Baricitinib Gets Emergency Use Authorization by FDA
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- เผยแพร่เมื่อ 4 ต.ค. 2024
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. Baricitinib Gets Emergency Use Authorization by FDA
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Note: this drug must be used in combination with Remdesivir.
Baricitinib is currently approved in the US for moderate to severe rheumatoid arthritis that is refractory to tumor necrosis factor blockers. FDA has issued emergency used authorization (EUA) for it to be used in combination with Remdesivir.
FDA’s Emergency Use Authorization (EUA)
www.fda.gov/ne...
Letter of authorization by FDA
www.fda.gov/me...
Clinical trial for Remdesivir and Baricitinib
www.niaid.nih....
NIH concludes that Remdesivir and Baricitinib accelerate recovery
www.niaid.nih....
What is Baricitinib?
It is a JAK/STAT second messenger system inhibitor.
en.wikipedia.o...
How do JAK/STAT system work?
www.ncbi.nlm.n...
en.wikipedia.o...
ACTT-2 Trial that is used by NIH to recommend Remdesivir and Baricitinib
clinicaltrials...
SOLIDARITY TRIAL that shows Remdesivir does not work
www.medrxiv.or...
www.medrxiv.or...
WHO asks to stop using Remdesivir
www.who.int/ne...
#drbeen #koolbeens #COVID19 ...
Disclaimer:
This video is not intended to provide assessment, diagnosis, treatment, or medical advice; it also does not constitute provision of healthcare services. The content provided in this video is for informational and educational purposes only.
Please consult with a physician or healthcare professional regarding any medical or mental health related diagnosis or treatment. No information in this video should ever be considered as a substitute for advice from a healthcare professional. ...
Disclaimer:
This video is not intended to provide assessment, diagnosis, treatment, or medical advice; it also does not constitute provision of healthcare services. The content provided in this video is for informational and educational purposes only.
Please consult with a physician or healthcare professional regarding any medical or mental health related diagnosis or treatment. No information in this video should ever be considered as a substitute for advice from a healthcare professional.
Hi Drbeen, I wanted to thank you for all these wonderful educational videos on the virus. The insights you and other doctors provide us "normal folks" is invaluable because our own personal doctors and our government medical organizations do not give us the sort of information that we need to enhance our immune systems in tune to fight it. I signed up for your service because they price was so low, and even though I have no need for all the great videos I am sure you produce for medical folks, I feel this was the only way I could give you some money for the wonderful work you have already done. Thanks you oh so much....you are providing wonderful information and I share it with my friends so they will get the info. Thanks!
I am also recovered and came back home after 6 days treatment with Remdesivir. Even on my bed I was listening you. You are blessing for students like me. I am from university of Missouri perusing my PhD in pathobiology.
What else was given along with it ?
Isn’t it amazing how they only approve 2nd line drugs which are not that effective. This really should make people outrageous
"Tomorrow is my off." Always such sad words to hear, but you've earned your day off, Dr. Been. Enjoy your time off.
Great Now l am understanding what it is like to be a medical student. Thanks for helping me to see how immune properties respond , their purpose and outcome s when meeting other substances to fight dis-easises 😁 thanx Dr. B for your thorough explanation.
Me and my wife both are in good health today. My oxygen level is stable. No weakness. I have some GIT symptoms.❤️🙏
Thank you Dr Been. Love your work.
Hi Drbeen, I'm from the UK and cannot thank you enough for the incredible work you are doing for the whole of humanity day after day. Just love your discussions and wonderful illustrations!
Question: what do you think about the study about the MMR vaccination giving protection against severe covid19? Thank you again!
Thanks for sharing, doc! I'm beginning to suspect that the politicization of treaments is a contributing factor in the high US death rate for this virus, who knows this might be the case for other pathologies too.
MMR vaccine has a great role in severity of covid.....
Dr John campbell of England add a video on yesterday on TH-cam 👍
My wife and me took MMR vaccine in month of may and July 2020 two doses.as in India health workers above the age of 30 were taking MMR while children are vaccinated since 1992 in India
Have you discussed Bamlanivimab yet? I would like to learn more about it since it is being distributed to hospitals throughout Texas.
“It’s a very simple mechanism, I hope I’m not making it complex”
Me: 🤯 🤯 🤯 ☠️
FDAs corruption is bad for your health !
