For those of you who don’t open the description. 👇🏻 ****PLEASE READ: I have received several complaints about the volume of the music in this video. I apologize, but it is too late to change anything about that. If you don't like the music or find distracting PLEASE mute the video and watch with closed caption. I am doing my best to be patient, but these comments are getting old. Also, there are literally thousands who have watched and haven't complained so... it can't be that bad. Thanks in advance!!!****
Appreciate the feedback. I don’t remember if it was this one but the music was a bit higher, but typically I have it down to as low as 2% and speech is up to 200%. Sorry it was distracting for you
Yes thus is horrible, I am neurodivergent (and have b6 toxicity) I cant separate the music so I ended up watching muted with subtitles. Its too loud.... and not right music for background.
It's important to check 2 things: 1) all studies done using B6, either alone or in combination with other substances (B1, B12, Folate, Biotin, R-LA etc.) did so with a maximum of 200mg/day and for a max of 24 weeks, most shorter. Some only 100g/day. Commercially available products such as MetaNX, Nuphoria etc. only have max 80mg/day and of B6 P5P (see next point) 2) that one takes, keeping point 1 above in mind, only B6 P5P and NOT the Pyridoxin HCl form. Pyridoxin HCl needs to be converted in the liver to P5P. It's this conversion process that is potentially harmful in high dosages over long periods of time. There are no cases, neither in "normal" dosages nor in "therapeutic" dosages over periods of time
@@moondrop3013 - How much did you take for how long? What are your symptoms? Vrolijk MF, Opperhuizen A, Jansen EHJM, Hageman GJ, Bast A, Haenen GRMM. (2017) The vitamin B6 paradox: Supplementation with high concentrations of pyridoxine leads to decreased vitamin B6 function. Toxicol In Vitro. 2017 Oct;44:206-212. doi: 10.1016/j.tiv.2017.07.009. Epub 2017 Jul 14. PMID: 28716455. „In conclusion, the present study strongly indicates that the neuropathy observed after taking a relatively high dose of vitamin B6 supplements is due to the vitamer that is used in the supplements, namely pyridoxine. The inactive form pyridoxine competitively inhibits the active pyridoxal-phosphate. As a consequence, the paradox arises that the symptoms of vitamin B6 supplementation are similar to those of vitamin B6 deficiency. Vitamin B6 supplements are used by a large number of people. The safety of vitamin B6 is debated and recently EFSA has lowered the upper limit for vitamin B6. The question is whether lowering the safe dose for vitamin B6 is the solution. Remarkably, even at relatively low dose, vitamin B6 supplementation has given rise to complaints. Our study indicates that the toxicity of vitamin B6 is not only determined by the dose, but by the vitamer in which it is taken. Perhaps it might be better to replace pyridoxine by pyridoxal or pyridoxal-phosphate as vitamin B6 supplements, which are much less toxic. In this way, the vitamin B6 paradox may potentially be prevented.“ also: Carlos-Alberto Calderon-Ospina, Mauricio Orlando Nava-Mesa & Ana María Paez-Hurtado (2021) Update on Safety Profiles of Vitamins B1, B6, and B12: A Narrative Review, Therapeutics and Clinical Risk Management, 16:, 1275-1288, DOI: 10.2147/TCRM.S274122 www.tandfonline.com/doi/full/10.2147/TCRM.S274122 Some excerpts: “Relevant original articles on neurotoxicity of vitamin B6 in humans obtained by our searches included seven case reports/series, one prospective study, and one case-control study (Table 1).Citation39-,Citation47 In half of them, neurotoxic side-effects of vitamin B6 were mostly due to very high doses and/or long-term treatment and resolved after treatment cessation.Citation39-Citation41 Specifically, reported clinical neuropathy cases occurred in a timeframe of 2-24 months depending on the administered dose: after 12 months or longer with doses of ≤2,000 mg/day, and after less than 12 months with doses >2,000 mg/day.Citation39-Citation46 The first clinical assessment study of pyridoxine-induced neurotoxicity in humans by Schaumburg et alCitation47 included seven patients with severe sensory neuropathy in the extremities after taking 2,000-6,000 mg/day pyridoxine for 2-40 months. Four of these individuals were not able to walk. All symptoms, assessed through objective neurological diagnosis, improved after medication discontinuation.Citation47 Another case series report by Parry and BredesenCitation46 studied 16 patients with neuropathy (all assessed by history and examination, seven electrophysiologically confirmed diagnoses, two sural nerve biopsies) after taking 100-5,000 mg/day pyridoxine for up to 72 months. Patients with doses ≤500 mg/day showed neuropathy after 23 months on average, while those taking 5,000 mg/day developed symptoms on average after around 3 months. In contrast, none of the patients taking 50 mg/day for 6 months).” And are you absolutely sure you DIDN'T take Pyridoxine HCL? Most multi-B vitaines include Pyridoxine HCL. And most high-dosage B6 is also Pyridoxine HCL. Why were you taking it in the first place?
@@moondrop3013 - - Vrolijk MF, Opperhuizen A, Jansen EHJM, Hageman GJ, Bast A, Haenen GRMM. (2017) The vitamin B6 paradox: Supplementation with high concentrations of pyridoxine leads to decreased vitamin B6 function. Toxicol In Vitro. 2017 Oct;44:206-212. doi: 10.1016/j.tiv.2017.07.009. Epub 2017 Jul 14. PMID: 28716455. „In conclusion, the present study strongly indicates that the neuropathy observed after taking a relatively high dose of vitamin B6 supplements is due to the vitamer that is used in the supplements, namely pyridoxine. The inactive form pyridoxine competitively inhibits the active pyridoxal-phosphate. As a consequence, the paradox arises that the symptoms of vitamin B6 supplementation are similar to those of vitamin B6 deficiency. Vitamin B6 supplements are used by a large number of people. The safety of vitamin B6 is debated and recently EFSA has lowered the upper limit for vitamin B6. The question is whether lowering the safe dose for vitamin B6 is the solution. Remarkably, even at relatively low dose, vitamin B6 supplementation has given rise to complaints. Our study indicates that the toxicity of vitamin B6 is not only determined by the dose, but by the vitamer in which it is taken. Perhaps it might be better to replace pyridoxine by pyridoxal or pyridoxal-phosphate as vitamin B6 supplements, which are much less toxic. In this way, the vitamin B6 paradox may potentially be prevented.“
see an answer to moondrop3013 ... having written that: I was diagnosed in 1999 with idiopathic peripheral neuropathy. Again in 2012. I was also diagnosed with diabetes Type 2 in 2014 (provoked through Spiricort given to suppress symptoms of Polymyalgia Rheumatica) and had a heart attack in 2019. For neuropathic pain relief I was started on Gabapentin and Cymbalta. Because of horrid cognitive side effects, Cymbalta was switched out for Effexor. Unfortunately, these cognitive side effects didn't stop, so I stopped using them. Since about 2014 I've been taking instead of the Cymbalta/Effexor & Gabapentin (as it stands 25. Nov. 2023): R-Lipoic Acid 300 (240) mg - 1-1-1-1 Acetyl-L-Carnitine 750 mg - 1-1-0-1 N-Acetyl Cysteine (NAC) 1000 mg - 1-0-1-0 Omega 3 (fish oil) 1000 mg - 1-0-1-0 Borage Oil 1000 mg (GLA = Gamma Linolenic Acid) - 1-1-1-0 (stopped 1. nov. 2023) Magnesium 100 mg - 1-1-1-1 These above have helped some. I came to use these through exclusionary processes. IOW, I'd take a substance for a while, noting sensations. Then I'd stop and see what happens. These above “passed” this exclusionary process. If I noticed an increase in severity of symptoms when stopping a substance, I could conclude, that it was actually helpful when I was taking it. I then added Benfotiamine starting on 15.08.2023. Helped greatly, most overt pain gone, but numbness still prevalent (time of writing 22.12.2023). Some stomach ache if dosage is over 150mg, so I take 100/150mg 1-1-0-0 / 150mg 0-0-1-0 and 250mg before going to bed (0-0-0-1) - I don't get stomach ache before going to sleep or during the night. I then added on September 5, 2023 (as it stands 25. Nov. 2023): Folic acid 1.7 mg 1-1-1-0 Biotin 5 mg 1-0-0-0 Methylcobalamin 1500 mcg 1-1-1-0 Vitamin B6 P5P 27mg 1-1-0-0 The 4 above plus Benfotiamine & R-Lipoic acid, according to this study, which has been cited many times in meta studies concerning use of supplements to treat neuropathy pain: Maladkar, M., Tekchandani, C. and Dave, U. (2014) Post-Marketing Surveillance of Fixed Dose Combination of Methylcobalamin, Alpha Lipoic Acid, Folic Acid, Biotin, Benfotiamine & Vitamin B6-Nutripathy for the Management of Peripheral Neuropathy. Journal of Diabetes Mellitus, 4, 124-132. dx.doi.org/10.4236/jdm.2014.42019 “Results: Treatment led to significant reduction from baseline score in various neuropathy symptoms from the 4th week itself. After 12 weeks of treatment, the mean pain score declined by 78.0%, numbness by 92.1% and muscle weakness by 96.9%. Also, there was 96.0% & 99.2% reduction in tingling & burning sensation respectively. No serious adverse events were reported. Conclusion: The current study confirms that fixed dose combination of Methylcobalamin, ALA, Folic Acid, Biotin, Benfotiamine & Vitamin B6 is effective & well tolerated in the management of peripheral neuropathy.” “This PMS included 497 patients with peripheral neuropathy and was conducted at 5 different centers by qualified investigators. The efficacy of the treatment was assessed based on improvement in parameters like neuropathic pain, numbness, muscle weakness, tingling and burning. Investigation of parameters was performed throughout the treatment period on: visit I (baseline), visit II (week 4), visit III (week 8) and visit IV (week 12).” “Patients with peripheral neuropathy were orally administered fixed dose combination of Methylcobalamin 1500 mcg, ALA 200 mg, folic acid 5 mg, biotin 5 mg, Benfotiamine 50 mg & vitamin B6 5 mg once daily for 12 weeks.” Hakim, M., Kurniani, N., Pinzon, R. T., Tugasworo, D., Basuki, M., Haddani, H., Pambudi, P., Fithrie, A., & Wuysang, A. D. (2018). Management of peripheral neuropathy symptoms with a fixed dose combination of high-dose vitamin B1, B6 and B12: A 12-week prospective non-interventional study in Indonesia. Asian Journal of Medical Sciences, 9(1), 32-40. doi.org/10.3126/ajms.v9i1.18510 nepjol.info/index.php/AJMS/article/view/18510 Baltrusch, Simone (2021) The role of Neurotropic B Vitamins in Nerve Regeneration, Biomed Res Int. 2021; 2021: 9968228. Published online 2021 Jul 13. doi: 10.1155/2021/9968228 www.hindawi.com/journals/bmri/2021/9968228/ Pinzon RT, Schellack N, Matawaran BJ, et al. (2023) Clinical Recommendations for the use of Neurotropic B vitamins (B1, B6, and B12) for the Management of Peripheral Neuropathy: Consensus from a Multidisciplinary Expert Panel. J Assoc Physicians India 2023;71(7):93-98. www.japi.org/y26464c4/clinical-recommendations-for-the-use-of-neurotropic-b-vitamins-b1-b6-and-b12-for-the-management-of-peripheral-neuropathy-consensus-from-a-multidisciplinary-expert-panel Silviana, Meyvita, Tugasworo, Dodik, Belladonna,Maria (2020) The Efficacy of Vitamin B1, B6, and B12 Forte Therapy in Peripheral Neuropathy Patients, DOI: doi.org/10.14710/dimj.v2i1.9549 Geller M, Oliveira L, Nigri R, Mezitis SG, Ribeiro MG, et al. (2017) B Vitamins for Neuropathy and Neuropathic Pain. Vitam Miner 6: 161. www.hilarispublisher.com/open-access/b-vitamins-for-neuropathy-and-neuropathic-pain-2376-1318-1000161.pdf Amorin Remus Popa, Simona Bungau, Cosmin MihaiI Vesa, Andrei Cristian Bondar, Carmen Pantis, Octavian Machiar, Ioana Alina DimulescuI, Delia Carmen Nistor Cseppento, Marius Rus, (2019) Evaluating the Efficacy of the Treatment with Benfotiamine and Alpha-lipoic Acid in Distal Symmetric Painful Diabetic Polyneuropathy, Revista de Chimie, Buchares, Original Edition- 70(9) DOI:10.37358/RC.19.9.7498, www.researchgate.net/publication/336529734_Evaluating_the_Efficacy_of_the_Treatment_with_Benfotiamine_and_Alpha-lipoic_Acid_in_Distal_Symmetric_Painful_Diabetic_Polyneuropathy H. Stracke, W. Gaus, U. Achenbach, K. Federlin, R.G. Bretzel, (2008) Benfotiamine in Diabetic Polyneuropathy (BENDIP): Results of a Randomised, Double Blind, Placebo- controlled Clinical Study, 2008 Nov;116(10):600-5. doi: 10.1055/s-2008-1065351. Epub 2008 May 13. pubmed.ncbi.nlm.nih.gov/18473286/ Carlos-Alberto Calderon-Ospina, Mauricio Orlando Nava-Mesa & Ana María Paez-Hurtado (2020) Update on Safety Profiles of Vitamins B1, B6, and B12: A Narrative Review, Therapeutics and Clinical Risk Management, 16:, 1275-1288, DOI: 10.2147/TCRM.S274122 www.tandfonline.com/doi/full/10.2147/TCRM.S274122
I had high levels of B6 and was told to stop taking it. Only trouble is I was not taking any B6 or B Complex or any other supplement containing B6. Then I started reading labels of products that the food industry adds B6 to and it was added to every single cereal except health food store brand cereals. Apparently the form of B6 is not being converted to the form used by the body which some vitamin companies are now using. However I don't know if this form can still cause toxicity. Just be careful of what's on the food labels listed under Ingredients.
