Institute for Neuro-Immune Medicine
Institute for Neuro-Immune Medicine
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Alternative Processing of Amyloid Precursor Protein In Alzheimer's Disease | Dr. Gregg B. Fields
Dr. Gregg B. Fields shares his latest research on Alzheimer’s disease and how toxic proteins in the brain might be playing a bigger role than we thought. His work explores how amyloid precursor proteins are processed inside the cell, leading to harmful fragments that can damage brain function.
He explains why traditional treatments haven’t worked as expected and introduces a new approach using focused ultrasound to open the blood-brain barrier. This innovative method allows treatments to reach the brain more effectively, and early trials are showing incredible results, like clearing out beta-amyloid plaques that build up in Alzheimer’s patients.
Tune in to learn about these exciting discoveries and how they’re bringing us closer to better treatments for this devastating disease.
Key points:
00:00 Introduction
02:27 Alzheimer’s prevalence and impact.
03:35 Brain changes and amyloid beta.
05:02 Beta and alpha secretase pathways.
06:49 Intracellular vs. extracellular processing.
08:26 MT5-MMP as beta secretase.
09:18 Chimeric experiments on MT5-MMP.
10:14 Identification of MT5-MMP binding partners.
13:23 Toxic effects of Aβ-alpha fragments.
19:52 Developing MT5-MMP inhibitors using collagen-like peptides.
20:55 Delivering Alzheimer's drug across the blood-brain barrier.
23:13 Focused ultrasound explained.
24:18 How focused ultrasound works.
30:22 Clinical trial results.
32:05 Role of the Focused Ultrasound Foundation.
33:28 Acknowledgements of collaborators and research funding.
Dr. Gregg B. Fields is a leading chemist specializing in extracellular protease-based diseases, including tumor metastasis, arthritis, and neurodegenerative disorders. He holds a B.S. and Ph.D. in chemistry and completed postdoctoral training at UC San Francisco. Since joining Florida Atlantic University (FAU) in 2014, he has served as Chair of Chemistry & Biochemistry, Executive Director of I-HEALTH, and Co-Director of the MCIFAU Cancer Center. In 2023, he became Interim Vice President for Research at FAU. Dr. Fields is a Fellow of the National Academy of Inventors (NAI) and AAAS, with over 330 publications and 250 invited lectures worldwide.
#AlzheimersDisease #BrainHealth #AlzheimersResearch
มุมมอง: 64

