasn't dead in ten days, I would be rabies-free.
That's exactly what happened.
I received my additional doses and now I am fine.
I wouldn't wish this experience on anyone. It's mentally and psychologically exhausting.
Even now, watching videos related to rabies makes me feel uncomfortable. It took me weeks to return to a normal sleep schedule and social life.
Please, if you get bitten, seek vaccination immediately.
so glad to know that you're okay now
rabies recently blown up in my country, not much cases, just because one case, but its going viral on internet cause someone upload it on tiktok. and now im terrified as hell after searching more and more about rabies. the 100% death rate when the symptoms appear is trully terrifiying
@@tukangeksperimen7844 yeah. No way to know you have it until you’re already dead. If you’re scared though, you can get the vaccine before being bitten and you’ll be fine. Just ask your doctor.
Thank you for sharing your story!
Why would you go to Morocco
Discovering a new culture it’s interesting for me
Rabies is truly terrifying. When you have it you may not know for months, but once you know your pretty much already dead. Lucky it’s not that common and hard to spread between people. I think only 1 person has ever survived so it’s maybe not deadly by amount of people, but by it’s effectiveness and death rate.
Basically if you get bit by a mammal, immediately get a vaccine
Raccoon skunk bat totally. Statistically rats are much less risky and squirrels have never been found to transmit rabies to a human in north america
@@ItsKoryn It's better not to respond to bots
@@ItsKoryn Terraria ain't just a 2D knockoff. That other guy still sucks though.
very impressive
Prions much terryfying tho
Fun fact, Rabies in Polish is called "Wścieklizna" after "Wściekły" which means "Mad" or "Enraged" since the animals with rabies act mad and enraged.
The dutch word is "Hondsdolheid" meaning "Dog Insanity" or more accurately "Thing that makes dogs go insane".
same in Russian
The word "rabies" itself is also the Latin word for rage.
In Finnish there are two words for rabies, the more popular one being "vesikauhu" which translates to "water horror" or more accurately "hydrophobia". The less popular one is "raivotauti" which means "rage disease".
In german its called "Tollwut", meaning "Crazy rage"
Honestly, I thought rabies was just "Woah-ho! that dog is foamin' from the mouth! Don't go near it, they're aggressive!" but this video has actually shown me what happens, and I'm so happy that these videos exist
@Mishan 🅥 you fool. I have witnessed the golden monkey
if a dog started running at me with foam from the mouth that dog is getting thrown to the highway!
Here come the beggars, but that aside, that's just one reason I prefer cats over dogs, even though I have scratches all over my body
Also search for Prions
@@javieralejandrotrianapaz6343 Cats can get rabies as well.
I'm a health inspector, and, in much of the United States, health inspectors are responsible for rabies management and tracking. In my state, rabies is still very much around and unfortunately a lot of people have to be vaccinated for it. Even more unfortunate, a full rabies treatment can cost anywhere from 5k to 10k+. It's disgraceful that a treatment, if you don't get you will 100% die, is so costly.
$450 for pre-exposure vaccination in Australia.
The majority of the Entire U.S. medical industry is a profiteering disgrace of greediness. As illness is involuntary, the prices charged are a national Shame. Simply a case of predatory capitalism.
What state is that?
@@chrysanthemumfire6456 south east united states. Rabies is rampant in all the states in the region. Though, to be fair, rabies is a problem in many states, not just the south east.
@@PlanetInline see, now that's at least reasonable.
It's actually pretty scary how good nature can be at killing us. Gives us a good perspective of how fragile we are.
True. A real Devil or God can eliminate us in a wipe.
@Mishan 🅥 ok I won't
Everything in nature has had thousands to billions of years of preparation to get ready to kill its pray. Nature is metal!
We are better in killing nature than nature is at killing us! We can destroy every living thing on this planet if we wanted to! But ofcourse that would also mean the end of us as well!
@Mishan 🅥 how about no
"Simple, Lyssa with its 5 proteins plays an UNO reverse card" Excuse me what the frick
This is one of the craziest cellular biology animations ever, you really packed this one full of the amazing stuff, I didn't know any of these intricacies of the immune system and I feel like everyone should have a working model like this in their head of what's actually going on inside them.
treatment after being bit by a rabid animal will result in one of the most horrible deaths known to mankind, therefore praise the science!
Your generosity towards healing my Herpes is incomparable , DRETIKO you assured me of getting healed just within 21days and it was so . I will keep letting the world know about your good work ❤❤
Also. I recommend cells at work anime.
2:18 How can some people think that this is a coincidence, this is pure engineering
@@asktoseducemiss434 You mean "not getting treatment", right? If you get treatment, you'll live!
thank you so much for an amazing video
Hi
Amazing indeed 🙀
Man watching these videos makes me realize... im really taking my body for granted. I mean we all act like were alone and nothing cares about us but there is always little creatures in you literally killing themselves to keep you alive . Really makes you think
You are those creatures though ;)
Not creatures, that's your body.
They're not creatures, they are programmed to do that. If you feel alone, remember your instincts are your brain's certified way of protecting you, without the conscious you even realizing.
Stay off the drugs, lizard Joe.
Did u know, ive been infected by lyssa once when i was like 3 in china. Im happy im alive now thanks to these people that decide to spend decades just to save maybe just one person even. It’s truly an example that everybody counts! ❤❤❤
In Finnish it's called "Vesikauhu" so basically "Waterhorror", which is a pretty straight forward way to say what the symptoms are
I have been absolutely terrified of rabies for many years. It scares the absolute living crap out of me, even though it isn't something I really have any real need to fear - I don't spend an inordinate amount of time outside or near wild animals. It's not something I'll likely encounter, but as soon as rabies comes up in a conversation, I break out in a cold sweat.
This was my first Kurzgesagt video that I've ever watched. Of _course_ it had to be about rabies.
Exactly the same
Britian doesn’t have rabies
My dad's a vet
Every time he spoke of rabies (especially after an encounter with a sick animal - most often a cow) the little, bubbly, chatty 8 year old me would be like O.O in a corner
You could theoretically get it from food from infected animals, like cows. There have been panicks from raw milk used in sold in products and later discovered one of their cattle was infected from a wild animal. Though no one was infected there was panic and some had to get shots.
Why don't you just get vaccinated? Problem solved
As someone who was exposed to a rabid animal when I was younger, I am very glad this vaccine exists. I might not be typing this comment today if it didn’t.