Thank you Kathy. I’ve learned SO much more from those commenting since I released this video. I’m amazed at how much B6 can be obtained through food alone to the point that supplementation shouldn’t really ever be needed other than diet. It’s very interesting what you say about cereals. Imagine how many Americans eat breakfast cereal!
@@KoalaBeer. You can't. The food manufacturers fortify their crap with things that don't need fortifying or are not a deficiency. & it's usually with the synthetic crap that does more harm than good. They are poisoning the population by design.
I got toxicity from only 25mg per day plus b6-rich diet. 18 months later I am still healing. B6 toxicity is a NIGHTMARE & can cause horrendous autonomic symptoms as well as the typical tingling/burning neuropathy. My entire body was affected! Please be extremely cautious with B6 - RDA is less than 2mg per day, which is easy to get from food. If you are having weird symptoms while supplementing or eating a high b6 diet, ask for the blood test.
Have you continued to see improvement across that entire span of time? I'm about 4 months into a second recovery, but this one is harder as the neurologic dysfunction was significantly worse by the time I figured out what was going on. Seems like the symptoms go on rotations, where something flares up (while other symptoms disappear), and about a week later it cycles to something else. Makes it difficult to really gauge the progression, even if, over time, it does seem the symptoms are weaker each time they are cycled on.
@@thomasc1270 your experience sounds pretty typical of b6 toxicity! Everyone I know who has had this, has symptoms go through weird cycles. For me it has felt like 3 steps forward, 5 steps back. Now that I've been healing for over a year, things are generally a lot better, but what will set off severe symptoms at this point is any time I get sick with a virus. I had a flu and then a few months later a cold, and after both illnesses by b6 toxicity symptoms got really, really bad - similar to when I was first coming off the supplements. So I think our bodies are just extra sensitive when we have the toxicity. Every month or so I've had one particular symptom that will be prominent - for awhile it was heart palpitations and blood pressure spikes, then another month or two it was chronic nausea, then for awhile it was fatigue and pain in my legs - and the symptom will almost always change after 4-6 weeks. Like the nerves were trying to "turn back on" in different parts of my body, or mis-firing in different areas. It DOES get better over time, but it seems to take forever. Hydration, gentle exercise and lots of sleep are what have helped me recover. Also, eating a balanced b6 diet that doesn't go above or below the recommended daily amount. But yeah sorry for the long response - SLOWLY over time I have seen improvement, but it is hard to tell because it takes so long. I hope you continue to heal and feel better!
@@thomasc1270 this is classic for B6 detoxification, it means your body is working to get rid of it. Detoxification can be more scary and tough than the initial symptoms you diagnosed it with. Dont give up, but ofc seek a doctor if it gets too much to handle, it is really not an easy road and you need support. Keep on drinking lots of slight salted (not tablesalt!!!) water and potassium to help the process flushing out the B6 stuck in your nerves. Like 4 liters spread out over the day. It can take years to clean your body but it will go easier over time.
@@jesseautumnmusic I experienced the same, my first 'attack' was last year June when I came home after my dads funeral abroad, I got struck with a bad flu like I normally never have, my immunity is top notch, Im never sick. I felt miserable for weeks and this flares came together which I didnt realise at that point, making it worse. I thought it was all part of the flu. I would wake up totaly confused and feel life draining out of me, my body feeling numb and sweating like crazy, I was afraid to die. The flares after this are always milder in nature, but anxiety rules and I had to eat every 4 hours or I would feel horrible. This lasted for like 3 to 4 months in weird cycles of symptomes and then I was symptom free for the rest of the year, until May arrived and I got a bad toothache. Right after that cleared this flares came back, again this terrifying feeling of going to die, hot flashes, palpitations the whole show randomly visited, now including high bloodpressure, palpitations, hot flashes, bloodsugar hikes, it would wake me up terrified etc. I went to doctor who declared my heart perfectly fine, had bloodtest which showed nothing worrying, and I went abroad to visit family more sick than alive so I did another bloodtest there, with more markers as I didnt need a doctor to do so. I was low on Vit D and chance for deficient on B12 even if it was within normal range, they noted it because some blood values indicated possible problems with absorbtion or red bloodcell problems. Also slight high TSH but nothing serious and further testing didnt show thyroid issues. So then I started to get neuropathy really bad, ice cold feet, and bloody hot torso, got struck by noro virus and cleared out my whole intestines. I was put on a very strict diet (basicly only fruit, vegetables and fish 3 times a week), anti inflamatory as I felt I was inflamed through my body. It made me even more sick, I lacked proteins and fats, it was loaded with B6 rich foods and I was also taking supplements overloading me even more. I went back to my normal diet but way more healthy and recovered my guts. What a trainride this was... after this noro virus attack last week I felt really clean and now with cronometer I track everything and feel so much better. Just mild neuropathy for now, though yesterday I had cramps in my legs. Next week it is finaly my turn to see a doctor after a 5 week waitinglist. I hope he will agree to a bloodtest once more. I also hope that my awarenes will avoid this flares to start up again come next summer. If B6 is causing all this, Im pretty sure Im well on the way to avoid it.
If you check the understand B6 toxicity group you will be shocked of how many people have high B6 in blood just from diet and small doses of supplements
That’s incredible really. I wouldn’t have imagined it was that common. Just goes to show just how important it is to truly get blood work before supplementing
@@parkinsonsdiseaseeducation saw a study that indicated b6 from food has a half life almost 30 times longer than that of supplements. So toxicity could just as easily be established from a steady diet of high b6 foods leading to over saturation especially in the case of inadequate exercise or dehydration.
30 times longer!!! That’s incredible. Wow, there is so much more to this than I ever imagined. Thank goodness for the Understanding B6T website. Thank you again for your input on this. I feel like the more I hear from those with toxicity the more I have learned. I never knew this video would spark such awesome conversation and help me to learn more in the process!!
@@parkinsonsdiseaseeducation it needs way more awareness, because I and many others fear that this is just the start of an epidemic on B6 toxicity, because they add it to literaly everything totally unneccesary. Imagine how much people eat cereals every day, drink all kind of chemical energy drinks, its added to dairy and vegetarian food, multivits are enhanced with 4 times daily dose and all these people who were prescribed to take extra vit B complex. Its pandoras box about to be openened. Its almost as if they do on purpose. And the form they supplement is what most people are toxic for. I get really sick if I eat anything with artificial B6 in it. And lately I also seem to be responding to chickenmeat which is super high in B6.
is happened to me. I actually became toxic and deficient simultaneously. I was prescribed folbic by my primary care physician for elevated homocysteine. When it didn't work, she doubled the dose (it didn't work because i later learned i have methylation issues and need the active form of b vitamins in order to utilize). I developed a terrible sensory neuropathy with a co-condition called erythromelalgia....but nobody knew why! Turns our b6 in any form is tricky and can make my neuropathy worse if i supplement minimally for too long. Yes, my condition is complex, but there are many others suffering. Be careful what you take.
I have high homocysteine levels as well as high b6 toxity. I was only taking between 5-8mg daily but for 10 years in a b-complex.Have a vibration type feeling i assume is neuropathy. I've been off all b vits except methyl b12 after finding out I have the MTHFR gene.The vibration is constant.I've had 9 hours one day this week where it stopped. Drink lots of water, avoid b6 foods.Any thoughts would be greatly appreciated.My doctor is good but doesn't really know how to help me.I dont have the money to go to functional doctors as she mentioned. Thanks
@@micheleharris5703 know that as the b6 leaves your body the symptoms get worse before getting better. Due to my methylation issues, it took 14 months for my blood levels to normalize. I had neuropathy on my entire body but feet were an agony. It does get better but takes time. Do sauna or room salt baths to help release. There are Facebook help groups on this. I learned a lot there.
I had vitamin B6 toxicity, went through months of hell. My dose? 200mg daily for only 36 days, I counted the tablets I took. So people can get toxic from way less and way shorter than 1000mg per day for at least a year. Just wanted to share my experience.
Thank you for sharing. That is disconcerting to me. How is one to know how much or how little to take of toxicity can happen at such a low dose?! The number I quoted was found in my research, but this video has provided some amazing feedback from folks like yourself. Were you ever told there is some type of issue metabolizing the B6 or that you’re storing too much, etc?
@@parkinsonsdiseaseeducation Unfortunately I was never told why so I have no idea, wish I knew the answer. But there are many B6 toxicity groups on Facebook with many people like me, all with our own stories, some got toxic without even supplementing but they had high B6 diets, so I always want to create awareness so this does not happen to other people. I was lucky enough to heal from it, but it takes time and it was very important to do my own research, and advocate for myself, since my doctors were all clueless about this. Awareness is key to helping people heal from this, or stopping people from supplementing when they do not need to. Thank you for your video.
Thank you, I’m glad that this video has been impactful. I feel like I am just starting to learn about this and the more I interact in the comments the more I learn!
It’s been 2 years for me. In the beginning I went through hell. My dose was much lower. Under 25 mg. Mostly from whole food supplements…but ate a diet unknowingly high in B6. Food B6 isn’t supposed to accumulate. It took 4 months of in and out of ER before a neurologist tested B6. I suspected that it had something to do with B vitamins and kept telling the doctors since every time I took even a low dose of whole food B vitamin the tingling in legs would become severe. I stopped taking them on my own early on an my numbers were still high at 4 months. Got back on dose under 10 and it got worse again. Still healing. Long process. Thanks for doing a video. 🙏
Hey Mike. Great question! The short answer is that it is stored in the muscles. This is a quote from our friends at understandingB6toxicity.com: "We’ve been told all our lives that all of the B vitamins are water-soluble. Well, that is partly true. What is not widely known is that vitamin B6 is stored extensively in our muscles. What is also not known is the effects of dehydration on B6 elimination. Lastly, the most important unknown is that B6 can be stored in nerve cells." I would highly recommend looking at their website here -> understandingb6toxicity.com/b6-toxicity/causes/
The B6 metabolites stays in the body for a number of days. So if you take a high dose daily, it can accumulate. On research paper recommended to take 100 mg once a week to avoid that accumulation. Most other B vitamins doesn't have this problem and can therefore be taken daily. B12 is also very different, since it's stored in the liver. But it doesn’t seems to have any toxicity as a supplement. Although those with the MTHFR genotype should take methylcobalamin, and not cyanocobalamin. By the way, folate, B6, and B12 belongs together. If you want to be sure getting effect of B12 supplementation.
Yes, thank you. I've been taking many Bs and have had burning sensation all over my body. I did some muscle testing and it came down to B5 and B6. I think in my case, burning skin, causing my face, arms, thighs, stomach to feel hot and burning and an hour , once a month. I only took 250mg, per day, maybe the accumulation was too much for me. As a firm believer in Chinese Traditional medicine, we are told we all have different body types, just like in Indian Ayurvedic medicine, both of which are plant based. I need the supplements as I believe that our soil (all over the world ) is depleted of minerals. Just sharing my experience. Thanks for this video. You are very clear 🙏
This is wonderful feedback, thank you. I’m sorry for your trouble with the symptoms, but hopefully you caught it soon enough to turn things around. Also, I apologize for the music in this video, it was too loud in the mix
For B6, toxicity has been established at doses as low as 5mg / day, over a long enough period of time (months or years). At 50mg/day, it usually occurs over a few months. At 250mg/day, you could establish toxicity in as little as a few weeks. This is especially prevalent with the Pyridoxine HCL form, as there appears to be some difficulty in metabolizing high doses, and we don't seem to understand the full ramifications of its interactions with our body. However, even the active form can cause neurological issues. So... 250mg would not be considered a low or reasonable dose at all, even in places with unreasonably high upper levels (like the US, which I believe has the highest upper level in the developed world at 100mg / day.)
I took 1,000 mg per day for 2.5 years. My health started to tank around this time, but I didn’t know why. I still don’t know if my symptoms are a part of this, or if I have a lot of other medical issues that coincidentally started at the same time :( I stopped the B6 in January, and then I felt like I started getting new unexplained medical problems. It’s all so confusing.
@@parkinsonsdiseaseeducationI joined the Facebook group. But I was suspended after one day for violating one of the rules: don’t comment on an old post. So I’m looking for a new group and resource. I don’t want to support a group who immediately suspends a member over something so minor. And after 1 day of membership.
I have an elevated level of B6 (pyridoxal 5 phosphate) in my blood: 48.8 micrograms, when the acceptable max should be 27.2 micrograms and I DO NOT take supplements. Why is that? No doctor is able to give me an explanation.
Good morning Stephanie. Obviously, I can’t give an individualized explanation for this; however, there are some generalities that I can share. B6 is found in our diet with specific foods. Also, almost multivitamins contain 100% recommended daily amount of B6. The bulk of B6 that comes in is stored in the muscles and can also be found in the bloodstream. I’m not the true expert on this, but have learned a ton from Understanding B6 Toxicity. I’d highly recommend their site: understandingb6toxicity.com/b6-toxicity/causes/
@@parkinsonsdiseaseeducationThanks again! The link has really been eye opening. I have started a KETO diet with intermittent fasting, so hopefully together with frequent exercise and lots and lots of water the problem should sort itself out in time. So glad I came across your video!!
I am suffering from b6 toxicity right now. It's hell. 4.5 months off the supplement- most issues are neurological, eye floaters, cognitive decline- it's a neurotoxin.
Gosh I’m sorry to hear about this. As important as B6 is for proper nerve function it can certainly be toxic if too high as in your case. Too much of even a good thing can be bad for you, which is unfortunate. Hopefully in time you’ll have some neuro repair
I took super vitamin b complex for months then recently took vitamin b12 and b6 , another product with zinc that also had it and protein powder. I started feeling off balanced ,uncoordinated. I stopped taking everything, drinking water 8 glasses . Slowly recovering from I guess ataxia increased anxiety.
To clarify, are you saying your right leg hurts when you urinate or that the overdose is causing you to have frequent urination AND pain in the right leg?
