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Dr Mark Pimentel has concerns regarding the lactobacillus strains and probiotic s for people suffering from IBS/SIBO. Some worrying research on Ecoli Nissle 1917 probiotic emerging as well.

Dr. Daniels, As a retired plant nutritionist who studied and taught growers how to manage the pH of the soil media I found your discussion highly informed, extremely detailed and very helpful and enlightening! Thank you! I will watch ALL your instructional videos and learn more! I understand your point that there have been no known civilizations that were 100% plant based. No argument. However, it is interesting that the well studied Okinawans of the WWII generation with great longevity were found to be about 95-97% plant based, pretty low calorie and definitely low in protein and fat by most any standards. And most notable is the diet record showed they derived 66% of calories from a root vegetable, sweet potato which fits your thesis perfectly. The Okinawan diet raises a question that I have puzzled about for some time. Given that ocean fish now contain a lot of heavy metals and toxins that were not in the fish or water at the higher present day level is there a good reason to include significant quantities of mackerel, sardines, etc today if we can have a reasonably high level of plant protein and avoid certain risks? Or is there a beneficial effect on a particular microbe from the fish that is key to pH and microbiome balance? DHA is always discussed, but confusing. What about TMAO? I beg your pardon if you have covered this in your other lectures and promise I will watch them all and study the details. Oh, one last question? Could you discuss the effects of green tea on an empty stomach unbuffered. There seems to be some cultural wisdom from India that suggests tea should never be taken on an empty stomach. It does seem to have some dramatic effects downstream in some situations, and no doubt there must be some significant effects on the microbiome even in the distal colon. Big money studies obviously suggest tea effects are positive, but your unbiased observations would be greatly appreciated!! Thanks for the great work! There is nothing like it that I have seen in print or online! Congratulations!! Very few in the world that qualify as a true GI Guru, but I have to hand it to you. Dr. Daniels! You have set the standard!

12:20 which issues happen if you only use one prebiotic? some functional medicine specialistis say recommend only acacia fiber as single prebiotic. resistant starch can lead to explosion of bad bacteria. do you agree?

So no to modified citrus pectin?

Seems like total nonsense to me. Different strains can have completely different effects. To categorize all lactobacillus as bad seems like an oversimplification since there is tons of data to show that some are incredibly beneficial. L. Reuteri for instance.

Hi there, may I know if your protocol for autoimmune disease work for rheumatoid arthritis? thank you.

I guess OVER-use of anything should be discouraged. However I stay firmly by my sauerkraut (home-made); at least 2 table-spoons every other day as a salad to my dinner plate brings me to a near orgasm, so I can't imagine it's bad for my body... Same goes for kefir, BUT NOT TOGETHER WITH SAUERKRAUT!!!

I went off the lacto probiotics and take just a bifido probiotic as you advised and my gut is so calm now

Are dried apples OK?

Everything you say makes sense, but I follow two of your protocols I bought into it, and I got worse taking the prebiotic shakes for the Akkermansia. My diarrhoea was worse and I was more toxic than ever now in another video. I seen you mention not to take the inulin if you have diarrhoea I thought your program would account for this anyhow, I’m back to square one because your protocol did not work for me I tried it for 10 days. Not sure if I should keep going, but I was in a lot of pain. My postmeal perennial blood sugar spiked more than before and the LPS was affecting my brain and nerve damage. Just getting worse after your program everything you say makes complete sense but when I tried it for 10 days straight, and every symptom got worse not sure where to go from here, but I am taking the sporre from megaspore biotic that seems to be good for me, but in another video, you mentioned that sports don’t work whatsoever I’m quite confused and not sure if I could keep taking the pre-biotics along with the Akkermansia because my situation seem to have gotten worse

This guy is abusive toward his audience

Hi and thanks from Germany. Where to get F. prausnitzii from? Am eating fresh things from my garden such as Yacon (Smallanthus sonchifolius) which has inulin. As a retired graduated biologist and professional horticulturalist I do my own experiments mainly in plant production.

Guy needs to be more popular! Influence people in a good way

Subscribed, greetings and thanks from a biologist living in Germany. Am growing yacon (Smallanthus sonchifolius) which is rich in inulin/fructooligosaccharides in my garden. Started different ways of fermentation of yacon tubers, even in Sauerkraut style. Plants have their own fascinating microbiomes: Some living in the rhizosphere and even inside the plant as endophytes, yes even inside things like apple seeds to promote the future seedling. Planning to produce joghurt with milk, yacon and specific bacteria. Am having a joghurt machine which controls temperature fluctuations. Please, do you have recommendations which bacteria to use? There is some inspiration from Dr. Davies book.

