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wow thank you !

Hi Tristan, great explanation and videos. Thank you so much. Can you please also do an advanced version of this including new drug Vs standard, and including different perspectives of costs. Thank you.

Thank you for this video. Can you do this for decision tree models?

you're brilliant. Thank you so much!

This was incredibly helpful. I cannot thank you enough!!!

Just going through all your Markov model videos, loving them!

Hello, i am enjoying the content! I am an undergraduate and may potentially take a Health Economics master's in the upcoming years. Would you be expected to learn R when doing the master's or can you choose between R and Excel? Best wishes, Jos

Hi Tristan, thank you for sharing knowledge and these great lectures. Can you please also create and share similar tutorials about partitioned survival models - focusing on extrapolating the survival curves, calculating state membership and patient simulation, in Excel and R.

Dear Tristan, Thank you for your clear videos, they truly are helpful. I face an issue: when I turn my PSA to 1 (using BETA distribution), some values of my transition matrix take negative values (always the one with the "1-SUM(...)"). I have 29 health states and thus multiple transition probabilities, some TPS are very close to 0 so I thought that was the reason but I increased the alpha and beta but the problem remained. Do you have an idea of what the problem is? Thank you. Kind regards, Yasmine

Thank you so much! It is very helpful! But I'd like to ask if we need to consider discount rate in this process? Thanks a lot!

Any new videos with the new bacon version in R? I am not sure which ages to use from the results txt file bacon produces as a result Any help would greatly be apprecited!

Thank you so much!, My professor used to do the half-cycle adjustment only in the first and the last cycle, is that also correct?

3:17 You can do all the exponential distribution probability computations "automatically" simply by taking the matrix exponential of a matrix of state-to-state hazard rates (with the leading diagonal set to the negative sum of rates each row). Example at en.m.wikipedia.org/wiki/Continuous-time_Markov_chain

Perfect. Thanks for this.

Great! Question: I want to do a very similar simulation, but in this case the transition probabilities change with time. For instance, a group of 50-year old men might transition to disease or dead in the first cycle. But in the second cycle they are 1 year older, so their chances of either transition increases, as does the probability of transitioning from diseased to dead (since the group of diseased people is also 1 year older). What do you think would be the best way to accomodate that?

is there a video on how to estimate the parameters from a population matrix of compositions

Such a pity you did not show us how to make the function from a model that has time-varying parameters. I used the code m_P["state1","state2", 1:10] <- p_state1_state2 just for the first 10 cycles, but R showed me an error saying that I used incorrect number of subscripts 😏 I don't know what to do

Hi, how do we determine the Alpha and Beta parameters?

Hi, Thank you for your video! it really very helpful. I have a question how do we determine the Alpha and Beta parameters?

You are a legend. Your video tutorials are very helpful. I'm trying to model early cancer and I'd need to calculate transition probabilities for three competing events occurring during even-free state. I was wondering how do I get the risk rate (λ) for the equation you mentioned in this video, if I only have cumulative incidence (in %) for each of the 3 competing events over time? Many thanks.

Sir how I can calculate life years? Please help me

Would it be possible for you to make a video for simple deterministic sensitivity analyses (one-way with a tornado diagram)? Great video!

Awesome, but the font colors are terrible for us

Hi! thank you for your videos. I'm begginer so what is qx mening? And could you rise your videos voice pls?

It's really helpful, thank you! Could you please explain why you set shape = 100 and 25? Are there any criteria for using these values? Sorry I could not catch up with this.

This is a great video, but what shortcut did you use to increase the size of the vertical bar to write over 3 lines at 10.53? Looks super useful!

Hello, can you explain how to know how many cycles to run. Shouldn't we keep running cycles until all patents are in dead state.?

Hi, Can you also provide make a video for vba codes for CEAC and Scatter plot.

Really a nice video! Your applications are clear and insightful. I just wonder how to conceptualize the initial amount of events (1000) in the first cycle. It is clear in the example of health economics. It is plausible that in the first observation, all statistical units are healthy. Less clear to me for the R-P-S example. Any further explanation is welcome

Hi doc I’m interested to talk to you please how can I contact you.. thanks

The r programme doesnt allow me to do the matrix mulitplication %*% I dont know why

Will we always have time-varying pay offs if we have time-varying transitions? ie are they always related with same values or not necessarily

Thank you

Related with the INMB, I've tried to calculate both option C and D in comparison with option A. Both of them (NMB C- NMB A) and (NMB D-NMBA) resulting the same amount, $25.000 with the 100.000 threshold. Which one should I choose between those two if we're using the NMB approach?

Can you also create videos on partition survival model from scratch

Is this basically a Monte Carlo simulation? Or is this different? You could get the mean and 5th and 95th percentile from the results at the end as the CI95?

Is the left facing arrow the same as the assignment command (<-)

Can you please make a video on export and import of Agricultural products. Both the TPM and MCA

Can you please make a video of Markov Chain on export data of commodities

Hi i am watching this video after 2 years. Is it possible to do for life insurance product pricing? Also may I ask are you an academic or professional (if so what)? Thank you!

If I use beta=alpha=1, will that be correct?

Hi there! I'm having troubles understanding the applicability of these survival functions for Markov modeling. For example, if I'm analyzing the cost-effectiveness of ACALABRUTINIB vs. IBRUTINIB as a second-line treatment, most oncology Markov models would have three states ("Progression-free," "PD," "Death"). Using these survival functions, how can I obtain the time-varying transition probabilities for these three states?

Where did you get the data for the matrix? Was this mentioned in a previous video? I can’t seem to find it?

Hi Sir I'm analyzing lung cancer screening by LDCT. This screening method has sensitivity and specificity. How do I put these two parameters into the Markov model for analysis? Please help me, many thanks.

Thank you very much for your videos. These videos are very helpful. It would be a great if you have a video of deterministic sensitivity analysis in Rstudio.

You lost me at 3:53!!

Thank you! I have found this a really good starting point for a budget impact analysis model. If you have any guidance about choices for distributions (even references to read) that would be really appreciated!

Tanx for your explanation🌹 . I have a question ,When we have an entervention such as screening every 5 years for example ,how we should inter it into the model?

is the rock paper scissors equal to the three states?

Omg you're a lifesaver!