@parkinsonsdiseaseeducation I had taken an overdose of B-complex tablets for 5-6 days, unaware of its consequences. Since then, I've been experiencing: Pain in my right leg and arm Sensations like ants crawling in my legs
@@parkinsonsdiseaseeducation "I researched online and found that overdose could lead to circulatory, neurological, or infectious issues. However, I only took the overdose for 6 days and stopped immediately."
@AR_raouf got it. Yes, so with vitamin B overdoses/toxicity you will get nerve symptoms since B vitamins directly impact the health and support of nerves. Excess B vitamins can result in nerve damage, so you need to stop the supplements and see a physician. The urination could be due to the nerve issues resulting in bladder control problems or it could simply be your body trying to get rid of the excess
@@parkinsonsdiseaseeducation "I was alarmed by my symptoms and worried about diabetes/prediabetes, but my low weight and minimal sugar intake are reassuring. Thank you, doctor, for alleviating my concerns."
I know 2 people with MTHFR mutation and double dose of B6 in the blood. Does it mean that it can’t be turned into active form and the body is in deficit? Do they have to supplement with the activated form? How to get rid of this blood excess? They don’t supplement.
I’m not going to recommend anything specifically as it’s not my scope of practice, but generally speaking it would not be advisable to supplement further with the MTHFR mutation. The mutation results in an inability to break down the vitamin B and if you supplement more that would result in even more B6 on the blood stream and they are already in excess. That would likely result in toxicity and some with the mutation have toxicity even when they don’t supplement from what I have heard
I notice on the daily amount list of ingredients on energy drinks, often there is 350 percent of daily requirement of vitamins… such as B complex vitamins… so understanding is essential. Possibly an every three days is often enough for such powerful things or tiny portions.
Hi Ric. Unless you have an issue breaking down and absorbing B vitamins in the gut (MTHFR gene mutation for example), I wouldn’t think just ingesting B6 in foods and energy drinks would necessarily cause toxicity. Now, supplementing plus dietary B6 may be risky. Have you heard of understandingB6toxicity.com?
I came here because i took P5P for the first time yesterday. and this morning had a headache ..which was completely unexpected, or out of the normal/ should not have been. Then i had an incident of lightheadedness today ..which rarely EVER occurs. my light tinnitus ALSO did not calm down today, as it typically does, this time of day, etc. i started reseaching today. Thank you for providing the link to the b6 toxicity website. Was an excellent read ..with what they said about Blood VOLUME issues causing headaches. Why did Dr. Stephen Cabral say in his video, right here on TH-cam, that B6 deficiency was the #1 thing he saw in his clinic. i added B6 because i take B9 and B12 for undermethlation ..which i don't know if i have, but most have. i do not eat cereal, or any packaged product like that, that could have B6 added to it. Dr. Berg says Pyridoxal HCL, which is synthetic, can cause B6 deficiency symptoms. Is he referring to B6 toxicity ?
I’m so glad their site was insightful. It really is very well put together. I can’t answer why Dr. Cabral said what he said. I originally recorded a video about neuropathy in Parkinson’s and stated that B6 and B12 are often deficient and this contributes to the neuropathic symptoms. I had advised to seek out supplementation with the guidance of a physician. Since that time I released THIS video when I learned about the results of toxicity when dosing is not done correctly. In answer to your last question, I do think that he meant toxicity, because from what I’ve read and learned since I released this video it seems that any form of B6 can result in toxicity
I'm surprised at the 1000 mg or more being excessive. Other authorities (academic and governmental) put the tolerable upper intake level (UL) at 100 mg/d, consistently. Other authoritative sources (including those referenced in the second sentence) say that even lower amounts may affect people with a genetically based inability to process pyridoxine to downstream metabolites. Here's more!: Some knowledgeable commentators state that the active form of B6, the downstream metabolite P5P (or pyrodoxal-5-phosphate, or PLP) can be consumed and tolerated at considerably higher amounts. (One source, a physician IIRC, really did say "7000 mg/d.")
Thank you David, you’re right, I’ve learned more from the comments than the research than I did prior to recording this video. The 1000 mg is outrageously high compared to levels that have actually resulted in toxicity from the anecdotal reports of folks in the comments
Wow! That’s incredible. I hadn’t heard of any cases where diet could also cause this to happen. From the literature I would say that’s exceptionally rare to get toxicity from diet plus a low dose of supplement
@@hawk28912 3 mg for 8 months. I used 1,5 mg for 8 months of the year in a multivitamine for most of my adult years though. After my pregnancy, 22 years ago, I had a few nerve problems...
so i just had a skin biopsy done after 4 yrs of suffering and the results were negative idk what else could be causing these symptom's on my left ankle it was 14mm and right was 19mm to even be considered for neuropathy it has to be under 7.1 i dont get this
Had you ever supplemented with B6 prior to seeking out testing? Or are you wondering if this could be it since there don’t seem to be other answers so far?
Recent blood tests showed I have high levels of Vitamin B6 (about 30% that higher end of range) and the supplements I was taking had only 0.85mg of Vitamin B6, just 50% of RDA (have taken them for about 2 years but neuropathy symptoms started 3 months ago).
@@parkinsonsdiseaseeducation It was a Multi Vitamin (sells in Amazon under Brad Stanfield Multi Vitamin) but none of the vitamins have RDA levels suggesting mega doses. I also take 1150 mg Omega-3 but I assume that doesn't include B6.
It isn’t really in my purview to give specific advice on dosage. Generally speaking, if you already have toxicity then I’d avoid B complex. If you’re asking how to avoid toxicity then I’d highly recommend going to www.understandingb6toxicity.com
You can have all the natural B6 you want that you get through food it's the synthetic version of B6 that's added to everything like multi vitamins energy drinks and fortified foods that's causing all the issues. Definitely stay away from energy drinks because that's what got me...had been drinking that poison for almost 10 years straight everyday several times a day.
The correct dose is the dose that you are missing and that is only determined by a blood test. There is no correct dose. Vitamins are taken to replace what is missing. If your levels are good then you dont need them. Don’t believe the commercial hype you do not need to take vitamins. Most vitamins come from a good diet. If you eat well then skip the vitamins and only take what you are low in and again that can only be determined by your blood test not by some one on TH-cam telling you to take something. Vitamin levels are an individual thing and no one but a blood test can determine that. Don’t believe the hype people are just tying to sell products. I am currently b6 toxic from p5p and it is awful and painful.
Immediate cessation of the supplements is key. Drinking lots of water to flush the vitamins from the system would also be important. Nothing more specific comes to mind, but I’d refer you to understandingb6toxicity.com to learn as much as you can.
I have Morton's toe. People with Morton's toe do not absorb B6. If it is not metabolised, do levels of B6 increase from normal dietary intake? I had my serum B6 levels checked and they were high even though I was not supplementing any B vitamins. I do not know what my tissue levels were.
I don’t have a definitive answer to your question, since it would seem contradictory that you have issues with absorption yet you have high B6 levels in the serum… I am not the expert specifically on B6 toxicity. Here is a link to a group that I feel is trustworthy: understandingb6toxicity.com/
I have Morton’s toe and was supplementing b6 with p5p for that reason and now have b6 toxicity. If you eat well you do not need to supplement. It can increase from food.
I was taking p5p related, because I had breast tenderness from a prolactinoma. This is the 2nd day in a row I've woken up with acute loss of proprioception in my left arm and hand. It is the weirdest feeling ever!
Got toxic after several months of low folid acid and b complex pills.Never thought this is possible. Now I am 5 weeks off and hope it is getting better soon.
Wow… the more I learn about this subject the more I feel like I don’t know. It seems some folks get toxic with seemingly little effort like on your example of B complex pills. That’s such a common supplement for folks .
Thank you for this vireo. Does excess B6 50 MG cause muscle twitches/fasciculations also? The label on the bottle says 2941% of daily requirement. I have stopped taking it after 2 days
I’m glad this video was helpful! In short, yes muscle fasciculations can be associated with B6 toxicity and nerve damage. It sounds like you made the right call to stop taking it
I have on my right hand the index and middle finger numbness and tingling and pain starts early hours in the morning and on the left hand is the same index and middle finger numbness and tingling and pain early hours in the morning, there must be a way to reverse it or am I fucked forever
My doctor’s tell me b vitamins are water soluble so they help somehow but that you can’t get to much if your also getting them from food. Is this not true?
Hey there Monsterdrumma! Who are your drummer heroes? Peart, Portnoy, Bruford? You can tell I'm a prog guy... Anyway, to answer your question, it is not always true from what I have learned. Generally speaking one will not get toxicity simply from the foods that we eat; however, in those with certain gene mutations such as with the MTHFR gene it is possible to get a higher dose by diet alone and therefore can result in toxicity.
I mean milligram. The original quote from Harvard University states 1000 mg, though from what I’ve since learned that is an extreme amount. Some folks can become toxic from supplementing B6 at much much lower levels as it turns out.
Generally diet should be enough as there are many foods that are rich in B6, but for anybody who has some deficiency it may be worth supplementing if using safe products at a safe recommended dose.
Have you been supplementing? Obviously you can stop, but if you haven’t been supplementing then I’m not sure. The other thing I’d keep in mind is the foods that may contain higher levels of B6. Hydrating would help for sure. Dehydration typically precedes toxicity
I take it before sleep and it does make your body produce more melatonin and i do feel the melatonin and it feels like its too much because its hard to make myself get out of bed and jump start my day. I feel a little weird. I think maybe every other day or perhaps even less
I don’t see why there would be a connection with B6 and taking B1 and B2 together. I don’t know for certain, but it wouldn’t make logical sense that supplementing B1 and B2 would have any effect on levels of B6
@@parkinsonsdiseaseeducation wat about taking b1 and it basically gave u a b2 deficiency even though u were taking it someone on a parkisons forum said b2 deficiency can cause b6 toxicity
I’m sorry I meant to reply to your other question. Yes, honestly I don’t know if that could happen. It sounds like anecdotal reports would suggest that it could, but I haven’t heard about it happening
@@parkinsonsdiseaseeducation I think it happened again i was taking b1 fat soluble along with b2 but somehow i became b2 deficient and raised my b6 my symtoms gots worse and now i have palpatations that wont go away
I don't know who shoul I believe. One say that more than 100mg of B6 per day is bad, othes that more than 500mg, this video says that up to 1000mg is okay. But I read that daily dose of the vitamit should be abot 1.5mg.
I empathize with your confusion. When I recorded the video I looked up information and quoted the 1000 mg figure from Harvard University here: www.hsph.harvard.edu/nutritionsource/vitamin-b6/#:~:text=Vitamin%20B6%20is%20a%20water,greater%20than%201%2C000%20mg%20daily. However, the link in the description is for Understanding Vitamin B6 Toxicity. I'd defer to their expertise on this. Here is their site: understandingb6toxicity.com/
@@parkinsonsdiseaseeducation I was diagnosed with toxicity two months ago after unknowingly taking 50mg of B6 in a magnesium supplement for 18 months. I recently found the Harvard site and couldn't believe what I was reading. I emailed them to advise them to update their information, but no response. I am in Australia and in the last two weeks - thanks to an 86 year old B6 sufferer contacting a journalist - the topic of b6 toxicity has been covered and gone rather viral. The public simply do not know the dangers, despite the warning labels on the back of our products. Hopefully we will see a significant shift in policy here soon and then maybe the US authorities might act as well.
It really isn't the B6 itself that is toxic, but the excessively high levels that can accumulate in the bloodstream that can lead to toxicity. It really shouldn't matter which type it is as any B6 molecule can lead to toxicity in excessive amounts. Don't take my word for it, I'd recommend going over to understandingB6toxicity.com
@@cdcd4358 well, the general advice is to immediately stop supplementing if you are taking B6 and to allow the body to flush it out and to heal from the damage. If the issue of accumulation is due to a gene mutation such as the MTHFR gene then that is another issue. I would again defer to the experts at understandingB6toxicity.com and of course I would defer to a physician specialist to give direct advice on this issue for individuals dealing with toxicity.
Thanks for the video. For the last three months I have had numbness and tingling in my fingers along the median nerve line. However, in my country I can't get a B6 level blood test- I have checked every lab and no-one offers it. For the last 18 months I have taken a vitamin supplement for over 50s and it has 200% of the RDA. My B12 levels are fine. Any ideas? Thanks
Hmmmm, well if the labs are normal for B12 it’s hard to blame the neuropathy on vitamin B deficiency. Unless you have an underlying condition such as diabetes that could cause neuropathy, I’d suspect a mechanical issue. It could be nerve impingement at the neck or at the wrist. In addition to that, myofascial trigger points in the shoulder blades and rotator cuff can also refer pain to the upper limbs that can very closely mimick nerve symptoms.
What country are you in? You might live near a country where you can order bloodtests without doctor prescription. I did in Netherlands, its not super cheap, but B6 tests goes for about 39 euros + 21 euro if you use a screening center to draw blood (but you could do it yourself as well if you have access to someone who can draw blood and a machine that can preserve the samples). You can also do cheaper test with just lanching a hole in your finger and squeeze blood out, but those tests are less reliable. It sounds weird to me they cant test you for this, sometimes they can send blood abroad for tests they cant do, but this is not a difficult test.
I had to wait through Labor Day weekend to call my doc to request tests for B6, iron (hemocrit), sodium, celiac disease, heavy metals (all potential causes of peripheral neuropathy). I was pretty sure that B6 was the cause, so stopped supplements with it so that I was down to the RDA. (I had been at 250 - 400mg/day. Ugh.) I have a long road to full recovery, but did think that my symptoms improved a tiny bit in the days following the change. I also added iron in case there was some anemia going on there. (There was/is.) Good luck!
Without suplementation my Vit6 is 38.5 while normal 21.5. for almost 2 yeras i have gait/balance issue an nausea. I was at all tupe of dr. No diagnosis. Finally i found myself that is probaly neuropathy. Now i am looking for the root cause. Thank you
600 mg of B6??? Cmon! You’re literally poisoning yourself. I won’t take 1 mg of that poison after what it did to me 12 years ago. I still suffer from symptoms of B6 toxicity. Stay away from it!
