What is Cell Line Development? Key Steps for Biopharmaceutical Production

Introducing cell-line development (CLD), this video covers the five key steps involved in CLD and where challenges arise. In order to manufacture a biopharmaceutical product, such as monoclonal antibodies (mAbs) and viral vectors, researchers need to determine the cell line best suited for producing the therapeutic. Once selected, they need to ensure that it withstands scale-up, maintaining the quality of the biologic produced at a manufacturing scale.
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0:00:00 - Introduction to Cell Line Development
0:00:24 - Challenges in Cell Line Development
0:00:36 - Step 1: Gene Cloning and Transfection
0:01:13 - Step 2: Clone Selection and Confirmatory Analytics
0:01:44 - Step 3: Cultivation and Media Optimization
0:02:07 - Step 4: Cell Line Evaluation and Characterization
0:02:32 - Importance of Step 4 in Manufacturing
0:02:40 - Step 5: Cell Banking
0:03:02 - Challenges in Each Step of Cell Line Development
0:03:06 - Modern Tools and Custom Services for Cell Line Development
0:03:16 - Check Out Sartorius for Latest Technologies
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#celllinedevelopment #cellbiology #mabs

[@bioscienceswithshahtareenswati]

very infomative

[@SartoriusGlobal]

Thank you! We're glad you liked our video. Keep watching for more exciting science insights! 🌟

[@samapikadash176]

Thank you sir !

[@SartoriusGlobal]

Thank you! We're thrilled you enjoyed the video. Stay tuned for more informative content like this! 🎩🔬