Correction: you would not be typing that comment today
i also lived because of vaccine
Yeah but it hurts like hell I had it when I was 7
@@crazykiller001schannel5 *correction. Might not be. There has been a handful of people who survived rabies. All through the Wisconsin protocol I believe.
You definitely wouldn't be typing this comment today if the vaccines were even half as bad.
Props to the storyboard artist or concepter or whomever in production who decided the person in the animation to be infected should be a child rather than one of the birbs, adds a real oomph emphasizing the scary reality of rabies
but, I'm not sure what the point of scaring anyone would be. They mention in the very next moments how effective the vaccine is. I think it's more important to scare people about the ideology of anti-vaxers. There's much less reason to scare people about rabies otherwise.
@@squirlmy People dont get rabies vaccines. Animals do. You assume if you get bit they will then give you a bad series of shots and hopefully catch and test the animal. BUT in many states in USA it is not required to rabies vax. In my state, it is not only required, but MUST be administered and tracked by a vet. For dogs, anyway. We also have a guy in my city who captures stray and feral cats to get them vaxed, spay/neuter then releases.
@@sophiesmith5922 People DO get the rabies vaccine, but only if there's a chance they've been exposed to infected animals. Cats and dogs get it as a preventative measure.
@@sophiesmith5922 people absolutely can get a rabies vaccine? Usually after an infection, though I think if you’re going to a high risk area you’ll get one too
@@sophiesmith5922 Actually, there is a rabies vaccine for people, and as the video explains, due to the slow speed of progression of the rabies virus, it can be given after you have become infected as long as it is given quickly.
Rabies is my number one fear, and this explains it well
I’m scared of it to. And yet my dumbass would try to pet a raccoon that was walking up to people.
@@axehead45 How did it go?
@@wolfamadeus6932 Luckily this hasn’t happened to me. But I know I’d be dumb enough to try it.
@@axehead45 Raccoons are friendly and sometimes walk up to people for food. But if a raccoon's alone and acts weirdly, then I wouldn't come close. Although, you should be cautious of any unfamiliar animal. Especially dogs, they are the most common cause of human deaths of rabies. Many people think that it's usual for stray dogs to be aggresive and don't take it seriously. Sometimes I see children playing with stray dogs.
These guys should have an entire tv show, these videos are so high quality it’s unreal.
True
I don't think they would do that
For sure!
@Mishan 🅥Dont translate
si obyčajný žebrák
Fun fact: March 18th 2025.
I find it interesting that humans went from using sticks and stones to somehow finding a way to figure out how each cell in the body works
Yeah its been crazy to watch all this happen over the years
@@carelesswhisker4155 how old are you????
Crazier still how little we know about such basic things. People still don't know how smell works.
Knowledge about cells is relatively recent
@Agustín Franco Idk, man, I would need to know the date of birth, but calendars weren't around until very recently.
So glad that content like this exists, spreading completely honest direct information and THEN explaining how you can fix the problem rather than just leaving viewers helpless
Well if that wasn't the case we would be all doomed
Hmm that's why this show is the best
Except when it comes to global warming, that's just pure propaganda
@@elgatochurro Which part is propaganda, "global warming is real" or "there's something you can/we will do about it"?
@@jasonwalton9553 global warming is propaganda
"Order the infected cell to kill itself" made me laugh maniacally.
oh thank god im not the only one
I thought I was just crazy
@@EllpaFox47 We could both be crazy...
I find illnesses where your mind fails before your body, considerably more terrifying than the other way round. Not only rabies, but diseases like dementia, or heavy metal poisoning. The thought of my humanity dying while my body lingers, and what effect that would have on my loved ones horrifies me.
I find the opposite more terrifying. Something like ALS where your body just stops working while your mind is entirely there and you have nothing to do but contemplate your doom
@@stdesy death is scary either way I guess
@@stdesy ALS is horrible
The advantage of your nervous system decaying first is that you're pretty much braindead, which means no more dread or contemplation for you.
@@diseasedworm9209 I know, learning about some neurological diseases that the patient can't avoid getting and can't heal from makes me sad
One of the things that really stuck with me from my teenage years, was reading of the first Neolithic cities in human history and how we found them. Entire cities of tens of thousands of people, sitting like they were waiting for someone to come back home, and nobody knows where the original inhabitants went. Disease is the number 1 suspect, as tribes later on said they were cursed lands where all the people died mysteriously or vanished. Pretty interesting how easily we forget that stuff.
Now thts a good point
Scary thought. Bacterial infections were also far more deadly back them do to no antibiotics.
The two cities that were both destroyed the same way in the same era are frightening as well. It's assumed they were destroyed by an asteroid air burst overhead because the only other known thing that can cause that much heat and send out a similar shockwave is a nuke. At least two cities 4000 miles apart in the time time frame.
I suspect Gobekli Tepe suffered pandemics and is why they were deliberately buried.
Humans have been living through outbreaks of Bubonic Plague for thousands of years by the time the Black Death returned to Europe. Imagine being the first city to experience it when absolutely no one had it before; the 1/3rd death rate from the Black Death would've been child's play in comparison. And even if you survive, well, every single skill is critical for your town and no plague will ever kill equal rates of each skill, you might have enough coopers but none of the smiths survived, or you have enough smiths but no millers, the complete loss of any one skillset could simply doom your town. It's really surprising we've been able to get as advanced as we have without being taken out by disease.
@@corrupt1user We are resilient indeed
4:03 Minor correction here: when the apoptotic signals are high enough to induce apoptosis into a cell, the affair isn't nearly so violent and explosive (that would be very bad and end up causing massive inflammation and necrosis in the local area). Rather, the cell "blebbs" and shrivels as it self digsets, with nearby macrophages consuming the little blebs in a very clean and contained way.
Yeah its true but there is no distinct apoptosis to be in reality but it happens with a mix of both necrosis and apoptosis called necroptosis. There is also ferroptosis and other stuff..
So they are right about the animation but can be clear about the terminology
Yep. That kind of ‘explosion’ is more similar to necrosis
@@65nidheeshkumarprabakaramo68 The extrinsic pathway for apoptosis induced by CD8 cytotoxic T cells involves FAS signaling and utilizes caspase 3 to activate apoptotic effectors, thereby inducing DNA and protein digestion within the cell and ultimately leading to blebbing from the membrane while containing the viral particles within those discrete membrane pieces. While recent literature have identified alternative routes such as necroptosis, it would appear that mechanism may be involved in the lysis of tumor cells.
Furthermore, from an evolutionary approach, it would appear counterproductive for the immune system to utilize necrosis in the case of viral infection due to how the rupture of infected cells results in the explosion of infectious particles into the surrounding matrix, thereby further propagating the infection.
