Omg these lectures are flawless I literally wanna cry from happiness. it’s been 8 years since they have been published but the best lectures I have ever watched
Its been 4 years. I dont know what college u went, but this comment represents me now. I was overwhelmed for understand nothing in class. Thanks my lecturer recommend this vid afterwards.
These Videos were post/published almost 2 years ago and am here enjoying every part of em...Biochemistry seemed so tough but now i feel like all i needed was to take a glimpse at these videos and thats was it...Thank you AK LECTURE your knowledge via is really more than helpful..
Am grateful for these free services.Biochemistry is now very easy for me. God bless and I hope to make a reasonable donation of this good course someday.Thanks and more strength
Thanks so much for all your lectures!!!!you should come to our university!!!you make biochemistry so easy and i appreciate your hard work and the way you structure your lectures in a way that everyone can understand!!!!!!!keep up the good work!!!
I feel like you just saved me so many hours of studying the long poorly worded book to understand what you just taught me in 10 minutes (thanks to 1.5 speed haha). You are awesome!!!!!
You go so much more in depth with these topics than my teacher, that I dont have to keep constantly asking myself "why does this happen" or "we seem a bit short on notes." Thanks for this :)
The efforts and the way of teaching is so frickin sick, prof! I have accepted the fact that most of the teachers have knowledge but they cannot convey it properly Except some who are god gifted like you❤
h ak million times of sorry! i didn't let you know after my exam and i saw your message just now! of course it did well. and just because of you:) i recommend your videos to every of my friends and will keep recommending... billions of thanks again...
i listen ur lecture it help me a lot in my exams ur way of teactng is awesome ...ii enjoy ur lecture it deeply penetrate in my mind thnx AK LECTUREs :)
A question, if the formation of a-helices and b-sheets depend exclusively on the H-bonds of the polypeptide backbone, and not on the side chains (which are variable), what does determine if an a-helix or b-sheet will take place? Because the N-H and C=O of the backbone will always be the same! You are a great teacher, thanks!
The amino acid residues within the polypeptide chain determine what conformation will occur. Proline, glycine, and charges amino residues disrupt the alpha helix so if they're found in a protein, that section will likely be a beta turn. Small hydrophobic residues like alanine and leucine, on the other hand, are perfect for forming alpha helices.
No se como hace, pero hace que in tema que parecia inabordable, parezca fácil. Creia que si no tenía una computadora de última generación, jamás lo iba a poder entender... Congratulations!!!
Your videos are really good. I understand everything better, when you explain it, even though I am from Austria and a native german speaker. You should teach at my University of Pharmacy :-)
love you lectures so much. you make things simple and easy to understand. i was wondering what references you use for this topic? hope i get a reply from you :)
Hello professor..I am Marchela-a chemistry student. I would like to ask some questions. 1. How to know the end of alpha -helix or beta sheet structure in protein? 2. What is the impact of having short loop and long loop in secondary protein and in which kind of protein that has long or short loop? Thank you for you responbility
I'm confused, question: "The peptide bonds have a double bond character" but I noticed all the drawings of the C-N bond appear as a single bond, is this "character" you're speaking of indicatory of a resonance occuring between the C=O double bond and the C-N bond? Thus causing it to have another double bond character as to not freely rotate? Tyvm! Excellent...really excellent lectures btw. Liked & subscribed.
One doubt: in carbohydrates(starch, glycogen) it was the alpha linkage which helps in compactness(twist and turn) and in proteins beta turn. My question is why the name is beta turn not alpha turn (in proteins) and is alpha turn exist?, if not then why?
Is there a list of amino acid sequences organized into the two main categories: 1. Alpha helix 2. Beta-pleated sheet? I recently made a program that randomly generates an amino acid sequence. The program stops when a stop codon is generated. That is, there's a 3/64 the program will stop after each amino acid is generated. However, I'm unable to find the necessary information to create a program of perfect information for the secondary structure.
I could not understand how the parallel beta sheet amino acid residues of polypeptide sheet form two hydrogen bonds with the amino acid of the opposite chain. Please elucidate further Waiting for an answer :D
Isn't the hydrogen bond in the a-helix also like an n+3 case rather than a "four units ahead" one? Sorry that line just got me confused but I completely get the point 😂
Good lecture bro, i have a question. can you show right handed and left handed cross over connection in parallel beta sheet. i have a doubt in understanding why the images in books look opposite ( i mean the right handed one looks left hand to me, I think i am interpreting those images wrongly)
"and what that means is..."
so beautiful.
thank you.
the amount of respect I have for just being able to draw out alpha helix, with detail and legibility. its beyond me
For non-English speakers, what could be a synonym for rad-like structure?
this is so helpful. thank u
Omg these lectures are flawless I literally wanna cry from happiness. it’s been 8 years since they have been published but the best lectures I have ever watched
Your videos are sick bro. Making this biochem significantly easier... summing 2 hour conversations into 14 mins. Thanks
Its been 4 years. I dont know what college u went, but this comment represents me now. I was overwhelmed for understand nothing in class. Thanks my lecturer recommend this vid afterwards.