I have no way to answer your question objectively because I don’t know any of your history. Do you have B6 toxicity? Why are you supplementing and why so much? Who advised you to take it?
I wouldn’t worry, I’ve seen varied numbers of folks having toxicity with supplementing. Doing it once isn’t likely enough unless you’ve had some past issues with metabolizing B6. To be on the safe side I would contact the folks at understandingb6toxicity.com They also have safe products for B6 on their site
Those are great questions. As to the first question I will leave specific recommendations to your physician. Generally speaking we get an adequate amount of B vitamins from diet without supplementation. And as to why it builds up, the short answer is that it is stored in the muscles. This is a quote from our friends at understandingB6toxicity.com: "We’ve been told all our lives that all of the B vitamins are water-soluble. Well, that is partly true. What is not widely known is that vitamin B6 is stored extensively in our muscles. What is also not known is the effects of dehydration on B6 elimination. Lastly, the most important unknown is that B6 can be stored in nerve cells." I would highly recommend looking at their website here -> understandingb6toxicity.com/b6-toxicity/causes/
@@parkinsonsdiseaseeducationyes, indeed, it’s complicated. And modern companies often include supplemental ingredients. Energy drinks especially! In Canada there are often people overdosing on alcohol and energy drinks…it’s been a problem. And how the liver becomes fatty can affect how the metabolic system works. Along with toxins in the diet.
The form doesn’t matter. Both cause nerve damage. Pyridoxine is just slightly harder to clear from the blood, but elevated pyridoxal, regardless of original form, will result in neurological dysfunction.
That’s a very good question. I’ve wondered the same thing, which was why I thought “gosh 1000 mg per day seems like it would take a lot of supplements to reach.”
Yes for sure, the B complexes can be good for neuropathy, but in the case of B6 some folks are taking by itself in too high of a dose and that’s leading to the issue.
Honestly, supplementing B6 in general is risky. So I don’t disagree. I’ve recommended people check out understandingB6toxicity.com for knowledge as well as for safe versions of B6.
@@parkinsonsdiseaseeducation Forgot about it 😂 ….. I have nerve weakness and nerve tremors throughout my body because of masturbation. Is dopamine good for my condition?
Yes, it was too high in the mix, though it’s not truly louder than me. Vocal is at 200% and music was maybe at 5%. I now ensure it’s at 2% max. This was one of the first I added music to. Thanks to that I now have to endure these comments for the rest of the time this video is on TH-cam. Thanks for watching anyway.
Hey there. I wish I had an answer for you, but with nerve damage there is so much unknown. How much damage is there, is the damage in the nerves or in the central nervous system. Only some neural tissue is “plastic” meaning it can change or repair. You might look into Zinc for enhancing nerve repair. If I’m not mistaken it has been known to help with the loss of taste and smell fools often have with C-19
@@parkinsonsdiseaseeducation thanks i just started taking vitamin d ala lions mane i get over 100 rda for zince about 200% im trying to heal my gut and gallbladder causing elevated liver enzymes got alot of inflammation in my body right now and it started last year when i took a methyl b12 i noticed my liver enzymes skyrocket
@@parkinsonsdiseaseeducation also one last thing now it seems i am deficienct in b6 now from doing a low b6 diet for 3 yrs that might have made things worse too but i will not touch a b vitmain ever again it messed me up bad
Sorry, it was meant to be a rhetorical question. I meant that nerve healing or regrowth depends on where the damage was done. Only some neural tissue can truly regenerate. Typically it has to be intact in some way first. For example if you sever the spinal cord it’s not likely to ever regrow axons, but if you bruise it it is likely to heal
Hey David 👋! I’m honored to have you on the channel. I subscribed to yours on my personal account and plan to sub as my channel also. Regarding the subject, have you run into other PWP who have had toxicity from supplements?
@@parkinsonsdiseaseeducation Hi Michael. I just found your channel today. One of my regulars, Tory Berch , asked me to have a look so I thought I would say hi. I’m always looking for active Parkinson’s channels contributing to Parkinson’s awareness because I believe there is massive void to fill out there. If you want to do something together let me know. On your topic of B6 toxicity, I did not know that was a thing
I’m so glad you did! Tory is a new subscriber and she and I happen to be in the same state! (OK). I’d greatly appreciate your continued feedback and hope you’ll keep watching. Do you do other media like FB or IG? Also, would you be open to coming onto my podcast sometime? I’d be honored to have you as a guest. It’s the Parkinson’s Warrior Podcast
Yes, apparently some folks can get toxicity from smaller doses. I’ve learned that there are some gene mutations that result in being predisposed to inability to metabolize B vitamins
No, actually Harvard University used that figure. I’ve learned from the multitude of comments on this video that toxicity can occur at much lower doses.
@@parkinsonsdiseaseeducation Seems most sources of RDV is 1.2 - 2.4 mg supplementation. The max amount formally was 100mg, however, this has changed to 12 or 20 more recently I believe? I was taking an unknown 50mg amount in zinc, mag sup. in addition to other sup and a high B6 diet, which led to serious probs. I would think anyone taking 1000mg would be extremely unwell. Thanks for the response 😃
@zannah6818 you’re welcome Zannah. To clarify, the quote I saw from Harvard said that 1000 mg was the cumulative dose in a daily period that could result in toxicity. But as you pointed out, supplementation may only be ONE source of B6 and you could get extra from diet and other supplements.
@@parkinsonsdiseaseeducation but I suppose the 5 mg that’s mixed with my magnesium will be well absorbed as magnesium is on top of it an a low dose of p5p
Why are you referencing 1,000mg as the level that's "too high of a dose"? For many people, even 50mg is too high. As you know, we only need around 1mg per day. 1,000mg is absolutely outrageous and will 100% lead to peripheral neuropathy. In Australia, supplement packaging that contains over 50mg is required to have prominent labeling communicating the danger of peripheral neuropathy. Yet here we are in the good ol' corporate America-loving USA with guidelines supporting 1,000mg/day. Honestly, when would a person ever want to take 1,000mg of B6 daily? I'd love to hear examples from a physician. The FDA and Mayo clinic are misinforming the public and putting health in danger by implying that people should not worry unless they're taking 1,000mg per day. This is highly irresponsible, and as someone just recovering from PN caused by B6 toxicity, I'm troubled by your reference to 1,000mg without a disclaimer that someone should never actually take that much. Like, ever. Here's how easy it is. In my case, I was incorrectly diagnosed with carpal tunnel and advised by physicians to load up on B6, which obviously only worsened the symptoms to the point that I did not sleep more than 20 minutes at a time, sitting upright on the couch due to the pain. I was taking in 250 - 400mg per day. I lived with this for nearly a year and not one physician, surgeon, nerve physician, or Functional Health Clinic even thought to look at B6 as the cause -- likely due to the aforementioned misinformation. Please be careful. I'd update the video with a disclaimer at the start where you talk about 1,000mg (and have it in large font on the screen) if I were you. Doubt it'd take a year at that level. Scary. Best of luck.
I’m sorry you felt that this was irresponsible. Unfortunately, I was likely misled by the research that I did for this video as I was quoting from a scholarly resource. This page from Harvard (I mistakenly said Mayo Clinic in the video) was where the 1,000mg reference was found. www.hsph.harvard.edu/nutritionsource/vitamin-b6/#:~:text=Vitamin%20B6%20is%20a%20water,greater%20than%201%2C000%20mg%20daily. Also, I never recommend taking ANY level of B6 in the video and pretty sure I recommended taking a blood test to check levels and to consult with a physician before supplementing.
If I could edit it out I would but that would mean Re-uploading the whole thing. Sorry. You could watch with subtitles on mute if it bothers you too much
It never ceases to amaze me how people will go out of their way to insult creators. If you have nothing more to contribute then I'll wish you a good day. :-)
@@parkinsonsdiseaseeducation HAHAHA Not knowing you, I had no idea of your pompous arrogance neither. Now, I can tell that you are showing a weird histrionic personality...
For those of you who don’t open the description. 👇🏻
****PLEASE READ: I have received several complaints about the volume of the music in this video. I apologize, but it is too late to change anything about that. If you don't like the music or find distracting PLEASE mute the video and watch with closed caption. I am doing my best to be patient, but these comments are getting old. Also, there are literally thousands who have watched and haven't complained so... it can't be that bad. Thanks in advance!!!****
Please ditch the music or make it barely noticeable. Currently it really distracts from the content. Thanks
Appreciate the feedback. I don’t remember if it was this one but the music was a bit higher, but typically I have it down to as low as 2% and speech is up to 200%. Sorry it was distracting for you
@@parkinsonsdiseaseeducation thanks 👍
Yep stopped video couldn’t concentrate
Sorry about that. Too late to change it now.
Yes thus is horrible, I am neurodivergent (and have b6 toxicity) I cant separate the music so I ended up watching muted with subtitles. Its too loud.... and not right music for background.
It's important to check 2 things:
1) all studies done using B6, either alone or in combination with other substances (B1, B12, Folate, Biotin, R-LA etc.) did so with a maximum of 200mg/day and for a max of 24 weeks, most shorter. Some only 100g/day. Commercially available products such as MetaNX, Nuphoria etc. only have max 80mg/day and of B6 P5P (see next point)
2) that one takes, keeping point 1 above in mind, only B6 P5P and NOT the Pyridoxin HCl form. Pyridoxin HCl needs to be converted in the liver to P5P. It's this conversion process that is potentially harmful in high dosages over long periods of time. There are no cases, neither in "normal" dosages nor in "therapeutic" dosages over periods of time
Where do you get this info? I am b6 toxic from p5p.
@@moondrop3013 - How much did you take for how long? What are your symptoms?
Vrolijk MF, Opperhuizen A, Jansen EHJM, Hageman GJ, Bast A, Haenen GRMM. (2017) The vitamin B6 paradox: Supplementation with high concentrations of pyridoxine leads to decreased vitamin B6 function. Toxicol In Vitro. 2017 Oct;44:206-212. doi: 10.1016/j.tiv.2017.07.009. Epub 2017 Jul 14. PMID: 28716455.
„In conclusion, the present study strongly indicates that the neuropathy observed after taking a relatively high dose of vitamin B6 supplements is due to the vitamer that is used in the supplements, namely pyridoxine. The inactive form pyridoxine competitively inhibits the active pyridoxal-phosphate. As a consequence, the paradox arises that the symptoms of vitamin B6 supplementation are similar to those of vitamin B6 deficiency. Vitamin B6 supplements are used by a large number of people. The safety of vitamin B6 is debated and recently EFSA has lowered the upper limit for vitamin B6. The question is whether lowering the safe dose for vitamin B6 is the solution. Remarkably, even at relatively low dose, vitamin B6 supplementation has given rise to complaints. Our study indicates that the toxicity of vitamin B6 is not only determined by the dose, but by the vitamer in which it is taken. Perhaps it might be better to replace pyridoxine by pyridoxal or pyridoxal-phosphate as vitamin B6 supplements, which are much less toxic. In this way, the vitamin B6 paradox may potentially be prevented.“
also:
Carlos-Alberto Calderon-Ospina, Mauricio Orlando Nava-Mesa & Ana María Paez-Hurtado (2021) Update on Safety Profiles of Vitamins B1, B6, and B12: A Narrative Review, Therapeutics and Clinical Risk Management, 16:, 1275-1288, DOI: 10.2147/TCRM.S274122 www.tandfonline.com/doi/full/10.2147/TCRM.S274122
Some excerpts:
“Relevant original articles on neurotoxicity of vitamin B6 in humans obtained by our searches included seven case reports/series, one prospective study, and one case-control study (Table 1).Citation39-,Citation47 In half of them, neurotoxic side-effects of vitamin B6 were mostly due to very high doses and/or long-term treatment and resolved after treatment cessation.Citation39-Citation41 Specifically, reported clinical neuropathy cases occurred in a timeframe of 2-24 months depending on the administered dose: after 12 months or longer with doses of ≤2,000 mg/day, and after less than 12 months with doses >2,000 mg/day.Citation39-Citation46 The first clinical assessment study of pyridoxine-induced neurotoxicity in humans by Schaumburg et alCitation47 included seven patients with severe sensory neuropathy in the extremities after taking 2,000-6,000 mg/day pyridoxine for 2-40 months. Four of these individuals were not able to walk. All symptoms, assessed through objective neurological diagnosis, improved after medication discontinuation.Citation47 Another case series report by Parry and BredesenCitation46 studied 16 patients with neuropathy (all assessed by history and examination, seven electrophysiologically confirmed diagnoses, two sural nerve biopsies) after taking 100-5,000 mg/day pyridoxine for up to 72 months. Patients with doses ≤500 mg/day showed neuropathy after 23 months on average, while those taking 5,000 mg/day developed symptoms on average after around 3 months. In contrast, none of the patients taking 50 mg/day for 6 months).”
And are you absolutely sure you DIDN'T take Pyridoxine HCL? Most multi-B vitaines include Pyridoxine HCL. And most high-dosage B6 is also Pyridoxine HCL. Why were you taking it in the first place?
@@moondrop3013 - - Vrolijk MF, Opperhuizen A, Jansen EHJM, Hageman GJ, Bast A, Haenen GRMM. (2017) The vitamin B6 paradox: Supplementation with high concentrations of pyridoxine leads to decreased vitamin B6 function. Toxicol In Vitro. 2017 Oct;44:206-212. doi: 10.1016/j.tiv.2017.07.009. Epub 2017 Jul 14. PMID: 28716455.