What can I get you smart and educated people started with today? What are we drinking?
It was actually incredible. I watched a couple videos of people who had rabies and one of the guys didn’t have the aggressiveness that’s associated with it. At least when he was being recorded, he was kind and polite the entire time, and was even willing to show how his throat denied him drinking water and how sensitive his skin got by letting the guy recording him open the window to his hospital room.
I have *no* idea how he managed to keep his cool and was even willing to show how rabies was impacting him.
I was surprised to learn that Rabies is such a simple virus, seeing as how the way the virus works and the symptoms it has is really complex
It's like a 16K demo
Well, kicking a president is a simple action, but can trigger world war.
@@ChenLiYong That's a hilarious but effective explanation.
@@ChenLiYong Yeah, the chess federation can get pretty protective of theirs.
RANDOM COMMENT FOR THE ALGORITHM
Apple is the bes of the only thing missing in this case was a great sense of the only news channel in a relationship with a lovely man and the Juice media
I had absolutely no idea rabies was almost certainly lethal once symptoms began showing. What a horrendous monster this virus is. Thanks for making this video. It will most definitely help raise awareness among people like me, who are still ignorant about the deadlines of this condition. Vaccination is ever so important.
It's also an incredibly painful death. Euthanasia is recommended
the thing with rabies is that getting vaccinated is optional, not mandatory unless you get bitten by a random animal, so many people just don't get vaccinated aheas for it.
100%. Actually 99.999999%. One girl survived after being put into a medically induced coma
Once the bite location starts to tingle it is all over. It can be weeks, months or even years before the virus starts it's journey from your muscle (where it has been multiplying) to your nervous system, but when that happens the site of where you were bitten will start to tingle. You'll feel pins and needles as the virus hitches a ride on your nervous system and when that happens you are now officially too late to be vaccinated and you best start making plans for your funeral.
in germany we lern in elemenatary school stay away from wild animals that dont avoid u an wild animal no matter waht it is that does not is cautious about u can be asign of rabies (Tollwut in german) wich is a leathal virus
especialy the children on the edges of the citys the small towns and villages get that taught
there might be areas where this is not the case or it changed over time but when i entered school 21 years ago that was standard we also get told to imedietly go to an aduld and tell if w where bit or scatched even if it was a stray cat and that there are other deseases too
It's amazing how much your animations evolved over the past couple of years. Just the Killer T-Cell model alone in this video is incredibly more detailed and accurate compared to your first Immune System video. Of course, the simpler animations will have a special place in my heart, but it's also great that you guys have been keeping up the quality to the channel's massive growth in every video!
Yea the animation is great and makes these newer biology videos much easier to understand
The Killer T Cell is the T lymphocyte right???
made by primary lymphoid organs?
@@BcI2 idk
@@BcI2 yea
This channel is a large team, there is not one person who makes this LOL, you know how much effort is required to make just this video? There most likely are several animators, colourists, 3D artists and so on.
My wife, a public health veterinarian, told me that you can reduce the chance of getting rabies from an animal bite by 50% if you scrub the bite site well with soap and water. The initial replication of the virus happens at the bite, not in the neurons.
As for dogs, in the US, we have pretty much eradicated canine rabies. Dogs, foxes, etc can get it, but almost always from another species.
Thank you for sharing
I'll do that, *and* take the vaccine
If you can't get a vaccine for rabies, you need to quickly chop above and off the infected limb
@@cebruthius As you should! Slay
@@agustinbarquero8898BAHHAHAHA idk why that amused me so much
"When you reach this stage, you are going to die."
I hope I'm not the only one who is horrified by that sentence. No other Kurzgesagt video involving infections has ever had such a mundane certainty of death stated like this. Even with Cytokine Storms, they say it's "very likely", but here, it's treated like a certainty of death, because it is. Honestly, the most chilling thing ever said on this channel.
Trust me kurzgesagt is gonna get WAY darker ☢
Yep, mortality rate is 100% when the symptoms start expressing themselves.
out of the 12 billion people who have gotten rabies and had the symptoms appear only TWO have lived
It's not an absolute certainty but very very close to that. As far as I could find, there are only 29 reported cases of rabies survivors worldwide (1st entrance in the list is from 1970) and only 4 of those made a complete recovery without long term consequences. Using Kurzgesagt's provided 60'000 deaths per year (8:30) that makes around 3 million deaths since 1970. So the survival rate is 29/3'000'000 = 0.00096% and the rate of complete recovery is 4/3'000'000 = 0.00013%
@@nicholasg.6175 Imagine somebody purposefully infecting you without you knowing. By the time you show symptoms, you are doomed.
There are few things in life that scare me the exact and powerful way that rabies does. My sister and I were coming home from the zoo once, when we saw a young raccoon in broad daylight, acting strangely, and noticeably unwell. Staggering up toward any person that came by. It should immediately set off alarm bells for you to see a raccoon acting that unafraid of humans.
That little guy caught sight of me, and a chase ensued. It would not leave me alone no matter where I went. First and only time I’ve been that viscerally afraid before. At that point I was weaving between cars, shouting “Help me” several times.
I had to make a few laps around some vehicles and frantically yell for my sister to unlock the door to our car, and then race back around and scramble inside before it could crawl under the car and get to me. We were sure to warn others around the parking lot not to go near that poor thing, some unsuspecting folks were *walking towards the raccoon with their children.*
Do not fuck around with sick animals. Rabies will fuck you up slowly and irreparably. As soon as you show symptoms, it’s all over.
Your generosity towards healing my Herpes is incomparable , DRETIKO you assured me of getting healed just within 21days and it was so . I will keep letting the world know about your good work ❤❤
Which country was this? Because in Europe it should be eradicated... Asking just out of curiosity not to judge.
@@nils9853 America most likely, has racoons and still has rabies.
@@nils9853I believe I say rabid raccoon 🦝 when going thru the Taco Bell drive thru. I feel bad I should’ve called someone it was a while ago though... my friend seen a rabid rabbit literally run and drown itself in his pond...he said it messed him up.
It doesn't even need to be a raccoon. I saw a feral rabid cat once. It stumbled around and walked in a zig zag. It would then fall after a few steps and try to stand up only to fall down again. Clearly not right.
I've seen it somewhere that there was a patient who survived rabies after the symptoms arose. She went into a coma, woke up after years of treatment, and had to learn basic motor functions like walking and speaking again.