@@vanessamumu1968 its been another year. This video = still relevant
I have been a loyal lover of the lectures, 3 years now
still relevant, and the best..
Still
These Videos were post/published almost 2 years ago and am here enjoying every part of em...Biochemistry seemed so tough but now i feel like all i needed was to take a glimpse at these videos and thats was it...Thank you AK LECTURE your knowledge via is really more than helpful..
Some more additional information: β-turns often consist of Glycine which provides flexibility and Proline, which provides steric constraints.
You're excellent, 4 years back I used to learn modern physics from ak lectures
Now as a medical student learning biochem
You are so versatile
6 years ago they were posted and still they are mesmerising.....you are god gifted mateeeee❤
You r one of the best teacher for me to come across . A great job and thus a great apreciation
Bt where r u now ?
No more uploads !?
this video was published when i was in 5th grade, and now, im a 1st yr college student who you just saved. tysmm
I used to hate this subject, but wow, you just made me fall in love with proteins.
Thank you so much
شكرا جزيلا لك
كان من الصعب فهم الروابط التي تجعل السلسلة تأخذ هذا الشكل لكن الرسم كان واضحا جدا
Am grateful for these free services.Biochemistry is now very easy for me. God bless and I hope to make a reasonable donation of this good course someday.Thanks and more strength
Sir, Thank you so much!! I have my biochemistry exam tomorrow and I rely on your videos to do well on it.
Thanks so much for all your lectures!!!!you should come to our university!!!you make biochemistry so easy and i appreciate your hard work and the way you structure your lectures in a way that everyone can understand!!!!!!!keep up the good work!!!
"wow, this is a H, not a N" 😂😂😂
13:26
That's one hell of a drawing. Huge props for that Helix
2022 and you taught me more than my prof in university. thank u so much !!
Thank you a lot ...the way you explain even a new born baby can even understand
I feel like you just saved me so many hours of studying the long poorly worded book to understand what you just taught me in 10 minutes (thanks to 1.5 speed haha). You are awesome!!!!!
i Don't know how i express my greatfullness. thanks a lot sir.
This guy always saves my life. I want to donate
Nicely explained men . You have explained the basic compositions of structure . It's good for me
You go so much more in depth with these topics than my teacher, that I dont have to keep constantly asking myself "why does this happen" or "we seem a bit short on notes."
Thanks for this :)
The efforts and the way of teaching is so frickin sick, prof!
I have accepted the fact that most of the teachers have knowledge but they cannot convey it properly
Except some who are god gifted like you❤
Your explanation unbelievable!!
i've my phD proficiency exam tomorrow and i'was prepared with your amazing videos. wish me luck:)
semiramis yilmaz good luck! let me know how it turns out!
+semiramis yilmaz how did it go ?
The world will never know"
Mona :P :*(
h ak million times of sorry! i didn't let you know after my exam and i saw your message just now! of course it did well. and just because of you:) i recommend your videos to every of my friends and will keep recommending... billions of thanks again...
Helpful stuff. But you didn't talk about omega loops :(
Very well explained sir. Clear explanation. You are a true inspiration....
excellent review videos for MCAT biochem, thank you
just22ish thats wonderful! :-) best of luck with the exam! definitely a mental marathon.
I swear this finally makes sense! thanks so much!!!!
Thank you so much. Made more sense than my lecturer. I'm a med student.......
i listen ur lecture it help me a lot in my exams ur way of teactng is awesome ...ii enjoy ur lecture it deeply penetrate in my mind thnx AK LECTUREs :)
13:26 that wow described my whole process of learning from this video 😂 Thank you soo much 💕
you explain in such a nice way that it makes me
so easy to understand
The best videos I have ever watched. Thank you for these wonderful explanations. Could you please explain omega loop as well?
Kind Regards
you are awesome, so easy to understand
clear explanation starting from basics thank you !
A question, if the formation of a-helices and b-sheets depend exclusively on the H-bonds of the polypeptide backbone, and not on the side chains (which are variable), what does determine if an a-helix or b-sheet will take place? Because the N-H and C=O of the backbone will always be the same!
You are a great teacher, thanks!
The amino acid residues within the polypeptide chain determine what conformation will occur. Proline, glycine, and charges amino residues disrupt the alpha helix so if they're found in a protein, that section will likely be a beta turn. Small hydrophobic residues like alanine and leucine, on the other hand, are perfect for forming alpha helices.
