Total Syntheses of Malettinins C and E

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  • เผยแพร่เมื่อ 22 ธ.ค. 2024

ความคิดเห็น • 4

  • @SimplifyingSynthesis
    @SimplifyingSynthesis  ปีที่แล้ว

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  • @KarimfeatLuca
    @KarimfeatLuca ปีที่แล้ว

    Nice and short synthesis, will definitely remember this expansion strategy to dearomatize and then create a good nucleophile :) Love your videos ❤

  • @sheldonwhite1886
    @sheldonwhite1886 ปีที่แล้ว

    There's a lot of diastereoisomers to separate after the oxidation of the phenol. It would be nice to shed a little light on how that separation was accomplished.

    • @SimplifyingSynthesis
      @SimplifyingSynthesis  ปีที่แล้ว +1

      They used a standard silica column with a hexanes/EtOAc gradient/ They don't discuss the separation in detail, just stating 'During the cyclization, a stereogenic center was newly formed; however, dienone 31 was obtained in 36% yield as a mixture of two diastereomers. The other stereoisomers were separated or decomposed.'