„In conclusion, the present study strongly indicates that the neuropathy observed after taking a relatively high dose of vitamin B6 supplements is due to the vitamer that is used in the supplements, namely pyridoxine. The inactive form pyridoxine competitively inhibits the active pyridoxal-phosphate. As a consequence, the paradox arises that the symptoms of vitamin B6 supplementation are similar to those of vitamin B6 deficiency. Vitamin B6 supplements are used by a large number of people. The safety of vitamin B6 is debated and recently EFSA has lowered the upper limit for vitamin B6. The question is whether lowering the safe dose for vitamin B6 is the solution. Remarkably, even at relatively low dose, vitamin B6 supplementation has given rise to complaints. Our study indicates that the toxicity of vitamin B6 is not only determined by the dose, but by the vitamer in which it is taken. Perhaps it might be better to replace pyridoxine by pyridoxal or pyridoxal-phosphate as vitamin B6 supplements, which are much less toxic. In this way, the vitamin B6 paradox may potentially be prevented.“
see an answer to moondrop3013 ...
having written that:
I was diagnosed in 1999 with idiopathic peripheral neuropathy. Again in 2012. I was also diagnosed with diabetes Type 2 in 2014 (provoked through Spiricort given to suppress symptoms of Polymyalgia Rheumatica) and had a heart attack in 2019. For neuropathic pain relief I was started on Gabapentin and Cymbalta. Because of horrid cognitive side effects, Cymbalta was switched out for Effexor. Unfortunately, these cognitive side effects didn't stop, so I stopped using them.
Since about 2014 I've been taking instead of the Cymbalta/Effexor & Gabapentin (as it stands 25. Nov. 2023):
R-Lipoic Acid 300 (240) mg - 1-1-1-1
Acetyl-L-Carnitine 750 mg - 1-1-0-1
N-Acetyl Cysteine (NAC) 1000 mg - 1-0-1-0
Omega 3 (fish oil) 1000 mg - 1-0-1-0
Borage Oil 1000 mg (GLA = Gamma Linolenic Acid) - 1-1-1-0 (stopped 1. nov. 2023)
Magnesium 100 mg - 1-1-1-1
These above have helped some. I came to use these through exclusionary processes. IOW, I'd take a substance for a while, noting sensations. Then I'd stop and see what happens. These above “passed” this exclusionary process. If I noticed an increase in severity of symptoms when stopping a substance, I could conclude, that it was actually helpful when I was taking it.
I then added Benfotiamine starting on 15.08.2023. Helped greatly, most overt pain gone, but numbness still prevalent (time of writing 22.12.2023). Some stomach ache if dosage is over 150mg, so I take 100/150mg 1-1-0-0 / 150mg 0-0-1-0 and 250mg before going to bed (0-0-0-1) - I don't get stomach ache before going to sleep or during the night.
I then added on September 5, 2023 (as it stands 25. Nov. 2023):
Folic acid 1.7 mg 1-1-1-0
Biotin 5 mg 1-0-0-0
Methylcobalamin 1500 mcg 1-1-1-0
Vitamin B6 P5P 27mg 1-1-0-0
The 4 above plus Benfotiamine & R-Lipoic acid, according to this study, which has been cited many times in meta studies concerning use of supplements to treat neuropathy pain:
Maladkar, M., Tekchandani, C. and Dave, U. (2014) Post-Marketing Surveillance of Fixed Dose Combination of Methylcobalamin, Alpha Lipoic Acid, Folic Acid, Biotin, Benfotiamine & Vitamin B6-Nutripathy for the Management of Peripheral Neuropathy. Journal of Diabetes Mellitus, 4, 124-132. dx.doi.org/10.4236/jdm.2014.42019
“Results: Treatment led to significant reduction from baseline score in various neuropathy symptoms from the 4th week itself. After 12 weeks of treatment, the mean pain score declined by 78.0%, numbness by 92.1% and muscle weakness by 96.9%. Also, there was 96.0% & 99.2% reduction in tingling & burning sensation respectively. No serious adverse events were reported. Conclusion: The current study confirms that fixed dose combination of Methylcobalamin, ALA, Folic Acid, Biotin, Benfotiamine & Vitamin B6 is effective & well tolerated in the management of peripheral neuropathy.”
“This PMS included 497 patients with peripheral neuropathy and was conducted at 5 different centers by qualified investigators. The efficacy of the treatment was assessed based on improvement in parameters like neuropathic pain, numbness, muscle weakness, tingling and burning. Investigation of parameters was performed throughout the treatment period on: visit I (baseline), visit II (week 4), visit III (week 8) and visit IV (week 12).”
“Patients with peripheral neuropathy were orally administered fixed dose combination of Methylcobalamin 1500 mcg, ALA 200 mg, folic acid 5 mg, biotin 5 mg, Benfotiamine 50 mg & vitamin B6 5 mg once daily for 12 weeks.”
Hakim, M., Kurniani, N., Pinzon, R. T., Tugasworo, D., Basuki, M., Haddani, H., Pambudi, P., Fithrie, A., & Wuysang, A. D. (2018). Management of peripheral neuropathy symptoms with a fixed dose combination of high-dose vitamin B1, B6 and B12: A 12-week prospective non-interventional study in Indonesia. Asian Journal of Medical Sciences, 9(1), 32-40. doi.org/10.3126/ajms.v9i1.18510 nepjol.info/index.php/AJMS/article/view/18510
Baltrusch, Simone (2021) The role of Neurotropic B Vitamins in Nerve Regeneration, Biomed Res Int. 2021; 2021: 9968228. Published online 2021 Jul 13. doi: 10.1155/2021/9968228 www.hindawi.com/journals/bmri/2021/9968228/
Pinzon RT, Schellack N, Matawaran BJ, et al. (2023) Clinical Recommendations for the use of Neurotropic B vitamins (B1, B6, and B12) for the Management of Peripheral Neuropathy: Consensus from a Multidisciplinary Expert Panel. J Assoc Physicians India 2023;71(7):93-98. www.japi.org/y26464c4/clinical-recommendations-for-the-use-of-neurotropic-b-vitamins-b1-b6-and-b12-for-the-management-of-peripheral-neuropathy-consensus-from-a-multidisciplinary-expert-panel
Silviana, Meyvita, Tugasworo, Dodik, Belladonna,Maria (2020) The Efficacy of Vitamin B1, B6, and B12 Forte Therapy in Peripheral Neuropathy Patients, DOI: doi.org/10.14710/dimj.v2i1.9549
Geller M, Oliveira L, Nigri R, Mezitis SG, Ribeiro MG, et al. (2017) B Vitamins for Neuropathy and Neuropathic Pain. Vitam Miner 6: 161. www.hilarispublisher.com/open-access/b-vitamins-for-neuropathy-and-neuropathic-pain-2376-1318-1000161.pdf
Amorin Remus Popa, Simona Bungau, Cosmin MihaiI Vesa, Andrei Cristian Bondar, Carmen Pantis, Octavian Machiar, Ioana Alina DimulescuI, Delia Carmen Nistor Cseppento, Marius Rus, (2019) Evaluating the Efficacy of the Treatment with Benfotiamine and Alpha-lipoic Acid in Distal Symmetric Painful Diabetic Polyneuropathy, Revista de Chimie, Buchares, Original Edition- 70(9) DOI:10.37358/RC.19.9.7498, www.researchgate.net/publication/336529734_Evaluating_the_Efficacy_of_the_Treatment_with_Benfotiamine_and_Alpha-lipoic_Acid_in_Distal_Symmetric_Painful_Diabetic_Polyneuropathy
H. Stracke, W. Gaus, U. Achenbach, K. Federlin, R.G. Bretzel, (2008) Benfotiamine in Diabetic Polyneuropathy (BENDIP): Results of a Randomised, Double Blind, Placebo- controlled Clinical Study, 2008 Nov;116(10):600-5. doi: 10.1055/s-2008-1065351. Epub 2008 May 13. pubmed.ncbi.nlm.nih.gov/18473286/
Carlos-Alberto Calderon-Ospina, Mauricio Orlando Nava-Mesa & Ana María Paez-Hurtado (2020) Update on Safety Profiles of Vitamins B1, B6, and B12: A Narrative Review, Therapeutics and Clinical Risk Management, 16:, 1275-1288, DOI: 10.2147/TCRM.S274122
www.tandfonline.com/doi/full/10.2147/TCRM.S274122
Are they the same thing? My b6 says pyridoxal on the front, on the back it says p5p meaning pyridoxal 5 phosphate....so what is pyridoxal HCI?
I had high levels of B6 and was told to stop taking it. Only trouble is I was not taking any B6 or B Complex or any other supplement containing B6. Then I started reading labels of products that the food industry adds B6 to and it was added to every single cereal except health food store brand cereals. Apparently the form of B6 is not being converted to the form used by the body which some vitamin companies are now using. However I don't know if this form can still cause toxicity. Just be careful of what's on the food labels listed under Ingredients.
Thank you Kathy. I’ve learned SO much more from those commenting since I released this video. I’m amazed at how much B6 can be obtained through food alone to the point that supplementation shouldn’t really ever be needed other than diet. It’s very interesting what you say about cereals. Imagine how many Americans eat breakfast cereal!
How do we stop it in food? …
@@KoalaBeer. Only eat whole food. Never processed junk that is slowly killing you (by design)
@@KoalaBeer. You can't. The food manufacturers fortify their crap with things that don't need fortifying or are not a deficiency. & it's usually with the synthetic crap that does more harm than good. They are poisoning the population by design.
I got toxicity from only 25mg per day plus b6-rich diet. 18 months later I am still healing. B6 toxicity is a NIGHTMARE & can cause horrendous autonomic symptoms as well as the typical tingling/burning neuropathy. My entire body was affected! Please be extremely cautious with B6 - RDA is less than 2mg per day, which is easy to get from food. If you are having weird symptoms while supplementing or eating a high b6 diet, ask for the blood test.
Great insight and suggestions. Thanks for your comments!
Have you continued to see improvement across that entire span of time? I'm about 4 months into a second recovery, but this one is harder as the neurologic dysfunction was significantly worse by the time I figured out what was going on. Seems like the symptoms go on rotations, where something flares up (while other symptoms disappear), and about a week later it cycles to something else. Makes it difficult to really gauge the progression, even if, over time, it does seem the symptoms are weaker each time they are cycled on.
@@thomasc1270 your experience sounds pretty typical of b6 toxicity! Everyone I know who has had this, has symptoms go through weird cycles. For me it has felt like 3 steps forward, 5 steps back. Now that I've been healing for over a year, things are generally a lot better, but what will set off severe symptoms at this point is any time I get sick with a virus. I had a flu and then a few months later a cold, and after both illnesses by b6 toxicity symptoms got really, really bad - similar to when I was first coming off the supplements. So I think our bodies are just extra sensitive when we have the toxicity. Every month or so I've had one particular symptom that will be prominent - for awhile it was heart palpitations and blood pressure spikes, then another month or two it was chronic nausea, then for awhile it was fatigue and pain in my legs - and the symptom will almost always change after 4-6 weeks. Like the nerves were trying to "turn back on" in different parts of my body, or mis-firing in different areas. It DOES get better over time, but it seems to take forever. Hydration, gentle exercise and lots of sleep are what have helped me recover. Also, eating a balanced b6 diet that doesn't go above or below the recommended daily amount. But yeah sorry for the long response - SLOWLY over time I have seen improvement, but it is hard to tell because it takes so long. I hope you continue to heal and feel better!
@@thomasc1270 this is classic for B6 detoxification, it means your body is working to get rid of it. Detoxification can be more scary and tough than the initial symptoms you diagnosed it with. Dont give up, but ofc seek a doctor if it gets too much to handle, it is really not an easy road and you need support. Keep on drinking lots of slight salted (not tablesalt!!!) water and potassium to help the process flushing out the B6 stuck in your nerves. Like 4 liters spread out over the day. It can take years to clean your body but it will go easier over time.
@@jesseautumnmusic I experienced the same, my first 'attack' was last year June when I came home after my dads funeral abroad, I got struck with a bad flu like I normally never have, my immunity is top notch, Im never sick. I felt miserable for weeks and this flares came together which I didnt realise at that point, making it worse. I thought it was all part of the flu. I would wake up totaly confused and feel life draining out of me, my body feeling numb and sweating like crazy, I was afraid to die. The flares after this are always milder in nature, but anxiety rules and I had to eat every 4 hours or I would feel horrible. This lasted for like 3 to 4 months in weird cycles of symptomes and then I was symptom free for the rest of the year, until May arrived and I got a bad toothache. Right after that cleared this flares came back, again this terrifying feeling of going to die, hot flashes, palpitations the whole show randomly visited, now including high bloodpressure, palpitations, hot flashes, bloodsugar hikes, it would wake me up terrified etc. I went to doctor who declared my heart perfectly fine, had bloodtest which showed nothing worrying, and I went abroad to visit family more sick than alive so I did another bloodtest there, with more markers as I didnt need a doctor to do so. I was low on Vit D and chance for deficient on B12 even if it was within normal range, they noted it because some blood values indicated possible problems with absorbtion or red bloodcell problems. Also slight high TSH but nothing serious and further testing didnt show thyroid issues. So then I started to get neuropathy really bad, ice cold feet, and bloody hot torso, got struck by noro virus and cleared out my whole intestines. I was put on a very strict diet (basicly only fruit, vegetables and fish 3 times a week), anti inflamatory as I felt I was inflamed through my body. It made me even more sick, I lacked proteins and fats, it was loaded with B6 rich foods and I was also taking supplements overloading me even more. I went back to my normal diet but way more healthy and recovered my guts. What a trainride this was... after this noro virus attack last week I felt really clean and now with cronometer I track everything and feel so much better. Just mild neuropathy for now, though yesterday I had cramps in my legs. Next week it is finaly my turn to see a doctor after a 5 week waitinglist. I hope he will agree to a bloodtest once more. I also hope that my awarenes will avoid this flares to start up again come next summer. If B6 is causing all this, Im pretty sure Im well on the way to avoid it.
