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GenomeTDCC
United States
เข้าร่วมเมื่อ 11 พ.ค. 2022
The GenomeTDCC, (Genome Technology Development Coordinating Center), aids the development of new approaches for characterizing the structure and function of the human genome by spurring collaboration among NHGRI grantees.
We amplify the voices of leading edge genomic technologists.
Check us out online at: GenomeTDCC.org
Follow us on LinkedIn, X, and Bluesky at: @GenomeTDCC
We amplify the voices of leading edge genomic technologists.
Check us out online at: GenomeTDCC.org
Follow us on LinkedIn, X, and Bluesky at: @GenomeTDCC
Nanopore ion sources deliver individual ions of amino acids and peptides directly into high vacuum
Nicholas Drachman and Derek Stein, Ph.D. of Brown University, discuss their innovative development in mass spectrometry-based proteomics, published in Nature Communications. They developed custom mass spectrometry nanopore ion sources to deliver single ions of individual amino acids and peptides directly into high vacuum from biologically relevant aqueous solutions. This work makes significant improvements over conventional electrospray ionization methods. This is a huge step forward for mass spectrometry-a technique used to measure the mass of molecules-and its significance in proteomics, where understanding protein structure and function is critical for advancing biology and medicine.
Read the full paper in Nature Communications: doi.org/10.1038/s41467-024-51455-x
#massspectrometry #nanopore #proteomics
Read the full paper in Nature Communications: doi.org/10.1038/s41467-024-51455-x
#massspectrometry #nanopore #proteomics
มุมมอง: 67
วีดีโอ
Genomics at Scale and on the Horizon
มุมมอง 76วันที่ผ่านมา
Stacey Gabriel, Ph.D., is a prominent researcher and geneticist at the Broad Institute of MIT and Harvard. Her contributions to genomic research are helping to pave the way for more personalized approaches to healthcare. Dr. Gabriel is deeply involved in studying genetic variation across human populations and has played a crucial role in developing and applying next-generation sequencing techno...
Synthetic Genetic Systems: A New Frontier in Genomics Research
มุมมอง 7221 วันที่ผ่านมา
Welcome to a deep dive into the world of molecular evolution. Dr. Steven Benner is the driving force behind some of the most groundbreaking advancements in synthetic biology, particularly through his work with Firebird Biomolecular Sciences and the Foundation for Applied Molecular Evolution (FfAME). *Links below!* In this video you will uncover the history and process for creating Artificially ...
Synthetic Genomics or "Genome Writing"
มุมมอง 766หลายเดือนก่อน
Renowned geneticist Jef Boeke, Ph.D., Institute for Systems Genetics, NYU Langone Health, discusses groundbreaking advancements in genetic engineering and synthetic biology, highlighting the innovative "Assemblatron," and the ambitious "Dark Matter Project." Boeke begins by explaining the concept of synthetic genomes and "Big DNA" and showcasing how scientists can design and construct DNA from ...
Investigating Epitranscriptomes
มุมมอง 90หลายเดือนก่อน
The epitranscriptome refers to the collection of chemical modifications on RNA molecules within a cell. These modifications occur post-transcriptionally, meaning they are added to RNA after it has been synthesized from DNA. The epitranscriptome encompasses modifications on various types of RNA, including messenger RNA (mRNA), transfer RNA (tRNA), ribosomal RNA (rRNA), and other non-coding RNAs....
High-Throughput Tagging of Endogenous Loci for Rapid Characterization of Protein Function
มุมมอง 61หลายเดือนก่อน
High-Throughput Insertion of Tags Across the Genome (HITAG) is a novel method designed to facilitate the study of protein function on a large scale. By leveraging a modified Cas9-based targeted insertion strategy that relies on nonhomologous end joining (NHEJ), HITAG allows for the rapid creation of libraries of cells, each containing a different protein of interest tagged at the C-terminus. Al...
Exploring new chromosome biology with complete, telomere-to-telomere (T2T) genomes
มุมมอง 149หลายเดือนก่อน
The announcement of the draft assembly of the human genome in 2000 was a landmark moment in the history of science. The Human Genome Project was a collaborative effort involving scientists from multiple countries, demonstrating the power of international cooperation in tackling complex scientific challenges. The project saw collaboration between public institutions and private companies, notabl...
Scalable Investigation of Gene Function in the Brain in vivo
มุมมอง 110หลายเดือนก่อน
Xin Jin, Ph.D., of Scripps Research, is exploring how genes influence brain function and behavior. Her work particularly focuses on the genetic regulation of neural circuits that control movement and decision-making. By manipulating gene expression in specific brain regions, she studies the resulting changes in neuronal activity and behavior to understand the molecular and cellular mechanisms u...
A Comprehensive Binding and Functional Map of Human RNA-Binding Proteins
มุมมอง 3302 หลายเดือนก่อน
Brenton Graveley, Ph.D., University of Connecticut Health Center, studies RNA binding proteins (RBPs) with a focus on understanding their roles in gene regulation. RBPs are crucial for post-transcriptional regulation, affecting processes such as splicing, polyadenylation, RNA stability, and translation. Dr. Graveley's research aims to identify RBPs and their targets, understand RBP functions, a...
Imaging 3D Genome
มุมมอง 14K2 หลายเดือนก่อน
3D genomics is the study of the three-dimensional structure and organization of the genome within the nucleus of a cell. Siyuan (Steven) Wang, Ph.D., Yale University, provides a historical overview of how this field has come to understand how the spatial arrangement of DNA influences gene expression, cellular function, and overall biological processes. Dr. Wang is a prominent researcher in the ...
