That "ah ha!" Moment when you understand what it's called conjugated. Your literally bonding it too something to make it big enough to work with the receptors. Well explained. Thank you!
Great way of learning. But a bit confused with the reason of conjugation. As far as I know "conjugate vaccine" is used to activate B cells by T cells (since only polysaccharides/sugar moieties cannot induce a durable response due to T cells independency). So, in the conjugate vaccine, a polysaccharide is attached to a protein part (since protein is recognized by T cells). Hence, a long-lasting memory response is possible due to conjugation of the polysaccharide.
Riham Khlifi Tallaki isn't it astonishing that most of our university professors suck, and yet we pay huge money to get to the universities? The system is rigged
sonia arora hemophilus influenza type b is a good example I know of. The antigenic epitope is the polysaccharide capsule of the bacteria (not the bacteria itself) which is not enough for virulence. Now polysaccharide antigens are not good enough to trigger a T helper cell mediated response, which means no immunologic memory. This means the vaccine would trigger A B-Cell mediated IgM response which is short lived. To fill this gap, the polysaccharide capsule is conjugated to a protein which would now trigger a T-cell mediated response and isotytpe switching to IgG resulting in memory. This probably is the entire point of creating conjugated vaccines (inducing memory to provide long term effective immunity)
That "ah ha!" Moment when you understand what it's called conjugated. Your literally bonding it too something to make it big enough to work with the receptors.
Well explained. Thank you!
You're welcome. Glad to hear that you're getting benefit from my lectures
you want to develop protective antibodies against the polysaccharide part of the bacteria not the protein component...
I used to watch your videos when I was in 12,now I'm a final year mbbs student
Man I am going older! 🤔. Thank you for supporting all these years
Great way of learning. But a bit confused with the reason of conjugation. As far as I know "conjugate vaccine" is used to activate B cells by T cells (since only polysaccharides/sugar moieties cannot induce a durable response due to T cells independency). So, in the conjugate vaccine, a polysaccharide is attached to a protein part (since protein is recognized by T cells). Hence, a long-lasting memory response is possible due to conjugation of the polysaccharide.
I watched many of you videos and I have to say you explain things much better than most of my uni lecturers. keep it up.
Riham Khlifi Tallaki isn't it astonishing that most of our university professors suck, and yet we pay huge money to get to the universities? The system is rigged
you forgot the subunit vaccine
Good job, but one thing is not clear that how these conjugated vaccines are avirulent?
sonia arora hemophilus influenza type b is a good example I know of. The antigenic epitope is the polysaccharide capsule of the bacteria (not the bacteria itself) which is not enough for virulence.
Now polysaccharide antigens are not good enough to trigger a T helper cell mediated response, which means no immunologic memory. This means the vaccine would trigger A B-Cell mediated IgM response which is short lived. To fill this gap, the polysaccharide capsule is conjugated to a protein which would now trigger a T-cell mediated response and isotytpe switching to IgG resulting in memory.
This probably is the entire point of creating conjugated vaccines (inducing memory to provide long term effective immunity)
Can u explain standardision vaccines
Very simply Great explaination
You're welcome
Good job and keep it up!
Nice explanation..Thank you
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This video was helpful
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Conjugated means hapten?
Yes hapten and carrier molecules used together
Ok thank you sir
THANK YOU SO MUCH SIR
You're welcome
Suman,Great work..Any example of Conjugated Vaccine !!
Pooja Vijaygopal hemophilus influenza type b vaccine
thank you so much!
Thank u
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Sir pls help me pls make video i. Hindi
TNK u sir
You're welcome
Sir pls make in hindi
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