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InsideTracker
United States
āđāļāđāļēāļĢāđāļ§āļĄāđāļĄāļ·āđāļ 9 āđāļĄ.āļĒ. 2012
Live healthier longer with a personalized Action Plan, combining data from:
ðĐļ Biomarkers
𧎠DNA
âïļ Wearables
ðĐļ Biomarkers
𧎠DNA
âïļ Wearables
Improvements in Biomarkers in a Digital Health Platform with Dr. Renee Deehan and Nimisha Schneider
In this episode of Longevity by Design, our host Dr. Gil Blander welcomes Dr. Renee Deehan and Nimisha Schneider from InsideTracker to discuss the role of personalized health and the advancements made through data science and artificial intelligence. Dr. Deehan elaborates on her background in molecular biology and how she transitioned to computational biology, emphasizing the importance of integrating large-scale biological data to develop high-resolution molecular models of diseases.
Nimisha Schneider shares her journey from basic immunology research to computational biology, highlighting the significance of building mathematical models to understand biological scenarios better. She explains how InsideTracker uses AI and machine learning to analyze users' blood biomarkers, genetic data, and fitness tracker information to provide personalized health recommendations. The discussion includes the integration of over 7,000 clinical studies into InsideTracker's AI engine, Segterra X, to offer tailored advice based on individual health data.
The conversation dives into the findings from a recently submitted study involving 20,000 users, showing significant improvements in key health markers like LDL cholesterol, A1c, and ApoB over several years. Dr. Deehan and Schneider stress the importance of lifestyle changes and sustained efforts to achieve long-term health benefits. They also discuss the challenges posed by genetic predispositions and how personalized recommendations can help mitigate these risks. The episode concludes with insights into future research directions and the continuous development of personalized health solutions at InsideTracker.
Key Insights
Personalized Health Interventions Show Sustained Improvements
A study involving 20,000 users of InsideTracker demonstrated that personalized health interventions correlate with significant and sustained improvements in key health markers. Users who followed personalized recommendations for nutrition, exercise, and lifestyle changes saw notable reductions in LDL cholesterol, A1c, ApoB, and many other biomarkers related to healthspan. These improvements were observed over several years, indicating the long-term efficacy of personalized health plans. The data suggests that consistent adherence to tailored health recommendations can help manage and even reverse risk factors associated with chronic diseases. This underscores the potential of digital health platforms to drive lasting positive health outcomes.
Genetic Risk Influences Health Outcomes
The study explored the relationship between genetic risk scores and health outcomes, particularly focusing on cholesterol levels and metabolic health. Users with higher genetic risk for high LDL cholesterol, total cholesterol, or Ferritin levels found it more challenging to improve these markers compared to those with lower genetic risk. Despite the genetic predisposition, significant improvements were still achievable with persistent lifestyle changes. This highlights the importance of understanding one's genetic risk as a factor in personal health management and the potential benefits of personalized interventions in overcoming genetic disadvantages. It also emphasizes that genetics is not a definitive determinant, and lifestyle changes can substantially mitigate genetic risks.
Activity Levels Correlate with Health Improvements
Analysis of fitness tracker data revealed that increased physical activity, measured via step count, was a key differentiator between users who successfully improved their health markers and those who did not. On average, users who increased their daily step count to around 11,000 steps showed significant improvements in cholesterol levels. In contrast, those who maintained lower activity levels saw less progress. Additionally, higher quality sleep, particularly increased REM sleep, was associated with better health outcomes. These findings illustrate the critical role of regular physical activity and good sleep hygiene in achieving and sustaining health improvements, providing actionable insights for users looking to optimize their health through lifestyle modifications.