Chromatin and Gene Regulation in Human Cells
มุมมอง 6232 หลายเดือนก่อน
Lacra Bintu, Ph.D., of Stanford University discusses her research focus on understanding the mechanisms of gene regulation and how cells make decisions based on their gene expression programs. Dr. Bintu's work combines approaches from molecular biology, biophysics, and computational biology to explore how transcription factors, chromatin modifications, and other regulatory elements interact to ...
SpliceRUSH: CRISPR-dCas13d-based deep screening of proximal and distal splicing-regulatory elements
มุมมอง 2593 หลายเดือนก่อน
Pre-mRNA splicing is an important step in gene expression. Antisense oligonucleotides (ASOs) can therapeutically modulate splicing by competing against endogenous splicing factors. The ASO therapeutic Spinraza/nusinersen, is the first efficacious treatment for spinal muscular atrophy (SMA), targeting an intronic splicing silencer downstream of Survival Motor Neuron 2 (SMN2) exon 7, rescuing SMN...
Expanded palette of RNA base editors for comprehensive RBP-RNA interactome studies
มุมมอง 3K5 หลายเดือนก่อน
RNA binding proteins (RBPs) are key regulators of RNA processing and cellular function. Several methods have been established to identify RNA targets of RBPs including antibody-free methods that use RNA base-editors (rBEs) fused to RBPs. Hugo Medina-Muñoz, PhD and Gene Yeo, PhD, MBA (University of California, San Diego) highlight the work published in Nature Communications describing an experim...
Slide-tags Enables Single-Nucleus Barcoding for Multimodal Spatial Genomics
มุมมอง 1.7K6 หลายเดือนก่อน
Combining the high-quality and high-throughput quantification of single-nucleus genomics measurements with the spatial context of tissue measurements comes *Slide-tags* , an innovative method in which single nuclei in intact tissue sections are tagged with spatial barcode oligonucleotides derived from DNA-barcode beads of known position. Hear from Andrew Russell, Jackson Weir, Naeem Nadaf, and ...
Large-scale evaluation of the ability of RNA-binding proteins to activate exon inclusion
มุมมอง 4.7K7 หลายเดือนก่อน
RNA-binding proteins (RBPs) mediate various cellular processes and play a major role in post-translational gene regulation of RNAs, including splicing. There are over 2000 predicted RBPs, many without an assigned RNA-binding function. Gene Yeo, PhD, MBA (University of California, San Diego) and Jonathan Schmok, PhD (The Arc Institute) discuss development of tethered function splicing reporter a...
A snoRNA-tRNA modification network governs codon-biased cellular states
มุมมอง 2.6K10 หลายเดือนก่อน
A snoRNA-tRNA modification network governs codon-biased cellular states
Observing inhibition of the SARS-CoV-2 helicase at single-molecule resolution
มุมมอง 24410 หลายเดือนก่อน
Observing inhibition of the SARS-CoV-2 helicase at single-molecule resolution
Translocation of full-length proteins through an engineered nanopore
มุมมอง 1.9K11 หลายเดือนก่อน
Translocation of full-length proteins through an engineered nanopore
Direct RNA Sequencing and Base Modifications
มุมมอง 6Kปีที่แล้ว
Direct RNA Sequencing and Base Modifications
Analyses of Genomic Architecture and Function - Panel Discussion
มุมมอง 1.8K2 ปีที่แล้ว
Analyses of Genomic Architecture and Function - Panel Discussion
Building the Vertebrate Body, One Cell at a Time - Sanjay Srivatsan
มุมมอง 2.5K2 ปีที่แล้ว
Building the Vertebrate Body, One Cell at a Time - Sanjay Srivatsan
Epigenomic Technologies for Mapping DNA Methylation in the Human Genome - Gang Fang
มุมมอง 2.2K2 ปีที่แล้ว
Epigenomic Technologies for Mapping DNA Methylation in the Human Genome - Gang Fang
Gene and Chromatin Perturbations - Lacra Bintu
มุมมอง 3.2K2 ปีที่แล้ว
Gene and Chromatin Perturbations - Lacra Bintu
Analyses of Genomic Architecture and Function - Introduction
มุมมอง 3.8K2 ปีที่แล้ว
Analyses of Genomic Architecture and Function - Introduction
Educational Opportunities to Enhance Diversity at NHGRI
มุมมอง 4.2K2 ปีที่แล้ว
Educational Opportunities to Enhance Diversity at NHGRI
Emerging Sequencing Technologies and Uses - Panel Discussion
มุมมอง 8K2 ปีที่แล้ว
Emerging Sequencing Technologies and Uses - Panel Discussion
What could possibly go wrong? 🤔
Using that for philosophy too. To improve logic.
Ok IM 😅😅
And what did you say that MRNA is the easiest?
So, looking back on this now. How has AI helped you. Also, using AI to solve the occupancy issue and the hypermodification problem. Also identifying different uradines methal uradines, modifications all the " major variances " . Bringing down cost. Just curious.
Thank you so much for you questions! Comments are not monitored by the speaker, but you can reach out to them directly by visiting their website rouhanifardlab.com/
Buna. Aveti grija sa nu va jucati de-a Dumnezeu.
شكرا 😊
Wonderful. I only wish I understood..
Talk about bias speakers. The first speaker, Professor Maglia is directly linked to Oxford Nanopore. The second & third speakers are linked with Oxford or other companies respectively. Dr. Maglia’s comment that Quantum Si is similar to a PacBio sequencer is highly inaccurate. Please don’t publicly state these inaccurate comments unless you have technological & scientific proof. V/R, Maj Toma Ghizdavu, MD, USA, Ret President, Disabled Veterans LLC
Dear Professor, thank you so much. Could you make a separate video on difference between bascalling error and signal intensity.
Thank you so much for you questions! Comments are not monitored by the speaker, but you can reach out to them directly by visiting their website rouhanifardlab.com/