Once got accidentally bit by a squirrel while in law school feeding it nuts. I didn't think anything of it, it was an accidental nip that drew blood. But then I thought, what about rabies? Did some research, found out squirrels almost never have rabies, didn't think anything else of it. Until, two weeks later, when I got a pretty severe sore throat. Suffice to say, that was over 20 years ago, so obviously not rabies, but for about a day...
I feel that, only watching this video makes me feel anxious as hell because I thought back to when some random cat snapped at my hand like half a year ago. Like the chances of that animal having had rabies are basically zero (rabies-free country, domestic cat) but I still get so paranoid
For about a day, you had the biggest scare in your life?
I misread that as a squirrel bit your nuts. That raises another question. Can rabies be transmitted through reproduction? Like if you have children while having rabies (with no symptoms obviously) would they be born with it?
I was going to say you are supposed to call them neurodivergent, but yeah, twenty years ago it was OK to call them nuts. So I guess I'm only slightly triggered. Still, you probably need to get fired after a healthy doxing.
@@themysticautistic5449 only if you have salivary glands in your goodies. Or if you spit on it for extra lube.
It’s crazy that 5 genes in a shell is able to kill us almost 100% of the time. Really shows how fragile the human body is
I love how unbelievably developed the human body is, yet diseases are so good at adapting they still thrive in it
Ok I don’t love it disease sucks but it’s fascinating lol
We are basically paper thin compared to nature
I’d think that the less cells you have,the easier it is to mutate and evolve
@@andrewchanathip we are nature ;)
The Milwaukee Protocol was, at one point, theorized as our best chance to combat rabies once it entered the body in the event that it was too late for the vaccine but before advanced symptoms developed. The idea was to put the patient in a medically induced coma and being pumped with antivirals as well as other drugs such as Ketamine. The suppressed brain activity would essentially slow the spread of the virus which would provide the body with extra time to combat the viral infection.
While it worked in one case which became the first known survival of rabies it also failed in over two-dozen other attempts and is only seen as a last resort.
A simillar technique was used to save a girl here in Brazil I think.
it has worked in a handful of cases, but even for the people that survive, the recovery is brutal. they had to be kept in a coma so long, that they had to relearn how to eat, walk, talk, etc again.
@@jastrckl funny thing is that cryopreservation therapeutics have been shown to kill lyssa in post-symptomatic animals, when used in conjunction with a vaccine. And the same "cold sleep" techniques actually PREVENT mental degradation in humans.
And yet the idea of dropping the core body temp of rabies patients to 80 degrees Fahrenheit, while keeping them comatose, to *save thier lives* is considered "cruel" by the AMA?! I'm suuuuuure it has NOTHING to do with said animal experiments showing that the cure rate was near 100%, and with only 8% of the vaccine material needed...
Sigh, THIS is why we are so "distrustful of vaccines", the behavior of the people who make money BY KEEPING US SICK. Never cut a deal with someone who benefits more from breaking it than keeping it, and TRUST is part of a DEAL between the customer and producer. Once it is lost it is NEVER coming the hell BACK! Fraud-ci et all have DESTROYED that trust for one of the most important discoveries ever made by man, the vaccine, to such a horrific degree that even *>>I
It’s got like a 25% success chance
mr krabs what the fuck are you doing with all that ketamine
5:52 the way he said “you are going to die.” Just cracked me up for some reason 😅😂😅
I find one of the most interesting and mystifying things about rabies is its frightening ability to easily jump species. Most viruses require mutation to be effective in a different organism and then its mutated form is usually then not effective against the original host.
That's because it is so simple and it exploits basic mechanisms that are fundamental to the biology of all mammals and as such, are unlikely to ever be modified by evolution. Another example of how often less is more, the simplest the solution, the most resilient it is
@@raffaeledivora9517 also the fact it hides from the immune system so well, it has very little pressure to change.
Nature tailor made it for Mammals. Its a deeply fascinating Virus.
@@raffaeledivora9517 "A designer knows he has achieved perfection not when there is nothing left to add, but when there is nothing left to take away."
@@raffaeledivora9517 it's actually not true, there are strains of the lyssavirus, that are associated with specific orders of animals. Rabies lyssavirus, most probably, started out with bats, but then later on shifted to Carnivora, that unfortunately encompasses all cats and dogs, and all of the descendants of their latest common ancestor - and that is fifth biggest group of mammals.
Fun fact: there seems to be a correlation between species the person was bitten by and how likely they are to contract the lyssavirus, with lagomorphs [so hares, rabbits and pikas] and rodents being less likely to transfer the virus.
Terrifying how our immune system is so complex and intricate but so many pathogens avoid it with ease
Your immune system is almost perfect, capable of holding off many bacteria and viruses, almost none get through.
Almost.
Also, your immune system evolves to become better and better, but so do your enemies. It's a race. And considering the fact that humans are not extinct, we are doing decently in this race.
Show some respect for your immune system, you don't know how hard it's working.
@@minecrafting_il I think its also important to mention that we have modern technology to help the immune system defend against certain illnesses which it would otherwise struggle with.
Well nature has had billions of years of competition, trial and error to develop, so it'd be weird if it wasn't that complex. That even a very simple virus like Rabies can defeat this with brutal effect is rather unsettling though.
Prions much terryfying
When I was camping as a young kid I wondered out loud if I could catch one of the thousands of tiny bats on the lake in a net. My parents didn't care because they obviously didn't expect a kid to catch a bat in the pitch black with a butterfly net. Sure enough, I did. I literally grabbed the thing out of the net with my bare hands and ran up to the camp site to show them. My dad right away told me to throw it away, and as I was holding it it started to try and chomp my finger. It thankfully didn't break skin and I never got rabies, but sheesh... seeing this video really made me realize how bad it would have been if I did.... (Only scary because bats are a more common carrier of rabies)
At least in the US, it’s recommended to get the rabies vaccine whether you think it broke skin or not. Better safe than sorry. Many doctors will even want you to get vaccinated if you notice a bat in your house, because it might have bit you in your sleep and the bites are basically invisible. If you don’t get the vaccine in the first week or so, you’re basically gonna die one of the most excruciating deaths.
Ok, but was the bat soft and fuzzy?
This is why parents should pay attention when their kids muse about things.
Similar story here. "I bet I could jump across that river!"
"Sure ya could, kid. Haha."
"Oh *beep*"
I did make it across, by the way. Jumped across some stones and a wet soggy log - about 30-40 feet wide, 6 or 8 feet deep. I was an adventurous 6 year old.