วีดีโอ

The Role of Patient Advocacy in Long COVID Treatment with Dr. Nancy Klimas and @ThriveNinety
มุมมอง 17714 ชั่วโมงที่ผ่านมา
Sign up for the COVID-UPP Study: redcap.nova.edu/redcap/surveys/?s=RMEDJ7LKCX&_gl=1*1h830h7*_gcl_au*MTM2NDA0MTQyOS4xNzE1MDA0ODAy Haylie Pomroy welcomes Dr. Nancy Klimas, Director of the Institute for Neuro Immune Medicine, along with special guests Katie Brennan and Andrea Henkel Burke of ThriveNinety. They share insights on how to recover from long COVID and how patient advocacy can make a hug...
Post-Exertional Malaise: The Price of Exertion with Dr. Melanie Hoppers
มุมมอง 339วันที่ผ่านมา
Post-Exertional Malaise: The Price of Exertion with Dr. Melanie Hoppers
Patient Testimonial | Kristin Soliday
มุมมอง 11114 วันที่ผ่านมา
Patient Testimonial | Kristin Soliday
The Effect of Mold and Heavy Metals on the Body with Dr. Theoharis Theoharides
มุมมอง 22314 วันที่ผ่านมา
The Effect of Mold and Heavy Metals on the Body with Dr. Theoharis Theoharides
The Role of Environmental Factors in Autoimmunity with Dr. Aristo Vojdani
มุมมอง 17021 วันที่ผ่านมา
The Role of Environmental Factors in Autoimmunity with Dr. Aristo Vojdani
How To Manage ME/CFS and Other Chronic Illnesses with Jamie Seltzer
มุมมอง 530หลายเดือนก่อน
How To Manage ME/CFS and Other Chronic Illnesses with Jamie Seltzer
Neurovascular Dysregulation During Exercise in ME/CFS and Long COVID
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Neurovascular Dysregulation During Exercise in ME/CFS and Long COVID
Disability Insurance Claims: What You Need to Know with Edward Dabdoub, J.D., M.B.A.
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Disability Insurance Claims: What You Need to Know with Edward Dabdoub, J.D., M.B.A.
Finding Hope After Long COVID: A New Path to Recovery
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Finding Hope After Long COVID: A New Path to Recovery
Gluten-Free Life: Thriving With Celiac Disease
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Gluten-Free Life: Thriving With Celiac Disease
RECOVER TLC: Lessons Learned and Next Steps | Jaime Seltzer, BS, MS
มุมมอง 283หลายเดือนก่อน
RECOVER TLC: Lessons Learned and Next Steps | Jaime Seltzer, BS, MS
Fighting Cancer with Immunotherapy: A Success Story
มุมมอง 352หลายเดือนก่อน
Fighting Cancer with Immunotherapy: A Success Story
A Guided 20-Minute Yoga Session with Daniel Valladares
มุมมอง 190หลายเดือนก่อน
A Guided 20-Minute Yoga Session with Daniel Valladares
The Hidden Dangers of Mold and Mycotoxins with Dr. Andrew Campbell
มุมมอง 6102 หลายเดือนก่อน
The Hidden Dangers of Mold and Mycotoxins with Dr. Andrew Campbell
A Guided 15-Minute Yoga Session with Daniel Valladares
มุมมอง 4232 หลายเดือนก่อน
A Guided 15-Minute Yoga Session with Daniel Valladares
Legal Advice for Chronic Illness Disability Claims
มุมมอง 4512 หลายเดือนก่อน
Legal Advice for Chronic Illness Disability Claims
Fat Loss for Women Over 50
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Fat Loss for Women Over 50
The Power of Prevention: The Pillars of a Healthy Life
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The Power of Prevention: The Pillars of a Healthy Life
Genetic and Epigenetic Modeling of Gulf War Illness | Byron C. Jones, Ph.D
มุมมอง 752 หลายเดือนก่อน
Genetic and Epigenetic Modeling of Gulf War Illness | Byron C. Jones, Ph.D
Environmental Toxins: How To Detoxify The Body
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Environmental Toxins: How To Detoxify The Body
Immunotherapy: The Future of Cancer Treatment
มุมมอง 5813 หลายเดือนก่อน
Immunotherapy: The Future of Cancer Treatment
Disability Insurance For Chronic Illness
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Disability Insurance For Chronic Illness
The Role Of The Nervous System In Chronic Illness
มุมมอง 6143 หลายเดือนก่อน
The Role Of The Nervous System In Chronic Illness
Inflammation: Root Causes And How To Manage It
มุมมอง 5323 หลายเดือนก่อน
Inflammation: Root Causes And How To Manage It
Finding Treatments for Fibromyalgia and ME/CFS
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Finding Treatments for Fibromyalgia and ME/CFS
Join Our Gulf War Illness Research
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Join Our Gulf War Illness Research
Making A Difference In Long COVID Studies
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Making A Difference In Long COVID Studies
The Science of Stress and Sleep for Optimal Performance
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The Science of Stress and Sleep for Optimal Performance
Clinical Pearls: Managing Chronic Illness
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Clinical Pearls: Managing Chronic Illness

ความคิดเห็น

  • @marciestoddard730
    @marciestoddard730 23 ชั่วโมงที่ผ่านมา

    an ultrasound would show an overgrowth of cysts, and other scans.

  • @Tf03
    @Tf03 3 วันที่ผ่านมา

    They know nothings it’s terrible. There always offended when you bring in notes, studies, literature and refuse to read them. I’m so fatigued it’s like please just listen to this one time so I don’t have to spend energy I don’t have finding someone else explaining my history blah blah

  • @Nisha-kl8rl
    @Nisha-kl8rl 4 วันที่ผ่านมา

    I recommend Planet Ayurveda to anyone dealing with CFS. Their herbal remedies are effective and safe.

  • @combabus
    @combabus 5 วันที่ผ่านมา

    My grandmother was diagnosed with "Hysteria" and my father and I with CFS or "Yuppie Flu" in the 1990's. I didn't have children so another generation would suffer like we did.

