SENS and their partners have had some good results in vitro (experiments on human cells in a dish) but not yet in mice (in vivo) with the exception of Senescent cell removal and allotopic expression of mitochondrial genes. Ezymes and IgM catabolic antibodies that break down intracellular and extra cellular aggregates have only been demonstrated in vitro. Senescent cells have only been removed in mice by germline genetic engineering in a kill swtich, and there is not yet a proposed method for mice already alive. Allotopic expression of the 13 mitochondrial genes has only been done in a rat model for one of the genes. If they can get some of these technologies working in mouse models then Aubrey will have a lot more evidence to back up his rejuvenation bio-medicine proposal and you will probably hear a lot more about SENS.
Reason's a pretty incredible guy. I remember stopping by his site and being intimidated by the sheer volume of material he manages to put out. I'll have to make reading that blog a daily ritual :)
I still can't fathom how this has not caught on yet. People are sleep walking though life missing the fact that we live in a time when, with even a modest focus, aging can be solved for all time. We live in a time when it is possible to reach a boundless future. We are the first to live in that time. In fact we are the only people to live in that time. Very soon, in historical terms, aging will be solved for good. De Grey and SENS are one of only 2 options now facing us that give us the chance to transcend this historical accident and make it to the other side.
***** Saw your comments on Robots. Good to see you setting people straight on the future. It's a far better place to live even than the present, which is perhaps the best place to date. Here's some more good anti-aging news www.sciencedaily.com/releases/2015/04/150430141803.htm Well this is interesting. Now if people ask my I can truthfully say, yes, yes I am a follower of Jesus Christ.
chris mcaulay Re: ridiculous that people aren't in full support of this. But this is changing faster now than ever. Here's the thing about it the idea. It doesn't take hole easily because it is so out of left field to people's experience. But it is an idea that once you get it, you don't lose it. In the world of ideas, there are 2 kinds of replicators, once that are highly contagious and ones that are very sticky. This fits in the sticky category. Hard to change people to thinking this way, but once they do, they keep it. I've been seeing a huge shift since I first started looking into anti aging over 30 years ago. Back in 1985 I could only find 4 authors who wrote about ending aging, and 2 of those were a married couple. Everyone else involved in anti-aging always threw in the caveat, "We are not trying to put more years in your life, just more life in your years," a caveat that used to make me sick to my stomach because this was from people paid government money to solve aging and they wouldn't even admit it was worth solving. It is finally starting to pick up momentum and be discussed and examined with companies devoted to solving it in ways that really do see it as an issue. I only hope it's in time for my mom.
First we thought we aged because of telomere shortening, and are still trying to work-out how to extend them. Then we found stem cells that can become the different cells that become the different organs of the human body. Recently we have found that it is waves of proteins that control the stem cells and tell them what cells and organs to become. and more recently we have found that a growth hormone controls the proteins that instructs the above. We have a good understanding of whats going on.
He's given this talk before & i still enjoyed it.
I thought exactly the same thing
SENS and their partners have had some good results in vitro (experiments on human cells in a dish) but not yet in mice (in vivo) with the exception of Senescent cell removal and allotopic expression of mitochondrial genes. Ezymes and IgM catabolic antibodies that break down intracellular and extra cellular aggregates have only been demonstrated in vitro. Senescent cells have only been removed in mice by germline genetic engineering in a kill swtich, and there is not yet a proposed method for mice already alive. Allotopic expression of the 13 mitochondrial genes has only been done in a rat model for one of the genes. If they can get some of these technologies working in mouse models then Aubrey will have a lot more evidence to back up his rejuvenation bio-medicine proposal and you will probably hear a lot more about SENS.
James Joyce I like this summary. What do you do to keep up on SENS and the state of aging research?
I read www.fightaging.org and donate to their fundraising drives!
Reason's a pretty incredible guy. I remember stopping by his site and being intimidated by the sheer volume of material he manages to put out. I'll have to make reading that blog a daily ritual :)
I still can't fathom how this has not caught on yet. People are sleep walking though life missing the fact that we live in a time when, with even a modest focus, aging can be solved for all time.
We live in a time when it is possible to reach a boundless future. We are the first to live in that time. In fact we are the only people to live in that time.
Very soon, in historical terms, aging will be solved for good.
De Grey and SENS are one of only 2 options now facing us that give us the chance to transcend this historical accident and make it to the other side.
***** Saw your comments on Robots. Good to see you setting people straight on the future. It's a far better place to live even than the present, which is perhaps the best place to date.
Here's some more good anti-aging news www.sciencedaily.com/releases/2015/04/150430141803.htm
Well this is interesting. Now if people ask my I can truthfully say, yes, yes I am a follower of Jesus Christ.
Tony Reno you're right - it is ridiculous that people aren't in full support of this!
Life can be very difficult for some people however there is always hope if we can solve our problems! :-)
chris mcaulay Re: ridiculous that people aren't in full support of this.
But this is changing faster now than ever.
Here's the thing about it the idea. It doesn't take hole easily because it is so out of left field to people's experience. But it is an idea that once you get it, you don't lose it.
In the world of ideas, there are 2 kinds of replicators, once that are highly contagious and ones that are very sticky. This fits in the sticky category. Hard to change people to thinking this way, but once they do, they keep it.
I've been seeing a huge shift since I first started looking into anti aging over 30 years ago. Back in 1985 I could only find 4 authors who wrote about ending aging, and 2 of those were a married couple.
Everyone else involved in anti-aging always threw in the caveat, "We are not trying to put more years in your life, just more life in your years," a caveat that used to make me sick to my stomach because this was from people paid government money to solve aging and they wouldn't even admit it was worth solving.
It is finally starting to pick up momentum and be discussed and examined with companies devoted to solving it in ways that really do see it as an issue.
I only hope it's in time for my mom.
***** A good one at that. See you in eternity.
I believe deGrey has given more TEDx talks than anyone else.
First we thought we aged because of telomere shortening, and are still trying to work-out how to extend them. Then we found stem cells that can become the different cells that become the different organs of the human body. Recently we have found that it is waves of proteins that control the stem cells and tell them what cells and organs to become. and more recently we have found that a growth hormone controls the proteins that instructs the above. We have a good understanding of whats going on.
He looks like Zakk Wylde.
1st