Episode highlights:
Introduction: 00:00:00
What is AI: 00:04:00
What is ML: 00:05:00
What is a foundation model? What is a large language model (LLM): 00:00:08
What are the limitation of LMM in text development: 00:14:00
How LLM is used for health and wellness questions? What InsideTracker developed in this domain: 00:17:00
What is Ask InsideTracker: 00:25:00
What is the difference between Ask InsideTracker and Chat GPT: 00:30:00
What is next for LLM in InsideTracker: 00:36:00
What is the future of LLM generally: 00:42:00
What would you recommend to a person who like to live better and longer: 00:47:00
Nimisha Schneider shares her journey from basic immunology research to computational biology, highlighting the significance of building mathematical models to understand biological scenarios better. She explains how InsideTracker uses AI and machine learning to analyze users' blood biomarkers, genetic data, and fitness tracker information to provide personalized health recommendations. The discussion includes the integration of over 7,000 clinical studies into InsideTracker's AI engine, Segterra X, to offer tailored advice based on individual health data.
The conversation dives into the findings from a recently submitted study involving 20,000 users, showing significant improvements in key health markers like LDL cholesterol, A1c, and ApoB over several years. Dr. Deehan and Schneider stress the importance of lifestyle changes and sustained efforts to achieve long-term health benefits. They also discuss the challenges posed by genetic predispositions and how personalized recommendations can help mitigate these risks. The episode concludes with insights into future research directions and the continuous development of personalized health solutions at InsideTracker.
Key Insights
Personalized Health Interventions Show Sustained Improvements
A study involving 20,000 users of InsideTracker demonstrated that personalized health interventions correlate with significant and sustained improvements in key health markers. Users who followed personalized recommendations for nutrition, exercise, and lifestyle changes saw notable reductions in LDL cholesterol, A1c, ApoB, and many other biomarkers related to healthspan. These improvements were observed over several years, indicating the long-term efficacy of personalized health plans. The data suggests that consistent adherence to tailored health recommendations can help manage and even reverse risk factors associated with chronic diseases. This underscores the potential of digital health platforms to drive lasting positive health outcomes.
Genetic Risk Influences Health Outcomes
The study explored the relationship between genetic risk scores and health outcomes, particularly focusing on cholesterol levels and metabolic health. Users with higher genetic risk for high LDL cholesterol, total cholesterol, or Ferritin levels found it more challenging to improve these markers compared to those with lower genetic risk. Despite the genetic predisposition, significant improvements were still achievable with persistent lifestyle changes. This highlights the importance of understanding one's genetic risk as a factor in personal health management and the potential benefits of personalized interventions in overcoming genetic disadvantages. It also emphasizes that genetics is not a definitive determinant, and lifestyle changes can substantially mitigate genetic risks.
Activity Levels Correlate with Health Improvements
Analysis of fitness tracker data revealed that increased physical activity, measured via step count, was a key differentiator between users who successfully improved their health markers and those who did not. On average, users who increased their daily step count to around 11,000 steps showed significant improvements in cholesterol levels. In contrast, those who maintained lower activity levels saw less progress. Additionally, higher quality sleep, particularly increased REM sleep, was associated with better health outcomes. These findings illustrate the critical role of regular physical activity and good sleep hygiene in achieving and sustaining health improvements, providing actionable insights for users looking to optimize their health through lifestyle modifications.
Episode highlights:
Introduction: 00:00:00
What is AI: 00:04:00
What is ML: 00:05:00
What is a foundation model? What is a large language model (LLM): 00:00:08
What are the limitation of LMM in text development: 00:14:00
How LLM is used for health and wellness questions? What InsideTracker developed in this domain: 00:17:00
What is Ask InsideTracker: 00:25:00
What is the difference between Ask InsideTracker and Chat GPT: 00:30:00
What is next for LLM in InsideTracker: 00:36:00
What is the future of LLM generally: 00:42:00
What would you recommend to a person who like to live better and longer: 00:47:00
āļĄāļļāļĄāļĄāļāļ: 135
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my knowledge is above the future because i have conversations with god
Yes yes yes. ts just so easy. So easy. Ive known for years. Since i waa a child.