Just want to thank you for doing what you do!

Yes but how do we fix our guts?

My suspicion is that the reason Bifidobacterium and Lactobacillus strains are high in people with IBS is that people with IBS are very likely to take a probiotic. This would fit well with the research showing supplementation of those can help manage IBS symptoms. It may very well be the case that those strains are beneficial and can improve symptoms, while also being the case that if you actually want to cure your dysbiosis you need to increase strains like F. prau and reduce the pathogenic overgrowth ones.

I didn't see fermented foods addressed. Kimchi, sauerkraut, miso, natto, tempeh, Kefir and cheeses like parmesan reggiano (and maybe Gouda, Emmental, Gruyere, Roqueforte, especially those made with raw milk) have all been shown to have beneficial effects on the gut microbiome, at least in small limited studies, and the research wasn't funded by entities with a conflict of interest either. If most the beneficial bacterial in the gut cannot survive outside of the gut, where do they come from?

Probably not great that a test showed I was below the detectable limit for Faecalibacterium prausnitzii

Have you ever looked at the recent studies on glioblastoma and the gut microbiome? I have GBM; that's why I'm interested.

Great podcast. I've been taking probiotics for over a year now and they've made no difference whatsoever. A complete waste of money.

You said, more often than not! Often times! I’ve listen to scientists whose expertise is gut health! As well as functional medicine physicians. I plain yogurt Greek yogurt and kimchi everyday. As well as vegetables to feed my good gut bacteria and will continue to do so…

Yeah but i have low good bacteria and also dont tolerate fermented foods. Stool analysis shows: Bacteroides species 2 x 10^9 KBE/g stool1x10^9 - 9x10^11 Bifidobacterium species 2 x 10^9 KBE/g stool 1x10^9 - 9x10^11 Lactobacillus species <1 x 10^5 KBE/g stool 1x10^5 - 9x10^7 Enterococcus species 3 x 10^6 KBE/g stool 1x10^6 - 9x10^7 Lactulose breath tests shows excess methane, hydrogen is not suspicious. methanobrevibacter smithii wasnt tested in stool but is probably there in excess or there wouldnt be excess methane.

I listened to this lecture probably on average 4-5 times what with starting and rewinding to re listen to interesting sections (essentially every single part of this amazing lecture). I am subscribed and I’m going to buy some of your protocols. The naturopathic world of natural medicine has been waiting for this breakthrough for some years. I have had to rewind my assumptions about lactobacillus. A difficult but necessary journey.

What are your credentials? I didn't see them on your website.

Sachromyleces boulardii?

What abt akermansia

I'm sold, I have bloating, perhaps SIBO, and probiotics make my condition worse, the problem I have now is how to avoid them.

So what is the alternative treatment. If that was mentioned I missed it.

I have watched many of your videos. I agree that probiotics and fermented foods haven't worked for me. In none of these presentations have I found an applicable approach to making things better for me.

are you familiar with bacilis subtilis from Japanese fermented natto and do you have any data on that regarding its effect on the microbiome?

Awesome, thank you

Thank you for the interesting video. I'm still not convinced (yet) about causation based on this alone. A few things I'd like to say: 1) You mentioned cross-feeding from akkermansia to prausnitzii, but some of your slides clearly show scenarios where prausnitzii is beneficial (all green), but akkermansia is detrimental (all orange). 2) There are different types of inulin: chicory, j-artichoke, b-agave, etc. They are all different molecules. Which one is most beneficial and why? 3) Prebiotics shouldn't be necessary anyway, as our bodies produce their own prebiotics. If our bodies own prebiotics, evolved over many millennia, can't fix the dysbiosis, then there's likely a deeper root cause behind the dysbiosis. 4) Do you think that there is too much oxygen in the gut causing this dysbiosis, and if so, what is causing the high oxygen levels?

"Probiotics", "microbiome" etc. - Just more silly stories to sell NON food and poisonous supplements to dumb people.

Wow so all the folks I follow for peri/menopause issues all suggest fermented foods and I make a reuteri yogurt Actually love it. 😮🤔what is a lady to do???

Fermented foods ..yogurt. Included...is heast like. ...and let the candida overgrowth..in the Stomac.....

my smallish screen so l can not read much of those small letters

So random question here. Do these fermented foods not convert to glucose once ingested? If so, can they then not create more issues, as sugar would, for someone with damaged stomach/intestine tissues?