Should this be used without remdesivir? The hospital wants to give this to my parents.
Question, Doctor Been, please provide more information on Teicoplanin.
Dr Mobeen can you review and discuss few home remedies for COVID -19,such as chicken soup,licorice,ginger ,brown algae,Thyme,medicinal mushrooms,unsweetened lemonade,fucoidan nasal wash,Astragalus, Andrographis,cinnamon,pineapple juice,etc.
I am an American trained internist but practice integrative/Alternative ,CAM,78 y. old,have had not cold/flu for ten years,and no COVID yet!.
Let us for a change,talk about that 85% of people who survive COVID,what are they doing right!? Thank you....Sorry I gave you a lot of homework.
God bless.
I am now highly cynical about the statistical use of median figures in favour of averages. I think all these studies should include both statistics as over time the median can be distorted from the average as the range of days increases. I'm willing to bet that the average number of days was the same for both groups and a difference was only seen in the median figures, and a very small one at that which hardly seems statistically significant. I note they give no real figures or .p values. This just looks like a lame attempt to prolong the use of Remdesivir when it has proven to be completely ineffective.
We used tofacititib. It didn't work.
Sir plz have discussion on diagnostics test of COVID 19 because a lot of publications saying patient can be positive for 90 days after recovery.Rt PCR result. Now I have healthy discussion with my Prof. That how can I have negative RT PCR after recovery. Please educate us sir
Do you comprehend that PCR is only looking for snippets of the viral RNA sequence? It may be that those snippets also exist in other viruses - perhaps even the common cold. I am also interested to know how the testing companies decide which snippets to use for ID. I am aware that several tests are using VERY HIGH amplification now as opposed to earlier in the epidemic. Peace
@@jflivingston I read some articles. That shows One can be positive for 90 days after recovery. Yes I know PCR is looking for snippets of viral RNA. But it’s not that specific. Can we have discussion on sensitivity on this forum? I want to learn more about that.
@@drsamuel21 I agree it would be a really good topic and I believe Dr. Syed would do a great job of addressing exactly your concern. I pointed out to you the term amplification - read about it on the internet as regards RT-PCR. You can be positive FOR SOME PIECE OF THE VIRUS and not even have that virus. You claim to be a PhD student - this ought to be trivial for you.
Not impressed.
Satish, not sure where you're from, but I hope nobody is impressed with 'merka or its institutions - I live here and the FDA is a shameful embarrassment. It's a tragedy that we are such a greedy, corrupt country. Peace
@@jflivingston I'm beginning to suspect that the politicization of treaments is a contributing factor in the high US death rate for this virus, who knows this might be the case for other pathologies too.
@@eelkeaptroot1393 You are correct! Simply examine Fauci's history with suppressing AIDS/HIV treatments! Also, look up the monoclonal antibody leronlimab (very small biotech) which has been clearly demonstrated to be highly effective in HIV suppression - it's been in a Phase 3 COVID trial now for ~5 months and is the ONLY drug which has actually saved severe/critical intubated patients - FDA approves useless drugs instead because they are owned by BIG PHARMA. US is a joke!
@@jflivingston Yeah, a joke or a nightmare I'm still working on it.
@@eelkeaptroot1393 It is actually a nightmare. This whole BS could have been over months ago and thousands less dead. They'll skate, all of 'em!
We asked our doctor if he would prescribe ivermectin if we got covid and he said he would not; he was not allowed to by his employer. If we got covid, would it be ok to buy the formulation for horses (that is available over the counter at farm/ranch stores) and calculate the dose to an appropriate number of milligrams for humans and take it?
www.exstnc.com/ Terri, here is a list of docs who will prescribe human ivermectin for you, scroll down to the USA list if you are in USA. Yes, apple flavored horse paste ivermectin 1.87% will work, it is dosed by pounds of body weight, but no medical provider would ever tell you this. Pounds are marked on the plunger. Durvet sells the brand I have and got on Amazon. I now know two separate people who have used it. One got sick last week and is already well. The other has been sick 3 days and already fevers are gone and she’s feeling better. She is taking D, C, zinc, Quercetin, melatonin and aspirin as well.
Locals from India say Ivermectin is available, over the counter, in some states in India. 30 tabs of 6 mg for $24 plus $25 shipping by DHL to the USA
Loofie doesn’t think much of this study
Ivermectin is the way to go!!!!