Biochem Med Tohoku
Biochem Med Tohoku
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細胞死（フェロトーシス）の抗老化作用を発見
東北大学 大学院医学系研究科 生物化学分野の西澤弘成 博士を中心とした研究グループが、Cell Reports誌に発表した研究成果の紹介です。
"BACH1 inhibits senescence, obesity, and short lifespan by ferroptotic FGF21 secretion"
www.cell.com/cell-reports/fulltext/S2211-1247(24)00731-9
フェロトーシスは近年報告された鉄依存性の細胞死で、生体内でがん細胞の除去機構として働くと考えられています。しかし、がん抑制以外にはフェロトーシスの生体内での役割はよく分かっていませんでした。
研究グループは、このフェロトーシス細胞から老化を抑える物質であるFGF21が分泌されることを発見しました。
さらに、フェロトーシス細胞から分泌されるFGF21によって、細胞の老化性変化やマウスの肥満、短命といった老化に関連する特徴が抑えられていることを突き止めました。
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　Nishizawa et al., Cell Reports volume 43, Issue 7, 114403, July 23, 2024 (CC-BY 4.0)
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Anti-Ageing Effects of Ferroptosis induced by BACH16:20Anti-Ageing Effects of Ferroptosis induced by BACH1
Anti-Ageing Effects of Ferroptosis induced by BACH1
มุมมอง 1122 หลายเดือนก่อน
The researchers led by Dr. Hironari Nishizawa at Department of Biochemistry, Tohoku University Graduate School of Medicine have published their findings in "Cell Reports". "BACH1 inhibits senescence, obesity, and short lifespan by ferroptotic FGF21 secretion" www.cell.com/cell-reports/fulltext/S2211-1247(24)00731-9 The group previously found that the BACH1 transcription factor induces ferroptos...
Bach2 and Irf4 ensure class switch recombination in B cells6:05Bach2 and Irf4 ensure class switch recombination in B cells
Bach2 and Irf4 ensure class switch recombination in B cells
มุมมอง 524 หลายเดือนก่อน
The research group led by Dr. Kyoko Ochiai has published their findings in the EMBO Journal. In this study, they found that the transcription factors Bach2 and Irf4 work together to ensure class switch recombination before plasma cell differentiation. In the absence of Bach2, Irf4 activates the plasma cell genes earlier, which leads to precocious plasma cell differentiation skipping class switc...
Fatty acids suppressing pancreatic cancer growth5:01Fatty acids suppressing pancreatic cancer growth
Fatty acids suppressing pancreatic cancer growth
มุมมอง 1115 หลายเดือนก่อน
A research group led by Dr. Yoshiteru Kagawa at the Department of Organ Anatomy, Tohoku University Graduate School of Medicine and Akane Suda, a medical student at the School of Medicine, has published their findings in Scientific Reports. 　Pancreatic cancer is difficult to resect surgically, and chemotherapy with anticancer drugs is a major part of treatment. However, it is often accompanied b...
Ferroptosis regulation by BACH1 (Direct to you from where it is happening vol.1)17:43Ferroptosis regulation by BACH1 (Direct to you from where it is happening vol.1)
Ferroptosis regulation by BACH1 (Direct to you from where it is happening vol.1)
มุมมอง 865 หลายเดือนก่อน
Direct to you from where it is happening seminar series in March 2024. Ferroptosis is a regulated cell death induced by iron-dependent lipid peroxidation. Here, Dr. Kazu Igarashi from Tohoku University, Japan, explains how the transcription factor BACH1 regulates ferroptosis. This mechanism seems important toward new therapeutics as exemplified here with diseases like Parkinson's disease and si...
Mitophagy regulation by heme in erythroid cells (full)4:49Mitophagy regulation by heme in erythroid cells (full)
Mitophagy regulation by heme in erythroid cells (full)
มุมมอง 537 หลายเดือนก่อน
A digest of the publication by Ikeda and Kato et al. in Feb 2023. Red blood cells are unique in that they lack mitochondria and other organelles. However, it is not clear how those organelles are removed during differentiation of red blood cells. Ikeda & Kato et al found that heme, whose synthesis is increased during the differentiation of red blood cells, triggers removal of mitochondria by au...
Mitophagy regulation by heme in erythroid cells (short)1:48Mitophagy regulation by heme in erythroid cells (short)
Mitophagy regulation by heme in erythroid cells (short)
มุมมอง 1137 หลายเดือนก่อน
A short digest of the publication by Ikeda and Kato et al. in Feb 2023. Red blood cells are unique in that they lack mitochondria and other organelles. However, it is not clear how those organelles are removed during differentiation of red blood cells. Ikeda & Kato et al found that heme, whose synthesis is increased during the differentiation of red blood cells, triggers removal of mitochondria...