I'm sorry I know this is a serious story, and I'm glad nothing bad happened, but the word "chomp" immediately made the bat sound adorable
That's scary, I did have some encounter with a bat once too, scary part was that it was flying around my bed and me thinking it was a moth
Your partnership with epic mountain is incredible the music used in this video is amazing
My best friend died from rabies. A bat bit him. He didn’t tell anybody, and it took about a month till he started showing symptoms. He eventually slipped into a coma and died. I miss him. RIP buddy.
What country are you from?
Same, my friends friend Died from it too, he didn't tell anyone after getting Bitten from a rabid dog
Thank you for your valuable information
Sorry to hear about it! It truly is the worst of nature
@Mela (ARYAN AF VIDEOS) bruh....
I love how he makes the entire explanation feel like a spy movie where they have to infiltrate and take down a huge compound and use it for themselves
This channel never disappoints and the quality is always to such a high standard, thank you for teaching me so much Kurzgesagt!
@@asktoseducemiss434 this person isn't kurzgesagt
This is a cool analogy! I used to picture a war scenario when I was studying imunology in college, it made the hole thing more interesting!
Scientifically accurate!
Of course you love. It's pure lies and propaganda in the form of cartoons for children.
What's interesting is there's a village of natives in the Amazon, and they all carry rabies antibodies. They're trying to figure out why they seemingly are naturally resistant to it. It's speculated that a ancestor developed rabies but it was more mild at the time and lived and she passed on the naturally immunity to her child and that child got bitten and lived and eventually everyone had developed a natural immunity to it
an ancestor*
They may also have the gene mutation that makes them immune to kuru as well, I know one of the amazon tribes has it
Possums are also naturally super resistant and we're not sure entirely why.
@@skylerthompson8652 Apparently it’s because compared to the other mammals rabies prefers, they have a much lower body temperature making them a less ideal host to replicate or survive in.
Supposedly they are getting subclinically infected with small amounts from bats and they developed immunity to this.
Resistance or survival from rabies is known from many other parts of the world. You could survive it too, but the risk is too high and so we never skip the vaccine.
Hello! So today I received my third rabies shot I’ve made just in case cos of your video . Just wanna let you know that the information was very convincing. And I have never heard that rabies is so dangerous before your video 🙏🏻
7:00 My mother knew someone who had rabies and bit another guy who got rabies. Although there are no "known" cases, we must not forget that in developing countries a lot of these cases are not registered in some central database.
Maybe someone can get rabies by kissing another person that has rabies.
@@urofan maybe sharing a drink?
@@urofan if there's a path the virus con take from your digestive system to your nervous system then almost certainly
@@darksoles1305 wouldn't say so.
@@darksoles1305 Precious Reynolds has two sisters and one brother so she could have shared a dark with them. They probably didn't drink from the same cup because she was sick.
I went down a rabies rabbit hole and while it's super scary, the disease isn't as widespread as it could be because it can only be transmitted once the virus has reached the saliva, at which point the animal is not only going to be symptomatic but will only have a few days to live. This makes it difficult to spread.
Rabies can be spread by a single individual more then once what do you mean? If a animal with rabies bites more then one person it will infect more then once.
@@MRblazedBEANS right but that's how all viruses work, but most of them have weeks or even months of viable contagious time, rabies only has a few days to work, and it can take months or even years for an infection to manifest. not exactly outbreak material unless you intentionally dumped a bucket of Rabies Saliva into a city water supply or something absurdly stupid.
@@MRblazedBEANS The guy didn't say anything about that though?
@@MRblazedBEANS You're arguing against a claim that was never made in the original comment. 🤔
@@MRblazedBEANS I didn't understand. What I meant was that the animal has only a short time to spread the virus and is also going to display symptoms during the time it can infect. This makes transmission more difficult than say, a virus that can be spread through the air from a host that has no symptoms and can spread the virus for a long duration.
I remember as a child reading a Guinness world records book and the deadliest disease was listed as Rabies, to me it was a commonly known fact but it seems many never knew about how terrifying it is.
That's because it's a billion dollar medical business for humans and animals, all based on fearmongering.
l knew rabies was deadly, but l thought it was dangerous to animals only. l guess thats because we've got a good-working vaccine l guess :]
I’ve heard of rabies lots of times but I’ve only realized how deadly it was this year.
It's barely even a problem as long as you get treated immediately. That is, if you have access to that
how high have you ever been, is this gods world or do the go pros, and barrel lens tell the truth here way ye, thanks for being such a great sharing spirit of a man, hurry back to terra firma , always stay as cool as you are wers my chute n my seat is it behind or a one man flier
Very informative.
Thank you!
I got super terrified in the middle of the video thinking "wow, I hope I never got near this virus", then I realize that I already was infected with it, but I didn't associate the name in my language with it in English! After trying to help a bat with rabies and getting bitten by it, I had to take almost one shot of vaccine/injection per day for 1 month... At the time I cursed to have to do that (I hate needles), but after this video, I'm glad I took them correctly.
That's scary, dang. I'm glad you're okay!
Damn bro
30 shots? PEP for Rabies is only 4 shots in the span of two weeks. Was this a long time ago or your doctor was paranoid?
my brother got bit by a stray dog and had to get vaccines too off course. till this day i am terrified of dogs when they get a little too close to me. the funny part is that i was the one who got traumatised by this incident not my brother. also i am glad that you survived.
@@PRubin-rh4sr oh what? That's weird, in my country the rabies vaccine is known to be 20+ needles or something as crazy as that, not entirely sure could be outdated rumor but that's what i heard
Really really nice video. As a molecular biologist who plans to study and specialise in Virology, I really apreatiate the simplicity and yet absolutely exact informations. Also, the detail of very beautiful animation is admirable
virology, immunology, microbiology, very complicated
1:20, The primary transmission vector where I grew up, in the state of Maryland, USA, was raccoons, not dogs. We were constantly being told/warned/terrified into being aware of any raccoons that were out during the day, as they are mostly nocturnal...although they Do come out in the daytime for the rare opportunity to eat an unusual treat or play with a new shiny object; and they start their food hunting during twilight, before it becomes completely dark. So, yeah; There were countless false reports about rabid raccoons being Everywhere. From the way of things, it was easy to believe that stepping outside just for a moment, to call the family cat or dog, or do anything, really, was pretty much a guarantee of being bitten by a swarm of crazed raccoons, and then slowly and painfully turned into a rabid, hybrid, zombie raccoon person, like in a real life Stephen King book. At least it was if you were seven years old...
the thing is, not only are raccoons nocturnal, but as wild animals they have an instinct to stay away from humans. Dogs tend to be not afraid of humans. You might have fun reading Steven King's "Cujo"!