  • @tomreid8598
    @tomreid8598 6 วันที่ผ่านมา

    'Every morning before you grt out of bed' - 25% of me/cfs patients are bedridden. I haven't left bed for 2 years. Know your audience

  • @NSU_INIM
    @NSU_INIM 6 วันที่ผ่านมา

    Learn more about us here. Website: www.nova.edu/nim/ Facebook: facebook.com/InstituteForNeuroImmuneMedicine Instagram: instagram.com/NSU_INIM/ Twitter: twitter.com/NSU_INIM

    • @NSU_INIM
      @NSU_INIM 6 วันที่ผ่านมา

      Sign up today for our newsletter. nova.us4.list-manage.com/subscribe?u=419072c88a85f355f15ab1257&id=5e03a4de7d

  • @magicalpatterns
    @magicalpatterns 7 วันที่ผ่านมา

    Does the needles could cause anaphylactic shock for Mcas patients? I wonder if we could try this

  • @bertcollard6619
    @bertcollard6619 7 วันที่ผ่านมา

    They mostly put gulfwar illnesses under mental health treatment from what I have seen with gulfwar veterans I know

  • @magicalpatterns
    @magicalpatterns 9 วันที่ผ่านมา

    My husband and I have a meeting before every doc appointment I have because of so much medical trauma. Now, him and my son are always present in my apartments and the treatment has improved significantly for the better compared to what it was when I went alone. I am mostly bedridden now but I suggest to always go with someone on your team. Also, don’t talk about more than 3 symptoms out of time. Don’t make appointments on Mondays or Fridays. No apps later in the afternoon. So many tips I have learned over the years I wish I can share more. I used to be a social worker now I need one and even knowing I have to prepare what to say and how to say it.

  • @tammygravis1462
    @tammygravis1462 9 วันที่ผ่านมา

    What happens when you get out of the mold?

  • @pamelamohn5931
    @pamelamohn5931 10 วันที่ผ่านมา

    The carnivore diet healed my asthma.

  • @danielpacheco4821
    @danielpacheco4821 12 วันที่ผ่านมา

    Yes this is what happened to me. Was fully vaccinated and no history of autoimmine conditions or any conditions really, then had very mild covid- 6 minths later had what i can only describe as a flare up where my body had ALOT of inflammation- very high c proten and sed rate it turned out and rhemtoid factor- saw a.rheumatologist and waant coming up for lupus and any specific autoimmune condition. Then i had vlood clots develop and a PE along with a TIA (ischemic stroke) all.within a 3 month period- and finally was diagnosed with APS with those antibodies found to be present in my blood. The chronic inflammation also damaged my blood vesssels and tissue.

  • @ana.e.b
    @ana.e.b 13 วันที่ผ่านมา

    and caused me to lose my other friends

  • @timreed353
    @timreed353 13 วันที่ผ่านมา

    FDA has now banned food coloring in processed food and drinks

  • @vishalchaudhary-nf6gr
    @vishalchaudhary-nf6gr 13 วันที่ผ่านมา

    Thank you, doctor, for covering interstitial cystitis in this video! My wife faced painful bladder issues for years until she tried Planet Ayurveda’s Mutrakrichantak Churna and Punarnava Capsules. My neighbor also benefited greatly from these herbal remedies!

  • @highwaydaytime7669
    @highwaydaytime7669 13 วันที่ผ่านมา

    There's no neuro toxins in cereal. What an outlandish and dangerous statement to bandy around

    • @scottsutter6686
      @scottsutter6686 13 วันที่ผ่านมา

      If a person has a histamine intolerance or even gluten intolerance, and one of the side effects is ADHD like, could you then call it a neuro toxin? If Red 40 had some evidence pointing to it being a factor in behavioral problems, could it possibly be considered a neurotoxin?

  • @manfredhoudek2385
    @manfredhoudek2385 14 วันที่ผ่านมา

    Read the book called "Grain Brain" David Perlmutter and Kristin Loberg. Be warned it will shock you.

  • @manfredhoudek2385
    @manfredhoudek2385 14 วันที่ผ่านมา

    Kellogg's is owned by the seventh day Adventist, so is Sanitarium. The Seventh Day Adventists for 200 years have been trying to move people away from eating meat. The reason isn't for health. They believe all pleasure should come from worshipping god, they think sex is for reproduction purposes only. They discovered the more animal protein people ate the more they had sex for pleasure. They own about 90% of the publishing house across the world and fund research to forcibly create a narrative of meat is bad, go vegetarian. That's why there's more research papers published on vegetarian diets than protein diets. They are fanatical on stopping people to stop getting sexual pleasure.

