NGBS2022 Talk 6: Atomic force microscopy uncovers invisible complexities of the genome - Alice Pyne

Uncovering the invisible complexities of the genome using atomic force microscopy
Speaker: Alice Pyne, University of Sheffield, UK
Chair: David Rueda, Imperial College, London/MRC-LMS, UK
Co-Chair: Geoff Holdgate, AstraZeneca, UK
Alice Pyne describes how she investigates the conformational dynamics of DNA using AFM. Working with manufacturers, she has driven improvements in commercial AFM cantilevers so they are uniform in size and softer which enables a step-change in the resolution and reproducibility of imaging. This has allowed her to examine the structure and dynamics of small DNA mini-circles and the effect of supercoiling and G-quadraplexes. She has also developed an automated processing pipeline software to generate quantitative AFM data that has both informed and validated MD simulations.
Read more about Alice Pyne’s work here:
pyne-lab.uk/
You can find more about the Next Generation Biophysics Symposium 2022 here:
www3.mrc-lmb.c...
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[@cazacuiulian9951]

Absolutely phenomenal 👏