Never been
Lee David Wilson David Harris Melissa
I found a soft shell HBOT chamber which reaches 2atm. I can measure pressure via a internal and external gages. I bought my chamber to treat radiation cystitis. I'm 67 and a retired hospitalist - ER physician. Nice to know there are other reasons for using HBOT. Thank you for such a interesting discussion.
I eat a lot of red meat, eggs and butter...my apo levels are fine. BTW - read a book saturated fats are not the problem...the oatmeal that you suggest is the problem.
"To reduce risk of heart disease, eat PUFAs" LOL Love inside tracker. But some of these recommendations are just dangerous.
Regarding the 44m mark on senescent cells and the transformative award.. do these cells eventually die, or do they continue to accumulate? If the latter, do they lack the ability to die because they ignore apoptosis/autophagy signaling, and therefore things like fasting/sauna/cold-plunges have not shown to be helpful?
Thanks, Simon & the channel here for this wealth of info Well done Thanks !
@Insidetracker Can you please share the â25% offâ discount code?
Actually Dr Phinney wrote that bookâĶ.
Just take Niacin at night and you'll wake up in ketosis. Waking up with a sharp mind is the best feeling ever.
Great interview! Strange that only 12 have liked. Me is 13
Being in a fed ketogenic state is our natural state. Ketones are required by our huge brains. Our problem is ketogenesis by the liver is too easily blocked by costantly eating sugars and starches. Your liver will always make all the glucose you need. You do not need to eat any. Any you eat is extra causing a problem of storage and disposal for the body leading to disease and obesity. Your liver will make all the ketones you need too if you let it.
Also blocked by excess protein.
OK. Sorry, Iâm out at 2 minutes, zero relatability
So incorrect were has she been studying under a rock? Theres no essential carbohydrate , carb adapted athletes perform better fasted, fat adapted , carbs are toxic , professor Tim Nokes would desmantel this ladies study
Should have a MD in the discussion.
As a metabolic health practitioner and sports coach some observations if I may: Trials on athletes for intense high level activity use people who are not fully fat adapted so I question the assumption that carbs are required at all. Indeed this has not been my experience. Full adaptation can take several months. For me personally it was 10 months. Increased power to weight ration with no drop off at extreme levels of short or medium activity 2 to 20 minutes. Lipids: High LDL is not detrimental to health apart from small dense or oxidised LDL in healthy people. A high HDL - Triglyceride ratio is. There is no correlation between atherosclerosis and high LDL. On keto, HDL and LDL normalise base on the individuals metabolism. Salt: Those in ketosis do not retain salt due to low insulin levels therfore dietary salt is essential. Ketones via dietary saturated fat are our natural and preferred method for energy supply. Autumn fruits would have historically increased body fat to see us through the winter. Insulin (amongst many other things) is our fat or energy storage hormone. Therefore a low carb high fat diet is optimal for human health. Supplements are unnecessary unless the soil has been depleted in a specific nutrient. Other excellent sources of ketogenic information in addition to Jeff Volk: Peter Brukner, Tim Noakes, Paul Mason, Malcolm Kendrick, Anthony Chaffee, Bart Kay, Stephen Phinney, Eric Westman, Bret Cher, Nadir Ali, Philip Ovadia, Gary Fettke there are many more.
Dan is a breath of fresh air.
My personal experience is that I have better recovery after a long ride after I started on my low carb diet.
and reduced to no DOMS
E-bikes are not healthy. The motor is electric and the cardiovascular system is not stimulated !
Some people argue that ketones are the primary(preferred) energy source for the body and glucose is a secondary source.
Humans need both glucose and ketones.
â@@petercyr3508the body makes all the glucose it needs without having to eat it.
@@petercyr3508 Many Drs and PhDs here say there is no need for carbs in the human diet. I believe they know what they're talking about.
I see doctors referencing research and lowering refined carbohydrates and list insulin sensitivity as number 1 and that does even make it on the list. Then lowering saturated fats.
What happened to the aging ketone discussion? Misleading an waste of time.