Extraordinary teaching 🤩
A left-handed α-helix results in steric hindrance between the side chains and the C=O groups from the amide/peptide bonds.
The notes on the board are so crisp I didn't even need to watch the whole video to understand!
seriously sir....ur lectures are awesome
u r also osm
BC
fantastic
No se como hace, pero hace que in tema que parecia inabordable, parezca fácil.
Creia que si no tenía una computadora de última generación, jamás lo iba a poder entender...
Congratulations!!!
you are an excellent teacher
Your videos are really good. I understand everything better, when you explain it, even though I am from Austria and a native german speaker. You should teach at my University of Pharmacy :-)
Give that man a cookie
Thank you🫡 شكرا
Thanks so much for making everything easier to understand!
Your explanation is something beyoooonnnnddd!!!!
very good video thanks for the amount of detail and effort!
Your videos are absolutely amazing !! thank you so much for all of them
Awesome lecture 👌
love you lectures so much. you make things simple and easy to understand. i was wondering what references you use for this topic? hope i get a reply from you :)
Dianne Galang good in lippincott biochem
You r doing a great job
Amazing lectures!
sir your lectures are amazing.
I also request you to make a video on Ramachandran plot.
Спасибо! Довольно доступно все объяснено)
Literally u r awesome sir🤩🤩
May god bless u always 🙌🙌🙌
U explain each and every concept very smoothly 🤍🤍
The R groups on the anti parallel lower chain have their chirality reversed (wedges should be dashes, and vice versa).
والله كفو, احسن من د نبيل تبعنا
You make it too easy! thank you thank you and one more thank you
that was very useful. we study this in the 3rd year High school in Algeria what about you ?
great! but i just want to know what is the difference between (loop region - beta turns - disordered region( ??
beautiful explanation!
You are amazing sir,hats-off
Just awesome . Thank you a lot..
Hello professor..I am Marchela-a chemistry student. I would like to ask some questions.
1. How to know the end of alpha -helix or beta sheet structure in protein?
2. What is the impact of having short loop and long loop in secondary protein and in which kind of protein that has long or short loop?
Thank you for you responbility
amazing lecture
kudos!!! Thank you so much for explaining everything in such detail
Thank you for the greattt explanation..
Still watching from 2024 and it’s gold for me❤
I'm confused, question: "The peptide bonds have a double bond character" but I noticed all the drawings of the C-N bond appear as a single bond, is this "character" you're speaking of indicatory of a resonance occuring between the C=O double bond and the C-N bond? Thus causing it to have another double bond character as to not freely rotate?
Tyvm! Excellent...really excellent lectures btw. Liked & subscribed.
Amazing thank you thank you from the bottom of my brain!
One doubt: in carbohydrates(starch, glycogen) it was the alpha linkage which helps in compactness(twist and turn) and in proteins beta turn.
My question is why the name is beta turn not alpha turn (in proteins) and is alpha turn exist?, if not then why?
thank you for the lecture, make me understand easily.. by the way, can u explain the omega loop structure too?
good work thanks
Thank you sir,it was so helpful for me 🤗
Is there a list of amino acid sequences organized into the two main categories: 1. Alpha helix 2. Beta-pleated sheet? I recently made a program that randomly generates an amino acid sequence. The program stops when a stop codon is generated. That is, there's a 3/64 the program will stop after each amino acid is generated. However, I'm unable to find the necessary information to create a program of perfect information for the secondary structure.
I mean ... he explains better than my professor ...
thank you a lot.. its really helpful....
Reallly helpful,Thanks
sir you are a great keep it up
you are just woww evenn... keep it up, do a series on organic chemistry maybe
Do you have a video on super secondary, and phi, psi, omega bondage?
Super secondary are motifs..go for Garet
Awesome! Thanks!
np!
I could not understand how the parallel beta sheet amino acid residues of polypeptide sheet form two hydrogen bonds with the amino acid of the opposite chain. Please elucidate further
Waiting for an answer :D
GENIUS!!!!!!!!!!!!!!
Please, which protein secondary structure is more stable as a single stand-alone element, alpha or b-sheet?
love your videos!
You haven't explained 4th type of secondary structure
Thank you so much, you're a lifesaver!
you're welcome!
Isn't the hydrogen bond in the a-helix also like an n+3 case rather than a "four units ahead" one? Sorry that line just got me confused but I completely get the point 😂
Perfect 👍🏻
Good lecture bro, i have a question. can you show right handed and left handed cross over connection in parallel beta sheet. i have a doubt in understanding why the images in books look opposite ( i mean the right handed one looks left hand to me, I think i am interpreting those images wrongly)
Thank you so much
Thank you so much Sir ❤️
Thank you!
Beta paleted structure is composed by alpha helix or directly?