If you check the understand B6 toxicity group you will be shocked of how many people have high B6 in blood just from diet and small doses of supplements
That’s incredible really. I wouldn’t have imagined it was that common. Just goes to show just how important it is to truly get blood work before supplementing
@@parkinsonsdiseaseeducation saw a study that indicated b6 from food has a half life almost 30 times longer than that of supplements. So toxicity could just as easily be established from a steady diet of high b6 foods leading to over saturation especially in the case of inadequate exercise or dehydration.
30 times longer!!! That’s incredible. Wow, there is so much more to this than I ever imagined. Thank goodness for the Understanding B6T website. Thank you again for your input on this. I feel like the more I hear from those with toxicity the more I have learned. I never knew this video would spark such awesome conversation and help me to learn more in the process!!
@@parkinsonsdiseaseeducation it needs way more awareness, because I and many others fear that this is just the start of an epidemic on B6 toxicity, because they add it to literaly everything totally unneccesary. Imagine how much people eat cereals every day, drink all kind of chemical energy drinks, its added to dairy and vegetarian food, multivits are enhanced with 4 times daily dose and all these people who were prescribed to take extra vit B complex. Its pandoras box about to be openened. Its almost as if they do on purpose. And the form they supplement is what most people are toxic for. I get really sick if I eat anything with artificial B6 in it. And lately I also seem to be responding to chickenmeat which is super high in B6.
is happened to me. I actually became toxic and deficient simultaneously. I was prescribed folbic by my primary care physician for elevated homocysteine. When it didn't work, she doubled the dose (it didn't work because i later learned i have methylation issues and need the active form of b vitamins in order to utilize). I developed a terrible sensory neuropathy with a co-condition called erythromelalgia....but nobody knew why! Turns our b6 in any form is tricky and can make my neuropathy worse if i supplement minimally for too long. Yes, my condition is complex, but there are many others suffering. Be careful what you take.
Great example of how this could happen. Thanks for sharing Suzanne.
I have high homocysteine levels as well as high b6 toxity. I was only taking between 5-8mg daily but for 10 years in a b-complex.Have a vibration type feeling i assume is neuropathy. I've been off all b vits except methyl b12 after finding out I have the MTHFR gene.The vibration is constant.I've had 9 hours one day this week where it stopped. Drink lots of water, avoid b6 foods.Any thoughts would be greatly appreciated.My doctor is good but doesn't really know how to help me.I dont have the money to go to functional doctors as she mentioned. Thanks
@@micheleharris5703 know that as the b6 leaves your body the symptoms get worse before getting better. Due to my methylation issues, it took 14 months for my blood levels to normalize. I had neuropathy on my entire body but feet were an agony. It does get better but takes time. Do sauna or room salt baths to help release. There are Facebook help groups on this. I learned a lot there.
I had vitamin B6 toxicity, went through months of hell. My dose? 200mg daily for only 36 days, I counted the tablets I took. So people can get toxic from way less and way shorter than 1000mg per day for at least a year. Just wanted to share my experience.
Thank you for sharing. That is disconcerting to me. How is one to know how much or how little to take of toxicity can happen at such a low dose?! The number I quoted was found in my research, but this video has provided some amazing feedback from folks like yourself. Were you ever told there is some type of issue metabolizing the B6 or that you’re storing too much, etc?
@@parkinsonsdiseaseeducation Unfortunately I was never told why so I have no idea, wish I knew the answer. But there are many B6 toxicity groups on Facebook with many people like me, all with our own stories, some got toxic without even supplementing but they had high B6 diets, so I always want to create awareness so this does not happen to other people. I was lucky enough to heal from it, but it takes time and it was very important to do my own research, and advocate for myself, since my doctors were all clueless about this. Awareness is key to helping people heal from this, or stopping people from supplementing when they do not need to. Thank you for your video.
Thank you, I’m glad that this video has been impactful. I feel like I am just starting to learn about this and the more I interact in the comments the more I learn!
It’s been 2 years for me. In the beginning I went through hell. My dose was much lower. Under 25 mg. Mostly from whole food supplements…but ate a diet unknowingly high in B6. Food B6 isn’t supposed to accumulate. It took 4 months of in and out of ER before a neurologist tested B6. I suspected that it had something to do with B vitamins and kept telling the doctors since every time I took even a low dose of whole food B vitamin the tingling in legs would become severe. I stopped taking them on my own early on an my numbers were still high at 4 months. Got back on dose under 10 and it got worse again. Still healing. Long process. Thanks for doing a video. 🙏
What symptoms did you get?
Isn't Vitamin B6 water-soluble? If it is, how can it build up in the system when the excess would be urinated on a daily basis?
Hey Mike. Great question! The short answer is that it is stored in the muscles. This is a quote from our friends at understandingB6toxicity.com: "We’ve been told all our lives that all of the B vitamins are water-soluble. Well, that is partly true. What is not widely known is that vitamin B6 is stored extensively in our muscles. What is also not known is the effects of dehydration on B6 elimination. Lastly, the most important unknown is that B6 can be stored in nerve cells." I would highly recommend looking at their website here -> understandingb6toxicity.com/b6-toxicity/causes/
@@parkinsonsdiseaseeducation That website is quite literally saving lives. Great video.
@Me-zo8yc thanks! I’m glad you were able to suffer through the music. ;-)
@@parkinsonsdiseaseeducation the music was easy compared to B6 overdose 😂👍🏻
The B6 metabolites stays in the body for a number of days. So if you take a high dose daily, it can accumulate.
On research paper recommended to take 100 mg once a week to avoid that accumulation.
Most other B vitamins doesn't have this problem and can therefore be taken daily.
B12 is also very different, since it's stored in the liver. But it doesn’t seems to have any toxicity as a supplement.
Although those with the MTHFR genotype should take methylcobalamin, and not cyanocobalamin.
By the way, folate, B6, and B12 belongs together. If you want to be sure getting effect of B12 supplementation.
Yes, thank you. I've been taking many Bs and have had burning sensation all over my body. I did some muscle testing and it came down to B5 and B6. I think in my case, burning skin, causing my face, arms, thighs, stomach to feel hot and burning and an hour , once a month. I only took 250mg, per day, maybe the accumulation was too much for me. As a firm believer in Chinese Traditional medicine, we are told we all have different body types, just like in Indian Ayurvedic medicine, both of which are plant based. I need the supplements as I believe that our soil (all over the world ) is depleted of minerals. Just sharing my experience. Thanks for this video. You are very clear 🙏
This is wonderful feedback, thank you. I’m sorry for your trouble with the symptoms, but hopefully you caught it soon enough to turn things around. Also, I apologize for the music in this video, it was too loud in the mix
For B6, toxicity has been established at doses as low as 5mg / day, over a long enough period of time (months or years). At 50mg/day, it usually occurs over a few months. At 250mg/day, you could establish toxicity in as little as a few weeks. This is especially prevalent with the Pyridoxine HCL form, as there appears to be some difficulty in metabolizing high doses, and we don't seem to understand the full ramifications of its interactions with our body. However, even the active form can cause neurological issues.
So... 250mg would not be considered a low or reasonable dose at all, even in places with unreasonably high upper levels (like the US, which I believe has the highest upper level in the developed world at 100mg / day.)
"I only took 250mg per day" LMFAO. That is nearly 50x the recommended value.
@@desudesu5283 Thanks!!! It came in a bottle of B6s! Ouch!!
I took 1,000 mg per day for 2.5 years. My health started to tank around this time, but I didn’t know why. I still don’t know if my symptoms are a part of this, or if I have a lot of other medical issues that coincidentally started at the same time :( I stopped the B6 in January, and then I felt like I started getting new unexplained medical problems. It’s all so confusing.
I’m sorry to hear this. Did you happen to check out the Understanding B6 website?
@@parkinsonsdiseaseeducationyes I started reviewing it today and joined the Facebook group. Hopefully I can start healing soon.
@@parkinsonsdiseaseeducationI joined the Facebook group. But I was suspended after one day for violating one of the rules: don’t comment on an old post. So I’m looking for a new group and resource. I don’t want to support a group who immediately suspends a member over something so minor. And after 1 day of membership.
I have an elevated level of B6 (pyridoxal 5 phosphate) in my blood: 48.8 micrograms, when the acceptable max should be 27.2 micrograms and I DO NOT take supplements. Why is that? No doctor is able to give me an explanation.
Good morning Stephanie. Obviously, I can’t give an individualized explanation for this; however, there are some generalities that I can share. B6 is found in our diet with specific foods. Also, almost multivitamins contain 100% recommended daily amount of B6. The bulk of B6 that comes in is stored in the muscles and can also be found in the bloodstream. I’m not the true expert on this, but have learned a ton from Understanding B6 Toxicity. I’d highly recommend their site: understandingb6toxicity.com/b6-toxicity/causes/
Thank you so much for your prompt reply. I will certainly check out the link. Hopefully a change in diet will help.
My pleasure! That site is a wealth of advice, I’m sure they may have some advice on dietary adjustment
@@parkinsonsdiseaseeducationThanks again! The link has really been eye opening. I have started a KETO diet with intermittent fasting, so hopefully together with frequent exercise and lots and lots of water the problem should sort itself out in time. So glad I came across your video!!
I’m so grateful for your feedback. Thank you! 🙏
I am suffering from b6 toxicity right now. It's hell. 4.5 months off the supplement- most issues are neurological, eye floaters, cognitive decline- it's a neurotoxin.
Gosh I’m sorry to hear about this. As important as B6 is for proper nerve function it can certainly be toxic if too high as in your case. Too much of even a good thing can be bad for you, which is unfortunate. Hopefully in time you’ll have some neuro repair
ya i kno the feeling been off it for awile and still suffering mild tingling mild burning itchy achy hot cold and so on
but i do think my issues with my liver are releasing histamine thats y i feel worse
How much u take/ day ? For how long ?
@@Medinalegend 3.5 months at 50mg a day
I took super vitamin b complex for months then recently took vitamin b12 and b6 , another product with zinc that also had it and protein powder. I started feeling off balanced ,uncoordinated. I stopped taking everything, drinking water 8 glasses . Slowly recovering from I guess ataxia increased anxiety.
im 30yo male. took p5p wich is activated b6 form .now my cheek tics when i blink my eye. i got my lesson so i will never take any supp
That’s a good call. It’s scary what can happen with supplanting. I had no idea before I heard about toxicity and the damage that can be done
P5p is good maybe there is b6 from ur diet?
Yes many foods have natural B6
@@parkinsonsdiseaseeducation
Not natural 🤣
How so? Vitamins are found naturally in food… You said something above about maybe it’s from your diet. Yes, you can get B6 from your diet
Bro b complex overdose cause frequent urination pain in right leg why?
To clarify, are you saying your right leg hurts when you urinate or that the overdose is causing you to have frequent urination AND pain in the right leg?
@parkinsonsdiseaseeducation I had taken an overdose of B-complex tablets for 5-6 days, unaware of its consequences. Since then, I've been experiencing:
Pain in my right leg and arm Sensations like ants crawling in my legs
@@parkinsonsdiseaseeducation
"I researched online and found that overdose could lead to circulatory, neurological, or infectious issues. However, I only took the overdose for 6 days and stopped immediately."
@AR_raouf got it. Yes, so with vitamin B overdoses/toxicity you will get nerve symptoms since B vitamins directly impact the health and support of nerves. Excess B vitamins can result in nerve damage, so you need to stop the supplements and see a physician. The urination could be due to the nerve issues resulting in bladder control problems or it could simply be your body trying to get rid of the excess
@@parkinsonsdiseaseeducation "I was alarmed by my symptoms and worried about diabetes/prediabetes, but my low weight and minimal sugar intake are reassuring. Thank you, doctor, for alleviating my concerns."
I know 2 people with MTHFR mutation and double dose of B6 in the blood. Does it mean that it can’t be turned into active form and the body is in deficit? Do they have to supplement with the activated form? How to get rid of this blood excess? They don’t supplement.
I’m not going to recommend anything specifically as it’s not my scope of practice, but generally speaking it would not be advisable to supplement further with the MTHFR mutation. The mutation results in an inability to break down the vitamin B and if you supplement more that would result in even more B6 on the blood stream and they are already in excess. That would likely result in toxicity and some with the mutation have toxicity even when they don’t supplement from what I have heard
I notice on the daily amount list of ingredients on energy drinks, often there is 350 percent of daily requirement of vitamins… such as B complex vitamins… so understanding is essential. Possibly an every three days is often enough for such powerful things or tiny portions.
Im just concerned about all the energy drinks I take. Im noticing b6 is in everyone of them 🤔
Hi Ric. Unless you have an issue breaking down and absorbing B vitamins in the gut (MTHFR gene mutation for example), I wouldn’t think just ingesting B6 in foods and energy drinks would necessarily cause toxicity. Now, supplementing plus dietary B6 may be risky. Have you heard of understandingB6toxicity.com?
Awesome. Thank you so much for your reply. Ill check it out. Merry Christmas
@riclee9504 Merry Christmas Ric!
I came here because i took P5P for the first time yesterday. and this morning had a headache ..which was completely unexpected, or out of the normal/ should not have been. Then i had an incident of lightheadedness today ..which rarely EVER occurs. my light tinnitus ALSO did not calm down today, as it typically does, this time of day, etc. i started reseaching today. Thank you for providing the link to the b6 toxicity website. Was an excellent read ..with what they said about Blood VOLUME issues causing headaches. Why did Dr. Stephen Cabral say in his video, right here on TH-cam, that B6 deficiency was the #1 thing he saw in his clinic. i added B6 because i take B9 and B12 for undermethlation ..which i don't know if i have, but most have. i do not eat cereal, or any packaged product like that, that could have B6 added to it. Dr. Berg says Pyridoxal HCL, which is synthetic, can cause B6 deficiency symptoms. Is he referring to B6 toxicity ?
I’m so glad their site was insightful. It really is very well put together. I can’t answer why Dr. Cabral said what he said. I originally recorded a video about neuropathy in Parkinson’s and stated that B6 and B12 are often deficient and this contributes to the neuropathic symptoms. I had advised to seek out supplementation with the guidance of a physician. Since that time I released THIS video when I learned about the results of toxicity when dosing is not done correctly. In answer to your last question, I do think that he meant toxicity, because from what I’ve read and learned since I released this video it seems that any form of B6 can result in toxicity
I’m 3x the level and only take about 300 mg daily. Mostly through a powdered drink.