Great guest.
Yeah, Rob's great! ð
Save money on transportation and get healthy exercise. Ride a bicycle to school, work or for fun. Cities need to do more to encourage people to ride bicycles. Safe protected bike lanes and trails are needed so adults and children can ride safely. Speak up for bicycles in your community. Bicycles make life and cities better. Ask your local transportation planner and elected officials to support more protected bike lanes and trails. Children should be riding a bicycle to school and not be driven in a minivan. E-bikes are bringing many older adults back to cycling.
Already being done in a small temperate country like the Netherlands.
Not going to happen people hate cyclist I cycle don't own a car it's take a risk everyday here in NZ
Most elderly people have problems getting up off the floor. As a child you spend a lot of time on the floor, adults do not. Doing yoga / stretching exercises on the floor can improve balance, mobility, flexibility and the ability to get up and down.. Just getting up and down to the floor in a controlled manner is difficult for many older adults. Play with your children on the floor. Bend over, get down and pull weeds in your garden. Play with a pet on the floor. The more effort you make to work on balance and flexibility will pay dividends as you age.
I am aged 65 and regularly get smashed into the floor as a full time judo coach. Full carnivore diet and extremely strong, fit healthy. For people with a less active lifestyle I totally agree.
I had to quit metformin bc it made me feel ill.ðĒonly took 500mg/d but terrible side effects.
STOP EATING SHIT AND SCAMMING US
I thought he had a man bun but it's just his chandelier ð
It's crazy how little attention this potentially revolutionary movement is getting. Everyone's obsessed with politics, Ukraine, Gaza etc.
Reading Age Later right now...alas, i cant do caloric restriction bc I'm skinny...lost weight and muscle mass due to chronic fatigue ðĒi'm on hi fat.
ok
They need to moderateâĶ heâs going on and on about the philosophy of overeating, can they reel him in? I kind of want to learn about glp-1âs (lolâĶ) seems like a nice guy tho
Question for Dr. Sinclair: If one eats one meal a day every day. His body adjust to it. After a few months he will not feel hungry. I dont see how body is going to an adversity at that point. Should we eat 3 meal a day occasionally?
well said. words of wisdom.
Go Shalane chase after them dreams
you are sooo smatr
This seems very strange, I use to be obese and then I got into body building, eating massive amounts of protein each day (150 ~ 200 grams) I also started weighing all of my food, to the point of walking around with a scale in my pocket weighing everything before putting it in my mouth. I am currently at a very low body fat percentage, if high protein inhibits weight loss, how am I here? I don't understand.
When mankind had become corrupted in the period preceding the flood, God said: 'My spirit shall not abide in man for ever, for he is flesh; his days shall be a hundred and twenty years' (Gen. 6:3).
The ONLY thing to reverse the aging proces is to heal all fears with selflove.
He does the one meal a day thing. Not sure what I think about that one. Says something about how mice have a similar metabolism to humans....was wondering why mice are always used for testing. The interesting one is salt and aging. I cut salt out of my diet. When I put it back in and it ages the face over night. Sugar and fruit actually make the face look younger: more vibrant. T
Is there a problem if my eye pressure are high.?
You talk non-sense Jamie. Speak as you eat
What about treating anemia with high doses of iron? Is it bad too?
1. Whole grains 2. Greens and garden vegetables 3. Tubers (like sweet potatoes) 4. Nuts (for snacks) 5. Beans Meat up to, 5 times a month Fish 2-3 times a week (very less amount) Few eggs No dairy Drink- water, tea (green/herbal) , wine (little bit)
I agree with her and I bcak this up with my own experience. (An anecdote? Or a case study?) th-cam.com/video/prQ0Kk_hwZQ/w-d-xo.html
Brilliant interview! Thank you for sharing this knowledge, and thank you Dr. Barzilai for your insight!
Thanks, I with 60 kilos weight can I take only 250 mg and obtein results?
You need to get up to date on your saturated fat info.