Besides this, quicksand and dinosaurs, which other things did we have a deep, deep fear of when we were younger that turned out to be completely misplaced?
Just avoid raccoons in general.
@@blakksheep736 The witch from Snow White and the monsters under your bed.
Very evocative description. Maybe you read a lot of horror stories. :)
this is the story of my heart.
for more than half a year I am very sensitive to animals that transmit rabies. even when I pass by, or see a dog I break out in cold sweat, and immediately run away from it. I don't even want to step on the floor of the house, if there are guests who have dogs. Even holding money I wash my hands 😭. I also consult a doctor every time I see a dog, I ask if I catch rabies if the virus evaporates in the air. In fact, I always felt that my life would not be long, even though I had never been bitten or scratched by an animal.
and every day I'm always in a panic. I don't know, because when I went to school I passed a dog. until I always buy handsanitazer and masks when leaving the house. oh god I'm tired of living in fear. every day there is something that makes me afraid of rabies.
and today I met a bat when running the motorbike at high speed and the bat was right in front of me but fortunately after I checked my body no one was bitten. and I am currently haunted by what if bat saliva gets into my eyes. and it always gets past me. i hope nothing happens what i want .
God bless
Remember God’s love. He will take care of you because he is your father. 1 John 4:18 reads, “There is no fear in love, but perfect love casts out fear. For fear has to do with punishment, and whoever fears has not been perfected in love.” No matter what happens, NOTHING gets past God. Whatever happens is God’s decision, so it will always be for the better. Jesus loves you, accept His peace through a prayer like this: God, I love you. Thank you for always taking care of me, please give me Your love because perfect love, the love only You can give, will eradicate fear from my life. Remember this: Jesus is the prince of peace. Accept His perfect love and His peace.
Also remember the end of the video:
Nature isn’t always scary, it can be beautiful.
God did say everything was good when He created the world. Nature is beautiful because God created it. Living in fear will only worsen it. Being afraid for your life and dying afraid will only waste life. Live life with peace and joy, because even IF (big IF) you die young, but you enjoy life, that will be more valuable than living 100 years in fear.
You're paranoid, go see a psychiatrist, then a psychotherapist.
That's called hypochondria (fear of diseases), seek therapy, god ain't helping ya
That's what happened to me, till I realized that it doesn't matter if we live long or short, there is a continuation for life, that's right, that's God.
I remember reading about a rabies case a few years ago, where a 5yo got bit by a bat, and since he hated needles so much, his dad didn’t want him to have to go through all the trauma and so didn’t take his son in to immediately get vaccinated. Kid died 2 weeks later.
that's so fucking stupid
it was either something other than rabies since thats too fast, or its fake news
@@SobeCrunkMonster or he got bitten superclose to the brain
@@ashthecuber648 like IN the brain. that would explain it.
@@credence7777777 if he was bitten in the brain it would have been a gg boys before even 2 hours
I was reading a book yesterday that mentioned this exact disease and how deadly it was, that was the first time I heard about it so this video couldn’t come at a better time. Thanks Kurzgesagt!
You’d never heard of rabies??!
@DONT go to my home page! Nobody asked nor cares
@@GIBBO4182 I heard about rabies, just didn’t know that it was the Lyssavirus. Especially in the context of the book, I would have never guessed.
@ahhhcool oooh scary shiver me timbers
@ahhhcool this isn't how you gain an audience
A few months ago I spent hours searching in TH-cam for how rabies works and got literally nothing. All videos just tell basic things like how symptoms look like, how it transmits through saliva, that it is deadly blah blah... You know, stuffs that everybody know since kindergarten.
But, your channel is truly one of a kind. I couldn't say how much appreciated I am.
Deeply, Really Thank you.
Thank you for everything.
4:00 every gamer after losing
Just wanted to point out that while the animation at 8:40 shows a squirrel foaming at the mouth, squirrels and small rodents are almost never found to be infected with rabies.
The leading hypothesis as to why is that in order to be infected the small animal has to get bit, but when the animal is that tiny they usually just die from the mauling before becoming infectious.
That's why if you get bit by a squirrel, rat, mouse, rabbit, etc. doctors will usually brush it off unless you specifically saw the animal showing symptoms (foaming, erratic/aggressive behavior, averse to water)
Why do doctors brush it off if there's even a small chance you might be infected? Shouldn't you get vaccinated anyways?
@@jay-tbl vaccines are not cheap
I don't think Doctor should brush it off just because _it isn't likely_ to have Rabies, if it does, then you're dead.
(What I meant was doctors should still check if you are infected so that if you are, you can go get the vaccines)
No they don't just "brush it off" lmao no idea why you just made that up. You get bit by animal you get a rabies vaccine.
i'd probably still push to have that person get a rabies shot. We don't mess around with cuts/pokes from rusty objects do we? Nope, we get tetinus shots
The fact that rabies is so good at avoiding and hiding from your bodies defences for years, invisible from the outside, and when it makes it to the brain stem and the symptoms start showing it is too late is scary as hell.
Agreed, like prior to this vid I knew it was bad but the fact it hides and highjacks the immune system is waaay scarier
@ahhhcool you do know that is illegal right? Oh wait, you’re a bot
Also Prions
@@zxcv97 prions for me are more scary because you cant really prevent their destruction once they enter your body (i might be wrong but last time i checked, there wasnt really anything we could do)
yeah reminds of Robbie Williams illness development.
it starts out as behavioral issues, which lead to isolation and then there's no turning back as the person is incapable of understanding, seeking help etc.
I always thought HIV was the sneakiest and scariest of viruses bc its "life" cycle is the equivalent of a swarm of deadly ninjas sneaking up on the most crucial parts of your immune system "army", going undetected right under their nose, and then taking them out with a single deadly punch to the throat. But then I saw this and realized that Rabies does all that but with the twist of torturing you to death 😳
Yeah it’s fucked
There still no vaccine for HIV. Your first impression is correct about the sneakiest and scariest virus !
And rabies has a 100% mortality rate except for a handful of people who’ve been treated with extremely intensive medical interventions and had to recover from serious brain damage. With the newer drugs, HIV is still incurable (it will come back if you stop taking the drugs), but it’s no longer a death sentence.