For some folks it’s super easy to become toxic
I'm surprised at the 1000 mg or more being excessive. Other authorities (academic and governmental) put the tolerable upper intake level (UL) at 100 mg/d, consistently. Other authoritative sources (including those referenced in the second sentence) say that even lower amounts may affect people with a genetically based inability to process pyridoxine to downstream metabolites. Here's more!: Some knowledgeable commentators state that the active form of B6, the downstream metabolite P5P (or pyrodoxal-5-phosphate, or PLP) can be consumed and tolerated at considerably higher amounts. (One source, a physician IIRC, really did say "7000 mg/d.")
Thank you David, you’re right, I’ve learned more from the comments than the research than I did prior to recording this video. The 1000 mg is outrageously high compared to levels that have actually resulted in toxicity from the anecdotal reports of folks in the comments
I am really struggling with B6 toxicity/ damaged nerves. I took a low dose but had a diet full with B6.
Wow! That’s incredible. I hadn’t heard of any cases where diet could also cause this to happen. From the literature I would say that’s exceptionally rare to get toxicity from diet plus a low dose of supplement
@@parkinsonsdiseaseeducation full muscle storage could have played a role and dehydration.
True. The dehydration especially I can see playing a part
How low was the dose
@@hawk28912 3 mg for 8 months. I used 1,5 mg for 8 months of the year in a multivitamine for most of my adult years though. After my pregnancy, 22 years ago, I had a few nerve problems...
so i just had a skin biopsy done after 4 yrs of suffering and the results were negative idk what else could be causing these symptom's on my left ankle it was 14mm and right was 19mm to even be considered for neuropathy it has to be under 7.1 i dont get this
Had you ever supplemented with B6 prior to seeking out testing? Or are you wondering if this could be it since there don’t seem to be other answers so far?
@@parkinsonsdiseaseeducation yes in 2016 from 6 mg b complex then in 2018 1 100mg and then jan 19 100mg never touched it again
@@parkinsonsdiseaseeducation then this past july i got a biopsy and it was negative feet
@@parkinsonsdiseaseeducation ya im still wondering if i get flareups from food but idk my liver is inflammed and it might be releasing histamine
Recent blood tests showed I have high levels of Vitamin B6 (about 30% that higher end of range) and the supplements I was taking had only 0.85mg of Vitamin B6, just 50% of RDA (have taken them for about 2 years but neuropathy symptoms started 3 months ago).
Hi Guillermo. Were the supplements you were taking specifically B6 or was it a multivitamin or B complex of some kind?
@@parkinsonsdiseaseeducation It was a Multi Vitamin (sells in Amazon under Brad Stanfield Multi Vitamin) but none of the vitamins have RDA levels suggesting mega doses. I also take 1150 mg Omega-3 but I assume that doesn't include B6.
@guillermofuentes151 wow, that’s pretty scary
I had this problem and the side effects were insane. Luckily I figured out my problem a couple years ago. Glad it's getting more widespread attention.
So can you please tell me how much B6 is okay to take? Thank you very much. Guess you shouldn't be taking B complex?
It isn’t really in my purview to give specific advice on dosage. Generally speaking, if you already have toxicity then I’d avoid B complex. If you’re asking how to avoid toxicity then I’d highly recommend going to www.understandingb6toxicity.com
You can have all the natural B6 you want that you get through food it's the synthetic version of B6 that's added to everything like multi vitamins energy drinks and fortified foods that's causing all the issues. Definitely stay away from energy drinks because that's what got me...had been drinking that poison for almost 10 years straight everyday several times a day.
The correct dose is the dose that you are missing and that is only determined by a blood test. There is no correct dose. Vitamins are taken to replace what is missing. If your levels are good then you dont need them. Don’t believe the commercial hype you do not need to take vitamins. Most vitamins come from a good diet. If you eat well then skip the vitamins and only take what you are low in and again that can only be determined by your blood test not by some one on TH-cam telling you to take something. Vitamin levels are an individual thing and no one but a blood test can determine that. Don’t believe the hype people are just tying to sell products. I am currently b6 toxic from p5p and it is awful and painful.
Daily requirement is maximum 1.5mg per day. No need to supplement. Get it from food.
How can you detox from too much vitamin b-6?
Immediate cessation of the supplements is key. Drinking lots of water to flush the vitamins from the system would also be important. Nothing more specific comes to mind, but I’d refer you to understandingb6toxicity.com to learn as much as you can.
I have Morton's toe. People with Morton's toe do not absorb B6. If it is not metabolised, do levels of B6 increase from normal dietary intake? I had my serum B6 levels checked and they were high even though I was not supplementing any B vitamins. I do not know what my tissue levels were.
I don’t have a definitive answer to your question, since it would seem contradictory that you have issues with absorption yet you have high B6 levels in the serum… I am not the expert specifically on B6 toxicity. Here is a link to a group that I feel is trustworthy: understandingb6toxicity.com/
@@parkinsonsdiseaseeducation thanks
@@Marshadow69 happy to help in any way I can! 😀
I have Morton’s toe and was supplementing b6 with p5p for that reason and now have b6 toxicity. If you eat well you do not need to supplement. It can increase from food.
Morton’s toe is also a natural variation present in healthy individuals. It is not necessarily caused by insufficient vitamin b6
I was taking p5p related, because I had breast tenderness from a prolactinoma. This is the 2nd day in a row I've woken up with acute loss of proprioception in my left arm and hand. It is the weirdest feeling ever!
That has to be bizarre. Nerve symptoms are always very strange feeling
Got toxic after several months of low folid acid and b complex pills.Never thought this is possible. Now I am 5 weeks off and hope it is getting better soon.
Wow… the more I learn about this subject the more I feel like I don’t know. It seems some folks get toxic with seemingly little effort like on your example of B complex pills. That’s such a common supplement for folks .
Do you think in this situation food with natural folat is okay?
Thank you for this vireo. Does excess B6 50 MG cause muscle twitches/fasciculations also? The label on the bottle says 2941% of daily requirement. I have stopped taking it after 2 days
I’m glad this video was helpful! In short, yes muscle fasciculations can be associated with B6 toxicity and nerve damage. It sounds like you made the right call to stop taking it
@@parkinsonsdiseaseeducation Thank you so much.
Take B6 only in the active form - Pyridoxal 5 Phosphate (P5P). Not Pyridoxine the (toxic) inactive form.
Yes! I got toxic from 50mg.
You’re still not stating active or inactive form. Just a blank statement I got toxicity from B6 says nothing. State which one…. PLEASE!!!!!
Thanks for sharing. I see there are foods with B6 in them, that's how I got here to your channel. Sn educated consumer is the best customer.
Thanks Joyce! Glad you landed here one way or another.
I have on my right hand the index and middle finger numbness and tingling and pain starts early hours in the morning and on the left hand is the same index and middle finger numbness and tingling and pain early hours in the morning, there must be a way to reverse it or am I fucked forever
That’s awful! So sorry you have to suffer with this
Have you tried Benfotiamine?
Do not get the regular B1. Must be Benfotiamine. Great for Neuropathy & the symptoms you mentioned. Good luck. 🙏
My doctor’s tell me b vitamins are water soluble so they help somehow but that you can’t get to much if your also getting them from food. Is this not true?
Hey there Monsterdrumma! Who are your drummer heroes? Peart, Portnoy, Bruford? You can tell I'm a prog guy...
Anyway, to answer your question, it is not always true from what I have learned. Generally speaking one will not get toxicity simply from the foods that we eat; however, in those with certain gene mutations such as with the MTHFR gene it is possible to get a higher dose by diet alone and therefore can result in toxicity.
@@parkinsonsdiseaseeducation ya the mthfr gene or some liver problems/gut can affect it too
do you mean 1000 milligram or microgram? because i'm drinking a redbull and it says 5mg per can (2mg per 100ml)
I mean milligram. The original quote from Harvard University states 1000 mg, though from what I’ve since learned that is an extreme amount. Some folks can become toxic from supplementing B6 at much much lower levels as it turns out.
There’s a difference between HCL version and P5P.
There is, but people are becoming toxic from P5P as well. Avoid both P5P and Pyridoxine HCL and get b6 from diet alone.
Caroh is correct
It’s not enough b6 in food these days to get enough
Generally diet should be enough as there are many foods that are rich in B6, but for anybody who has some deficiency it may be worth supplementing if using safe products at a safe recommended dose.
@@parkinsonsdiseaseeducation Is there also evidence for this? since all the clinical trial I have found used Pyridoxine HCL
Mines high how do I reverse it ? Water or… was 122 …
Have you been supplementing? Obviously you can stop, but if you haven’t been supplementing then I’m not sure. The other thing I’d keep in mind is the foods that may contain higher levels of B6.
Hydrating would help for sure. Dehydration typically precedes toxicity
Yeah now that this has happened to me and other people let's get to the main point here and how do you reverse it!
I’m not the expert on that topic at all. I’d recommend going to www. understandingb6toxicity.com and they can provide a lot of useful information
I take it before sleep and it does make your body produce more melatonin and i do feel the melatonin and it feels like its too much because its hard to make myself get out of bed and jump start my day. I feel a little weird. I think maybe every other day or perhaps even less
do u happen to kno if taking b1 or b2 together can raise b6 to toxic levels or no idea thank you
I don’t see why there would be a connection with B6 and taking B1 and B2 together. I don’t know for certain, but it wouldn’t make logical sense that supplementing B1 and B2 would have any effect on levels of B6
@@parkinsonsdiseaseeducation wat about taking b1 and it basically gave u a b2 deficiency even though u were taking it someone on a parkisons forum said b2 deficiency can cause b6 toxicity
@@parkinsonsdiseaseeducation or u dont kno
I’m sorry I meant to reply to your other question. Yes, honestly I don’t know if that could happen. It sounds like anecdotal reports would suggest that it could, but I haven’t heard about it happening
@@parkinsonsdiseaseeducation I think it happened again i was taking b1 fat soluble along with b2 but somehow i became b2 deficient and raised my b6 my symtoms gots worse and now i have palpatations that wont go away
I don't know who shoul I believe. One say that more than 100mg of B6 per day is bad, othes that more than 500mg, this video says that up to 1000mg is okay. But I read that daily dose of the vitamit should be abot 1.5mg.
I empathize with your confusion. When I recorded the video I looked up information and quoted the 1000 mg figure from Harvard University here: www.hsph.harvard.edu/nutritionsource/vitamin-b6/#:~:text=Vitamin%20B6%20is%20a%20water,greater%20than%201%2C000%20mg%20daily.
However, the link in the description is for Understanding Vitamin B6 Toxicity. I'd defer to their expertise on this. Here is their site: understandingb6toxicity.com/
@@parkinsonsdiseaseeducation I was diagnosed with toxicity two months ago after unknowingly taking 50mg of B6 in a magnesium supplement for 18 months. I recently found the Harvard site and couldn't believe what I was reading. I emailed them to advise them to update their information, but no response. I am in Australia and in the last two weeks - thanks to an 86 year old B6 sufferer contacting a journalist - the topic of b6 toxicity has been covered and gone rather viral. The public simply do not know the dangers, despite the warning labels on the back of our products. Hopefully we will see a significant shift in policy here soon and then maybe the US authorities might act as well.
I took 100mg, after getting twiches, the twitching stopped, so did the tingling.
I’m reading this trying to understand. You took 100mg then STOPPED? Is that when it got better?
There's 2 types of Vitamin B6. Which one is the 1 that is toxic?
It really isn't the B6 itself that is toxic, but the excessively high levels that can accumulate in the bloodstream that can lead to toxicity. It really shouldn't matter which type it is as any B6 molecule can lead to toxicity in excessive amounts. Don't take my word for it, I'd recommend going over to understandingB6toxicity.com
@parkinsonsdiseaseeducation how can you detoxify from B6?
@@cdcd4358 well, the general advice is to immediately stop supplementing if you are taking B6 and to allow the body to flush it out and to heal from the damage. If the issue of accumulation is due to a gene mutation such as the MTHFR gene then that is another issue. I would again defer to the experts at understandingB6toxicity.com and of course I would defer to a physician specialist to give direct advice on this issue for individuals dealing with toxicity.
Take ONLY the active form: Pyridoxal 5 Phosphate.
Forget the inactive form: Pyridoxine.
Thanks for the video. For the last three months I have had numbness and tingling in my fingers along the median nerve line. However, in my country I can't get a B6 level blood test- I have checked every lab and no-one offers it. For the last 18 months I have taken a vitamin supplement for over 50s and it has 200% of the RDA. My B12 levels are fine. Any ideas? Thanks
Hmmmm, well if the labs are normal for B12 it’s hard to blame the neuropathy on vitamin B deficiency. Unless you have an underlying condition such as diabetes that could cause neuropathy, I’d suspect a mechanical issue. It could be nerve impingement at the neck or at the wrist. In addition to that, myofascial trigger points in the shoulder blades and rotator cuff can also refer pain to the upper limbs that can very closely mimick nerve symptoms.
@@parkinsonsdiseaseeducation thank you!
What country are you in? You might live near a country where you can order bloodtests without doctor prescription. I did in Netherlands, its not super cheap, but B6 tests goes for about 39 euros + 21 euro if you use a screening center to draw blood (but you could do it yourself as well if you have access to someone who can draw blood and a machine that can preserve the samples). You can also do cheaper test with just lanching a hole in your finger and squeeze blood out, but those tests are less reliable. It sounds weird to me they cant test you for this, sometimes they can send blood abroad for tests they cant do, but this is not a difficult test.