'There are Lies then there are damned lies then there are Statistics.' Stats and data used for inferring or criticism can be a motherlode of all lies. Many have benefitted by many i mean in millions with yoghurt, kefir, and many other fermented products. It cant be a lie so something else must be..

Kefir fixed my horrible histamine sensitivity. I couldnt eat any other fermented foods now i can. Its about type of bacteria in there, proper balance of vitamins B production. If i would drink enriched kefir my fingers would become blue. Because plain kefir has antihistamine bacteria while other fermented things have prohistamine ones but proper ones let body calm down and turn back off sensitivity genes.

So what are the quantities of oats we need to consume that will achieve 3 grams of beta-glucan?

Do I see a product placement in future videos?

A correlational presence of Bifidobacteria and Lactobacillus in the diseases you cited does not indicate that they are causative or even accelerative of those conditions. It could just be that they are hardier than other bacteria and are thus likelier to survive upon the intake of antibiotics or antacids. I say this owing to the benefits these strains are known to bring from a trove of research and anecdotes. E Coli is the opposite, where research and anecdotes attest to its harm. As you said, these are anaerobic strains, so are viable and easy to sell. Maybe this is the whole point, that they are nature's solution to dysbiosis. They are administered into the gut and remain there for a transient period in which they wipe out the actual pathobionts and relieve dysbiosis. Then, the beneficial aerobic species you cited have the latitude to return to healthy levels. In an ideal world, the beneficial aerobic bacteria would be easily accessible and affordable, but that is not the case, while I highly doubt that nature is letting us down, so I truly believe that Bifidobacteria Lactobacillus, as well as Bacilis, Saccharomyces and Akkermansia, are the keys to restoring good gut health. Fibres and prebiotics are impossible in cases of dysbiosis, hence why the carnivore diet sees so much success in healing people's guts. Thank you for sharing your perspective and serving to improve my understanding of the gut microbiome.

This is an angry comment. My lactobacillus made me do it!

A lot of what you say in this presentation sounds plausible - but there is a really serious problem with it. You say that your position is justified by the data and you purport to present that data to us - but unfortunately you really don't do so in any scientifically credible way. For example right now I'm looking at your graphs where you have orange and green sections on what appear to be histograms above various conditions, and you tell us that this shows that, for example, Roseburia is beneficial whereas Enterococcus is associated with ill health. But, the problem is you never really explain what that graph is showing, where the figures come from or what the statistical significance of them is. In short, whilst it looks, visually, like convincing data it actually doesn't really make any sense. Take, the case of covid. First off one can wonder what the height graph over covid is supposed to represent. You give some units on the left hand side but there is no legend to explain what those units are. We are supposed to assume that they mean something since you have different heights above different conditions, but you don't actually say what they signify. Secondly, you divide the graph into two sections. Where does this division into two sections come from? In particular what does the green section actually represent? You don't really explain it at all, just tell us that having a big green section is good, and having a big orange section is bad - but you could do a much better job explaining what those sections actually mean and where the data that they're based on comes from. I'm certainly open to the idea that your argument is a good one, and I certainly think that there is a very strong case to be made that prebiotics represent a much better approach to modifying the gut biome than probiotics, but without a better presentation of the data, I just can't say that you really make the case at all.

I like the information, what is the connection everyone tells specific Lactobacillus strain for vaginal health and recurrent UTl?

I had really bad 'IBS" for six years nothing helped. then I had some investigations and found out my issue was inflammatory kind of gut problems - erosions and ulcers - particularly at distal end of small intestine but everywhere. About twenty erosioned areas - and loss of villi that were not related to celiac apparently. Anyway, then COVID hit and I couldn't follow up with more biopsies, I had what looked like Crohn's but came back negative for the faecal test. So delays doing further 'balloon' scope with biopsy. I had a camera pill, colonoscoppy and endoscopy. anyway, when covid restrictions relaxed and I had to have another procedure, due to bone infection risk (dental) was put on antibiotics and guess what. All my gut issues were fixed in literally three days - pain and bloating gone, soon after I found I could eat anything - never looked back. that was in 2020. I can demolish any fruit/veg/nut/legume without any bloating. Of course meats were never an issue. Lived on m eat and milk instead of the liquid meal replacement I was prescribed at one stage - sugar and seed oil not good.

How can you praise F prau so much and fail to know that B coagulants is one of the most effective way to increase it. Yes spore probiotics aren't on the charts but who cares we know when people take certain spore bacteria, other bacteria go up. This effect is useful and not utilizing it is not smart.

Would love a discussion with you and Dr. Davis.

You have 0 data that shows lactobacillus ruiteri as being non effective. There is tons of data showing its incredible effects