This last Coronavirus killed well over a million Americans and will kill a few million more before it fizzles out, and has permanently disabled two of my three siblings who’ve had it with “long COVID.” Pneumonic viruses are the only ones to be truly fearful of, since people can do everything perfectly and then lose their entire families to death.
as someone who's currently studying HIV for a biology exam tmr, thanks for the illuminating description, i really need it
"Your immune cells will see these parts in the window and order the infected cell to kill itself" had me dying
*sees wrong component in cell window*
⚡⚡⚡👨🏿⚡⚡⚡
@@navyntune8158you should apop now ⚡⚡⚡
Infected Cell: *shows virus*
Immune Cell: "cringe kys"
lowtierimmunesystem
That one was good I also loved the one about the uno reverse card😁😁
its my favorite and subsequently the most horrifying disease! its strange how this specific virus family either virtually does nothing, or puts you in the dirt so fast.
+Roanoke Gaming Do you think rabies is the deadliest virus or there could a rival to it
Hi chekmark guy!
Its a guy with a checkmark
Ayo; didn't expect to see you here of all places.
Hey sorry but ur videos thumbnails traumatized me, thank u
I've always found it hard to explain MHC class proteins so being able to display it is quite useful. I know it doesn't cover the class II's but I always find it incredibly useful to show these videos to people as my drawing ability is so horrible that I tend to mess up too much to get the point across. (also the motor proteins are borderline impossible to properly explain so that incredible drawing will help too)
On a completely separate note, I find it intriguing that rabies maintains a lysogenic stage even while active, conventional knowledge is that if a virus is active it is always chewing through cells as well as creating plenty of MHCI markers so it is always impressive to find an exception to the rule. It also is puzzling to me as to how an infection that does not destroy a cell still ends up killing or at least disabling it. Perhaps the viral proteins simply oversaturate protein production making it impossible for crucial proteins to be made meaning it would simply disable the neurons rather than killing them.
You should definitely check out the book they wrote, it's called "Immune: A Journey into the mysterious system that keeps you alive". It's basically like a dummy's guide to your immune system, but it also has all sorts of wonderful illustrations that make the complexity of the immune system a bit easier to understand. It's obviously not meant to be like an actual serious immunology book, and it oversimplifies a lot of things, but it's still something I recommend checking out. I'm a big science nerd so I always love learning something new about the hidden and unappreciated complexity of my body or the world around me.
@Merik
When it comes to brain function, just slightly throwing things out of whack would, presumably, be enough to cause major problems.
So the cells may be fine individually, and yet the overall effects would still be deadly, perhaps.
@Cewla
More like a manual ferry, I suppose.
Except they don't drag themselves along the rope, but walk with sucky feet.
The only survivors of rabies that I know of were intentionally kept in a coma to deal with brain swelling (I understand that this was _not_ effective in all attempts), so it's possible that the fatal aspect of the disease is actually a side-effect rather than a direct result of viral action.
@@qwertydavid8070 I mean I've already done both beginner and intermediate levels of immunology on the university level so that one will at most help me to explain it to others. I mean no offence in that, it's just the difference between typical secondary education that everyone gets vs university level science is in an entire other realm when it comes to complexity.
Most of what you learn will be 50-200 years out of date in high school and by the time you hit 3rd year (which is the intermediate immunology course) you're pretty much caught up to modern standards.
5:52 the bluntness of this statement hit me in the face so violently
"You are going to die. :)"
Well, it's true. You can literally count on one hand the amount of people in all of human history that have survived rabies without the vaccine. The odds are pretty much nil that you won't die, and even if you lived somehow, enjoy the severe brain damage
Listening to a rabies victim screaming uncontrollably while scratching the walls to get away from a glass of water is a sound that will haunt you for the rest of your life. Not even kidding...
@Thanks Damn youre mad col
@Thanks been on the internet since the wild old days of reality shock sites and gore sites and rabies is stil absolutely at the top of the heap for living terror shit.
@Joy Word herpes? what that has to dowith lyssa?
@Thanks Imagine trying to gatekeep being scared by something. All you've done is make yourself sound like the type to go on the dark web and watch executions. Because normal internet use is actually pretty darn tame for most people who don't seek out violence and gore. Maybe try to fake just a bit of respect for the disease and the people it's affected and those who've experienced it first hand - not through their monitor - instead of just trying to one up everyone like a middleschooler who just found out about the tor browser.
That's not really how it works, though? Hydrophobia isn't like being afraid of spiders. It means your body will automatically reject any attempt to drink water or get near it. You're not "clawing at the walls" to get away from a glass of water. I think you made this up, or saw something that was a work of fiction because that's not how rabies infected humans behave.
Signed, a biologist with a medical background.
I’ll admit, staying up all night is not exactly a good state of being. But it does come with the distinct perk of catching Kurzgesagt uploads early.
@Mishan 🅥 yay when do I die
@Mishan 🅥 nobody asked.
Likewise… it’s midnight here XD
Me living in europe: 🌞
Where i am its mid afternoon lol
2:30 I saw one of those on Star Wars.
Of all the scary things on earth, rabies is the one that is truly terrifying
Chill brother it's preventable and intransmissible human to human
imagine if rabies would go airborne
@@OneFluffyKiriko since even covid almost made healthcare system collapse, I would give us 3 months before the end of the world unless it was still preventable.
@@OneFluffyKiriko You get 28 Days Later but less chaotic
We found the most impressionable person in the comments
Only 29 documented people have survived rabies. 18 of them had severe damage like complete paralysis. One of the 18 died five years later, anyway. 4 had moderate damage like partial paralysis. 3 had mild side effects likes weakness, poorer coordination, or involuntary movements. Only two made a complete recovery with no noticeable symptoms. Also, only 2 of the 29 people who recovered weren't vaccinated. Most of the 29 cases' vaccination failed. Out of the two complete recovery cases, one (17 yr old from Turkey) received one dose of a rabies vaccine post-exposure (you should get 4 doses plus immunoglobulin). The other case (6 yr old from USA) received a dose of a vaccine just two days before symptoms showed up (18 days after the bite), which is definitely too late. It's said that after 3 days, it's too late to get vaccinated and this is 6 times that, so it's unclear how much the vaccine helped. Neither of these patients were treated with the Milwaukee Protocol or Recife protocol since the American kid's case happened in 1970 (Milwaukee Protocol was first used in 2003) and the other kid's case was in Turkey in 2008, only 5 years after the Milwaukee protocol's first use in a different country. That said, it's not very common to use the Milwaukee protocol. Only 36 patients were treated with it, out which 5 survived, yielding it a 14% survival rate compared to 0% of people: 29 people including those who survived using the Milwaukee protocol out of so many people: 59,000 dead every year worldwide (that's every year, not total).