  • @NSU_INIM
    @NSU_INIM 14 วันที่ผ่านมา

    Learn more about us here. Website: www.nova.edu/nim/ Facebook: facebook.com/InstituteForNeuroImmuneMedicine Instagram: instagram.com/NSU_INIM/ Twitter: twitter.com/NSU_INIM

    • @NSU_INIM
      @NSU_INIM 14 วันที่ผ่านมา

      Learn more about INIM’s Research Studies: www.nova.edu/nim/research-studies/index.html

  • @danijeanes5078
    @danijeanes5078 14 วันที่ผ่านมา

    Do what do you suggest

  • @cristinamiro7
    @cristinamiro7 16 วันที่ผ่านมา

    Is there an investigation into Copper overload, as related to immune disregulation and chronic EBV. I had a copper IUD implanted some 4 years before mono.

  • @cristinamiro7
    @cristinamiro7 16 วันที่ผ่านมา

    In my case, emotional exhaustion is an important PEM trigger.

  • @michellemilano9067
    @michellemilano9067 18 วันที่ผ่านมา

    Are you able to tell us what medications helped Kristen in her recovery? Thanks

  • @salobrena6442
    @salobrena6442 19 วันที่ผ่านมา

    good advice.. we cannot trust big pharma about anything.. stay clean

  • @kozmikwolfe
    @kozmikwolfe 19 วันที่ผ่านมา

    No way in hell I’m getttin past this video after 5 minutes- like seriously it’s absolutely obnoxious

  • @kozmikwolfe
    @kozmikwolfe 19 วันที่ผ่านมา

    This video is irritating me when I’m am already in pain- like stop with the advertisement every 15 seconds so annoying. Not a good loook

  • @AruneshAgrawal-pp1oh
    @AruneshAgrawal-pp1oh 19 วันที่ผ่านมา

    My uncle had been suffering from Celiac Disease for years, but after using the natural solutions from IAFA Ayurveda, he found complete relief within just three months. The treatment was effective and gentle, helping him regain his health.

  • @paparoysan
    @paparoysan 20 วันที่ผ่านมา

    thank you! yes, it is a great idea to list details what we can give to our doctors..and pls, where we can listen to that Friday presentation? ❤

  • @NSU_INIM
    @NSU_INIM 20 วันที่ผ่านมา

    Learn more about us here. Website: www.nova.edu/nim/ Facebook: facebook.com/InstituteForNeuroImmuneMedicine Instagram: instagram.com/NSU_INIM/ Twitter: twitter.com/NSU_INIM

    • @NSU_INIM
      @NSU_INIM 20 วันที่ผ่านมา

      Learn more about INIM’s Research Studies: www.nova.edu/nim/research-studies/index.html

  • @matthewosborne7801
    @matthewosborne7801 21 วันที่ผ่านมา

    I have chronic fatigue and so many people are like i have chronic fatigue because im always tired many people dont understand its more then that i get extreme nausea,dizziness,light headed and low immune support many more symptoms as well people just dont get how hard it can be.

  • @Breathe_with_Kashi
    @Breathe_with_Kashi 21 วันที่ผ่านมา

    You are blessed with health wealth and peace ❤ big fan ❤ expected the same thou ❤

  • @Breathe_with_Kashi
    @Breathe_with_Kashi 21 วันที่ผ่านมา

    Serving humanity best ❤ you are blessed with peace, harmony and health forever ❤ big fan ❤ expecting the same ❤

  • @ranm1ac
    @ranm1ac 22 วันที่ผ่านมา

    My wife was experiencing the lack of energy from a very vibrant independent woman to low energy less desire to interact and has now had a stroke. Correlation ?

  • @annahallgren1055
    @annahallgren1055 25 วันที่ผ่านมา

    Sensitivity to light/sound/temperature, etc is also very common symptoms.