I had to wait through Labor Day weekend to call my doc to request tests for B6, iron (hemocrit), sodium, celiac disease, heavy metals (all potential causes of peripheral neuropathy). I was pretty sure that B6 was the cause, so stopped supplements with it so that I was down to the RDA. (I had been at 250 - 400mg/day. Ugh.)
I have a long road to full recovery, but did think that my symptoms improved a tiny bit in the days following the change. I also added iron in case there was some anemia going on there. (There was/is.) Good luck!
Without suplementation my Vit6 is 38.5 while normal 21.5. for almost 2 yeras i have gait/balance issue an nausea. I was at all tupe of dr. No diagnosis. Finally i found myself that is probaly neuropathy. Now i am looking for the root cause. Thank you
I’m glad this video gave you some guidance! 😊
Hello, ive been taking 600mg for two weeks, is it reversable or how long would take the cure?
600 mg of B6??? Cmon! You’re literally poisoning yourself. I won’t take 1 mg of that poison after what it did to me 12 years ago. I still suffer from symptoms of B6 toxicity. Stay away from it!
That does seem like a high level
I have no way to answer your question objectively because I don’t know any of your history. Do you have B6 toxicity? Why are you supplementing and why so much? Who advised you to take it?
I concurre, the music is distracting as heck! Are you here. To educate or confuse?
There’s no reason to be a jerk. You obviously didn’t read the top pinned comment or the description. Move on
@@parkinsonsdiseaseeducation 👍
I just took b6 while ago and now I’m nervous and haven’t heard of this. It’s 100mg but will I be fine?
I wouldn’t worry, I’ve seen varied numbers of folks having toxicity with supplementing. Doing it once isn’t likely enough unless you’ve had some past issues with metabolizing B6. To be on the safe side I would contact the folks at understandingb6toxicity.com
They also have safe products for B6 on their site
@@parkinsonsdiseaseeducation very helpful comment
I’m glad it was helpful.
Is. It safer to just take a B complex??also how does it build up if its water soluble
Those are great questions. As to the first question I will leave specific recommendations to your physician. Generally speaking we get an adequate amount of B vitamins from diet without supplementation. And as to why it builds up, the short answer is that it is stored in the muscles. This is a quote from our friends at understandingB6toxicity.com: "We’ve been told all our lives that all of the B vitamins are water-soluble. Well, that is partly true. What is not widely known is that vitamin B6 is stored extensively in our muscles. What is also not known is the effects of dehydration on B6 elimination. Lastly, the most important unknown is that B6 can be stored in nerve cells." I would highly recommend looking at their website here -> understandingb6toxicity.com/b6-toxicity/causes/
@@parkinsonsdiseaseeducationyes, indeed, it’s complicated. And modern companies often include supplemental ingredients. Energy drinks especially! In Canada there are often people overdosing on alcohol and energy drinks…it’s been a problem. And how the liver becomes fatty can affect how the metabolic system works. Along with toxins in the diet.
Hi. I heard that the Pyridoxal 5-Phosphate version of B6 works a lot better than HCL and isn't toxic.
I’d say ask the experts at Understanding B6 Toxicity. Here is a link to their site: understandingb6toxicity.com/
The form doesn’t matter. Both cause nerve damage. Pyridoxine is just slightly harder to clear from the blood, but elevated pyridoxal, regardless of original form, will result in neurological dysfunction.
Thanks for your input
@@thomasc1270
U wrong!
th-cam.com/video/FS18XMGcT40/w-d-xo.html
@@thomasc1270
Thanks. Do you know where to find this info in scientific literature?
How are there supplements with such high doses when the supposed rda for b6 is around 2mg????
That’s a very good question. I’ve wondered the same thing, which was why I thought “gosh 1000 mg per day seems like it would take a lot of supplements to reach.”
how mutch toxicity ? is 28 or 35 mg dangerous ?
is the "Chlorhydrate de pyridoxine" (Vitamine B6) dangerous ?
I would highly recommend the Understanding B6 toxicity website for deeper expertise in this area. understandingb6toxicity.com
Yes, that's the particularly toxic form of B6.
Does anyone deal with major anxiety and ocd symptoms?
My daughter does. Magnesium helps some.
b2 deficiency can also raise b6 levels watch out for that
Great tip for others to pay attention to
Diabetics are told to take methl folate and methyl by all the time
Yes for sure, the B complexes can be good for neuropathy, but in the case of B6 some folks are taking by itself in too high of a dose and that’s leading to the issue.
I wouldn't even take more than 50mg per day.
Honestly, supplementing B6 in general is risky. So I don’t disagree. I’ve recommended people check out understandingB6toxicity.com for knowledge as well as for safe versions of B6.
B6 p-5-p tremendously help me with anxiety, sleep, erection issues and testosterone. 🤷🏾♂️
It could certainly help with neurological functions, as B6 supports nerve tissue. Not sure about the testosterone.
On the testosterone part it helped by bringing my prolactin down.
@tineeazyabuvall151 very interesting, I see that’s it’s commonly used to lower prolactin levels. 😮
There is 500 mg tablets supplement b6 maybe it different between one to other ? 😅
It may vary depending on the type of B6 supplement. But that’s a LOT for one tablet!!
@@parkinsonsdiseaseeducation
TH-cam deleted my comment 🤣🤣🤣
@@Medinalegend Which comment? I still see the one you left earlier?? 🤔😆
@@parkinsonsdiseaseeducation
Forgot about it 😂 ….. I have nerve weakness and nerve tremors throughout my body because of masturbation. Is dopamine good for my condition?
I’m speechless… 😂
I can hear the music in the background.
Yes, it was too high in the mix, though it’s not truly louder than me. Vocal is at 200% and music was maybe at 5%. I now ensure it’s at 2% max. This was one of the first I added music to. Thanks to that I now have to endure these comments for the rest of the time this video is on TH-cam. Thanks for watching anyway.
@@parkinsonsdiseaseeducation Understandable. Thanks anyway.
Something I didn’t think about, could you try with subtitles and see if that’s any better?
@@parkinsonsdiseaseeducation Yes great idea! I will do that thank you!
You’re welcome. Please let me know if there is any problem there, this one should have subtitles added
How long for nerve damage to heal I think covid made mine worse
Hey there. I wish I had an answer for you, but with nerve damage there is so much unknown. How much damage is there, is the damage in the nerves or in the central nervous system. Only some neural tissue is “plastic” meaning it can change or repair. You might look into Zinc for enhancing nerve repair. If I’m not mistaken it has been known to help with the loss of taste and smell fools often have with C-19
@@parkinsonsdiseaseeducation its in the nerves not central
@@parkinsonsdiseaseeducation thanks i just started taking vitamin d ala lions mane i get over 100 rda for zince about 200% im trying to heal my gut and gallbladder causing elevated liver enzymes got alot of inflammation in my body right now and it started last year when i took a methyl b12 i noticed my liver enzymes skyrocket
@@parkinsonsdiseaseeducation also one last thing now it seems i am deficienct in b6 now from doing a low b6 diet for 3 yrs that might have made things worse too but i will not touch a b vitmain ever again it messed me up bad
Sorry, it was meant to be a rhetorical question. I meant that nerve healing or regrowth depends on where the damage was done. Only some neural tissue can truly regenerate. Typically it has to be intact in some way first. For example if you sever the spinal cord it’s not likely to ever regrow axons, but if you bruise it it is likely to heal
Hi Michael, good information, thanks
Hey David 👋! I’m honored to have you on the channel. I subscribed to yours on my personal account and plan to sub as my channel also. Regarding the subject, have you run into other PWP who have had toxicity from supplements?
@@parkinsonsdiseaseeducation Hi Michael. I just found your channel today. One of my regulars, Tory Berch , asked me to have a look so I thought I would say hi. I’m always looking for active Parkinson’s channels contributing to Parkinson’s awareness because I believe there is massive void to fill out there. If you want to do something together let me know.
On your topic of B6 toxicity, I did not know that was a thing
I’m so glad you did! Tory is a new subscriber and she and I happen to be in the same state! (OK). I’d greatly appreciate your continued feedback and hope you’ll keep watching. Do you do other media like FB or IG? Also, would you be open to coming onto my podcast sometime? I’d be honored to have you as a guest. It’s the Parkinson’s Warrior Podcast
I got neuropathy from only 300mg/day.
Yes, apparently some folks can get toxicity from smaller doses. I’ve learned that there are some gene mutations that result in being predisposed to inability to metabolize B vitamins
Background music is way too loud. Geez!
I know. I know. I know. See pinned comment for heavens sake 😂
Are you a music composer too.good.
I did not compose this music :-)
I don't take b6 and got a 147 smh my doctor doesn't even care about it
So strange to be indifferent to it
That means you're taking too much b6 in your diet, find out which foods contain the most b6 & switch up diet plan
That’s a good suggestion Joseph
Did you get this resolved?
@@frankied6412 nope still don't understand and doctors don't seem to think it's a big deal 😕
?? 1000mg... Is this incorrect? Do you mean 1000mcg?
No, actually Harvard University used that figure. I’ve learned from the multitude of comments on this video that toxicity can occur at much lower doses.
@@parkinsonsdiseaseeducation Seems most sources of RDV is 1.2 - 2.4 mg supplementation. The max amount formally was 100mg, however, this has changed to 12 or 20 more recently I believe? I was taking an unknown 50mg amount in zinc, mag sup. in addition to other sup and a high B6 diet, which led to serious probs. I would think anyone taking 1000mg would be extremely unwell. Thanks for the response 😃
@zannah6818 you’re welcome Zannah. To clarify, the quote I saw from Harvard said that 1000 mg was the cumulative dose in a daily period that could result in toxicity. But as you pointed out, supplementation may only be ONE source of B6 and you could get extra from diet and other supplements.
My magnesium has 5 mg of b6 b5p ..an now I’m nervous to continue
I also have a b complex vitamin with 10 mg in it p5p
So I put that on hold ..
Prudent to put it on pause. Read more at understandingb6toxicity.com
They also have supplements that are alternative safer versions for B6
@@parkinsonsdiseaseeducation but I suppose the 5 mg that’s mixed with my magnesium will be well absorbed as magnesium is on top of it an a low dose of p5p
Why are you referencing 1,000mg as the level that's "too high of a dose"? For many people, even 50mg is too high. As you know, we only need around 1mg per day. 1,000mg is absolutely outrageous and will 100% lead to peripheral neuropathy. In Australia, supplement packaging that contains over 50mg is required to have prominent labeling communicating the danger of peripheral neuropathy.
Yet here we are in the good ol' corporate America-loving USA with guidelines supporting 1,000mg/day. Honestly, when would a person ever want to take 1,000mg of B6 daily? I'd love to hear examples from a physician.
The FDA and Mayo clinic are misinforming the public and putting health in danger by implying that people should not worry unless they're taking 1,000mg per day. This is highly irresponsible, and as someone just recovering from PN caused by B6 toxicity, I'm troubled by your reference to 1,000mg without a disclaimer that someone should never actually take that much. Like, ever.
Here's how easy it is. In my case, I was incorrectly diagnosed with carpal tunnel and advised by physicians to load up on B6, which obviously only worsened the symptoms to the point that I did not sleep more than 20 minutes at a time, sitting upright on the couch due to the pain. I was taking in 250 - 400mg per day. I lived with this for nearly a year and not one physician, surgeon, nerve physician, or Functional Health Clinic even thought to look at B6 as the cause -- likely due to the aforementioned misinformation.
Please be careful. I'd update the video with a disclaimer at the start where you talk about 1,000mg (and have it in large font on the screen) if I were you. Doubt it'd take a year at that level. Scary. Best of luck.
I’m sorry you felt that this was irresponsible. Unfortunately, I was likely misled by the research that I did for this video as I was quoting from a scholarly resource. This page from Harvard (I mistakenly said Mayo Clinic in the video) was where the 1,000mg reference was found. www.hsph.harvard.edu/nutritionsource/vitamin-b6/#:~:text=Vitamin%20B6%20is%20a%20water,greater%20than%201%2C000%20mg%20daily.
Also, I never recommend taking ANY level of B6 in the video and pretty sure I recommended taking a blood test to check levels and to consult with a physician before supplementing.
yep and they dont thats the funny things about it
That music in the background was highly annoying.
😐
Love the music gaha
I regret my choice.
@@parkinsonsdiseaseeducation hey its good taste. might be a little loud for some but the actual music is really nice
@brandonyoung4910 lol I thought so too, but I really wish I’d mixed the audio with the music much much lower. Believe me, I’ve heard the disdain haha
You will like Dr berg videos he has a lot of info too. Thanks for this video!
Yes, he’s a Chiropractor. Does he do a lot of PD videos?
I couldn’t watch this video. The music is so annoying
Sorry about that, it ended up too loud. I need to add a warning in the description because so many people comment on the stupid music
I like having burning skin it's exciting!
🤔
P5P is safe
From what I’ve heard since the video was released, any form of B6, whether synthetic or not, can result in toxicity of taken in too high of a quantity
The music is bloody awful.
Where have I heard this before? 🤔 😂
P5P doesn't cause toxicity
Before I published this video I had no idea what P5P was. I had only heard of B6 possibly resulting in toxicity.
@@parkinsonsdiseaseeducation yes well just saying it here so people know p5p is awesome
He should delete this video
Why would that be? This is information people need to know
Please stop that music!!!!!!!
If I could edit it out I would but that would mean Re-uploading the whole thing. Sorry. You could watch with subtitles on mute if it bothers you too much
1:25 👌👌👌
This could be interesting, but the background music is too distracting.
I know… it’s my life’s regret at this point
Stop the background music.
🤷🏻♂️
❤ for the algorithm
Thank you kindly Dina. :-)
You sound educated, why not taking the time to learn how to make YT videos? :)
It never ceases to amaze me how people will go out of their way to insult creators. If you have nothing more to contribute then I'll wish you a good day. :-)
@@parkinsonsdiseaseeducation HAHAHA Not knowing you, I had no idea of your pompous arrogance neither. Now, I can tell that you are showing a weird histrionic personality...
Stop the background music
Too late for this video