Thank you, that's very interesting. Could you explain what the Milwaukee procedure is?
@@solar0wind it's a very complicated, 22-stage (at its current version) treatment protocol that involves a lot of different drugs, but the main point is keeping the person heavily sedated for a certain amount of time.
@@hkfarewell0898007 what about that Recife Protocol?
@@hkfarewell0898007 I think by now most research is about why it ever worked as opposed to why it doesn't.
Wold you have the link for that info? It's really usefull for me and my academic research team
The level of detail they give us, even when they are simplifying stuff, just leaves you in awe, thank you so much for an amazing video!
The pug faced asian dragon in the end killed me more effectively, than any lyssa virus could. The video was very educative, and easy to understand.
A man in my country, Chile, survived after the onset of symptoms. Like his case, there are very few survivors in the world. He is truly a legend to survive that.
yes because they are built differently but never take any risk and one should get vaccinated ASAP if bitten by an animal
how bad of a brain damage did he suffer?
@@kristijanoros7208 The neurological sequelae he suffers are: Impairment of movement (imbalance), color blindness, mild amnesia (he doesn't recognize old friends faces for example), imbalanced corporal temperature (sometimes high, sometimes low compared to the mean corporal temperature). And he got kinesiology treatment for almost 2 years to begin to walk again, because when he woke up, he couldn't walk. But if you ask me, he cheated death with 'mild' sequelae. It could have been worse.
So what's his name? Gonna need a source on this chief
Bro needs to pass his genes down
The quality of these videos never fail to absolutely amaze me. Thinking of all the hundreds of hours that the Kurzegat team spent bringing us top quality and truly honest videos for the sake of science just refreshes us from the extremely toxic and useless ways this wonderful platform is being abused.
I usually don’t comment on videos but I really had to express my thanks for the team and their dedication as well as remind everyone to like these videos as well as subscribe to the other language Channels so more people can see this.
Have a nice day!
I agree. The videos are a brilliant hybridization of aesthetics, animation and knowledge, and I adore how engaging they are while still giving lots of information while being up-front when things are simplified.
*thousands of hours
5:08 killer t cell : im gonna delete you
Rabies : no u *pull out uno reverse card*
0:50 The monkey “ so the zombies are afraid of water eh? Don’t worry mom I’m safe.”
Rabies is the single most thing that terrifies the hell out of me out of everything else
Its just so scary to think about its effects almost like entire point of this disease was to kill someone in the worst possible way
If it counts for anything, diseases such as "Mad cow disease" (Bovine Spongiform Encephalopathy), or the similar condition in humans (Creutzfeldt-Jakob Disease) are FAR scarier. While they aren't common, they're 100% fatal, there is no treatment for them, there is no current diagnostic test that can be used to detect the disease before death, and usually symptoms don't appear until you're well into your 50's/60's, regardless of when you were exposed. It presents very similarly to dementia, so it can be difficult to diagnose, but unlike dementia, people suffering from CJD tend to not survive more than a year past the appearance of symptoms. Even more wild is the fact that it can be caused by a rare genetic mutation, and that mutation can be passed to your children, increasing their chances of developing CJD on their own without being infected. It is caused by a misfolded protein, called a prion, and these prions induce misfolding in normal proteins. And since it is just a protein, you cannot just "disinfect" contaminated surfaces, and it cannot be "killed", per se. Because it's not alive, it can stay on surfaces for upwards to two years, remaining infectious the entire time. CJD is the reason why most countries do not allow people to donate blood if they spent more than 3 months in the UK between 1980 and 1996.
As a medical lab technologist, there is not a virus or bacteria that scare me more than prions. And not because they are common, or super infectious or anything like that, but rather because they're so insidious. Imagine rabies, except it cannot be detected until you die, it presents similarly to dementia and can be missed, it can potentially remain on surfaces for years infecting you long after the surface was contaminated, it doesn't present symptoms for 10-40 years after infection, and it's 100% fatal. At least you can be protected from rabies, and there are very successful treatments up until the final stage of infection. Id much rather take my chances with Ebola or Lissavirus.
Nothing scarier than getting a call from a doctor that the CSF you just processed last week came from a patient who is now suspected of having CJD (or worse, now confirmed). You have no idea where those prions potentially have ended up, and the amount of cleaning of the lab that occurs because of them is mind boggling.
@Kurzgesagt, you should totally do a video on prion diseases!!
Hey i can ask you ? . I guess is you from to USA . So i think you scary bat :"(
naglaria fowleri:hold my brains
No need to be terrified of it. Just get a vaccine.
You know cancer exists?
I want a real time war strategy game based on the human immune system
I think there actually is one by the creators of plague inc! It's called bio inc or something like that, gotta look it up
Edit: yep, it's bio inc!
Ok
@@marias1609 i think he means a RTS game and the battlegolround is inside the human body 😜, units are cells etc. It would be interesting since it can be made like RTS in space and you can move in 3D space and the campaign will be fighting off bacterial infections, fungus ones viruses etc and also play as the virus to defeat the human body😬🤔.
@@sirab3ee198 yessir
INMUNE SYSTEM: TOTAL WAR
What’s interesting is that even the incredibly small percentage of ppl that have survived rabies show signs of mental deterioration and cognitive issues afterwards showing that truly no one leaves unscathed.
Hey Kurzgesagt, could you do a video on prion diseases/ the Mad Cow disease outbreaks? It would be very interesting and fit with the theme you have of extremely deadly brain diseases.
Prion diseases are WAY WAYYY worse than rabies
Impossible to cure
Cant move
Just here to appreciate the subtle Wilhelm scream at 7:58, since no one else seems to have mentioned it. Enjoyed the video very much, also loved learning about the transparency trick!
I just wanted to comment this
🤣
This is one of the most terrifying biology lessons I've ever gotten.
Same
I never had lyssa, but I did have encephalitis when I was young, my neurologist is pretty sure that's why I have brain damage now. I got it from a mosquito bite. Pretty scary stuff, I'm happy to be alive, but it definitely puts stuff in perspective and makes you realize how lucky we are to have access to medicine and hospitals
Malaria I guess
I'm sorry for you! But, it's a blessing that you lived
@@javieralejandrotrianapaz6343 or an encephalitis virus sadly
Japanese encephalitis @@javieralejandrotrianapaz6343
I also have encephalitis! I have it from unnoticeable strep infection