  • @stuartgower
    @stuartgower 25 วันที่ผ่านมา

    Thank you, Haylie . Really enjoyed you as a host .your questions, analogies etc. Really enjoyed Dr Aristo Vojdani scientific expertise and gratitude for his deep commitment as an immunologist and desire to design effective, affordable, specific lab tests that identify the many specific immune cells and mediators associated with autoimmune diseases. My question is; my 26 yr old son was diagnosed with long haul covid, thyroid dysregulation, MCAS, and histamine Intolerance; how important is the targeting the destruction of the spike Proteins verse the down regulating the autoimmune cells and mediators in restoring the body to perfect health? Is a hunt, search and deactivate spike proteins through AI drug discovery the wrong approach ? Is not the very presence of spike proteins diffusely seeded in the body causing this hyperimmune state ?

  • @analaurarubio7705
    @analaurarubio7705 29 วันที่ผ่านมา

    Cómo se llama el dr por favor

    • @e.zwegat7130
      @e.zwegat7130 15 วันที่ผ่านมา

      Dr Andrew Campbell

  • @allysonmccormack5529
    @allysonmccormack5529 หลายเดือนก่อน

    Who diagnosed this ? Immunologist? I’ve been seeing big one for potential MCAS with minimal help

  • @rebeccadavis8046
    @rebeccadavis8046 หลายเดือนก่อน

    The Dr can run a light with a camera up in your bladder. The lining of the bladder has a different texture the doctor can tell by doing this.

  • @psd9684
    @psd9684 หลายเดือนก่อน

    Thank you! You can't possibly know how helpful this is! We live in an area where the doctors just brush off patients with ME/CFS.

    • @Truerealism747
      @Truerealism747 28 วันที่ผ่านมา

      Have you got heds with your CFS if so look into mcas

  • @lilyarobles6148
    @lilyarobles6148 หลายเดือนก่อน

    Como se llama el Medico ?

    • @e.zwegat7130
      @e.zwegat7130 15 วันที่ผ่านมา

      Dr Andrew Campbell

  • @renu653
    @renu653 หลายเดือนก่อน

    Genius doctor

  • @RWelsh-ro9gb
    @RWelsh-ro9gb หลายเดือนก่อน

    As to lumping or splitting pt populations, it would help to understand Dr. Richard Horowitz MD's MSIDS, Multi-Systemic Infectious Disease Syndrome questionnaire because it provides a map for teasing out the possible causes and even diagnoses from a pt population with many overlapping symptoms or presentations. He has already thought about this, so it would offer a great jumping off point.

  • @RWelsh-ro9gb
    @RWelsh-ro9gb หลายเดือนก่อน

    Bravo!👏 *Patient Inclusion* as an Ethical Imperative in research and clinical trials from the beginning just makes sense. *Authentic engagement* with people who have lived experience will certainly only strengthen and expedite the process. This also means it's the most efficient way to utilize research dollars.

  • @ThePublicHealthHarlot
    @ThePublicHealthHarlot หลายเดือนก่อน

    Inflammation above and below the neck which is def true.

  • @expotube1
    @expotube1 หลายเดือนก่อน

    8 min mark = chart of symptoms

  • @dollymadeson2151
    @dollymadeson2151 หลายเดือนก่อน

    Wow, that’s disgusting!! 🤮 It doesn’t exist????😢

  • @FreddieAP
    @FreddieAP หลายเดือนก่อน

    Huh. Acute exercise intolerance, I've also seen it called post exertional euro-immune exhaustion... and post-exertional malaise of course.

  • @FreddieAP
    @FreddieAP หลายเดือนก่อน

    Very interesting.

  • @RonaldMarcotte-hs7qn
    @RonaldMarcotte-hs7qn หลายเดือนก่อน

    So the bottom line is you’ve been spending billions of dollars on Gulf War research and never treated one go for veteran while Gulf or Veterans are have miserable lives and her dying from their conditions and VA refuses to compensate them for their conditions.

  • @RonaldMarcotte-hs7qn
    @RonaldMarcotte-hs7qn หลายเดือนก่อน

    I was diagnosed with the Gulf War Illness, chronic fatigue, irritable, bowel sleep apnea all kinds of different issues and October 2000 never been treated to several studies. It’s 2024 and I’m still you know I have chronic fatigue and sleep apnea not being compensated not being treated. I have a TBI injury that Las Vegas VA refuses to treat me for any of these conditions..